Bullous pemphigoid (BP) is a chronic and the most frequent immune-mediated subepidermal blistering
disorder which mainly affects elderly individuals. The autoantibodies produced following
T-cell dysregulation are directed against BP180 (BPAg2) and BP230 (BPAg1), hemidesmosomal proteins
located in the basement membrane zone (BMZ) of the epidermis. BP may present with polymorphic
dermatological features including non-bullous manifestations and blisters. Therefore, a wide range
of differential diagnoses such as eczema, urticaria, pemphigus and the differentials for subepidermal
blister with eosinophils such as epidermolysis bullosa acquisita (EBA) and bullous drug eruptions should
be considered in such cases. The associations of solid organ internal malignancies and BP are quite rare and
vary between studies. Here, we present a case of paraneoplastic bullous pemphigoid (PNBP) in a patient
with underlying renal cell carcinoma who was initially diagnosed with worsening hand-foot syndrome (HFS)
which has led to withdrawal of his oral chemotherapy treatment.