1.Clinical experience of cartilage allograft.
Kyung Suck KOH ; Doo Young OH ; Jeong Hoon KANG ; Sang Hoor HAN ; Kun Chul YOON
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1998;25(4):573-580
Bony defect is one of the most common problems in craniomaxillofacial surgery. Although aurogenous bone graft is the best choice for the treatment of bone defect, it provides many problems such as donor site morbidity, irregular absorption, and limited amount of harvest. To overcome the shortcomings of autogenous bone graft many bone substitutes have been introduced. The ideal bone substitution is to have characteristics such as cheap, easy to obtain, rapid fusion to recipient bone, hard structure, long maintenance of shape and volume, low infection rate, and low exposure rate. Among those bone substitutes which have been widely used we chose lyophilized cartilage allograft because of low antigenecity, low resorption rate, easiness of carving and ling term preservation. From August 1993 to August 1997, 66 patients had been performed craniomaxillofacial reconstruction with lyophilized cartilage allograft. Orbital wall reconstruction and correction of enophthalmos were 24, correction of cleft lip and nose deformity were 19, temporal augmentations were 7, and others 16. Complications such as infection, exposure were not common. And partially removed cartilage was proved some calcification. Radiologic follow-up presented well positioned lyophilized cartilage allograft. Two radiologic works revealed haziness of bone density at the site of cartilage allograft. This suggests the ossification of lyophilized cartilage allograft. Together with liw infection rate, low exposure rate, and good framework for osteoconduction, lyophilized cartilage allograft are regarded as one of the good bone substitutes.
Absorption
;
Allografts*
;
Bone Density
;
Bone Regeneration
;
Bone Substitutes
;
Cartilage*
;
Cleft Lip
;
Congenital Abnormalities
;
Enophthalmos
;
Follow-Up Studies
;
Humans
;
Nose
;
Orbit
;
Tissue Donors
;
Transplants
2.A case of prenatal ultrasonographic diagnosis of thoracic ectopia cordis.
Yung Hyun OH ; Yong Hoon CHO ; Young Don YOON ; Tae Bok SONG ; Bong Suck OH
Korean Journal of Obstetrics and Gynecology 1992;35(7):1065-1070
No abstract available.
Diagnosis*
;
Ectopia Cordis*
3.Successful Treatment of Infantile Cerebral Hemorrhage.
Chang Rak CHOI ; Suck Hoon YOON ; Jin Un SONG
Journal of Korean Neurosurgical Society 1979;8(2):457-466
It is established that intracranial hemorrhage is relatively common benign intracranial diseases in adult. This is very rare in children reports are limited to a few cases or to those cited in reviews of series of intracranial hemorrhage in adult group. We wish to report three cases of large intracranial hematoma in three infants. The diagnosis was greatly facilitated by the CT scan and the treatment did by the microsurgical methods.
Adult
;
Cerebral Hemorrhage*
;
Child
;
Diagnosis
;
Hematoma
;
Humans
;
Infant
;
Intracranial Hemorrhages
;
Tomography, X-Ray Computed
4.Free muscle flap reconstruction following resection of the skull base tumour.
Hae Cheon CHOI ; Sang Hoon HAN ; Kyung Suck KOH ; Kun Chul YOON ; Bok Sung CHUNG
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1993;20(6):1257-1265
No abstract available.
Skull Base*
;
Skull*
5.Total Excision of an Arterio-Venous Malformation of the Corpus Callosum: Case Report.
Choon Woong HUH ; Suck Hoon YOON ; Jin Un SONG
Journal of Korean Neurosurgical Society 1980;9(1):281-286
The arteriovenous malformations(AVMs) of the corpus callosum are distinct anatomical and surgical entities. The AVMs of the corpus callosum are supplied by the pericallosal arteries if the malformations are located in the anterior and middle portion of the callosum and the AVMs of the splenium are usually fed by the pericallosal and posterior cerebral arteries. Radical excision of the callosal AVMs became successful with microsurgical techniques since a few years ago. The authors report a case of the callosal AVM, who had subarachnoid hemorrhage twice prior to this admission, and the studies with angiography and computed tomography revealed an AVM involing the middle portions of the corpus callosum. Radical excision of the AVM was accomplished by microsurgical techniques without neurologic sequela.
Angiography
;
Arteries
;
Corpus Callosum*
;
Posterior Cerebral Artery
;
Subarachnoid Hemorrhage
6.A Case of Microgliomatosis of the Brain.
Choon Jang LEE ; Suck Hoon YOON ; Jin Un SONG
Journal of Korean Neurosurgical Society 1979;8(1):171-178
A rare case of microgliomatosis(reticulum cell sarcoma) of the brain is reported. The tumor was located in the left parietal lobe and the right cerebellar hemisphere and the vermis. V-P Shunt was performed and left parietal craniotomy was done for removal of tumor. The patient received radiation therapy and chemotherapy for brain tumor with a good result Histogenesis and therapy of the microgliomatosis are briefly discussed.
Brain Neoplasms
;
Brain*
;
Craniotomy
;
Drug Therapy
;
Humans
;
Parietal Lobe
;
Rabeprazole
7.Correlation of Tc-diphosphonate bone scintigraphic findings and histologic grade in prostatic adenocinoma.
So Jin LEE ; Chang Yoon PARK ; Jong Doo LEE ; Jin Suck SUH ; Jin Kyung HAHM ; Nam Hoon CHO
Journal of the Korean Radiological Society 1993;29(6):1356-1360
Prostatic adenocarcinoma is a common genitourinary malignancy which frequently is assiciated with bony metastasis at initial diagnosis. The detection of bony metastasis is important because it often alters the therapeutic strategy. The radionuclide one scintigraphy is known to be the most sensitive diagnostic method in detecting bony metastasis from prostatic adenocarcinoma. In the histologic grading of prostatic adenocarcinoma, the Gleason's grading system is the most widely employed one which is based on the degree of glandular differentiation and the growth patterns of tumor in relation to the prostatic stroma. The purpose of this study is to know the correlation of Gleason's grade and bone scintigraphic findings in prostatic carcinoma. We analyzed 99mTc-diphosphonate bone scintigraphies of 19 cases with prostatic adenocarcinoma confirmed by transurethral prostatic biopsy. Ten of the 19 cases showed asymmetrical multiple radioisotope uptake suggesting bony metastases and their Gleason's grade were 4 or 5 in seven cases. The remaining three cases were Gleason's grade 2 or 3. Another nine cases showed symmetrical radioisotope uptake with normal renal imaging suggesting no bony metastases and their Gleason's grade were 1,2 or 3 in seven cases. The remaining two cases of these nine cases were Gleason's grade 4 and 5. As the results, there was a correlation between the Gleason's grade and bone scintigraphic findings. The asymmetrical multiple skeletal uptake of radioisotope may suggest that the Gleason's grade is likely to be higher.
Adenocarcinoma
;
Biopsy
;
Diagnosis
;
Methods
;
Neoplasm Metastasis
;
Radionuclide Imaging
8.A mandibulotomy approach to malignant neoplasms of oral cavity and oropharynx.
Hong Chul KIM ; Sang Yoon KIM ; Bong Jae LEE ; Kwang Chol CHU ; Kyung Suck KOH ; Sang Hoon HAN
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(1):117-122
No abstract available.
Mouth*
;
Oropharynx*
9.Microvascular Free Tissue Transfers for Reconstruction of Irradiated Lesions in the Head and Neck.
Soo Wook CHAE ; Kyung Suck KOH ; Joo Bong KIM ; Sang Hoon PARK ; Sang Hoon HAN ; Taik Jong LEE ; Soon Yuhl NAM ; Sang Yoon KIM
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1999;26(3):340-344
Radiation therapy is an effective cancer treatment modality as a primary treatment in early cancer and as an adjuvant treatment in advanced cancer, especially in head and neck lesions, but it also causes irreversible chronic damages to overlying normal tissues that may lead to wound complications. As well, at the microscopic level, radiation injury causes both stasis and occlusion of small vessels. Therefore, surgical reconstruction of previously-irradiated lesions in the head and neck poses a great problem. Fifth-six patients with head and neck lesions underwent 57 microsurgical reconstructions between 1990-1998. Thirteen patients were irradiated before surgery. The previous radiation dose was 30-75.6 Gy. The free tissue transfer was successful in 52 of the 57 microsurgical reconstructions(91.2%). The success rate was 92.3%(12/13) in previously-irradiated patients and 90.9%(40/44) in nonirradiated patients. Postoperative complications, such as flap loss, fistula, and infection, developed in 4 irradiated patients and 8 nonirradiated patients. Overall complication rate was 30.8%(4/13) in previously-irradiated patients and 18.2%(8/44) in nonirradiated patients. Although the failure rate of previously-irradiated patients was higher than that of nonirradiated patients, there was no statistically significant difference between them. Thus, free tissue transfers in patients with previously-irradiated head and neck lesions are suitable for one-stage reconstruction.
Fistula
;
Head*
;
Humans
;
Neck*
;
Postoperative Complications
;
Radiation Injuries
;
Wounds and Injuries
10.Effect of Estradiol-induced E2IG5 on Breast Cancer Cell Line.
Jeong Yoon SONG ; Yeon Soo CHANG ; Suck Hwan KOH ; Sung Wha HONG ; Soo Myung OH ; Choong YOON ; Yong Koo PARK ; Jae Hoon PARK
Journal of the Korean Surgical Society 2005;68(1):1-8
PURPOSE: Estrogens control the development and cell proliferation of various tissues including the normal mammary epithelial cells, where they induce the expression of the immediate and delayed hormone-responsive genes. The proliferative effects of estrogen have been attributed to its ability to increase the expression of the key cell cycle regulatory genes responsible for cell cycle progression. However, the regulation of cell proliferation is only one aspect of estrogen function. It has also been well documented that estrogen plays a critical role in the etiology and progression of human breast and gynecological cancers. This tumorigenic effect of estrogen might be associated with its anti- apoptotic activities such as of Bcl-2 induction. The aim of this study was to clarify the role of E2IG5, which is an estrogen-induced downstream effector molecule, in breast cancer cell lines. RESULTS: This study shows that E2IG5 is a pro-apoptotic protein that is localized to the mitochondrial membrane via two distinct transmembrane domains. When over-expressed, it induces a mitochondrial permeability transition with the resultant of release cytochrome c and caspase activation. However, three out of four breast cancer cell lines lost their estrogen dependence of E2IG5 expression, which suggests the possible involvement of E2IG5 in the development of breast cancer. CONCLUSION: These results suggest that breast cancer cells may loose their pro-apoptotic signals and selectively use the proliferative mechanism of estrogen, which drives the normal mammary epithelial cells to transform into cancer cells. Further studies using breast cancer tissues will be needed.
Breast Neoplasms*
;
Breast*
;
Cell Cycle
;
Cell Line*
;
Cell Proliferation
;
Cytochromes c
;
Epithelial Cells
;
Estradiol
;
Estrogens
;
Genes, Regulator
;
Humans
;
Mitochondrial Membranes
;
Permeability