1.On the Effect of Morphine Hydrochloride on the Mesenteric Mast cells of Albino Rats.
Man Soo PARK ; Ho Suck KANG ; Soo Yun PAK ; Kum Duck CHOI
Yonsei Medical Journal 1970;11(1):16-21
Histological studies were carried out on the degranulation of mesenteric mast cells of white rats caused by injections of morphine and nalorphine hydrochloride intravenously and the following conclusions were obtained. 1. By the injection of morphine hydrochloride fairly significant degranulation of the mesenteric mast cell was observed. 2. In various experimental doses of morphine hydrochloride the cytological change of the degranulation was not proportional to the doses of it in cases given more than 12mg./kg. of body weight. 3. The degranulating effect of the mesenteric mast cell by the injection of morphine hydrochloride was significantly inhibited by an adrenalectomy.
Adrenalectomy
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Animal
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Male
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Mast Cells/drug effects*
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Mesentery/drug effects*
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Morphine/antagonists & inhibitors
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Morphine/pharmacology*
;
Nalorphine/pharmacology
;
Rats
2.A Case of Superior Vena Cava Syndrome Caused by Klebsiella Pneumonia.
Ju Young KIM ; Chae Man LIM ; Seon Hee KIM ; Yun Ho CHU ; Youn Suck KOH ; Woo Sung KIM ; Won Dong KIM
Tuberculosis and Respiratory Diseases 1994;41(1):58-62
Superior vents lava(SVC) syndrome is mostly related to a malignant process, but many different benign causes haute also been described. We report a case of SVC syndrome caused by Klebsiella pneumonia diagnosed by sputum culture and serial chest X-ray changes. A 27-year-old man had been in stable health until three days before admission, when he complained of pleuritic chest pain, facial flushing, and shortness of breath. Examination of the head and neck disclosed edema of face and both arms, and jugular venous distention to the angle of the jaw. The chest auscultation resealed decreased breath sound without crackle on right upper lung field. The chest roentgenogram showed homogenous air space consolidation on right upper lobe, asociated with downward displacement of minor fissure and contralateral displacement of trachea, but air bronchogram was not seen. We began antibiotic therapy under impression of pneumonia after assailable culture was taken from blood and sputum. SVC scintigraphy showed stasis of drain of right brachiocephalic vein at the proximal portion with reflux into the right internal jugular vein and faintly visible SVC via the collaterals. Sputum culture resealed Klebsiella pneumoniae. Antibiotic therapy resulted in a cure of infection and disappearance of facial swelling. Follow-up SVC scintigraphy after 20 days showed normal finding. We first report a case of SVC syndrome caused by klebsiella pneumonia
Adult
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Arm
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Auscultation
;
Brachiocephalic Veins
;
Chest Pain
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Dyspnea
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Edema
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Flushing
;
Follow-Up Studies
;
Head
;
Humans
;
Jaw
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Jugular Veins
;
Klebsiella pneumoniae
;
Klebsiella*
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Lung
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Neck
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Pneumonia*
;
Radionuclide Imaging
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Respiratory Sounds
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Sputum
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Superior Vena Cava Syndrome*
;
Thorax
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Trachea
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Vena Cava, Superior*
3.Acute Paraplegia Following Lumbar Puncture in a Patient with Cervical Disc Herniation.
Jae Won DOH ; Sun Chul HWANG ; Suck Man YUN ; Hack Gun BAE ; Kyeong Seok LEE ; Il Gyu YUN ; Soon Kwan CHOI ; Bark Jang BYUN
Journal of Korean Neurosurgical Society 2001;30(8):1042-1046
The incidence of paraplegia following drain of cerebrospinal fluid(CSF) by lumbar puncure below a spinal block is rare, and most of them occurred in spinal tumor. We report a case of acute paraplegia following lumbar puncture for computed tomography myelography(CTM) in a 42-year-old man who sustained a cervical disc herniation. Four hours after lumbar puncture for CTM, sudden paraplegia was developed. After emergent anterior cervical discectomy and fusion with cervical plating, the patient recovered completely. To the authors' knowledge, this is the first case of spinal shock complicating lumbar puncture for routine myelography in a patient with cervical disc herniation. The prompt recognition of this unusual complication of lumbar puncture may lead to good clinical outcome. Instead of CTM requiring lumbar puncture, MRI should be considered as the initial diagnostic procedure in a patient of cervical disc herniation associated with myelopathy. We discuss the possible mechanisms of acute paraplegia following lumbar puncture with literature review.
Adult
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Diskectomy
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Humans
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Incidence
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Magnetic Resonance Imaging
;
Myelography
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Paraplegia*
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Shock
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Spinal Cord Diseases
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Spinal Puncture*
4.Study on the Clonality of Endothelial Cell Proliferation in Plexiform Lesions in Patients with Pulmonary Hypertension Associated with CREST Syndrome.
Sang Do LEE ; Yong Gam JEON ; Ji Hyun LEE ; Tae Sun SHIM ; Chae Man LIM ; Yun Suck KOH ; Woo Sung KIM ; Dong Soon KIM ; Won Dong KIM ; Rubin M TUDER
Tuberculosis and Respiratory Diseases 1999;47(2):150-160
BACKGROUND: The CREST syndrome is an indolent form of progressive systemic sclerosis. Although its clinical progress is indolent, pulmonary hypertension(PH) associated with CREST syndrome have grave prognosis with over 40 percent mortality rate at 2 year follow-up. But the pathogenesis of pulmonary hypertension in this disease is not known, and classified as either primary or secondary PH. Clonality of endothelial cell proliferation in plexiform lesion is a molecular marker which allows distinction between primary and secondary PH. We performed this study to know whether the PH associated with CREST syndrome is a variant of primary PH or is a secondary PH. METHODS: We assessed the X-chromosome inactivation based on the methylation pattern of the human androgen-receptor gene by PCR(HUMARA). Endothelial cells in plexiform lesions from female patients(n=3) with PH associated with CREST syndrome were microdissected from paraffin blocks. Vascular smooth muscle cells and lung parenchyma were also microdissected for clonality studies. RESULTS: The proliferating endothelial cells in 14 plexiform lesions were all polyclonal. Similarly proliferated smooth muscle cells from 5 vessels with medial hypertrophy were also polyclonal. CONCLUSION: These results suggest that the pulmonary hypertension associated with CREST syndrome has different pathogenesis from primary PH and to be classified as secondary PH.
CREST Syndrome*
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Endothelial Cells*
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Female
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Follow-Up Studies
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Humans
;
Hydrogen-Ion Concentration
;
Hypertension, Pulmonary*
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Hypertrophy
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Lung
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Methylation
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Mortality
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Muscle, Smooth, Vascular
;
Myocytes, Smooth Muscle
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Paraffin
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Prognosis
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Scleroderma, Diffuse