Objective To observe the changes of AGEs,NO and eyesight in patients with diabetic retinopathy(DR) treated by Aminoguanidine(AG) combined with Doxium.Methods 120 patients with DR were divided into treatment and control groups at random.Two groups were treated routinely with general treatment on DM and the treatment group was added routine dose of aminoguanidine(AG) and Doxium while the control group were treated with urokinasel.After 8 weeks,AGEs,NO and eyesight were determined.Results The level of NO and eyesight in treatment group were higher markedly than control group,AGEs in treatment group were lower most markedly than control group.Conclusion Aminoguanidine and Doxium can improve DR effectively.

Objective To explore the application conditions of 22 S rule (one of the Westgard rules) in single concentration quali‐ty control .Methods The application scope of 22 S rule was used into the same batch detection of single‐concentration quality control materials .Results The 22 S rule improved the detection rate of system errors .Conclusion 22S rule should be applied to two detec‐tions within a batch when using one quality control material ,as to improve the detection of system error more efficiency .