Twenty nine cases of segmental tibial fracture were treated at Ewha Womans University Hopital, Department of Orthopedic Surgery, during the period from January, 1970 to December, 1984. The following results were obtained. 1. Most common fracture level was type I, high middle segment, occurred about 12 cases (41.4%). 2. In view of the higher incidence of open fracture (16 cases, 55.1%) and comminuted fracture (22 cases, 75.9%), fracture was caused by high velocity. 3. Various external and internal fixation methods were applied, but higher union rate was seen in the cases of Küntscher nailing and plating with bone graft. 4. Excluding the cases of type V, average union rate was 28.5 weeks and open fracture (ave. 29.6 weeks) required more longer union rate than closed fracture (ave. 26 weeks). 5. Higher rate of complication (21 cases, 72.4%) was noted than other types of tibial fracture. 6. Good result was obtained for treatment of 5 cases of delayed union or non-union by plating and bone graft than any other methods.
Clinical Study ; Female ; Fractures, Closed ; Fractures, Comminuted ; Fractures, Open ; Humans ; Incidence ; Orthopedics ; Tibia ; Tibial Fractures ; Transplants

PURPOSE: To assess the effect of the remnants after lens extraction on posterior capsular opacification with lens epithelial cell culture through in vitro capsular bag model. METHODS: After isolating porcine lens capsules, sterile non-toxic PMMA (polymethyl- mathacrylate) tension ring was inserted into the capsule. These were placed in organ culture medium up to 6 weeks. The grade of cell coverage of the posterior lens capsule was recorded to check the proliferative activity. RESULTS: In the process of cell culture, outgrowth of the epithelial cells was observed across the posterior capsule after a lag period. The rate of cell coverage was dependent upon the added factors. The proliferative activity was the greatest in the group where lens cortical and nuclear materials were added, and other groups showed no difference from a control group. CONCLUSIONS: To reduce posterior capsular opacification, it is important that we should not leave the lens cortical material behind during cataract surgery.
Capsules ; Cataract Extraction* ; Cataract* ; Cell Culture Techniques ; Epithelial Cells* ; Organ Culture Techniques ; Polymethyl Methacrylate

PURPOSE: We compared the perifoveal capillary ring state and the size of the macular ischemic area in patients with the macular edema, then analyzed the effect of grid photocoagulation on macular edema. The aim of the present study was to evaluate visual prognosis and to determine treatment modality of macular edema with macular ischemia in branch retinal vein occlusion (BRVO). METHODS: We did retrospective clinical analysis on the macular edema and macular circulatory state using clinical records, and performed fluorescein angiography in 89 patients (92 eyes) who were diagnosed with BRVO at Inha University Hospital from June 1996 through October 2000 and were followed for over 6 months. RESULTS: The incidence of macular edema was not statistically correlated with occlusion site of retinal vein, size of macular ischemic area and perifoveal capillary ring state. The initial visual acuity was a statistically significant factor in the prognosis of final visual acuity. The macular ischemic area was statistically correlated with initial visual acuity, and the perifoveal capillary ring state was not correlated with initial and final visual acuities. The improvement of visual acuity after grid photocoagulation for macular edema was noted in patients with intact perifoveal capillary ring state and small macular ischemic area. CONCLUSIONS: The only facator to final visual acuity is initial visual acuity. Prospective study is needed to evaluate effect of early treatment of macular edema with grid photocoagulation at an early stage of BRVO in patients with intact perifoveal capillary ring state and small macular ischemic area.
Capillaries ; Fluorescein Angiography ; Humans ; Incidence ; Ischemia* ; Light Coagulation ; Macular Edema* ; Prognosis* ; Retinal Vein Occlusion* ; Retinal Vein* ; Retinaldehyde* ; Retrospective Studies ; Visual Acuity

PURPOSE: To evaluate the treatment results and prognostic factors after radiotherapy in stage IIB uterine cervix cancer. MATERIALS AND METHODS: We retrospectively analyzed the records of 90 patients with stage IIB uterine cervix cancer who received radiotherapy between 9/94 and 12/99. Age was ranged from 28 to 79 years (median 57). Tumor size was > or = 4 cm in 64 patients. Preteatment SCC level was measured in 76 patients. Twenty nine patients received conventional radiotherapy (QD) and the others received modified hyperfractionated radiotherapy (BID). Only 7 patients in BID had tumor size <4 cm. All patients received high dose rate brachytherapy (4 Gy x 7 or 5 Gy x 6). No patient received concurrent chemotherapy during radiotherapy. Follow up period was ranging from 9 to 76 months (median 38). RESULTS: The 5-year overall and disease free survival rates were 73.4% and 71.6%, respectively. Local recurrences occurred in 10% of patients, and distant metastasis in 18.9%. There was a significant correlation between OS/DFS and tumor size (<4 cm; OS 95.2%, DFS 91.4%, > or = 4 cm; OS 63.4%, DFS 63.4%). Pretreatment SCC level was one of prognostic factors only in univariate analysis. CONCLUSION: With modified hyperfractionated radiotherapy, there was very low local recurrence rate (6.6%) and high 5-year overall and disease free survival rate (75.4% and 70.5%), which is comparable to results after concurrent chemoradiotherapy in bulky, locally advanced stage IIB uterine cervix cancer.
Brachytherapy ; Cervix Uteri* ; Chemoradiotherapy ; Disease-Free Survival ; Drug Therapy ; Female ; Follow-Up Studies ; Humans ; Neoplasm Metastasis ; Radiotherapy* ; Recurrence ; Retrospective Studies

PURPOSE: To evaluate the clinical effects of excimer laser refractive surgery on eyes with residual refractive error after implantation of ReSTOR(R) multifocal intraocular lenses. METHODS: We retrospectively reviewed the medical records of 10 eyes of 6 patients who had undergone cataract surgery with implantation of multifocal intraocular lenses. Photorefractive keratectomy (PRK) (5 eyes) and laser-assisted in situ keratomileusis (LASIK) (5 eyes) was performed on 10 eyes with residual refractive error. RESULTS: After cataract surgery and before laser surgery, the mean spherical equivalent (SE) was -0.34 +/- 0.89 D and the mean astigmatism was 2.08 +/- 0.55 D. Six months after laser surgery, the mean SE was -0.33 +/- 0.30 D (p = 0.354) and the mean astigmatism was 0.23 +/- 0.28 D. The changes in astigmatism between paired preoperative and postoperative values were statistically significant (p < 0.0001). At 6 months after surgery, uncorrected distance visual acuity significantly improved to 0.11 +/- 0.10 (log MAR) (p < 0.0001) There were no significant changes in the best corrected distance visual acuity and uncorrected near visual acuity (p = 0.073, p = 0.100). CONCLUSIONS: On the basis of predictability and stability, excimer laser surgery appears to be a clinically useful procedure to correct residual refractive error after implantation of ReSTOR(R) multifocal intraocular lenses.
Astigmatism ; Cataract ; Eye ; Humans ; Keratomileusis, Laser In Situ ; Laser Therapy ; Lasers, Excimer ; Lenses, Intraocular ; Medical Records ; Photorefractive Keratectomy ; Refractive Errors ; Refractive Surgical Procedures ; Retrospective Studies ; Visual Acuity

PURPOSE: To compare the axial lengths, anterior chamber depths, and keratometric measurements and to predict postoperative refractions of AL-Scan(R), IOL master(R), and ultrasound. METHODS: A total of 40 eyes in 30 patients who received cataract surgery were included in the present study. The axial length, anterior chamber depth, and keratometry were measured by 2 types of partial coherence interferometry (AL-Scan(R) and IOL master(R)) and ultrasound. The SRK/T formula was used to calculate IOL power, and the predictive error which subtracts predictive refraction from postoperative refraction was compared among the ocular biometry devices. RESULTS: Axial lengths were 23.08 +/- 0.62 mm, 23.09 +/- 0.62 mm, and 22.99 +/- 0.62 mm measured by AL scan(R), IOL master(R), and ultrasound, respectively. Axial length measured by ultrasound was statistically significantly shorter than AL scan(R) and IOL master(R) (p < 0.001, p < 0.001, respectively). The anterior chamber depth and keratometry were 3.11 +/- 0.06 mm and 44.82 +/- 1.34 D measured by AL scan(R), and 3.13 +/- 0.06 mm and 44.85 +/- 1.26 D measured by IOL master(R), respectively. The differences of anterior chamber depth and keratometry between the 2 devices were not statistically significant (p = 0.226, p = 0.331, respectively). The mean absolute prediction errors were 0.44 +/- 0.35 D, 0.40 +/- 0.34 D, and 0.39 +/- 0.30 D in AL-Scan(R), IOL master(R) and ultrasound, respectively, and were not statistically significantly different (p = 0.843, p = 0.847, p = 1.000, respectively). CONCLUSIONS: The ocular biometric measurements and prediction of postoperative refraction using AL-Scan(R) were as accurate as IOL master(R) and ultrasound.
Anterior Chamber ; Biometry* ; Cataract* ; General Surgery ; Humans ; Interferometry ; Ultrasonography

PURPOSE: The therapeutic effects of amniotic membrane transplantation (AMT) contain anti-fibrosis, anti-inflammation and facilitation of epithelialization. Thus we investigated whether applying of amniotic membrane (AM) ointment could get the same effect as AMT. METHODS: Alkali burn was induced by applying 6 mm round filter paper which was soaked with 1 N NaOH, onto the central cornea for 60 seconds on both eyes of 10 white rabbits. Then we applied AM ointment on one eye and base ointment on the other eye, four times a day for 1 week. The corneas were harvested for histopathologic studies at 1 day and 3 weeks. Corneal opacity and thickness were measured in 3 days and 1, 2, 3 weeks. RESULTS: In the AM ointment applicated group, the number of the infiltrated PMNs (polymorp-honuclear cells) and apoptotic keratocytes were significantly less than that of the control group (P<0.05). The degree of lipid peroxidation and myofibroblast differentiation were less than those of the control group. Corneal opacity and corneal edema were less in AM ointment group than control group. CONCLUSIONS: AM ointment application after alkali burn is beneficial to reduce inflammation, keratocyte apoptosis and lipid peroxidation, and is considered to suppress corneal haze by these effects. Therefore, this report may be a basic study for the AM ointment research to treat recalcitrant keratitis.
Alkalies ; Amnion ; Apoptosis ; Ascorbic Acid* ; Burns ; Cataract ; Cornea ; Corneal Edema ; Corneal Opacity ; Epithelial Cells* ; Fibronectins ; Hydrogen Peroxide* ; Hydrogen* ; Inflammation ; Keratitis ; Lipid Peroxidation ; Myofibroblasts ; Rabbits

In this study, high frequency oscillatory ventilator was designed and constructed. Using designed by phase-lock loop system, in order to accurately and easily treat both the outlet volume and rpm. A system has been designed and is being evaluated using CD4046A PLL IC. We use this PLL IC for the purpose of motor controls. The device consists of PLL system, pumping mechanism, piston, cylinder, and special crank shaft are required. This system characteristics were as follows: 1) Frequency: 20-1800 rpm 2) Outlet air volume: 1-50 cc
Ventilators, Mechanical*

PURPOSE: To evaluate the usefullness of color vision test for early detection of abnormal choroidal circulation of central serous chorioretinopathy (CSCR) METHODS: We investigated the color vision defect in central serous chorioreinopathy at active and resolved phase on both eyes and to identify the relation between fluorescein angiography (FAG), indocyanine green angiography (ICGA) finding and color vision defect. We examined the color vision with the Neitz anomaloscope OT-II, Farnsworth-Munsell 100-hue test, Ishihara pseudoisochromatic plate in 72 eyes of typical acute CSCR patients. We also performed ICGA in 13 eyes revealed color vision defect in fellow eye and 13 eyes not revealed color vision defect in fellow eye at resolved phase. RESULTS: Dyschromatopsia was detected in CSCR at active and resolved phase on both eyes. Most of them showed blue-yellow color defect. Location of leaking point was associated with red-green color defect in active affected eyes. Dyschromatopsia of fellow eyes at resolved phase was associated with abnormal choroidal circulation on ICGA finding. CONCLUSIONS: We suggest that color vision test, as a non-invasive screening test, might be useful for early detection of abnormal choroidal circulation of CSCR.
Angiography ; Central Serous Chorioretinopathy* ; Choroid ; Color Vision Defects ; Color Vision* ; Fluorescein Angiography ; Humans ; Indocyanine Green ; Mass Screening

A 24-year-old male visited our hospital because of pain in both flanks. His biochemistry profile showed an elevated serum creatinine level and low serum uric acid level. History taking revealed that he had undertaken exercise prior to the acute kidney injury (AKI) event, and he stated that family members had a history of urolithiasis. His renal profile improved after hydration and supportive care during hospitalization. Although the patient was subsequently admitted again due to AKI, his status recovered with similar treatment. Since the diagnosis of the patient was familial renal hypouricemia with exercise-induced AKI, we performed genotyping of SLC22A12, which encodes human urate transporter 1. The diagnosis was confirmed by the detection of a homozygous mutation of W258X. We herein, report a case of familial renal hypouricemia confirmed by genotyping of SLC22A12, and review the relevant literature.
Acute Kidney Injury ; Biochemistry ; Creatinine ; Diagnosis ; Hospitalization ; Humans ; Male ; Uric Acid ; Urolithiasis ; Young Adult