PURPOSE: To describe HRCT findings in five patients with pathologically proved acute interstitial pneumonia MATERIALS AND METHODS: This study included 5 patients with pathological and clinical diagnosis of acute interstitial pneumonia. Mean age of the patients was 40(range, 31-53 years). CT scans were reviewed by two chest radiologists retrospectively. CT scans were assessed for the presence and distribution of ground-glass attenuation, air-space consolidation, interlobular septal thickening, honeycombing, and pleural effusion. RESULTS: The area of ground-glass attenuation and air-space consolidation were seen at HRCT in all 5 patients. These lesions were distributed diffusely in both lungs, but involved predominantly subpleural lungs in 2 patients and posterior lungs in 3 patients. Three patients had mild interlobular septal thickening. None of them showed honeycombing. Three of the 5 patients died within 52 days of initial manifestation. CONCLUSION: Acute interstitial pneumonia differs from the more chronic form of idiopathic interstitial pneumonia in their HRCT findings.
Diagnosis ; Humans ; Idiopathic Interstitial Pneumonias ; Lung ; Lung Diseases, Interstitial* ; Pleural Effusion ; Retrospective Studies ; Thorax ; Tomography, X-Ray Computed

Bites and Stings ; Bone Screws ; Humans ; Lip ; Mandible ; Mastication ; Orthodontics ; Osteogenesis, Distraction ; Osteotomy ; Tooth ; Tooth Mobility ; Walking

PURPOSE: To determine the CT factors which predict positive results of bronchoscopic biopsy in cases of lung cancer with CT-bronchus sign. MATERIALS AND METHODS: In 30 patients who on CT showed a lung mass with CT-bronchus sign and who had undergone bronchoscopic biopsy, lung cancer was confirmed histopathologically and/or clinically. The CT findings were evaluated for the location, nature and size of the mass, and the type of CT-bronchus sign, and the diagnostic rate of bronchoscopic biopsy and of CT findings was compared. RESULTS: Seventeen of 30 patients (56.7%) were diagnosed by bronchoscopic biopsy and their diagnostic rates according to the location were as follows: 100% (10/10) in cases involving the lobar bronchus; 60% (6/10) in cases involving the proximal segmental bronchus and 10% (1/10) in cases involving the distal segmental bronchus. In 20 cases of peripheral lung cancer, 16.7% (1/6) of masses with less than 3cm in diameter, 44.4% (4/9) of masses with more than 3cm and less than 6cm, and 40.0% (2/5) of masses with more than 6cm were diagnosed bronchoscopically. In addition, 57.1% (4/7) of cases with abrupt bronchial obstruction, 33.3% (3/9) with a patent bronchus within the mass, 0% (0/3) with bronchial displacement or a marginally located bronchus and 0% (0/1) with tapered bronchial obstruction were diagnosed on bronchoscopic biopsy. One of two cases with perilesional lymphangitic spread and two of four cases with a large cavity were diagnosed bronchoscopically. CONCLUSION: In cases of lung cancer, bronchoscopic biopsy is a useful initial diagnostic method where the mass is located in 1cm proximal to segmental bronchial bifurcation and is more than 3cm in diameter, there is CT-bronchus sign with abrupt bronchial obstruction or a patent bronchus within the mass, and associated perilesional lymphangitic spread or large air-cavity. In most cases where there is peripheral lung mass less than 3cm in diameter, however, bronchoscopic biopsy alone is not adequate, and the use of a further diagnostic modality is required.
Biopsy* ; Bronchi ; Humans ; Lung Neoplasms* ; Lung*

BACKGROUND: Hepatitis B virus(HBV) DNA integration is one of the cause of hepatocellular carcinoma (HCC). Epidemiologic evidences indicate that HBV infection is associated with the high risk of development of HCC. We wanted to evaluate the HBV DNA integration in hepatocellular carcinoma. So we detected HBV DNA by PCR in aseptically obtained 37 HCC tissues. METHODS: A total 37 surgical specimens from HCC patients were evaluated. Patient's serologic findings were analyzed retrospectively. Serologic markers were tested by radioimmunoassay. Genomic DNA was extracted from HCC paraffin blocks by microwave oven method. PGR was done. RESULTS: The sensitivity of HBV DNA PCR was 100 fg. Among 37 Patients tested, 30 cases of HCC patients had HBV DNA in their liver tissue. Among 25 HBs Ag positive patients, 23 had PCR positive results. All of the anti-HBc positive patients had HBV DNA. CONCLUSIONS: These findings are highly suggestive of HBV infection in the development of hepatocellular carcinoma. Detection of HBV DNA in patients with hepatocellular carcinoma is highly suggestive of HBV infection in the development of hepatocellular carcinoma.
Carcinoma, Hepatocellular* ; DNA ; Hepatitis B virus* ; Hepatitis B* ; Hepatitis* ; Humans ; Liver ; Microwaves ; Paraffin ; Polymerase Chain Reaction* ; Radioimmunoassay ; Retrospective Studies

No abstract available.
Adult* ; Femur* ; Humans

The object of this study was to evaluate how friction that occurs during the sliding movement of an orthodontic archwire through orthodontic brackets is differently affected by variant designs and ingredients of brackets and archwires and bracket-archwire angles. In order to simulate the situations which could occur during orthodontic treatment with fixed appliances, 4 types of brackets (Gemini(R), a stainless steel twin bracket; Mini Uni-Twin(R), a stainless steel bracket with a single bracket design and narrow mesio-distal width; Clarity(R), a metal-reinforced ceramic bracket; Transcend(R), a ceramic bracket) and 3 types of orthodontic archwires (0.016", 0.016 x 0.022" stainless steel, 0.016" Nitinol) were used and the bracket-archwire angles were controlled as 0 degrees, 3 degrees, 6 degrees, and 9 degrees, Gemini(R) significantly showed the lowest static and kinetic frictions (P < 0.001). Clarity showed the highest static and kinetic frictions with a bracket-archwire angle of 0 degrees, and Transcend at 6 degrees and 9 degrees (P < 0.001). An 0.016 x 0.022" stainless steel rectangular archwire significantly showed the highest static and kinetic frictions (P < 0.01). The lowest static and kinetic frictions were observed when the bracket-archwire angles were 0 degrees and 3 degrees with 0.016" stainless steel round archwires (P < 0.01), and 6 degrees and 9 degrees with 0.016 Nitinol (P < 0.001). The static and kinetic frictions were increased as the bracket-archwire angles were increased (P < 0.001).
Ceramics ; Friction* ; Humans ; Orthodontic Brackets* ; Stainless Steel

Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, is a rare idiopathic histiocytosis that most commonly involves the cervical lymph nodes, Extranodal involvement occurs in 30- 40% of cases, most often in the head and neck. Characteristic histological findings include emperiopolesis (intracellular engulfment) of lymphocytes and S-100 protein positivity. Treatment of Rosai-Dorfman disease is unnecessary unless the disorder becomes life-threatening, since the disease will resolve spontaneously in most patients. We experienced a case of extranodal RDD at the nasal cavity as the initial lesion prior its nodal involvement. The patient was a 18-year-old woman who complained of nasal obstruction for 4 years and had a submandibular mass that persisted during the last 3 months. Histologically, all specimens taken from the left nasal cavity, the left submandibular mass and the left upper jugular lymph node showed heavy infiltration of plasma cells, lymphocytes and sheets of macrophages with abundant pale cytoplasm which replaced the existing organ architecture.
Adolescent ; Cytoplasm ; Female ; Head ; Histiocytosis ; Histiocytosis, Sinus* ; Humans ; Lymph Nodes ; Lymphocytes ; Macrophages ; Nasal Cavity* ; Nasal Obstruction ; Neck ; Plasma Cells ; S100 Proteins ; Salivary Glands*

PURPOSE: To search for CT findings which helpfully differentiate mucinous from nonmucinousbronchi-oloalveolar carcinoma and to assess the difference in stages between the two types of tumors. Twenty-two patients with pathologically proven bronchioloalveolar carcinoma (BAC) were included inthis study. On the basis of CT findings, tumors were classified as either solitary or multiple and as eithermass/nodule, consolidation, or mixed type. CT stages of the tumors were determined by two radiologists andconclusions were reached by consensus. RESULTS: Twelve patients had nonmucinous BACs and ten had mucinous BACs.Among the ten cases of mucinous BAC, six were solitary and four were multiple. These were mass/nodule (n=3),consolidation (n=5), and mixed pattern (n=2). In contrast, among the twelve cases of nonmucinous BAC, six weresolitary and six were multiple. All were mass/nodule, except for one mixed type. Among the mucinous BACs, threewere operable and seven (above stage IIIa) were inoperable. Among the nonmucinous BACs, four were operable andeight were inoperable. CONCLUSION: Consolidation was more common in mucinous BAC and mass/nodule was more commonin non-mucinous BAC (p<0.05). There was no difference in tumor stages between mucinous and nonmucinous types ofBAC (p>0.05).
Adenocarcinoma, Bronchiolo-Alveolar ; Consensus ; Humans ; Mucins*

Sorafenib is an oral multikinase inhibitor with clinical activity against hepatocellular carcinoma (HCC) and renal cell carcinoma. Administration of sorafenib carries a variety of adverse cutaneous reactions. Common adverse effects induced by sorafenib include hand-foot skin reactions, facial erythema, splinter subungual hemorrhage, and alopecia. Although erythema multiforme (EM) related to sorafenib has been reported, delayed-type cutaneous hypersensitivity reactions are rare in patients treated with sorafenib and there has been no case of Stevens-Johnson syndrome (SJS) reported so far. We recently experienced 3 cases of delayed-type cutaneous hypersensitivity related to administration of sorafenib. The first case was a 47-year female had targetoid erythematous rashes on her arms 12 days after starting sorafenib for HCC. The rashes spread from the arms to the trunk rapidly except for the hands and feet, and erosive lesions developed in the oral mucosa and lips. She was diagnosed as SJS. The second case was an 81-year-old male had maculopapular eruptions with multiple targetoid lesions on the trunk, arms, and legs 10 days after starting sorafenib for his HCC. There was no evidence of mucosal involvement. He was diagnosed with EM. The last one was a 20-year-old female developed generalized maculopapular eruptions in the whole body 10 days after starting sorafenib for the treatment of HCC. All 3 patients completely recovered after discontinuation of sorafenib.
Aged, 80 and over ; Alopecia ; Arm ; Carcinoma, Hepatocellular ; Carcinoma, Renal Cell ; Erythema ; Erythema Multiforme ; Exanthema ; Female ; Foot ; Hand ; Hemorrhage ; Humans ; Hypersensitivity* ; Hypersensitivity, Delayed ; Leg ; Lip ; Male ; Mouth Mucosa ; Skin ; Stevens-Johnson Syndrome ; Young Adult

We performed thoracoscopic resection for diagnosis in a 41 year-old-female presenting with multiple pulmonary nodules in both lung fields, which was detected incidentally on routine chest x-ray and followed by additional exmaminations including chest CT scan and percutaneous needle aspiration biopsy under the presumptive diagnosis of metastatic cancer. During thoracoscopy, the result of the frozen section analysis of multiple masses revealed strong evidence of leiomyoma. In her past medical history, she had undergone myomectomy, and hysterectomy, 7 years ago and 10 years ago, respectively. Based on permanent, special staining of specimen, estrogen receptor assay and review of past specimen of uterine myoma, the final diagnosis was benign metastasizing leiomyomata from uterine myoma, the report was very uncommon in Korean and English literatures. The patient has been followed up for 2 years without special therapy, such as hormonal therapy.
Biopsy, Needle ; Diagnosis ; Estrogens ; Frozen Sections ; Humans ; Hysterectomy ; Leiomyoma* ; Lung Neoplasms ; Lung* ; Multiple Pulmonary Nodules ; Needles ; Thoracoscopy ; Thorax ; Tomography, X-Ray Computed