China ; Humans ; Occupational Diseases ; prevention & control ; Occupational Health ; legislation & jurisprudence ; Occupational Health Services ; organization & administration ; standards

Endometrial Hyperplasia ; genetics ; pathology ; Female ; Genital Neoplasms, Female ; genetics ; pathology ; Humans ; Tandem Repeat Sequences ; Uterine Cervical Neoplasms ; etiology

The origin and development of "five elements motion and six kinds of qi" acupuncture technique are reviewed, and acupuncture for treatment and prevention of disorders of "five elements motion and six kinds of qi" is summarized. Also its principle is analyzed. Problems such as the inconformity of acupoint selection, lack of systematic theory are discussed. It is pointed out that, instead of indiscriminate copy, treatment should be based on the observation of the transportation and transformation of qi; it is suggested that the classics should be inherited and innovated, combining the tradition with contemporary, and according to a sixty-year cycle, the acupuncture technique of "five elements motion and six kinds of qi" can be improved systematically for promotion and application.
Acupuncture Points ; Acupuncture Therapy ; history ; methods ; Books ; history ; China ; History, Ancient ; Humans ; Medicine in Literature ; Meridians ; Qi ; history

The patients with primary enuresis complicating with hemirachischisis were treated by routine manipulations as well as the acupoints and manual methods to unblock and regulate Governor Vessel. Excellent effects have been obtained.

microRNA (miRNA) refers to small (19-25 nt) single-stranded noncoding RNA molecules that work as post-transcriptional regulator for gene expression by binding to 3' untranslated regions of target mRNA,thus inducing its digestion,degradation and translational repression.Many studies have confirmed that dysregulation of miRNA expression can cause disruption of the hematopoietic system and contribute to leukemogenesis by regulating the expression of some oncogenes and anti-oncogenes.The unique miRNA expression profiles associated with cytogenetic aberrations and mutational status of protein-coding genes may reveal insight into the biology of these leukemia types.This review discussed the latest studies on miRNA expression in different cytogenetic and molecular subtypes of acute myelocytic leukemia and acute lymphoblastic leukemia.

Objective To investigate the application values of 3 kinds of crossmatching method saline medium method,polybrene test and microcolumn gel test in the neonatal blood transfusion security.Methods 174 newborns needing blood transfusion were simultaneously performed the isotype crossmatching by the saline method,polybrene test and microcolumn gel test.The irregular antibody and the direct antiglobulin test were routinely conducted,the samples with positive irregular antibody were further per-formed the antibody specificity identification.Results 14 cases (8.05%)of crossmatching incompatibility were found by the saline method,1 case (0.57%)by the polybrene test and 62 cases (35.63%)by the microcolumn gel test;among which,31 cases were secondary side crossmatching incompatibility caused by positive direct antiglobulin test,1 was the incompatibility of 3 methods caused by anti-D antibodies.The difference between the polybrene test and the microcolumn gel test was of statistical significance (P <0.05).Conclusion The blood crossmatching by the microcolumn gel test in blood transfusion of newborns requires quite few amount of blood sample,is simple to operate and easy to be standardized.With results clearly and easily measured and sensitivity higher than that of polybrene test,its result is clear and easy to be judged,its sensitivity is higher than that of the polybrene test, which has the important significance for ensuring the neonatal blood transfusion safety.

Saxagliptin belongs to the class of dipeptidyl peptidase-4(DPP-4) inhibitors which are novel oral glucose-lowering agents with uniquely mechanism in patients with type 2 diabetes mellitus. Clinical efficacy without increasing hypoglycemia of saxagliptin as single agent as well as in combination with other medications used for the treatment of type 2 diabetes mellitus has been well established in several randomized trials. In addition, a cardiovascular outcome study of SAVOR shows that saxagliptin does not increase the risk of a composite of non-fatal myocardial infarction, non-fatal stroke or cardiovascular death meeting the primary safety objective. The efficacy and safety studies were hereby reviewed.

BACKGROUND:Under normal physiological conditions, there is a homeostasis between the osteogenic and adipogenic differentiation of human bone marrow mesenchymal stem cel s. Osteogenic differentiation is an important process in the formation of skeleton in which differentiated and mature osteoblasts are indispensable. OBJECTIVE:To explore the role of miR-106a and its target gene, bone morphogenetic protein receptor 2 (BMPR2) in the differentiation of human bone marrow mesenchymal stem cel s into osteoblasts. METHODS:Human bone marrow mesenchymal stem cel s were induced to differentiate into osteoblasts by osteoblast-specific induction medium, and this process was detected by western blot and alkaline phosphatase staining. Overexpression of miR-106a was elicited by transfecting miR-106a mimics and the BMPR2 knockdown achieved by RNA interference. The expression levels of miR-106a and BMPR2 were detected by real-time PCR and western blot, respectively. The interaction of miR-106a and BMPR2 was verified by TargetScan software and dual luciferase report experiment assay. RESULTS AND CONCLUSION:The expression of miR-106a was decreased whereas the expression of BMPR2 increased with the progress of osteogenesis differentiation. When miR-106a was overexpressed, alkaline phosphatase activity was declined and the expressions of runt-related transcription factor 2 and osteocalcin, markers of osteogenesis differentiation, both decreased. The expression of BMPR2 was decreased as wel . BMPR2 was predicted to be the target gene of miR-106a by TargetScan software and this prediction proved by dual luciferase report experiments assay. Additional y, osteogenesis differentiation was inhibited by knocking down the expression of BMPR2. These results indicate that miR-106a regulates the differentiation of bone marrow mesenchymal stem cel s into osteoblasts by targeting BMPR2.

There has been controversies on whether using intravenous or intraarterial thrombolytic therapy around the onset of acute ischemic stroke within 3 hours.This article summarizes the main arguments of different neurologists.

ICU is the important place of ventilator associated pneumonia, the occurrence of fatality rate in patients with ventilator associated pneumonia is higher. In this paper, the cause of the ventilator associated pneumonia in ICU and nursing research progress are summarized, that enhance their awareness of the importance of nursing care and the use of normative evidence-based nursing in clinical practice thinking and nursing process, explore the nursing methods of more appropriate, to reduce the incidence of ventilator associated pneumonia in ICU is of great help.