1.Clinical significance of S-100B protein in children with different degrees of amniotic fluid meconium contamination
Lina QI ; Haiying SUN ; Mingqiang SI ; Chang SU
Chinese Journal of Biochemical Pharmaceutics 2017;37(6):393-394
Objective Detection of S-100B protein in different degree meconium pollution level in serum of children with value.MethodsIn 2012 June to 2013 December in our department were simple meconium stained amniotic fluid in term newborns in 73 cases, and set up for the observation group, and according to the amniotic fluid pollution degree is divided into 47 cases of amniotic fluid of Ⅰ-Ⅱdegree pollution group and 26 cases in grade Ⅲmeconium group during the same period, selected 20 cases without amniotic fluid contamination in term healthy newborns for the control group, the groups were compared in S-100B protein content difference.ResultsⅢmeconium stained amniotic fluid were within 6h serum S-100B was significantly higher than that in control group(P<0.01), and the degree of contamination of amniotic fluidⅠ-Ⅱgroup compared with the control group, no significant difference(P>0.05).Ⅲ meconium stained amniotic fluid in children with 72h also increased.ConclusionThird degree meconium stained amniotic fluid but normal Apgar score of newborns may still exist in clinical brain injury, so pay close attention to.
2.Somatic Mutational Analysis of MEN1 and Phenotypic Correlation in Sporadic Parathyroid Tumors .
Young Su CHAE ; Hee Jin KIM ; Sun Wook KIM ; Myung Chul CHANG
Journal of the Korean Surgical Society 2009;76(1):15-22
PURPOSE: MEN1 gene mutation causes multiple endocrine neoplasia type 1. It also suggests that somatic MEN1 gene mutation plays a role in sporadic endocrine tumor. In this study, we examined whether somatic mutations of MEN1 gene are responsible for sporadic parathyroid tumors and correlate with clinical manifestations of parathyroid tumors. METHODS: Somatic mutation of MEN1 gene in the formalin-fixed, paraffin-embedded parathyroid tumor tissue from 8 adenomas, 2 carcinomas and 1 hyperplasia were analyzed by direct sequencing. Clinicopathological parameters were reviewed from medical records and compared with the mutational data. RESULTS: Eight of eleven (73%) sporadic parathyroid tumors had somatic MEN1 mutations of 14 different types. In the 14 types, 13 were a point mutation which is composed of 8 missense mutations, 2 nonsense mutations and 3 silent mutations. One of 14 types is a frameshift deletion of 27 base pairs in exon 2. Somatic mutation was frequent in the exon 2 and exon 10. Four types of polymorphism were found. There was no correlation between the presence of mutations and clinicopathological phenotype of parathyroid tumors. CONCLUSION: This result suggests that somatic mutation of MEN1 gene plays a definite role in sporadic parathyroid tumor formation.
Adenoma
;
Base Pairing
;
Codon, Nonsense
;
Exons
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Hyperplasia
;
Medical Records
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Multiple Endocrine Neoplasia Type 1
;
Mutation, Missense
;
Phenotype
;
Point Mutation
3.Sexual behavior in cervical cancer patients.
Haeng Su KIM ; Tchan Kyu PARK ; Dong Up HAN ; Ki Hong CHANG ; Hyung Sun KIM
Korean Journal of Obstetrics and Gynecology 1993;36(8):3317-3325
No abstract available.
Humans
;
Sexual Behavior*
;
Uterine Cervical Neoplasms*
4.Health Promotion Lifestyle According to Self-Perception of Obesity and Objective Status Measured by Bioelectric Impedance Analysis in College Women.
Eun Young CHANG ; Jeong Sun KIM ; Su Jin SHIN
Journal of Korean Academy of Nursing 2009;39(5):693-699
PURPOSE: The purpose of this study was to identify congruence between self-perception and objective status of obesity according to %Fat, and to investigate health promotion lifestyle in college women. METHODS: The participants were a convenience sample of 392 college women who were eligible and agreed to participate in this study. Respondents were asked questions using a health promotion lifestyle profile and were evaluated for their body composition using InBody 3.0. The data were analyzed with SPSS 14.0 program, which was used for Chi square, ANOVA, and post-hoc comparison with Scheffe. RESULTS: The major findings were as follows; 1) Overall, 41.8% of participants misclassified their perceived status of weight by %Fat standards and kappa was 0.329. 2) Two percent were underweight by BMI but overweight by %Fat and 39.0% normal weight by BMI but overweight by %Fat. 3) There were significant differences in health promotion lifestyle according to self-perception of body weight but there was no difference in health promotion lifestyle according to %Fat standards. CONCLUSION: These findings suggest the necessity for development and application of tailored health promotion program based on self-perception of body weight and %Fat in order to reform incorrect body image and health behavior in college women.
Adolescent
;
Adult
;
Body Composition
;
Body Mass Index
;
Female
;
Health Behavior
;
*Health Promotion
;
Humans
;
*Life Style
;
Obesity/*psychology
;
Overweight
;
Questionnaires
;
*Self Concept
;
Universities
;
Women/*psychology
;
Young Adult
5.Strumal Carcinoid of the Ovary: Report of a case.
Su Kyeong YEON ; Kyo Yeong LEE ; Chang Seog KANG ; Sang In SHIM ; Sun Moo KIM
Korean Journal of Pathology 1993;27(2):187-190
Strumal carcinoma of the ovary is rare tumor of germ cell origin characterized by intimate mixture of thyroid tissue and carcinoid. We report a strumal carcinoid tumor associated with ipsilateral follicular cyst and contralateral mature cystic teratoma of the ovary in a 47-year-old woman. Histologically it was composed largely of trabeculae partly of insular carcinoid and focally of individual thyroid follicles. Many cells in the carcinoid areas and even some follicular areas contained abundant argyrophile granules, and they also, in the corresponding areas, demonstrated thyroglobulin. Electron microscopic findings revealed abundant neurosecretory granules and colloid material in the same cell. We agree that this tumor is derived from hybrid showing thyroid and neuroendocrine differenciation.
Female
;
Humans
;
Cysts
6.Initial application of digital tomosynthesis for detection of pulmonary nodules
Zhiyuan SUN ; Hong SU ; Yane ZHAO ; Bing JU ; Shuanghui CHANG ; Qiuju HU ; Guangming LU
Chinese Journal of Radiology 2010;44(1):33-36
Objective To discuss the value of digital tomosynthesis for detection of pulmonary nodules. Methods Thirty patients suspected of having pulmonary nodules underwent chest radiography, digital tomosynthesis and CT examination. Above image data were transferred to postprocessing work station and were reviewed by 2 radiologists with 3 years of chest-radiology diagnosis experience in a double-blind method. The number, location and size of nodules were recorded. Then, 2 radiologists reviewed the all images once more, and discuss in consensus. The sensitivities of chest radiography and digital tomosynthesis for detection of pulmonary nodules were respectively calculated according to the CT results. Chi-square test was used for radiography, digital tomosynthesis and CT examination. Results Of 30 patients, 21 were detected having pulmonary nodules by X-ray radiography and 9 were negative, the total number of 40 nodules was detected, while 89 nodules in 26 patients were detected by digital tomosynthesis, and only 4 patients were negative. CT demonstrated 102 nodules in 27 patients, and 3 patients were negative. Taking CT as "gold standard", the sensitivities of X-ray radiography and digital tomosynthesis were 27.4%(28/102)and 87.2%(89/102), X~2=4.35, P<0.05, respectively. Conclusion Digital tomosynthesis has a high sensitivity for detection of pulmonary nodules compared with X-ray radiography, and could be an excellent and necessary supplementary technique of X-ray radiography.
7.From the perspective of embryonic development on genetic pathogenic factors of pituitary stalk interruption syndrome
Xing SU ; Chengzhi WANG ; Anping WANG ; Kun ZHAO ; Taoguang WU ; Yi SUN ; Jie SUN ; Zhengyao CHANG ; Qinghua GUO ; Yiming MU
Chinese Journal of Endocrinology and Metabolism 2017;33(8):702-704
Pituitary stalk interruption syndrome (PSIS) is a newly discovered rare endocrinological syndrome characterized by structrual defect of pituitary and multiple deficiencies of a series of hypothalamic hormones, and thus leading to a cluster of clinical symptoms. This review will illustrate the genetic pathogenic factors influence on embryonic development, and briefly introduce the current studies of Whole-Exome Sequencing on PSIS.
8.The Study on Active and Environmental Tobacco Smoke in Biological Samples among High School Students in Korea.
Sun Ha JEE ; Su jung KIM ; So young WON ; Ho Sang SHIN ; Chang Su KIM ; Hee Ja KIM
Korean Journal of Epidemiology 2002;24(1):83-92
PURPOSE: The objective of this study was to determine the active and environmental tobacco smoke (ETS) in biological samples (plasma, saliva and urine) among high school students in Korea. METHODS: Study samples were from 99 nonsmoker or smoking volunteers from high school in Kyungki-do in 2000. ETS was defined as the having smokers of their family members or their friends. Urinary samples were extracted with ethyl ether at pH 10.5, and the extract was injected in GC-NPD. Plasma or saliva was extracted with methylene chloride at pH 10.5 and the quantification was performed with GC-MS (SIM). Peak shapes and quantitation of nicotine and cotinine were excellent, with linear calibration curves over a wide range of 1 to 3000 ng/mL. RESULTS: The results are as followings1. The prevalence of smoking among study subjects were 18.2% among males and 6.1% among females. A 69.7% of total subjects among both males and females were exposed at ETS. 2. The primary metabolite cotinine of nicotine was good indicator of ETS exposure in nonsmokers. Salivary cotinine was found to be highly correlated to the concentration of cotinine in plasma (r=0.9480). 3. Urine cotinine was increased among those with smokers in their family members, while salivary or blood cotinine was increased among with smoking friends. 4. Blood cotinine was highly correlated with salivary cotinine, but it was relatively poorly correlated with urine cotinine. CONCLUSIONS: In conclusion, the results show how the students in high school in Korea suffer from secondhand smoke. It appeared that salivary cotinine was easy to collect and best way to predict the ETS among adolescents
Adolescent
;
Calibration
;
Cotinine
;
Ether
;
Female
;
Friends
;
Gyeonggi-do
;
Humans
;
Hydrogen-Ion Concentration
;
Korea*
;
Male
;
Methylene Chloride
;
Nicotine
;
Plasma
;
Prevalence
;
Saliva
;
Smoke*
;
Smoking
;
Tobacco Smoke Pollution
;
Tobacco*
;
Volunteers
9.Duodenal gangliocytic paraganglioma: report of a case.
Chang ZHANG ; Jian WU ; Su-an SUN ; Hai-yan LIU ; Wu-bi ZHOU ; Xiu-fang LI ; Yun JIN
Chinese Journal of Pathology 2012;41(1):55-56
Chromogranin A
;
metabolism
;
Diagnosis, Differential
;
Duodenal Neoplasms
;
metabolism
;
pathology
;
surgery
;
Ganglioneuroma
;
metabolism
;
pathology
;
Gastrointestinal Stromal Tumors
;
metabolism
;
pathology
;
Humans
;
Male
;
Middle Aged
;
Neurofibroma
;
metabolism
;
pathology
;
Paraganglioma
;
metabolism
;
pathology
;
surgery
;
Phosphopyruvate Hydratase
;
metabolism
;
S100 Proteins
;
metabolism
10.Changes in Knowledge about AIDS, Attitude toward AIDS Patients and Intention to Use Condoms after AIDS Education.
Soon Bok CHANG ; Hee Sun KANG ; Su Rin SHIN ; Hyun Ju CHAE
Journal of Korean Academy of Community Health Nursing 2006;17(3):397-406
No abstract available.
Condoms*
;
Education*
;
Humans
;
Intention*