1.Malignant Prostatic Hemangiopericytoma.
Tae Hoon LEE ; Dong Ik KIM ; Jung Min SIM ; In Su JUN ; Sung Joo HONG ; Min Sung LEE
Korean Journal of Urology 2002;43(4):346-349
Hemangiopericytoma is a relatively uncommon vascular tumor. It was first described by Stout and Murray in 1942. Here, we report a case of a primary prostatic hemangiopericytoma, which has been reported approximately <10 cases. This may be the first case of a prostatic hemangiopericytoma in Korea. A 35-year-old male patient presented with an episode of dysuria and perineal discomfort over the past 3 months. The radiological and histological features indicated a malignant hemangiopericytoma. Systemic chemotherapy was selected as the primary treatment. After 5 cycles of chemotherapy, the size of masses of the prostate and lung decreased. Four months after then, the patient died from hemoptysis.
Adult
;
Drug Therapy
;
Dysuria
;
Hemangiopericytoma*
;
Hemoptysis
;
Humans
;
Korea
;
Lung
;
Male
;
Prostate
2.Malignant Prostatic Hemangiopericytoma.
Tae Hoon LEE ; Dong Ik KIM ; Jung Min SIM ; In Su JUN ; Sung Joo HONG ; Min Sung LEE
Korean Journal of Urology 2002;43(4):346-349
Hemangiopericytoma is a relatively uncommon vascular tumor. It was first described by Stout and Murray in 1942. Here, we report a case of a primary prostatic hemangiopericytoma, which has been reported approximately <10 cases. This may be the first case of a prostatic hemangiopericytoma in Korea. A 35-year-old male patient presented with an episode of dysuria and perineal discomfort over the past 3 months. The radiological and histological features indicated a malignant hemangiopericytoma. Systemic chemotherapy was selected as the primary treatment. After 5 cycles of chemotherapy, the size of masses of the prostate and lung decreased. Four months after then, the patient died from hemoptysis.
Adult
;
Drug Therapy
;
Dysuria
;
Hemangiopericytoma*
;
Hemoptysis
;
Humans
;
Korea
;
Lung
;
Male
;
Prostate
3.Effects of MBL2 polymorphisms in patients with diisocyanate-induced occupational asthma.
Seung Hyun KIM ; Su Jin BAE ; Sailesh PALIKHE ; Young Min YE ; Hae Sim PARK
Experimental & Molecular Medicine 2015;47(4):e157-
Diisocyanate (DI) is the most common cause of occupational asthma (OA) in Korea. Mannose-binding lectin (MBL) initiates the lectin complement activation pathway following oxidative stress and plays an important role in the regulation of inflammatory processes. To determine whether there is a genetic association between MBL2 polymorphisms and DI-OA, 99 patients with DI-OA, 99 asymptomatic exposed controls (AECs) and 144 unexposed normal controls were enrolled in this study. Three polymorphisms (-554 G>C, - 431A>C and - 225 G>C) in the MBL2 promoter were genotyped, and serum MBL levels were determined by enzyme-linked immunosorbent assay. Functional variabilities in the promoter polymorphisms were analyzed by a luciferase reporter assay and electrophoretic mobility shift assay (EMSA). A significantly higher frequency of haplotype (ht) 2 [CAG] was noted in the DI-OA group compared with the AEC group (P=0.044). The patients with DI-OA carrying ht2 [CAG] had significantly lower PC20 methacholine levels (P<0.001) than the non-carriers. The serum MBL levels were significantly higher in the DI-exposed subjects (both the DI-OA patients and AECs) carrying ht1 [GAG] (P=0.028). Luciferase activity was significantly enhanced in ht1 [GAG] compared with ht2 [CAG] in human hepatocarcinoma cells (Hep3B) (P=0.002). The EMSA showed that a - 554G probe produced a specific shifted band compared with the - 554C probe. These findings suggest that decreased serum MBL levels due to polymorphisms of the MBL2 gene may increase susceptibility to the development of DI-OA in DI-exposed individuals.
Adult
;
Alleles
;
Asthma, Occupational/diagnosis/*etiology
;
Cell Line
;
Female
;
Forced Expiratory Volume
;
Gene Frequency
;
Genotype
;
Haplotypes
;
Humans
;
Immunoglobulin E/immunology
;
Immunoglobulin G/immunology
;
Isocyanates/*adverse effects/immunology
;
Male
;
Mannose-Binding Lectin/blood/*genetics
;
Middle Aged
;
*Polymorphism, Genetic
;
Polymorphism, Single Nucleotide
;
Protein Binding
;
Transcriptional Activation
;
Young Adult
4.The changes of nociception and the signal molecules expression in the dorsal root ganglia and the spinal cord after cold water swimming stress in mice
Jing-Hui FENG ; Su-Min SIM ; Jung-Seok PARK ; Jae-Seung HONG ; Hong-Won SUH
The Korean Journal of Physiology and Pharmacology 2021;25(3):207-216
Several studies have previously reported that exposure to stress provokes behavioral changes, including antinociception, in rodents. In the present study, we studied the effect of acute cold-water (4°C) swimming stress (CWSS) on nociception and the possible changes in several signal molecules in male ICR mice.Here, we show that 3 min of CWSS was sufficient to produce antinociception in tailflick, hot-plate, von-Frey, writhing, and formalin-induced pain models. Significantly, CWSS strongly reduced nociceptive behavior in the first phase, but not in the second phase, of the formalin-induced pain model. We further examined some signal molecules' expressions in the dorsal root ganglia (DRG) and spinal cord to delineate the possible molecular mechanism involved in the antinociceptive effect under CWSS.CWSS reduced p-ERK, p-AMPKα1, p-AMPKα2, p-Tyk2, and p-STAT3 expression both in the spinal cord and DRG. However, the phosphorylation of mTOR was activated after CWSS in the spinal cord and DRG. Moreover, p-JNK and p-CREB activation were significantly increased by CWSS in the spinal cord, whereas CWSS alleviated JNK and CREB phosphorylation levels in DRG. Our results suggest that the antinociception induced by CWSS may be mediated by several molecules, such as ERK, JNK, CREB, AMPKα1, AMPKα2, mTOR, Tyk2, and STAT3 located in the spinal cord and DRG.
5.The changes of nociception and the signal molecules expression in the dorsal root ganglia and the spinal cord after cold water swimming stress in mice
Jing-Hui FENG ; Su-Min SIM ; Jung-Seok PARK ; Jae-Seung HONG ; Hong-Won SUH
The Korean Journal of Physiology and Pharmacology 2021;25(3):207-216
Several studies have previously reported that exposure to stress provokes behavioral changes, including antinociception, in rodents. In the present study, we studied the effect of acute cold-water (4°C) swimming stress (CWSS) on nociception and the possible changes in several signal molecules in male ICR mice.Here, we show that 3 min of CWSS was sufficient to produce antinociception in tailflick, hot-plate, von-Frey, writhing, and formalin-induced pain models. Significantly, CWSS strongly reduced nociceptive behavior in the first phase, but not in the second phase, of the formalin-induced pain model. We further examined some signal molecules' expressions in the dorsal root ganglia (DRG) and spinal cord to delineate the possible molecular mechanism involved in the antinociceptive effect under CWSS.CWSS reduced p-ERK, p-AMPKα1, p-AMPKα2, p-Tyk2, and p-STAT3 expression both in the spinal cord and DRG. However, the phosphorylation of mTOR was activated after CWSS in the spinal cord and DRG. Moreover, p-JNK and p-CREB activation were significantly increased by CWSS in the spinal cord, whereas CWSS alleviated JNK and CREB phosphorylation levels in DRG. Our results suggest that the antinociception induced by CWSS may be mediated by several molecules, such as ERK, JNK, CREB, AMPKα1, AMPKα2, mTOR, Tyk2, and STAT3 located in the spinal cord and DRG.
6.Effect of Sulfonylureas Administered Centrally on the Blood Glucose Level in Immobilization Stress Model.
Naveen SHARMA ; Yun Beom SIM ; Soo Hyun PARK ; Su Min LIM ; Sung Su KIM ; Jun Sub JUNG ; Jae Seung HONG ; Hong Won SUH
The Korean Journal of Physiology and Pharmacology 2015;19(3):197-202
Sulfonylureas are widely used as an antidiabetic drug. In the present study, the effects of sulfonylurea administered supraspinally on immobilization stress-induced blood glucose level were studied in ICR mice. Mice were once enforced into immobilization stress for 30 min and returned to the cage. The blood glucose level was measured 30, 60, and 120 min after immobilization stress initiation. We found that intracerebroventricular (i.c.v.) injection with 30 microg of glyburide, glipizide, glimepiride or tolazamide attenuated the increased blood glucose level induced by immobilization stress. Immobilization stress causes an elevation of the blood corticosterone and insulin levels. Sulfonylureas pretreated i.c.v. caused a further elevation of the blood corticosterone level when mice were forced into the stress. In addition, sulfonylureas pretreated i.c.v. alone caused an elevation of the plasma insulin level. Furthermore, immobilization stress-induced insulin level was reduced by i.c.v. pretreated sulfonylureas. Our results suggest that lowering effect of sulfonylureas administered supraspinally against immobilization stress-induced increase of the blood glucose level appears to be primarily mediated via elevation of the plasma insulin level.
Animals
;
Blood Glucose*
;
Brain
;
Corticosterone
;
Glipizide
;
Glyburide
;
Immobilization*
;
Insulin
;
Mice
;
Mice, Inbred ICR
;
Plasma
;
Tolazamide
7.Tracheoesophageal Fistula with Tracheal Dilatation in a Patient with a Tracheostomy Using a Home Mechanical Ventilator.
Byounghoon KIM ; Min Sun JOO ; Yoo Na KIM ; Tae Rim SHIN ; Sang Myeon PARK ; Dong Gyu KIM ; Yun Su SIM
Korean Journal of Medicine 2014;87(1):87-91
Patients with tracheostomies requiring prolonged home mechanical ventilation are increasing in number rapidly. A tracheoesophageal fistula is a relatively unusual complication, but this case resulted in a fatal outcome. We describe a tracheoesophageal fistula with tracheal dilation in a 72-year-old female who had a prolonged tracheostomy and nasogastric tube, using a home mechanical ventilator. On enhanced CT images, the tracheostomy tube was well located within the trachea with no abnormal finding. However, chest enhanced CT images obtained 5 months later showed marked circumferential wall thickening of the trachea with tiny ulceration, a markedly increased diameter of the tracheal lumen, and a tracheoesophageal fistula. In patients using home mechanical ventilators, the location and cuff pressure of the tracheostomy tube and the nasogastric tube should be evaluated routinely.
Aged
;
Dilatation*
;
Fatal Outcome
;
Female
;
Humans
;
Respiration, Artificial
;
Thorax
;
Trachea
;
Tracheoesophageal Fistula*
;
Tracheostomy*
;
Ulcer
;
Ventilators, Mechanical*
8.ERRATUM: Author's English name correction. A single hospital survey of anaphylaxis awareness among health care providers and medical students.
Dae Hong SEO ; Young Min YE ; Su Chin KIM ; Ga Young BAN ; Ji Hye KIM ; Yoo Seob SHIN ; Hae Sim PARK ; Soo Young LEE
Allergy, Asthma & Respiratory Disease 2016;4(3):231-231
This erratum is being published to correct of author name.
9.A case of angioedema associated with losartan.
Min Cheul KIM ; Jong Su KIM ; Jae Wook CHUNG ; Hyun Ju SONG ; Jeong Hee CHOI ; Yu Jin SUH ; Chang Hee SUH ; Dong Ho NAHM ; Hae Sim PARK
Journal of Asthma, Allergy and Clinical Immunology 2003;23(1):95-98
Angioedema is a non-pitting edema that occurs in the skin and mucus membranes. It is known that major etiologies include hereditary deficiency of C1 esterase inhibitor, temperature extreme, trauma, food sensitivity, and medications such as penicillin, aspirin, NSAIDS and ACE inhibitors. ACE inhibitors are blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, and increasing local levels of bradykinin, a potent vasodilator. This increased bradykinin has been theorized to cause angioedema and cough in patients on ACE inhibitors. However, there has been very few causes of angioedema induced by angiotensin II receptor blocker. This is the first report of a patient presenting angioedema induced by losartan -angiotensin II receptor blocker- in this century.
Angioedema*
;
Angiotensin I
;
Angiotensin II
;
Angiotensin-Converting Enzyme Inhibitors
;
Anti-Inflammatory Agents, Non-Steroidal
;
Aspirin
;
Bradykinin
;
Cough
;
Edema
;
Hereditary Angioedema Types I and II
;
Humans
;
Losartan*
;
Membranes
;
Mucus
;
Penicillins
;
Receptors, Angiotensin
;
Skin
10.A single hospital survey of anaphylaxis awareness among health care providers and medical students.
Dae Hong SEO ; Young Min YE ; Su Chin KIM ; Ga Young BAN ; Ji Hye KIM ; Yoo Seob SHIN ; Hae Sim PARK ; Soo Young LEE
Allergy, Asthma & Respiratory Disease 2016;4(2):133-139
PURPOSE: Anaphylaxis is a rapidly progressive allergic reaction that requires precise recognition and immediate management. However, health care providers, awareness of anaphylaxis has not been acknowledged. The aim of this study is to investigate the extent of knowledge and principal management skills on anaphylaxis among medical personnel and students. METHODS: We performed a questionnaire survey on knowledge, education, and managing skills for anaphylaxis to physicians, nurses, health personnel, and medical students in Ajou University Medical Center, from 26 June to 31 October, 2014. The survey contained 2 main sections: questions about demographic data and 2 types of questionnaire (type I for all participants and type II for only medical staffs) for self-assessment on anaphylaxis. RESULTS: A total of 1,615 participants (128 doctors, 828 nurses, 436 students, and 223 health personnel) completed the survey. For questionnaire I, the percentages of correct answers in doctors, nurses, medical students, and health personnel were 77.5%, 56.4%, 47.8%, and 28.0% respectively, showing significant differences between groups (P<0.001). For questionnaire II, 93% of doctors and 75.6% of nurses indicated epinephrine as the drug of choice, and 79.7% of doctors and 71.3% of nurses selected the correct intramuscular route. More than 3 quarters of the doctors (80.5%) selected epinephrine within the first 5 steps of treatment, but only 48% included epinephrine within the first 3 steps. CONCLUSION: Our study showed considerable lack of knowledge on anaphylaxis among health care providers, especially on the specific management steps of anaphylaxis. As significant gaps on overall knowledge of anaphylaxis were observed between different groups of medical personnel, regular education should be implemented for each department in the health care setting.
Academic Medical Centers
;
Anaphylaxis*
;
Delivery of Health Care*
;
Education
;
Epinephrine
;
Health Personnel*
;
Humans
;
Hypersensitivity
;
Self-Assessment
;
Students, Medical*