No abstract available.
Immune System* ; Neuropeptides* ; Substance P*

No abstract available.
Humans* ; Macrophages* ; Monocytes* ; Substance P*

No abstract available.
Colon* ; Humans* ; Substance P* ; Tetrodotoxin*

No abstract available.
Dental Pulp* ; Humans* ; Interleukin-8* ; Substance P*

No abstract available.
Animals ; Calcitonin* ; Nasal Mucosa* ; Rats* ; Substance P*

BACKGROUND: Despite concern about information of neuropeptide, the has been no baseline study of neuropeptide in Koreans. OBJECTIVE: The purpose of the study was to investigate the skin sinsitivity of substance P and VIP in normal healthy persoas. METHODS: We prepared 1000pM, 100pM, 10pM solution of substan P 1-11, substnace P 1-7, substnace P 7-11, and VIP. We injected intradermally 50ul of the br ve solutions on 12 sites of both forearms in addition plaebo. We measured the size of the area of flare and wheal along time. We repeated the same test after antihistamine intake. RESULTS: Flare and wheal respinses were dose dependent. Injection of substance P 1-7 did not evoke wheal responses and injection of substance P 7-11 did not wake flare responses. Flare responses of substance P 1-11, ubstance P 7-11, VIP were inhibiteb antihistamine and wheal responses of VIP were inhibitedly antihistamine. CONCLUSION: N-terminal of subtance P is responsible for flarers onses and C-terminal of substnace P is responsible for wieal responses. Flare responses of sisance P were mediated by histamine but wheal responses osubstance P were direct effect on postcapillary venule. Flare and wheal responses of VIF were mediated by histamine.
Forearm ; Histamine ; Humans ; Neuropeptides ; Skin ; Substance P* ; Venules

<p>OBJECTIVETo investigate the effects of substance P on cultured rat osteoclasts.p><p>METHODSNeurokinin-1 (NK1) receptor expression in osteoclasts was examined by immunohitochemical method, and changes of bone resorption activity caused by substance P and NK1 receptor antagonists were detected by pit formation assay.p><p>RESULTSImmunoreactivity for NK1 receptor was distributed in the cytoplasm of osteoclasts. The average of pit formation areas significantly increased with addition of substance P (10(-7)-10(-4) mol/L) (P < 0.05), but the number of pitformations did not change (P > 0.05). NK1 receptor antagonists inhibited the enhancement of the bone resorption by substance P addition.p><p>CONCLUSIONThe findings suggested that substance P may stimulate osteoclasts and result in bone resorption by the mediation of NK1 receptor.p>
Animals ; Osteoclasts ; Rats ; Receptors, Neurokinin-1 ; Substance P

The neurokinin Substance P is widely distributed in the central nervous system and has been extensively studied in various functional aspects. Substance P has been reported to have memory-promoting, reinforcing, and anxiolyticlike effects when administered systemically or locally. N-terminal fragment of Substance P has memory-promoting effects, whereas the C-terminal sequence of Substance P has been shown to have a memory-reinforcing effect. These properties of Substance P are thought to be mediated through activation of the nucleus accumbensventral pallidum circuitry. Substance P facilitates long-term potentiation (LTP) in the hippocampus, and the distribution of ERK neurons seems to overlap with that of NK1 neurons. Hippocampal ERK activation is critical for the induction of LTP. In conclusion, Substance P might have a neuroprotective capacity in parallel with its recovery promoting actions.
Central Nervous System ; Hippocampus ; Learning* ; Long-Term Potentiation ; Memory* ; Neurons ; Substance P

BACKGROUND AND OBJECTIVES: Angiotensin -converting enzyme (ACE) inactivates bradykinin, substance P, and neurokinin A, which are thought to play important roles in the pathogenesis of inflammatory diseases. An insertion/deletion (I/D) poly - morphism in the ACE gene was reported to be associated with atopy in a Czech population. MATERIALS AND METHODS: Using the polymerase chain reaction, we investigated the frequencies of the genotypes and alleles of the ACE gene in 137 patients with allergic rhinitis and 498 healthy control subjects. RESULTS: There was no difference in the frequencies of the genotypes in the controls and patients with allergic rhinitis (p>0.05). The D allele was more frequent in patients with allergic rhinitis, but the difference was not statistically significant (p>0.05). CONCLUSION: Our results indicate that I/D polymorphism in the ACE gene is not related to susceptibility to allergic rhinitis in the Korean population.
Alleles ; Angiotensins ; Bradykinin ; Genotype ; Humans ; Neurokinin A ; Polymerase Chain Reaction ; Rhinitis* ; Substance P

Acute pancreatitis is an inflammatory disorder which is developed by multiple etiologies such as gallstone, alcohol, hypertriglyceridemia, etc. The pathogenesis of acute pancreatitis is not fully clarified yet. However, it is widely accepted that intracellular premature activation of pancreatic digestive enzyme is the earliest initiating event. Intracellular premature enzyme activation is associated with co-localization with lysosomal enzyme cathepasin B and zymogen granule. The autodigestive injured pancreas is subject to inflammatory injury. Over the past few years, significant evidence has been accumulated stating that synthesis and release of proinflammatory cytokines and chemokines are responsible for local pancreatic injury and systemic dispersion of inflammation. Recently, a neurogenic mechanism of inflammation such as substance P and NK-1R has been elucidated in the pathogenesis of acute pancreatitis.
Chemokines ; Cytokines ; Enzyme Activation ; Gallstones ; Hypertriglyceridemia ; Inflammation ; Pancreas ; Pancreatitis* ; Substance P