1.LEGAL REGULATIONS DEVELOPMENT ISSUES OF EUTHANASIA
Sugarmaa A ; Byambaa J ; Tserenbat M
Innovation 2017;11(3):20-23
Although the Health Law of Mongolia and other legal acts do not prohibit euthanasia and patient hasa rightto refuse treatment. But on the opposite side the criminal law prohibition is still valid by the explanation of Supreme court of Mongolia.
If doctors do euthanasia with patients or their loved ones, then doctors have a risk to suits with the sanction of imprisonment for 10-15 years, according to the 2002 Mongolian criminal law’s code 91.1 and it is considered as crime. The Supreme Court interpretation states that doctor must be judged by 91.1 if he/she does euthanasia with the permission of the victim. Legal practitioners of environmental health officers and the lack of action identified for families and patients of consumer awareness, attitude is the basis of our research. The aim of the study is to determine legal knowledge and the attitude of the medical staffs, caregivers of medical clients and palliative patient. This is because in order to achieve integrated understanding of medical and law sciences issues is required in this area of specific research.
2.Validation of lubben social network scale (lsns-18) with older adults in Mongolia
Mongolian Medical Sciences 2013;164(2):42-49
Background: Standardized instruments are needed for rigorous research, quality clinical practice and informed policy-making. In Mongolia, a confluence of current social, demographic and geographic factors augment the need for reliable means to assess social isolation among older adults. This study aims to identify, translate and validate such a measure. Method: We conducted the study in two phases. We first selected the 18-item Lubben Social Network Scale and followed Brislin’s 6-step model to translate the instrument from English to Mongolian. The second phase involved psychometric testing of the Mongolian version (LSNS-18-M). We recruited 198 Mongolians aged ≥ 55 years from six hospitals in Ulaanbaatar. All participants also completed the SF-12; the 15-item Geriatric Depression Scale; and measures of objective and subjective Social Isolation’ of these, 27 completed a re-test of the LSNS-18-M.Results: The LSNS-18-M showed strong psychometric properties. Cronbach alpha coefficients were high for the overall scale (0.89) and for family (0.85), friend (0.91) and neighbor (0.89) subscales. Infraclass correlation coefficients for the total scale (0.99) and family (0.99), friend (0.98) and neighbor (0.99) subscales were also high in the test-retest subsample. With respect to convergent validity, LSNS-18-M scores were inversely related to Social Disconnectedness (r=-0.55, p<0.001)and Perceived Isolation (r=-0.65, p<0.001) and with the GDS-15 (r=-0.31, p<0.001). Although not related to either subscale of the SF-12, the LSNS-M-18 was inversely associated with self-rated health status (r=-0.27, p<0.01). Mean LSNS-18-M scores successfully differentiated three levels of Social Disconnectedness and three levels of Perceived Isolation, indicating good discriminate validity.Finally, content validity was good. Items on the LSNS-18-M loaded cleanly on the same three factors as the original LSNS-18. Inter-factor correlations ranged from 0.23 to 0.77, all three factors correlated with total LSNS-18-M scores at p<0.001, and together they accounted for the majority of variance in total LSNS-18 scores.Conclusion: The LSNS-18-M has excellent reliability and satisfactory validity and holds significant promise for assessing social isolation among older adults in Mongolia.
3.Evaluation on implementation of preventive activities of non-communicable diseases
Enkhzul T ; Sugarmaa M ; Amarsaikhan D ; Delgermaa V
Mongolian Medical Sciences 2013;166(4):44-47
Background: Mongolia is one of the most influenced countries by non-communicable diseases among developing countries. Non-communicable diseases, including cardiovascular diseases, cancers, respiratory diseases, diabetes, and injuries have become the major causes of morbidity and mortality in Mongolia.Goal: To assess impact of preventive intervention activities of non-communicable diseases in framework of the Millennium challenge account (MCA) health projectMethods: We conducted 17 focus group discussions (FGD) from March to April 2013 in primary and secondary health care settings, of which six in urban and eleven in rural areas.We identified themes concerning the current situation of NCD related health services from the perspective of health professionals, and insights into institutional and professional experiences related to management, implementation and coordination of the newly implemented MCA-Mongolia NCD prevention and control project.Results: As a result of the health project, NCD related knowledge and skills of health professionals have improved through progressive training, and development of guidelines and manuals. During the project, availability of equipment supplies has improved. Accordingly, medical equipment and laboratory reagents needed for early detection of NCDs were provided to primary and secondary health care settings, despite some challenges in the implementation of the project. As result of theproject implementation, increased public awareness on NCDs, and attitude change were considered as the biggest changes.Conclusion: The health project was considered as successful to provide knowledge on the best practice in NCD prevention.
4.Health and Social Work Activities of the Russian Orthodox Church in Buryatia
Mongolian Medical Sciences 2018;186(4):57-59
Technologies of social and medical work to improve the social status of citizens and their health are used in various spheres of life. One of them is the work of the Russian Orthodox Church (ROC), which does a lot to preserve the health of the country›s population, to help the sick, the disabled, the elderly and other needy groups. The article attempts to analyze the forms and methods of medical and social work carried out at churches in the Republic of Buryatia. The efficiency of the performed work is analyzed, the groups of the population who seek help in Orthodox churches are considered. Conclusions are drawn that medical and social technologies of work which are used by the Russian Orthodox Church, promote decrease in diseases of a narcological profile and abortions among the population. Also, medical and social work carried out by the Church increases the social function of the ROC and reduces social tension in society.
5. DIAGNOSTIC TREATMENT SITUATION OF BIPOLAR DISORDER
Gantsetseg T ; Khishigsuren Z ; Odongerel S ; Minjmaa R ; Nyamtsetseg J ; Sarantsetseg T ; Sugarmaa SH ; Gantulga J ; Tuya N
Innovation 2015;9(1):28-33
WHO informed that across world an average of 565 young people aged 10 to 29 die every day through interpersonal violence. Some studies mentioned that anxiety was most frequently occurred as one of the psychological onsequences among victims of child abuse. Recent research on effects of adverse early life experiences on central nervous system as stress systems (hypothalamus-pituitary-adrenal axis-HPA) has provided a greater understanding of the link between childhood abuse and susceptibility to anxiety disorder. Therefore, this research was done to study anxiety among abused adolescents, some physical parameters and level of cortisol in saliva.Total number of participants were 149 children aged between 11-16 years (number cases were 53, matched control subjects were 96). The Spence Children’s Anxiety Scale (SCAS; Spence, 1997) is a 38-item self-report uestionnaire that assesses multiple symptoms of childhood anxiety isorders based on current diagnostic criteria. All participants were measured the cortisol in the saliva by Cortisol ELISA kit, Sigma, USA. Average age of all subjects in the study was 13.52±1.57 and 102 of all subjects were female and 47 were male. All anxiety symptoms of case group was statistically significance higher (p<0.01) than control group. The average amount of salivary cortisol of case group was (21.3±8.1 ng/ml) statistically significantly lower (p<0.01) than average amount of control group (31.56±16.9 ng/ml). Anxiety was more frequently occurred among abused children and blunted cortisol responses might indicate a level of impaired HPA functioning that could constitute a vulnerability to psychopathology with exposure to anxiety.
6. CURRENT STATE OF LAPAROSCOPIC SURGERY FOR THE WOMEN WITH REPRODUCTIVE PROBLEMS
Sugarmaa E ; Kherlen О ; Nyam-Od G ; Lhagvadorj G ; Bayarmaa E ; Erkhembaatar Т
Innovation 2015;9(3):66-67
Today, in technologically updated world medicine, laparoscopy is more preferable than the common, open surgery procedures. There is a lack of scientific studies on laparoscopic surgery in gynecology, especially its present state and further tendencies. Therefore it served us as the background of the study.Retrospective study was conducted on 2016 laparoscopic surgery histories, which were performed in 2010-2014, at Mongolian state and private obstetric-gynecological hospitals and clinics. The study was developed by the program SPSS21.In 2010-2014 totally 2016 laparoscopic surgeries was performed: 713 – in First Maternity Hospital, 653 – in Bayangol hospital, 429 - inASE hospital, 221 – in National Cancer Center of Mongolia. The patients were classified by their age, education state, and citizenship. Mean age of these patients was 33.03 ±7.6(min 12, max 70). By educations: the 72.4% (1460) of them were high educated, 18.2%(367) has the secondary education, 4.7%(95) – college education, 4.5%(91) – 8th grade education, and 0.2%(3) – elementary school education or non-educated. The 81.8 %( 1649) patients were citizens, the 18.15 %( 366) – from rural areas. And only 0.05% (1) was the foreigner. We noted 7 %( 14) cases that shifted from laparoscopic surgery to open procedure. The post surgery average bed day was 2.7 ±1.3 (min 1, max 12), duration of the laparoscopic surgery 58.46 ±31.6 minutes (min 10, max 260). The average amount of blood loses during the surgery was 76.17 ±69.3( min 5, max 700),The relevance of the surgery duration and preoperative bleeding was(r-0.445). Various diagnoses were involved in the study: the 25.9% (524) of them had second infertility, ovarian endometriosis cyst- 10.5% (212), ectopic pregnancy- 9.4% (189), hydrosalpinx- 7.5% (152), endometrioma ≥ 4.5 cm - 6.3% (128), ovarian follicularcyst- 6.3% (128), ovarian cancer- 5.7% (115), primary infertility- 5% (101), ovarian dermoids cyst-4.3% (86), endometrioma ≤ 4.5cm- 3.4% (68), others-15.7%. Surgical procedures are classified by their purposes: 29% (584) of surgery for examine the fallopian tube using contrast for medium and divide adhesion, 17.6% (354) – to remove ovarian cyst, 12.8% (259) – to examine fallopiantube using contrast and remove ovarian cyst, 9.4% (189) – to remove fallopian tube, 7% (142)- to remove endometrioma, 6.3% (128) – to examine uterine tube using contrast dye, 6% (121)-ot do hysterectomy, 11.9%- for other reasons. The 76.7% of all surgeries were done within one hour and there was moderate correlation between duration of surgery and bleeding (r-0.445). The secondary infertility was the most common diagnosis. And the laparoscopic manage of adhesion and hystersalpingography were performed more. According to the study, non-cancerous growth of uterus was 9.7 and the 6% of it surgeries was laparoscopic myomectomy.
7.A summative content analysis: identifying content of “Health behavior change” in undergraduate curriculum of school of public health
Saranchuluun O ; Oyun Ch ; Sugarmaa M
Mongolian Medical Sciences 2018;183(1):29-34
Justification:
Researchers highlighted an importance of health professionals’ participation (1), (2), a role on behavior change in primary health care services (3)evidence based health policy and program (4)(5) байгааг and health promotion to reduce a prevalence of both communicable and non-communicable diseases in Mongolia. Mongolian National University of Medical Sciences trains public health researchers and health social workers in the last ten years. It has been developed a guideline of required compulsory professional competence in which, students of SPH should acquire knowledge, skills including behavior change strategy and implement interventions, behavior change assessment at individual, family, group and community levels.
Purpose:
Aim of this research is to identify key words and content of "health Behavior" and "health Promotion" in undergraduate courses of School of public health (SPH) and compare with a content of compulsory professional competence requirements.
Methodology and Materials:
We used a summative content analysis [6] to identify key words and content of ‘’health behavior’’ and ‘’health promotion’’ in 140 courses between 2009 and 2016 and compared with 17 required compulsory professional competence in blue print guideline [7].
Results:
Planned academic hours of ‘’health behavior and promotion’’ in courses of health social work was insufficient and they covered several theories with no content of implementation, application, evidence based practices and examples. For students of public health researchers, there are required compulsory 8 skills of health behavior, however skills and knowledge were slightly covered in courses of ”food safety”, “health of kids and adolescent” and “occupational health”.
Conclusion
Undergraduate courses for health social workers and public health researchers were based solely on “individual health behavior theories’’. The included content of the theory, application of organization and community behaviors was insufficient in the existing “health behavior” course.
8.High performance liquid chromatograohy method for determination of alkaloid, method validation in Norbu-7 granule
Sugarmaa B ; Battulga B ; Lkhaasuren R ; Badamtsetseg S ; Tsetsegmaa S ; Khurelbaatar L
Mongolian Medical Sciences 2021;195(1):64-69
Introduction :
The roots of Sophora Flavescentis is one of the key ingredient in Norbu 7 traditional medicine, the
bioactive compound being quinolizidine alkaloids, matrine and oxymatrine. A high performance liquid
chromatography (HPLC) method was used to determine matrine, oxymatrine simultaneously in the
traditional medicine. The HPLC method was tested and validated for selective determination of matrine
and oxymatrine in the Norbu 7 granule. The proposed method was validated for linearity, precision
(system precision, method precision, intermediate or inter- day precision) and accuracy, stability in
analytical solution, system suitability and ruggedness.
Goal:
The goal of this study was to develop validated determination method of alkaloid in Norbu 7 granule
for quality control.
Material and Method:
HPLC analysis was performed on Chromecore amino bonded silica gel as the stationary phase (250
mm : 4.6 mm i.d., 5µm) using mixture of acetonitrile, dehydrated ethanol and 3% phosphoric acid
(80:10:10) as the mobile phase, 220 nm as the UV light detection.
The research methodology was approved by Research Ethic Review Committee of Mongolian
University of Pharmaceutical Science on 16th of November, 2020.
Results:
The calibration curve of oxymatrine showed good linearity (R2=0.9955) within the established range
of 8 – 64 µg/ml. The limit of detection (LOD) and quantification (LOQ) were 10.13 µg/ml and 30.71 µg/
ml respectively. Good results were achieved with repeatability (%RSD < 2.0) and recovery (93.08 –
104.32%).
Conclusion
The method was found to be selective, accurate, reproducible and the other components did not
interfere with determinations. It was successfully used to analyze the granule traditional medicine with
7 different plant formulation and additives. The HPLC method can be used to evaluate and control
quality, stability of Norbu 7 granules.
9.Technological study to convert traditional powder medicine into modern dosage formulation
Ganchimeg G ; Lkhaasuren R ; Odchimeg B ; Badamtsetseg S ; Sugarmaa B ; Bayanmunkh A ; Lkhagva L ; Tsetsegmaa S ; Khurelbaatar L
Mongolian Medical Sciences 2021;195(1):38-42
Introduction:
The Mongolian people have been using traditional medicine for hundreds of years. However, there is
a need to produce traditional medicinal dosage forms such as capsules, tablets, decoctions easier to
drink, store and transport, and to standardize not only finished product, but the raw materials used for
traditional medicines in line with the current drug production, drug quality and safety requirements.
Therefore, in this study, we aim to standardize five ingredients of a traditional powder medicine,
which have been widely used for colds and flu in Mongolian, Chinese and Tibetan traditional medicine
practice, and to convert the powder drug into tablet form using qualified raw materials.
Materials and Methods:
The study to convert multi-ingredient traditional powder into tablet was carried out at the Experimental
production pharmaceutical technology unit and Pharmaceutical chemistry Laboratory of the Drug
research institute, Monos Group, and the Quality control laboratory of medicine of Monos Pharm LLC.
Result
All raw materials were standardized and wet granulation method was used to prepare granules for
the tableting with qualified raw materials. 4 different models of the tablet form was prepared and
investigated. It was determined that model X-2 fully meets the general requirements for the tablet
form.
10.Method validation of total iridoids in “Darmon” tablets by spectrophotometric method
Selbenchal B ; Sugarmaa B ; Odchimeg B ; Ganchimeg G ; Battulga B ; Badamtsetseg S ; Bayanmunkh A ; Tsetsegmaa S ; Lkhagva L ; Khurelbaatar L ; Lkhaasuren R
Mongolian Pharmacy and Pharmacology 2021;19(2):6-12
Introduction:
A joint research team of the Drug Research Institute аndMonos pharm Co.ltd is conducting an experiment to produce of “Darmon” tablets.Idridoids are one of the predominant biological active compound in “Darmon” tablets and will be an important indicator of the quality of the drug.
Objectives:
This is the first report on the determination of iridoids by spectrophotometric method in “Darmon” tablets.
Methods:
The amount of total iridoids of “Darmon” tablets was confirmed by spectrophotometry and the absorbance was measured at 238 nm. Geniposide (98%, Xilong Scientific Co., Ltd) was used as the standard substance.
Results:
The developed spectrophotometric method showed good linearity (R2=0.9989), high precision (RSD<2%) and a good recovery (96.01-104.48%). All the validation parameters of the spectrophotometric method were found to be within the permissible limits according to the ICH guidelines.
Conclusions
The method was robust, accurate and reliable for the quality control of “Darmon” tablets.