1.One Year Follow-up Evaluation of Metastatic Brain Tumors - with Relevant to the Poor Prognosis.
Hyeong Joong YI ; Choong Hyun KIM ; Jae Min KIM ; Koang Hum BAK ; Suck Jun OH
Journal of Korean Neurosurgical Society 2001;30(9):1108-1114
OBJECTIVE: Prognostic factors of metastatic brain tumors have been widely reported and their operative indications also have been extended gradually even to the poor grade patients. Authors intended to analyze the causative factors for the clinical outcome of metastatic brain tumors, especially with relevant to the poor prognosis by one year follow-up evaluation. PATIENTS AND METHODS: The authors retrospectively studied the clinical characteristics of 46 cases(35 patients) with metastatic brain tumors among 466 cases(437 patients) which were operated on due to the brain tumor, during the period between January 1994 to June 1999. Statistical analysis was performed by using SPSS 8.0(r). A p-value of less than 0.05 was considered clinically significant. RESULT: Among the variable clinical factors in patients with metastatic brain tumors, Karnofsky Performance Scale (KPS) score of less than 70(16 patients), uncontrolled primary tumor(8 patients), and surgical resection without further adjuvant therapy(9 patients) showed statistically significant poor prognosis; p value of 0.002, 0.032, and 0.001, respectively. Other tested variables, such as old age(greater than 65 years; 10 patients), gender(male; 20 patients), type of primary cancer(primary undefined; 6 patients, lung cancer; 15 patients), location(infratentorial; 9 patients, sellar; 5 patients), number of lesion(multiple; 12 patients), and number of operation(multiple craniotomy; 7 patients) were not related to the poor prognosis. CONCLUSIONS: The most common primary site of distant metastasis was lung. The poorer prognosis was highly correlated with various factors including low KPS score(<70), no postoperative adjuvant therapy, and uncontrolled primary tumors.
Brain Neoplasms*
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Brain*
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Craniotomy
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Follow-Up Studies*
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Humans
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Lung
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Lung Neoplasms
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Neoplasm Metastasis
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Prognosis*
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Retrospective Studies
2.A Case of Congenital Lumbosacral Dermal Sinus Associated with Recurrent Meningitis(Case Report).
Seong Hoon LEE ; Nam Kyu KIM ; Hwan Yung CHUNG ; Kwang Myung KIM ; Suck Jun OH
Journal of Korean Neurosurgical Society 1989;18(7-12):1124-1128
Recurrent episode of meningitis in infants and children frequently constitute a frustrating and distressing, both in determination of course and treatment. The authors are reporting a infected case of congenital dermal sinus with dermoid cyst in the subarachnoid space of cauda equina and conus medullaris which was cured after complete removal of cyst and sinus tract.
Cauda Equina
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Child
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Conus Snail
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Dermoid Cyst
;
Humans
;
Infant
;
Meningitis
;
Spina Bifida Occulta*
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Subarachnoid Space
3.Significance of Intraoperative BAEPs Monitoring during Microvascular Decompression Surgery.
Tae Joon KIM ; Yong KO ; Young Soo KIM ; Seong Hoon OH ; Kwang Myung KIM ; Nam Kyu KIM ; Suck Jun OH
Journal of Korean Neurosurgical Society 2000;29(5):635-639
No abstract available.
Microvascular Decompression Surgery*
4.Lumbar Spinal Instability and Its Radiologic Findings.
Kyoung Hoon YANG ; Nam Kyu KIM ; Young Soo KIM ; Yong KO ; Seong Hoon OH ; Suck Jun OH ; Kwang Myung KIM
Journal of Korean Neurosurgical Society 2000;29(1):78-86
No abstract available.
5.Surgical Clues of Distal Anterior Cerebral Artery(DACA) Aneurysms.
Sung Bum KIM ; Hyeong Joong YI ; Jae Min KIM ; Koang Hum BAK ; Choong Hyun KIM ; Suck Jun OH
Journal of Korean Neurosurgical Society 2000;29(12):1555-1562
No abstract available.
Aneurysm*
6.Preoperative Angiographic Value in Anterior Clinoidectomy for Surgery of Internal Carotid-Posterior Communicating Artery(IC-PC) Aneurysms.
Jae Hoon KIM ; Jae Min KIM ; Hyeong Joong YI ; Koang Hum BAK ; Choong Hyun KIM ; Suck Jun OH
Journal of Korean Neurosurgical Society 2000;29(9):1188-1194
No abstract available.
Aneurysm*
7.Prior Use of 3-Hydroxy-3-Methyl-Glutaryl-Coenzyme A Reductase Inhibitor, Simvastatin Fails to Improve Outcome after Experimental Intracerebral Hemorrhage.
Cheol Su JWA ; Hyeong Joong YI ; Suck Jun OH ; Se Jin HWANG
Journal of Korean Neurosurgical Society 2011;50(5):403-408
OBJECTIVE: Contrary to some clinical belief, there were quite a few studies regarding animal models of intracerebral hemorrhage (ICH) in vivo suggesting that prior use of statins may improve outcome after ICH. This study reports the effect of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG CoA) reductase inhibitor, simvastatin given before experimental ICH. METHODS: Fifty-one rats were subjected to collagenase-induced ICH, subdivided in 3 groups according to simvastatin treatment modality, and behavioral tests were done. Hematoma volume, brain water content and hemispheric atrophy were analyzed. Immunohistochemical staining for microglia (OX-42) and endothelial nitric oxide synthase (eNOS) was performed and caspase-3 activity was also measured. RESULTS: Pre-simvastatin therapy decreased inflammatory reaction and perihematomal cell death, but resulted in no significant reduction of brain edema and no eNOS expression in the perihematomal region. Finally, prior use of simvastatin showed less significant improvement of neurological outcome after experimental ICH when compared to post-simvastatin therapy. CONCLUSION: The present study suggests that statins therapy after ICH improves neurological outcome, but prior use of statins before ICH might provide only histological improvement, providing no significant impact on neurological outcome against ICH.
Animals
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Atrophy
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Brain
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Brain Edema
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Caspase 3
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Cell Death
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Cerebral Hemorrhage
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Hematoma
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Inflammation
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Microglia
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Models, Animal
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Nitric Oxide Synthase Type III
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Oxidoreductases
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Rats
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Simvastatin
8.Cerebral Aneurysms Arising from Unbranched Site of Intracranial Arteries.
Young Jin KIM ; Jae Min KIM ; Hyeong Joong YI ; Koang Hum BAK ; Choong Hyun KIM ; Suck Jun OH
Journal of Korean Neurosurgical Society 2000;29(4):521-527
No abstract available.
Arteries*
;
Intracranial Aneurysm*
9.Posterior Interspinous Fusion Device for One-Level Fusion in Degenerative Lumbar Spine Disease : Comparison with Pedicle Screw Fixation - Preliminary Report of at Least One Year Follow Up.
Ho Jung KIM ; Koang Hum BAK ; Hyoung Joon CHUN ; Suck Jun OH ; Tae Hoon KANG ; Moon Sool YANG
Journal of Korean Neurosurgical Society 2012;52(4):359-364
OBJECTIVE: Transpedicular screw fixation has some disadvantages such as postoperative back pain through wide muscle dissection, long operative time, and cephalad adjacent segmental degeneration (ASD). The purposes of this study are investigation and comparison of radiological and clinical results between interspinous fusion device (IFD) and pedicle screw. METHODS: From Jan. 2008 to Aug. 2009, 40 patients underwent spinal fusion with IFD combined with posterior lumbar interbody fusion (PLIF). In same study period, 36 patients underwent spinal fusion with pedicle screw fixation as control group. Dynamic lateral radiographs, visual analogue scale (VAS), and Korean version of the Oswestry disability index (K-ODI) scores were evaluated in both groups. RESULTS: The lumbar spine diseases in the IFD group were as followings; spinal stenosis in 26, degenerative spondylolisthesis in 12, and intervertebral disc herniation in 2. The mean follow up period was 14.24 months (range; 12 to 22 months) in the IFD group and 18.3 months (range; 12 to 28 months) in pedicle screw group. The mean VAS scores was preoperatively 7.16+/-2.1 and 8.03+/-2.3 in the IFD and pedicle screw groups, respectively, and improved postoperatively to 1.3+/-2.9 and 1.2+/-3.2 in 1-year follow ups (p<0.05). The K-ODI was decreased significantly in an equal amount in both groups one year postoperatively (p<0.05). The statistics revealed a higher incidence of ASD in pedicle screw group than the IFD group (p=0.029). CONCLUSION: Posterior IFD has several advantages over the pedicle screw fixation in terms of skin incision, muscle dissection and short operative time and less intraoperative estimated blood loss. The IFD with PLIF may be a favorable technique to replace the pedicle screw fixation in selective case.
Back Pain
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Follow-Up Studies
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Humans
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Incidence
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Intervertebral Disc
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Muscles
;
Operative Time
;
Skin
;
Spinal Fusion
;
Spinal Stenosis
;
Spine
;
Spondylolisthesis
10.A case of Creutzfeldt-Jakob disease.
Jae Kwan CHA ; Myung Ho KIM ; Suck Jun OH ; Eun Kyung HONG
Journal of Korean Medical Science 1991;6(3):273-278
Creutzfeldt-Jakob disease (CJD) is presumably caused by a slow infectious pathogen or prion. The principal clinical features of Creutzfeldt-Jakob disease are dementia, pyramidal and extrapyramidal symptoms and signs, cerebellar dysfunction, and myoclonus. The patient rapidly deteriorates, declines to a vegetative state, becomes comatous, and is ultimately dead within several months. The authors present a case of Creutzfeldt-Jakob disease, proved by clinical findings, typical serial EEG, and pathologic features.
Creutzfeldt-Jakob Syndrome/*diagnosis/pathology/radiography
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Electroencephalography
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Female
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Humans
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Middle Aged
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Tomography, X-Ray Computed