1.Neuropeptide and immune system : the role of substance P.
Journal of the Korean Pediatric Society 1993;36(11):1495-1501
No abstract available.
Immune System*
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Neuropeptides*
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Substance P*
2.Substance P augments TNF production in human monocytes derived macrophages.
Hae Ran LEE ; Ho WEN-ZHE ; Steven D DOUGLAS
Pediatric Allergy and Respiratory Disease 1993;3(2):64-73
No abstract available.
Humans*
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Macrophages*
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Monocytes*
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Substance P*
3.Effect of substance P and Tetrodotoxin in motility of isolated perfused human colon.
Byoung yoon RYU ; Soon Kang LEE ; Hea Wan LEE ; Hong Ki KIM ; Chang Sig CHOI
Journal of the Korean Surgical Society 1993;45(4):471-478
No abstract available.
Colon*
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Humans*
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Substance P*
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Tetrodotoxin*
5.The pattern of three-demensional distribution of substance P and calcitonin gene-related peptides(CGRP) immunoreactive fibers in the nasal mucosa of rats.
Seung Kyu CHUNG ; Masaru OKAYAMA
Korean Journal of Otolaryngology - Head and Neck Surgery 1992;35(4):512-518
No abstract available.
Animals
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Calcitonin*
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Nasal Mucosa*
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Rats*
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Substance P*
6.Experimental study on the impact of photodynamic therapy on the tissue structure of normal nasal mucosa in rabbit.
Shanshan WANG ; Yongwang HUANG ; Huijuan YIN ; Xiaowei GAO ; Jie OUYANG ; Xuebing LIU
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2014;49(11):937-942
<p>OBJECTIVETo study the reactive changes of normal nasal mucosa in rabbit under photodynamic therapy (PDT) and to make a preliminary research for the treatment of allergic rhinitis (AR) with PDT.p><p>METHODSTwenty-four New Zealand rabbits were divided into 2 groups, an experimental group and a control group with 12 rabbits in each group. PDT was applied to the experimental group, while the control group was given no treatment. The nasal mucosa was sampled separately from the same position of the rabbits from the 2 groups on 1st, 3rd, 7th, 14th, 21st, 28th day. Histomorphological changes of the sampled nasal mucosa were observed under light microscope and transmission electron microscope (TEM). The damage of three tachykinins: substance P (SP), neurokinin A (NKA) and neurokinin B (NKB) of nerve fibers was observed after immunohistochemical staining.p><p>RESULTSCompared with the control group, the nasal mucosa tissues from the experimental group had serious inflammatory reaction with basal layer damaged on the 1st and 3rd day after PDT application, the epithelial cells of nasal mucosa were arranged in disorder, and part of cilium shortened and became abnormal or even disappeared, each organelles damaged obviously; on the 7th, 14th, 21st day, it could be seen that ciliated cell, columnar cell and goblet cell started regeneration, basal cell and lamina propria glands proliferated, and the glands appeared secretion phenomenon; on the 28th day, ciliated columnar epithelium took back the nasal mucosas with small amount of microvilli, and mucous granules were found in the column cells. Nasal immunohistochemical staining of the experimental group from various stages showed that three kinds of neuropeptides were not expressed.p><p>CONCLUSIONSNormal rabbit nasal mucosas will be temporarily damaged after PDT application, the damaged nasal mucosa begin to recover in one week, and return to normal in about four weeks. Most structure and functions have recovered at the fourth week except some nerve endings.p>
Animals
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Cilia
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Inflammation
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Nasal Mucosa
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Neuropeptides
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Photochemotherapy
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Rabbits
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Substance P
7.Substance P and VIP = induced Flare and Wheal Responses in Normal Healthy Persons.
byung Jick RYU ; Jee Ho CHOI ; Jai Kyoung KOH ; Kyung Jeh SUNG
Korean Journal of Dermatology 1995;33(3):497-503
BACKGROUND: Despite concern about information of neuropeptide, the has been no baseline study of neuropeptide in Koreans. OBJECTIVE: The purpose of the study was to investigate the skin sinsitivity of substance P and VIP in normal healthy persoas. METHODS: We prepared 1000pM, 100pM, 10pM solution of substan P 1-11, substnace P 1-7, substnace P 7-11, and VIP. We injected intradermally 50ul of the br ve solutions on 12 sites of both forearms in addition plaebo. We measured the size of the area of flare and wheal along time. We repeated the same test after antihistamine intake. RESULTS: Flare and wheal respinses were dose dependent. Injection of substance P 1-7 did not evoke wheal responses and injection of substance P 7-11 did not wake flare responses. Flare responses of substance P 1-11, ubstance P 7-11, VIP were inhibiteb antihistamine and wheal responses of VIP were inhibitedly antihistamine. CONCLUSION: N-terminal of subtance P is responsible for flarers onses and C-terminal of substnace P is responsible for wieal responses. Flare responses of sisance P were mediated by histamine but wheal responses osubstance P were direct effect on postcapillary venule. Flare and wheal responses of VIF were mediated by histamine.
Forearm
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Histamine
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Humans
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Neuropeptides
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Skin
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Substance P*
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Venules
8.Substance P regulates function of osteoclasts via neurokinin-1 receptor.
Ying-ming SUN ; Song-jiao LUO ; Yu-hui ZHAO
West China Journal of Stomatology 2006;24(1):60-62
<p>OBJECTIVETo investigate the effects of substance P on cultured rat osteoclasts.p><p>METHODSNeurokinin-1 (NK1) receptor expression in osteoclasts was examined by immunohitochemical method, and changes of bone resorption activity caused by substance P and NK1 receptor antagonists were detected by pit formation assay.p><p>RESULTSImmunoreactivity for NK1 receptor was distributed in the cytoplasm of osteoclasts. The average of pit formation areas significantly increased with addition of substance P (10(-7)-10(-4) mol/L) (P < 0.05), but the number of pitformations did not change (P > 0.05). NK1 receptor antagonists inhibited the enhancement of the bone resorption by substance P addition.p><p>CONCLUSIONThe findings suggested that substance P may stimulate osteoclasts and result in bone resorption by the mediation of NK1 receptor.p>
Animals
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Osteoclasts
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Rats
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Receptors, Neurokinin-1
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Substance P
9.Pathogenesis of Acute Pancreatitis.
Hanyang Medical Reviews 2007;27(1):42-48
Acute pancreatitis is an inflammatory disorder which is developed by multiple etiologies such as gallstone, alcohol, hypertriglyceridemia, etc. The pathogenesis of acute pancreatitis is not fully clarified yet. However, it is widely accepted that intracellular premature activation of pancreatic digestive enzyme is the earliest initiating event. Intracellular premature enzyme activation is associated with co-localization with lysosomal enzyme cathepasin B and zymogen granule. The autodigestive injured pancreas is subject to inflammatory injury. Over the past few years, significant evidence has been accumulated stating that synthesis and release of proinflammatory cytokines and chemokines are responsible for local pancreatic injury and systemic dispersion of inflammation. Recently, a neurogenic mechanism of inflammation such as substance P and NK-1R has been elucidated in the pathogenesis of acute pancreatitis.
Chemokines
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Cytokines
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Enzyme Activation
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Gallstones
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Hypertriglyceridemia
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Inflammation
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Pancreas
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Pancreatitis*
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Substance P
10.Distribution of Neuropeptides-Containing Neurons in the Superior Colliculus of the Cat Brain.
Wol Bong CHOI ; Moo Ho WON ; Mi A SON
Journal of the Korean Ophthalmological Society 1993;34(5):457-467
The distribution and morphology of cholecystokinin-8 (CCK 8)-, neuropeptide Y (NPY)-, Substance P (SP)- and vasoactive intestinal polypeptide (VIP)-immunoreactivity were examined in the cat superior colliculus (SC) by means of immunohistochemistry. Judging from this study, some neuropeptides-IR neurons may be present in the superficial layers of the sc. And these neurons and neuropeptides may be involved in the functions of the superficial layers.
Animals
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Brain*
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Cats*
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Immunohistochemistry
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Neurons*
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Neuropeptide Y
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Neuropeptides
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Substance P
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Superior Colliculi*
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Vasoactive Intestinal Peptide