1.Analysis of the Factors Affecting the Success of Weight Reduction Programs.
Jungsun KIM ; Sue Kyung PARK ; Yun Jeong LIM
Yonsei Medical Journal 2007;48(1):24-29
Obesity is a risk factor for numerous health problems. Behavior therapy is important for obesity treatment. The aim of the present study was to identify the parameters that are associated with successful weight reduction. A database of 123 subjects who underwent weight reduction programs at the Center for Health Promotion, Samsung Medical Center from June 2001 through November 2004 was retrospectively analyzed. The goal of the program was to reduce the body weight by more than 5% during the follow-up period. The study population was divided into 2 categories (the success group and the failure group) based on the outcome of weight reduction. We analyzed the demographic, laboratory and clinical parameters to determine the predictors of successful weight reduction. The prevalence of success group was 36.6% (45/123). Significant correlations for successful weight reduction were found for the follow up period and the frequency of medical visits. Our results suggest that strong motivation was the most important factor for successful weight reduction.
2.Pigmentation after Gold Thread Implantation by Illegal Cosmetic Procedure.
Sue Jeong KIM ; Cho Ah LIM ; Myung IM ; Young LEE ; Jeunghoon LEE ; Young Joon SEO
Korean Journal of Dermatology 2017;55(6):376-378
No abstract available.
Pigmentation*
3.Pigmentation after Gold Thread Implantation by Illegal Cosmetic Procedure.
Sue Jeong KIM ; Cho Ah LIM ; Myung IM ; Young LEE ; Jeunghoon LEE ; Young Joon SEO
Korean Journal of Dermatology 2017;55(6):376-378
No abstract available.
Pigmentation*
4.Seasonal Variation of Food Intake in Food Frequency Questionnaire among Workers in a Nuclear Power Plant.
Jae Jeong YANG ; Sue Kyung PARK ; Hyun Sul LIM ; Kwang Pil KO ; Younjhin AHN ; Yoon Ok AHN
Journal of Preventive Medicine and Public Health 2007;40(3):239-248
OBJECTIVES: This study was conducted to investigate the systematic error, such as seasonal change or inadequate food items, in a food frequency questionnaire administered to workers in a Nuclear Power Plant, Korea. METHODS: We performed three repeat-tests with 28 subjects on May 13, July 8 and Dec 16, 1992. Our food frequency questionnaire (FFQ) comprised 84 foods organized into 7 food-groups, and was composed of the items of usual intake frequency (8 categories) and the amount per intake (3 or 4 categories) over the previous year. We compared the means of intake frequency and the frequency of the portion-size according to each season using Repeated Measures ANOVA and Pearson's chisquare test with Fisher's exact test. RESULTS: We found the significant seasonal changes of several food items in intake frequency measurement. These items were typical seasonal foods such as mandarin orange, plum and green vegetables, while the single questions consisted of inadequate food items such as thick beef or similar soup and various kimchi products. Significant seasonal changes in portion-size were found in only two items: cooked rice-brown and fresh.frozen fishes. CONCLUSIONS: The systematic errors observed could caused loss of validity in the FFQ. Consideration should be given for seasonal variation in FFQ survey and methodological concerns are needed to improve the quality for measuring usual diet pattern.
*Diet Surveys
;
Humans
;
Korea
;
*Power Plants
;
Questionnaires
;
Reproducibility of Results
;
*Seasons
5.Risk Factor Analysis for Development of Asymptomatic Carotid Stenosis in Koreans.
Yun Jeong LIM ; Young Wook KIM ; Yeon Hyen CHOE ; Chang Seok KI ; Sue Kyung PARK
Journal of Korean Medical Science 2006;21(1):15-19
Many risk factors for atherosclerosis have been proposed to identify high risk individuals. We conducted a retrospective study to determine the risk factors for development of carotid stenosis (CS) in Koreans. Database of 2,805 subjects who underwent a check up of carotid artery for health examination were analyzed. Stenosis (%) of common carotid artery or proximal internal carotid artery was examined with ultrasonography. Subjects were divided into 2 groups (Group I; CS <10%, Group II; CS > or =30%). We compared demographic, laboratory and clinical data between 2 groups to determine the risk factors of CS. One hundred ninety seven subjects (7.0%) were categorized as Group II. At age- and sex-adjusted multivariate analysis, diabetes mellitus, hypertension, cerebrovascular disease, ischemic heart disease, hyperlipidemia, aspirin medication, current smoking, fasting glucose, total cholesterol, low density lipoprotein-cholesterol (LDL-C) and leukocyte count were significant risk factors of CS. At stepwise logistic regression analysis, age, hypertension, hyperlipidemia, LDL-C and leukocyte count were independent risk factors. At subgroup analysis by smoking, age and leukocyte count were independent risk factors in smoker and age and hypertension in nonsmoker.
Adult
;
Age Factors
;
Aged
;
Carotid Stenosis/blood/*epidemiology/etiology
;
Cholesterol/blood
;
Comparative Study
;
Female
;
Humans
;
Korea/epidemiology
;
Lipoproteins, LDL Cholesterol/blood
;
Logistic Models
;
Male
;
Middle Aged
;
Multivariate Analysis
;
Prevalence
;
Retrospective Studies
;
Risk Factors
;
Smoking/adverse effects
6.Gene transfer using liposome-complexed adenovirus seems to overcome limitations due to coxsackievirus and adenovirus receptor-deficiency of cancer cells, both in vitro and in vivo.
Sang Young HAN ; Yoon Jong LEE ; Haeng Im JUNG ; Sung Wook LEE ; Sue Jeong LIM ; Seung Hee HONG ; Jin Sook JEONG
Experimental & Molecular Medicine 2008;40(4):427-434
Use of adenoviruses as vehicle for gene therapy requires that target cells express appropriate receptors such as coxsakievirus and adenovirus receptor (CAR). We show here that CAR-deficiency in cancer cells, that limits adenoviral gene delivery, can be overcome by using adenovirus complexed with the liposome, Ad-PEGPE [1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(poly-ethylene glycol)-2000]. We first confirmed that CT-26 mouse colon cancer cells are deficient in CAR by RT-PCR, and then showed that CT-26 cells infected with Ad-GFP/PEGPE exhibited highly enhanced expression of green fluorescent protein (GFP), compared with those infected with Ad-GFP. GFP expression depends on the dose of liposome and adenovirus. Luciferase expression in livers treated with Ad-luc/PEGPE was about 1,000-fold less than those infected with Ad-luc. In a liver metastasis mouse tumor model developed by intrasplenic injection of CT-26 cells, luciferase expression following i.v. injection of Ad-luc/PEGPE was significantly higher in tumors than in adjacent non-neoplastic liver. Following systemic administration of Ad-GFP/PEGPE, GFP expression increased in tumors more than in adjacent liver while the reverse was true following administration of Ad-GFP. In the latter case, GFP expression was higher in liver than in tumors. This study demonstrates that systemic delivery of PEGPE-adenovirus complex is an effective tool of adenoviral delivery as it overcomes limitation due to CAR deficiency of target cells while reducing hepatic uptake and enhancing adenoviral gene expression in tumors.
*Adenoviridae/genetics/metabolism
;
Animals
;
Colonic Neoplasms/*genetics/metabolism/pathology/*therapy
;
Dose-Response Relationship, Drug
;
Gene Therapy
;
*Gene Transfer Techniques
;
Genetic Vectors
;
Green Fluorescent Proteins/genetics
;
Liposomes/administration & dosage/chemistry/pharmacokinetics/*therapeutic use
;
Liver/drug effects/metabolism
;
Male
;
Mice
;
Mice, Inbred BALB C
;
Mice, Transgenic
;
NIH 3T3 Cells
;
Phosphatidylethanolamines/administration & dosage
;
Polyethylene Glycols/administration & dosage
;
Receptors, Cytoplasmic and Nuclear/deficiency/genetics
;
Receptors, Virus/deficiency/*genetics
;
Transcription Factors/deficiency/genetics
;
Tumor Cells, Cultured
7.Pigmentation after Intravenous Iron Injection Treated with 1064 nm Nd:YAG Laser and 595 nm Pulse Dye Laser.
Eun Hwa LIM ; Sue Jeong KIM ; Young LEE ; Young Joon SEO ; Chang Deok KIM ; Jeung Hoon LEE ; Myung IM
Korean Journal of Dermatology 2015;53(4):315-318
Ferric carboxymaltose is a non-dextran?iron complex used in patients with iron deficiency. However, iron injections may lead to long-lasting brown discoloration secondary to extravasation at the injection site. We herein report a case involving a patient who developed pigmentation after intravenous iron injection and was successfully treated with combined laser therapy. A 36-year-old woman presented with circumscript pigmentation on her left arm after having undergone intravenous iron injection for the treatment of iron deficiency anemia. Histopathologic examination revealed basal hypermelanosis and dermal infiltration of siderophages. Combined therapy with 1064 nm Nd:YAG laser and 595 nm pulsed dye laser was performed to treat the lesion, and marked improvement was noted after five sessions.
Adult
;
Anemia, Iron-Deficiency
;
Arm
;
Female
;
Humans
;
Hyperpigmentation
;
Iron Compounds
;
Iron*
;
Laser Therapy
;
Lasers, Dye*
;
Pigmentation*
8.Pigmentation after Intravenous Iron Injection Treated with 1064 nm Nd:YAG Laser and 595 nm Pulse Dye Laser.
Eun Hwa LIM ; Sue Jeong KIM ; Young LEE ; Young Joon SEO ; Chang Deok KIM ; Jeung Hoon LEE ; Myung IM
Korean Journal of Dermatology 2015;53(4):315-318
Ferric carboxymaltose is a non-dextran?iron complex used in patients with iron deficiency. However, iron injections may lead to long-lasting brown discoloration secondary to extravasation at the injection site. We herein report a case involving a patient who developed pigmentation after intravenous iron injection and was successfully treated with combined laser therapy. A 36-year-old woman presented with circumscript pigmentation on her left arm after having undergone intravenous iron injection for the treatment of iron deficiency anemia. Histopathologic examination revealed basal hypermelanosis and dermal infiltration of siderophages. Combined therapy with 1064 nm Nd:YAG laser and 595 nm pulsed dye laser was performed to treat the lesion, and marked improvement was noted after five sessions.
Adult
;
Anemia, Iron-Deficiency
;
Arm
;
Female
;
Humans
;
Hyperpigmentation
;
Iron Compounds
;
Iron*
;
Laser Therapy
;
Lasers, Dye*
;
Pigmentation*
9.Detection and Quantification of Residual Cellular DNA in the Production of Recombinant HPV-16 L1 Virus-Like Particles.
Hwa Kyung SON ; Hye Sung JEONG ; Young Lim KIM ; Soon Nam KIM ; Jin Ho SHIN ; Hong Ki MIN ; Baik Lin SEONG ; Sue Nie PARK
Journal of Bacteriology and Virology 2006;36(4):271-278
A number of recombinant proteins isolated from cell sources are being produced for biopharmaceuticals. Although most biopharmaceuticals are highly purified, there is a safety concern that such recombinant products could be contaminated with impurities including adventitious virus, mycoplasma, endotoxin and oncogenic DNA. Residual DNA in recombinant biopharmaceuticals is a potential risk factor and must be evaluated and removed to meet the regulatory guidelines. Recombinant HPV type 16 L1 VLPs, recombinant protein produced in Spodoptera frugiperda (Sf) 9 insect cells, is a HPV subunit vaccine candidate which has been studied as a preventive vaccine of cervical cancers. In this study, we performed detection and quantification of residual cellular DNA in the production of recombinant HPV type 16 L1 VLPs. HPV-16 L1 VLPs were purified by processes including detergent lysis, sonication treatment, sucrose cushion centrifugation, CsCl equilibrium density centrifugation, and DNase treatment which was added to inactivate residual cellular DNA after CsCl centrifugation step. We have developed a precise assay based on a dot-blot hybridization using digoxigenin random primed labeling DNA probes for the detection and quantification of residual cellular DNA during the purification process and final products. Detection limit of residual cellular DNA was 0.1 ng in this assay and the amount of residual cellular DNA in the final product was 0.5 ng~1 ng per 100 microgram of protein. This study describes safer and more sensitive methods alternative to radioactive techniques employed for residual cellular DNA quantification of biopharmaceuticals produced by recombinant protein technology and presents method validation data demonstrating precision and reproducibility.
Centrifugation
;
Deoxyribonucleases
;
Detergents
;
Digoxigenin
;
DNA Probes
;
DNA*
;
Human papillomavirus 16*
;
Insects
;
Limit of Detection
;
Mycoplasma
;
Recombinant Proteins
;
Risk Factors
;
Sonication
;
Spodoptera
;
Sucrose
10.Comparisons of the Short-Term Angiographic Outcomes of Cypher and Taxus Stents Implanted in the Same Patient.
Min A PARK ; Jung Nam RYU ; Tae Hyung LIM ; Hyun Seung YOO ; Hyun Ah YOON ; Jeong Mo KOO ; Sue Ee LEE ; Jeung Hoan PAIK ; Kyung Ho KIM ; Jin HAN ; Tae Ho PARK ; Kwang Soo CHA ; Moo Hyun KIM ; Young Dae KIM
Korean Circulation Journal 2006;36(8):600-604
BACKGROUND AND OBJECTIVES: Drug-eluting stents (DES) have been shown to substantially reduce both angiographic and clinical restenosis. Cypher(R) (sirolimus-eluting stent, Cordis, Johnson and Johnson, Florida, USA) and Taxus(R) (paclitaxel-eluting stent, Boston Scientific, Boston, USA) are the two most widely used DESs, and they both have distinct pharmacological properties and release kinetics. It has been not studied whether these two DESs show different angiographic outcomes when they are simultaneously implanted in the same patient. SUBJECTS AND METHODS: We retrospectively analyzed the angiographic findings of the short-term follow-up in 34 patients (average age: 63 year old, 9 women) in whom both Cypher and Taxus stents were implanted at the same time for the treatment of obstructive coronary lesion. RESULTS: There was no significant difference in the basal angiographic characteristics of the lesions that had two stents deployed in terms of the AHA/ACC classification, reference diameter, the percent diameter stenosis and minimal luminal diameter. The post-procedure results were similar between the two stents. At 6 months follow-up, the Cypher stent displayed significantly less in-stent lumen loss compared with the Taxus stent (0.16+/-0.04 mm vs 0.27+/-0.04 mm; respectively, p=0.040) and a smaller percent diameter stenosis (15.9+/-1.3% vs 19.9+/-2.2%, respectively, p=0.049). CONCLUSION: The Cypher stent showed significantly less luminal loss during short term follow-up compared with the Taxus stent when implanted in the same patient. This result suggests that in a given individual patient, the Cypher stent induces less neointimal proliferation than does the Taxus stent.
Classification
;
Constriction, Pathologic
;
Coronary Restenosis
;
Drug-Eluting Stents
;
Florida
;
Follow-Up Studies
;
Humans
;
Kinetics
;
Middle Aged
;
Paclitaxel
;
Phenobarbital
;
Retrospective Studies
;
Sirolimus
;
Stents*
;
Taxus*