PURPOSE: To evaluate the outcome of the part-time occlusion therapy with near activities in monocular amblyopic patients according to gender, age, severity of amblyopia, and the cause of amblyopia. METHODS: Fifty eight patients who were prescribed part-time occlusion therapy with near activity from July 1998 to October 2004, were included in this retrospective study. All patients were divided into groups by gender, age, severity of amblyopia, and the cause of amblyopia. Main outcome measures were best corrected visual acuity, line improvement, and success rate. RESULTS: At the end of patch therapy, visual acuity improved from baseline by an average of 3.2+/-2.5 lines (0.33+/-0.26 log MAR), and follow-up period was 19.71+/-14.61 months (1.62+/-1.20 years). At the last follow-up, visual acuity improved from baseline by an average of 3.7+/-2.4 lines (0.38+/-0.26 log MAR), and follow-up period was 37.41+/-25.83 months (3.08+/-2.12 years). The success rate was 86% (50 patients) at the end of patch therapy. In 44 patients out of 50 patients (88%), the visual acuity was maintained. While 43 patients out of 47 patients who were less than 7 years old (91%) achieved success, 7 patients out of 11 patients 7 years or older (64%) achieved success (p=0.035). CONCLUSIONS: Six-hour part-time occlusion treatment combined with near activities appears to be favorable in treating 58 children during follow-up of mean 3.08 years. The significant factor was the age at initial treatment.
*Activities of Daily Living ; Amblyopia/physiopathology/*therapy ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Male ; Retrospective Studies ; *Sensory Deprivation ; Time Factors ; Treatment Outcome ; Visual Acuity/physiology

PURPOSE: To evaluate the outcome of the part-time occlusion therapy with near activities in monocular amblyopic patients according to gender, age, severity of amblyopia, and the cause of amblyopia. METHODS: Fifty eight patients who were prescribed part-time occlusion therapy with near activity from July 1998 to October 2004, were included in this retrospective study. All patients were divided into groups by gender, age, severity of amblyopia, and the cause of amblyopia. Main outcome measures were best corrected visual acuity, line improvement, and success rate. RESULTS: At the end of patch therapy, visual acuity improved from baseline by an average of 3.2+/-2.5 lines (0.33+/-0.26 log MAR), and follow-up period was 19.71+/-14.61 months (1.62+/-1.20 years). At the last follow-up, visual acuity improved from baseline by an average of 3.7+/-2.4 lines (0.38+/-0.26 log MAR), and follow-up period was 37.41+/-25.83 months (3.08+/-2.12 years). The success rate was 86% (50 patients) at the end of patch therapy. In 44 patients out of 50 patients (88%), the visual acuity was maintained. While 43 patients out of 47 patients who were less than 7 years old (91%) achieved success, 7 patients out of 11 patients 7 years or older (64%) achieved success (p=0.035). CONCLUSIONS: Six-hour part-time occlusion treatment combined with near activities appears to be favorable in treating 58 children during follow-up of mean 3.08 years. The significant factor was the age at initial treatment.
*Activities of Daily Living ; Amblyopia/physiopathology/*therapy ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Male ; Retrospective Studies ; *Sensory Deprivation ; Time Factors ; Treatment Outcome ; Visual Acuity/physiology

We characterized and compared the characteristics of Ca2+ movements through the sarcoplasmic reticulum of inferior oblique muscles in the various conditions including primary inferior oblique overaction (IOOA), secondary IOOA, and controls, so as to further understand the pathogenesis of primary IOOA. Of 15 specimens obtained through inferior oblique myectomy, six were from primary IOOA, 6 from secondary IOOA, and the remaining 3 were controls from enucleated eyes. Ryanodine binding assays were performed, and Ca2+ uptake rates, calsequestrins and SERCA levels were determined. Ryanodine bindings and sarcoplasmic reticulum Ca2+ uptake rates were significantly decreased in primary IOOA (p < 0.05). Western blot analysis conducted to quantify calsequestrins and SERCA, found no significant difference between primary IOOA, secondary IOOA, and the controls. Increased intracellular Ca2+ concentration due to reduced sarcoplasmic reticulum Ca2+ uptake may play a role in primary IOOA.
Sarcoplasmic Reticulum Calcium-Transporting ATPases ; Sarcoplasmic Reticulum/*metabolism ; Ryanodine Receptor Calcium Release Channel/metabolism ; Ryanodine/metabolism ; Oxalates/metabolism ; Oculomotor Muscles ; Ocular Motility Disorders/*metabolism/*pathology ; Muscles/*pathology ; Models, Statistical ; Middle Aged ; Male ; Humans ; Female ; Child, Preschool ; Child ; Calsequestrin/metabolism ; Calcium-Transporting ATPases/metabolism ; Calcium/metabolism/*pharmacokinetics ; Blotting, Western ; Aged ; Adult ; Adolescent

OBJECTIVES: The purpose of this study was to evaluate the effect of periodontal health promotion and oral hygiene in children using a vibrating toothbrush. METHODS: Forty-seven volunteers aged between 7-15 years participated in this study at local care centers from January to February 2013. A vibratory toothbrush for children was designed with the bristles operating on a self-vibration system that separated the head-neck part of the toothbrush from the handle. The toothbrush was designed with the aim of massaging the gingiva and reducing gingival inflammation. The papillary marginal attachment (PMA) index and O'Leary plaque index were measured by oral examinations before and at 4 weeks after brushing with the vibrating toothbrush. RESULTS: The PMA index and O'Leary plaque index were reduced from 39.20 to 25.42 (P<0.001) and from 5.56 to 2.78 (P<0.001), respectively. CONCLUSIONS: These results suggested that vibrating toothbrushes designed for children can be helpful in promoting gingival health and improving oral hygiene.
Aged ; Child ; Diagnosis, Oral ; Gingiva ; Gingivitis ; Health Promotion ; Humans ; Inflammation ; Oral Hygiene

PURPOSE: Currently, when injecting botulinum a toxin into the extraocular muscle, EMG (Electromyography) is used for accurate location. In this study, we examined the effects of subtenon botulinum toxin injection without EMG guidance by quantifying the morphological changes of the extraocular muscle fibers in rabbits. METHODS: Using 10 New Zealand white rabbits, 10 units of botulinum a toxin in 0.1 ml of normal saline was injected into the subtenon space of the superior rectus muscles, 5 mm from the muscle insertion in right eyes. As a control, 0.1 ml of normal saline was injected into the subtenon space of the superior rectus muscles in left eyes. At 3 weeks after injections, the bilateral superior rectus muscles of each rabbit were carefully dissected from the globe. Cross-sections of 5 micrometer thickness were obtained at the site, 5 mm from the insertion of each superior rectus muscle. Sections were stained with Masson's trichrome and observed by light microscopy. Using Image-Pro Plus software, the diameter of the orbital layer myofibers was measured and statistical analysis was done using the Kruskal-Wallis test. RESULTS: The average diameter of the orbital layer fiber cells after botulinum toxin injection was 11.5+/-2.26 micrometer at 3 weeks, whereas that of the control was 14.4+/-3.77 micrometer. The difference was statistically significant (p<0.01). CONCLUSIONS: The diameter of myofibers in the orbital layer was reduced after subtenon botulinum a toxin injection. Further studies on the duration of botulium toxin in subtenon space and the change in the size of myofibers depending on the dosage of botulinum toxin will be necessary.
Botulinum Toxins ; Botulinum Toxins, Type A* ; Microscopy ; Muscles ; Nerve Block* ; Orbit ; Rabbits

OBJECTIVE: The purpose of the study was to evaluate the safety and efficacy of tension-free vaginal tape (TVT) placement for surgical treatment of stress urinary incontinence (SUI) in women. METHODS: A retrospective study of 38 cases with SUI underwent the TVT procedure underlying local anesthesia at Daedong and Sewoong Hospital from March 2000 to December 2000, followed up more than six months who included in the study. RESULT: Operation times ranged from 20 to 53 minutes with a mean of 37.5 minutes. The mean blood loss was 90 mL. One major complication was encountered -bladder perforation (2.5%) and urinary retention was developed in 4 cases (10.5%). Length of hospital stay ranged from 0.8 to 11.3 days with a mean of 1.8 days. On postoperative follow-up from 6.1 to 17.5 months, thirty-three patients (87%) were cured, four (10.5%) were significantly improved and one was failed (2.5%). CONCLUSION: Althouth the follow-up period was short, the TVT procedure seemed to be a safe and effective method for the treatment of stress urinary incontience.
Anesthesia, Local ; Female ; Follow-Up Studies ; Humans ; Length of Stay ; Retrospective Studies ; Suburethral Slings* ; Urinary Incontinence ; Urinary Retention

No abstract available.
Candida* ; Cerebrospinal Fluid Shunts ; Meningitis*