OBJECTIVE : To prepare the sustained release tablets of salbutamol sulfate,and to establish the method of quality control.METHODS: The sustained release tablets were prepared by using salbutamol sulfate, lactose, sodium carboxymethyl starch, HPMC, EC, and MCC and coated with enteric soluble acrylic resin.HPLC was employed to determine the content of salbutamol sulfate, while at the same time dissolution grade in vitro was determined, and stability was investigated.RESULTS: : The detectable concentration of salbutamol sulfate showed a good linear correlation with peak area in the range of 1.25～20.00?g/ml.The average recovery of salbutamol sulfate was 98.60% (RSD=0.66%).The prepared tablets showed a timing release 5 hours after administration.No evident changes in dissolution were found in all tests of stability.CONCLUSION: The formulation of the preparation is reasonable; the preparation technique is simple and feasible, and the quality is stable and controllable.

Objective To investigate the hospital acquired infections in the Traditional Chinese Medicine Division of Nanshan People's Hospital, Shenzhen so to improve the infection control. Method The hospital acquired infection cases in the Traditional Chinese Medicine division during the time from May 1,2006 to May 1, 2007 were reviewed. The risk factors of acquired infections in hospital for Ankylosing Spondylitis patients were analysed and summed up. Result The hospital infection rate was 5.1% (22/435), while the total hospital acquired infection rate in the hospital was 3.2% (957/29 846). Among the 22 patients, 6 cases were ankylosing spondylitis cases. The rate of hospital acquired infection in ankylosing spondylitis patients in the division was as high as 25.0% (6/24) in contrast to the rate of zero in other wards. Further analysis showed that taking cellulotoxic drugs was the main risk factor of hospital acquired infection in ankylosing spondylitis patients (P <0.01). Conclusion The patients treated with cellulotoxic drugs should be monitored for hospital acquired infection so as enhance the early control.

Objective To comparatively study on clinical effectiveness of dinoprostone(propess). Misoprostol and oxytocin in promoting cervical ripening and induced lbor. Methods A tolal of 180 patients with singleton gestation and with indications for labor induction were randomly assigned to 3 groups, respectively. Women were randomiged to receive propess 10mg(dinoprostone group) or misoprostal 25ug (misoprostal group) in posterion vaginal fomix and intravenous 0.5%～1% oxytocin (oxytocin group). Results Propess was better than oxytocin in promoting cervical ripening. The time to labor starting, membrane rapture and delivery was significantly shorter in the propess group than in the oxytoein group after applying medicine 24h later,the successful induced labor rate were 80.0% and 20.0%(P <0.01). The effectiveness of the propess group and the misoprostol group in promoting cervical ripening and induced labor was similar(P>0.05).Conclusion Propess can be used in promoting cervical ripening and induced labor safely and effectively.