Background: Research of histo and cytometry in comparative healthy and pathological condition is not so much in our country. Therefore, it is making a demand to do stereometrical research study on tissues, cells and nucleus.Goal: To study and to determine stereometrical indices, mathematic model of hepatocytes and nucleus in condition of comparatively healthy, acute intoxication, chronic inflammation and cancer of Mongolians.Materials and Methods: It was prepared sections for histometric materials. Linear measurements of hepatocytes and nucleus were carried out by computer-microscope “Leica” with program Diskus 3.2 version from German. On linear measurement in condition of comparatively healthy, acute intoxication, chronic inflammation and cancer were processed by mathematic modeling.Results: Volume distribution of hepatocyte’s cytoplasm χ2st=15.51>χ2 F=4.31; (P<0.001), and hepatocyte’s nucleus χ2 st=12.59>χ2 F=10.74 in comparatively healthy (normal) conditions pursues normal distribution formula, however, the volume of hepatocyte’s cytoplasm and nucleus follows Maxwell formula of abnormal distribution χ2 st=23.68>χ2 F=10.44; (P<0.001), χ2 st=15.51>χ2 F=6.90; (P<0.001) in a condition of acute intoxication and volume of hepatocyte’s cytoplasm and nucleus χ2 st=23.68>χ2 F=8.03; (P<0.001), χ2 st=15.51>χ2 F=4.32; (P<0.001) in a condition of chronic inflammation. And volume distribution of hepatocyte’s cytoplasm χ2 st=8.27>χ2F=19.68; (P<0.001), and hepatocyte’s nucleus χ2st=3.41>χ2F=3.82 incondition of cancer. There is no statistically significant difference (P<0.001) between observation and theoretical frequencies of average values of hepatocyte’s cytoplasm and nucleus volume, which confirms that the result is true and accurate.Conclusions:1. Volume of hepatocyte’s cytoplasm is 2184.18±36.98 mkm3 in comparatively healthy (normal) conditions, 4153.17±84.18 mkm3 in a condition of acute intoxication, 4887.84±75.51 mkm3 in a condition of chronic inflammation and 13143.88±4.29 mkm3 in a cancer condition. Volume of nucleus is 299.94±36.98 mkm3 in comparatively healthy (normal) conditions, 873.59±13.86 mkm3 in a condition of acute intoxication, 888.65±13.51 mkm3 in a condition of chronic inflammation and 2924.57±2.12 mkm3 in a cancer condition.2. Volume of hepatocyte’s cytoplasm was increased 2 times, volume of hepatocyte’s nucleus was increased 3 times in a condition of acute intoxication and volume of hepatocyte’s cytoplasm was increased 2.2 times, volume of hepatocyte’s nucleus was increased 2.9 times (P< 0.001) in a condition of chronic inflammation. However volume of hepatocyte’s cytoplasm was increased 6.5 times, volume of hepatocyte’s nucleus was increased 9.7 times in a condition of cancer.

Background: Cigarette smoking is known to reduce appetite and body weight. This effect is mainly mediated by nicotine. Quit smoking without nicotine replacement therapy often result in increased body weight. Even though number of studies explored different levels of effects of smoking, there are few studies which address short-term effect of smoking on metabolism. Aim: To study short-term effect of smoking on appetite, body weight and blood glucose level of mice (Experimental animal) Objectives:
- To study effect of smoking on appetite
- To study effect of smoking on body weight
- To study effect of smoking on blood glucose and anxiety Methods: Inbred strain, Balb/c mice (n=20) were used. Mice were divided into two groups control (n=7) and treatment (n=9) group. Smoking treatment conducted in 5 days consequently in treatment group, three times a day with cigarette smoke. During experiment both control and treatment groups were monitored for food intake, water intake, body weight. In the end of the experiment blood glucose and anxiety levels were measured. In addition, liver, white adipose tissue and brown adipose issue were sampled comparison. Results: Short-term (5 days) treatment of smoking of treatment group result in significant difference in food and water intake (p<0.05) as well as tendency to lowering blood glucose and reduction of mesenterial, perirenal, epidydimal, white adipose tissues and brown adipose revealed tendency to reduction of mesenterial white adipose with control group. (Mes. White adipose tissue weights 0.44g in control group, 0.23g in treatment group). There was not significant difference in blood glucose test and anxiety test evaluated by time spent on alleys and transition between alleys in two groups. Conclusion
1. Cigarette smoking significantly reduced food and water intake in mice (or experimental animal).
2. Smoking didn’t affect body weight, but inhibited normal body weight gain.
3. Short-term treatment of smoking was not enough to change blood glucose level and anxiety behavior of mice.