Objective To explore the clinical efficacy of tirofiban in treatment of patients with high-risk non-ST-segment elevation of acute coronary syndrome (NSTE ACS),in order to improve the level of treatment effect. Methods 90 cases with high-risk NSTE ACS from January 2011 to April 2013 were randomly divided into control group and observation group. The control group were received treatments of conventional aspirin,clopidogrel, anticoagulation,coronary angiography (CAG)and percutaneous coronary intervention (PCI),while the observation group were added tirofiban therapy an the basis of control group. After the treatment,the differences of cardiovascular adverse events,thrombolysis in myocardial infarction (TIMI)flow grade and complications in both two group were observed and compared. Results There were significant differences in major adverse cardiovascular events in the distal vascular blockage,surgery without reflux,recurrent angina and myocardial infarction and post-PCI TIMI flow grade 2 and 3 (P<0.05),but not in bleeding complications,TIMI flow grade 0 and 1 before and after PCI treatment. Conclusion Tirofiban is safe and effective in treatment of high-risk NSTE ACS in interventional procedures. It can improve TIMI flow, increase tissue perfusion and reduce postoperative complications.

Objective To assess the value of LEEP for diagnosis and treatment in patients with cervical lesion.Methods 128 patients with cervical lesion were treated by LEEP.The transformation zohe of the cervix was completely excised in every case.All specimens after LEEP were sent for pathological diagnosis.The duration of the management,the amount of bleeding,the complains of the patients as well as the close follow up after treatment were all noted and recorded in detail.Results The procedure time of LEEP was short and about 6.2 minutes without anesthesia.The bleeding of LEEP was 8.4ml,the complications were few and the cure rate was high.Conclusion LEEP is safe and effective method in treatment of cervical diseases.Standardization of operation procedure and the follow-up can get satisfactory effects.

OBJECTIVE:To define the basic elements clinical pharmacists should possess in clinical treatment team.METHODS:The purpose of setting clinical pharmacists system was investigated.Different working scope and different professional requirements of clinical pharmacists and physicians were explored.The basic elements clinical pharmacists should possess in clinical treatment team were found out.RESULTS&CONCLUSION:Clinical pharmacist system of our country is a significant progress of the hospital clinical system.Clinical pharmacists in the clinical treatment team must have four basic elements:clinical responsibility,clinical action,clinical ability and clinical effect.Only in this way,could clinical pharmacists in the clinical treatment team become an irreplaceable part.

AIM: To observe the clinical effects of daniston danshentong c apsule in treatment of patients with nodular-cystic acne. METHODS: A group of patients (31 cases finished their observation in all 35 cases) wa s selected to take daniston danshentong capsule ( 0.25 g/capsule), 4 capsules three times daily. After continuous taking the agent for 8 weeks, the dosage ch anged to be 3 capsules three times daily. The treatment lasted for 12 weeks. RESULTS: The total effective rate was 83.9 %. Compared the mean number of the nodular-cystic acne before treatment (23?11) with that after 2 weeks of treatment (19?9), after 4 weeks (15?6), after 8 weeks (9?6), and aft er 12 weeks (7?7), all of the P values were less than 0.01 . The effective rate increased gradually along with administration time lengtheni ng. CONCLUSION: Daniston danshentong capsule is effective in tre atment of nodular-cystic acne, and eight-week course is a suitable for the tre atment.

Objective To evaluate the long-term therapeutic effect of Ruangan pills on advanced schistosomiasis combined with ascites. Methods The data of 54 advanced schistosomiasis patients with ascites were collected,and the patients were divid-ed into two groups namely a treatment group and a control group according to whether taking Ruangan pills. The effective rates,im-provement status of symptoms and levels of serum albumin(ALB)and hyaluronic acid(HA)of the two groups were compared. Re-sults The effective rates of the treatment group and control group were 92.59%and 44.44%,respectively,and the difference be-tween them was statistically significant(P<0.05). After the treatment for 9 and 12 months,the percentages of patients without as-cites and patients with symptom improvement in the treatment group were 77.78%and 92.59%,92.59%and 96.30%,respective-ly,while those in the control group were 29.63%and 37.00%,48.15%and 51.85%,respectively,and the differences between the two groups by different time were all statistical significant(all P<0.05). After the treatment for 9 months,the percentages of patients with the normal levels of ALB and HA were 88.89% and 59.26%,while those in the control group were 40.74% and 14.81%,respectively,and the differences between the two groups were statistically significant(both P < 0.05). Conclusion The long-term treatment of Ruangan pills can not only improve clinical symptoms but also control the ascites recurrence,however, the therapeutic effect and the recurrence rate of ascites in longer-term still need further observation.

Objective:To use defibrillators calibration detection method, some problems could be find out and analyzed. Moreover, the quality safety of defibrillators calibration can be guaranteed. Methods:According to WSB 64-2003 verification regulation for cardiac defibrillators and cardiac defibrillator-Monitors, and the practical experience of effective detection methods, defibrillation analyzer verification can be used to detect the performance parameters of cardiac defibrillators. Results:In accordance with the effective test method, through regular check, not only can cardiac defibrillators risk be eliminated but also quality safety of clinical use and the life safety of patients will be safeguarded. Conclusion:The quality control can prevent medical accidents that caused by facility loses, at the same time, if we are pay attention to the daily maintenance, the defibrillator can be played a role in emergency time.

AIM: To investigate the effects of pueraria lobata isoflavones (PLIs) on neuropeptide-Y(NPY)-induced myocardiac cell hypertrophy in vitro. METHODS: Rat cardiomyocytes cultured in vitro were randomized to control, NPY, NPY+PLIs and PLIs group. The protein synthesis in cardiomyocytes was assessed by [~3H-Leu] uptake, C-jun mRNA by RT-PCR and CaN activity by histochemistry. RESULTS: The rate of [~3H-Leu] uptake, the C-jun mRNA expression and the CaN activity of myocardiac cells in 100 nmol/L NPY group were higher than those in control (P

Skin microbiome maintain homeostasis with the host, and affect skin barrier and immune function. The components of skin microbiome are diverse and specific, and are affected by multiple factors. The predominance of Staphylococcus aureus and decrease in diversity of skin microbiome are a characteristic of atopic dermatitis. The overgrowth of S. aureus can aggravate inflammatory reactions in AD. S. epidermidis, although another predominant bacterium in AD, exerts an immunoprotective role by regulating skin barrier?associated immunoreactions through the dendritic cells, interleukin (IL)?17A?producing Th17 cells/IL?17 pathway, and by suppressing the overgrowth of S. aureus. Malassezia can induce and aggravate inflammatory reactions in AD through colonization, sensitization, cross reactions, and other mechanisms. Studies on skin probiotics may provide new directions for the treatment of AD.

Protein kinase C(PKC) is the main signaling molecule of the diacylglycerol dependent protein kinase C signal transducting system.PKC plays an important role in the generation and progress of cancer.The activation of PKC is associated with the proliferation,differentiation,apoptosis,migration and multidrug resistance(MDR) of tumor cells.It may become a novel anti-tumor strategy to block the proliferation and drug resistance signal transduction passageways with new specific PKC inhibitors directed at the PKC subgroup in tumor cells.

[Objective] To observe the effect of Pueraria Lobata isoflavones (PLI) on neuropeptide-Y-induced (NPY) vascular smooth muscle cell (VSMC) proliferation. [Methods] Experiment system for VSMC was set up as 4 groups: control group (with DME culture fluid, free of blood serum; group A), model group (with NPY culture fluid; group B), control + PLI group (with PLI culture fluid; group C) and model + PLI group (with NPY and PLI culture fluid; group E). Quantitative fluoroimmunohistochemistry techniques were applied to examine the mean fluorescent values of proliferating cell nuclear antigen (PCNA), platelet derived growth factor (PDGF) and C-myc expression. [Results] The levels of PCNA, PDGF and C-myc expression in model group were higher than control group (P