The iodine deficiency disorders surveillances were performed in different historical periods according to different surveillance plans in China as various monitoring purposes.Compared with other editions of surveillance plan,the biggest changes were to observe the urinary iodine level,the salt iodine level and the goiter rate in children and pregnant women in the county level in this National Iodine Deficiency Disorders Surveillance Plan (the 2016 edition).In this paper,the implementation details on this surveillance plan were further interrelated,which would play an instrumental role for the staff in iodine deficiency disorders prevention and control.

ICU is the important place of ventilator associated pneumonia, the occurrence of fatality rate in patients with ventilator associated pneumonia is higher. In this paper, the cause of the ventilator associated pneumonia in ICU and nursing research progress are summarized, that enhance their awareness of the importance of nursing care and the use of normative evidence-based nursing in clinical practice thinking and nursing process, explore the nursing methods of more appropriate, to reduce the incidence of ventilator associated pneumonia in ICU is of great help.

Objective To study the clinical efficacy of acupuncture combined with Rood therapy for post-stroke upper limb functional disorder. Methods Ninety patients which met the inclusion criteria were randomly divided into integrated group (acupuncture +Rood therapy), acupuncture group, and Rood therapy group, 30 in each group. The therapeutic effect of the three groups was evaluated after treatment for 6 courses, one course covering 7 days. Results (1) After treatment for 6 courses, the total effective rate of the integrated group, acupuncture group, and Rood therapy group was 93.33%, 76.67%, 63.33%, respectively. The results of Mann-Whitney test showed that the integrated group had better effect than acupuncture group and Rood therapy group, the difference being significant(P<0.05).(2) After treatment, muscle tension of the integrated group and acupuncture group was much improved as compared with that before treatment(P<0.01), but Rood therapy group showed no obvious changes in muscle tension before and after treatment(P>0.05). (3) After treatment, FMA scores and MBI scores were markedly increased in the three groups(P<0.001 compared with those before treatment). The integrated group had better effect on improving FMA scores and MBI scores than acupuncture group and Rood therapy group , and the resul ts of ANOVO test showed that t he differences were signficiant(P<0.05). Conclusion Acupuncture combined with Rood therapy has certain clinical efficacy for post-stroke upper limb functional disorder, and the effect is better than acupuncture or Rood therapy alone.

Saxagliptin belongs to the class of dipeptidyl peptidase-4(DPP-4) inhibitors which are novel oral glucose-lowering agents with uniquely mechanism in patients with type 2 diabetes mellitus. Clinical efficacy without increasing hypoglycemia of saxagliptin as single agent as well as in combination with other medications used for the treatment of type 2 diabetes mellitus has been well established in several randomized trials. In addition, a cardiovascular outcome study of SAVOR shows that saxagliptin does not increase the risk of a composite of non-fatal myocardial infarction, non-fatal stroke or cardiovascular death meeting the primary safety objective. The efficacy and safety studies were hereby reviewed.

The patients with primary enuresis complicating with hemirachischisis were treated by routine manipulations as well as the acupoints and manual methods to unblock and regulate Governor Vessel. Excellent effects have been obtained.

microRNA (miRNA) refers to small (19-25 nt) single-stranded noncoding RNA molecules that work as post-transcriptional regulator for gene expression by binding to 3' untranslated regions of target mRNA,thus inducing its digestion,degradation and translational repression.Many studies have confirmed that dysregulation of miRNA expression can cause disruption of the hematopoietic system and contribute to leukemogenesis by regulating the expression of some oncogenes and anti-oncogenes.The unique miRNA expression profiles associated with cytogenetic aberrations and mutational status of protein-coding genes may reveal insight into the biology of these leukemia types.This review discussed the latest studies on miRNA expression in different cytogenetic and molecular subtypes of acute myelocytic leukemia and acute lymphoblastic leukemia.

Objective To compare the effects of three kinds digestive tract reconstruction after radical gas-trectomy for gastric cardia carcinoma.Methods The data of 150 patients underwent radical gastrectomy for gastric cardia cancer patients were analyzed.According to the reconstruction of digestive tract,they were divided into group A (55 cases),group B (46 cases),group C(49 cases).Patients in group A underwent jejunal anastomosis.Patients in group B underwent esophageal empty intestine Roux-en-Y anastomosis.Patients in group C underwent esophageal gas-tric wall anastomosis.All were follow-up for 12 months.Results During the follow-up period,the rate of reflux esoph-agitis in group A were significantly lower than that in B group (1.82%vs 19.57%,χ2 =6.966,P=0.008),the rate of reflux esophagitis in B group were significantly lower than that in C group (19.57%vs 38.78%,χ2 =4.212,P=0.042) .12 months after operation,overall health,constipation,diarrhea,nausea and vomiting index score of group A was significantly lower than those of group B and group C (all P<0.05).Conclusion The esophagus jejunum Roux-en-Y anastomosis is suitable for radical total gastrectomy in the treatment of gastric cardia carcinoma.The jeju-nal interposition anastomosis after proximal radical gastrectomy in the treatment of gastric cardia carcinoma shows low incidence of reflux esophagitis and high quality of life.

The aim of joint development and sharing of institutional repository is to reveal and use the primary literature in military colleges and universities, and help scientific researchers, teachers and students to discover and use such re-sources .The ideas on joint development and sharing of institutional repository in military colleges and universities were thus analyzed, and the related problems were elaborated with suggestions put forward for their solution.

Objective:To explore the influence of cardiac pacing at different sites on left atrial structure and function . Methods:A total of 62 patients ,who needed cardiac pacing therapy because of bradycardia in our hospital from Jan 2012 to Jan 2014 ,were selected .According to the implanted sites of pacing electrode ,patients were equally divided into right ventricular cardiac apex group (RVA group) and right ventricular outflow tract group (RVOT group) . Left atrial volume before atrial contraction (LAVp) ,minimum left atrial volume (LAVmin) ,maximum left atrial volume (LAVmax) ,left atrial active emptying fraction (LAAEF) and left atrial passive emptying fraction (LA-PEF) etc .were compared between two groups before and after cardiac pacing therapy .Results:There were no sig-nificant difference in all indexes between two groups before treatment ,P>0.05 all .Compared with RVA group af-ter six-month pacing treatment ,there were significant reductions in LAVp [ (29.5 ± 3.2) ml vs .(27.1 ± 3.5) ml] , LAVmin [ (18.6 ± 2.0) ml vs . (17.2 ± 2.7) ml] ,LAVmax [ (48.9 ± 4.8) ml vs .(46.1 ± 5.1) ml] and LAAEF [(47.2 ± 4.5)% vs .(43.5 ± 4.2)% ] ,and significant rise in LAPEF [(40.9 ± 5.3)% vs .(43.6 ± 3.9)% ] in RVOT group ,P<0.05 or <0.01. Conclusion:Effect of right ventricular outflow tract pacing is more than that of right ventricular cardiac apex pacing and may be used as a replacement of right ventricular cardiac apex .

BACKGROUND:Under normal physiological conditions, there is a homeostasis between the osteogenic and adipogenic differentiation of human bone marrow mesenchymal stem cel s. Osteogenic differentiation is an important process in the formation of skeleton in which differentiated and mature osteoblasts are indispensable. OBJECTIVE:To explore the role of miR-106a and its target gene, bone morphogenetic protein receptor 2 (BMPR2) in the differentiation of human bone marrow mesenchymal stem cel s into osteoblasts. METHODS:Human bone marrow mesenchymal stem cel s were induced to differentiate into osteoblasts by osteoblast-specific induction medium, and this process was detected by western blot and alkaline phosphatase staining. Overexpression of miR-106a was elicited by transfecting miR-106a mimics and the BMPR2 knockdown achieved by RNA interference. The expression levels of miR-106a and BMPR2 were detected by real-time PCR and western blot, respectively. The interaction of miR-106a and BMPR2 was verified by TargetScan software and dual luciferase report experiment assay. RESULTS AND CONCLUSION:The expression of miR-106a was decreased whereas the expression of BMPR2 increased with the progress of osteogenesis differentiation. When miR-106a was overexpressed, alkaline phosphatase activity was declined and the expressions of runt-related transcription factor 2 and osteocalcin, markers of osteogenesis differentiation, both decreased. The expression of BMPR2 was decreased as wel . BMPR2 was predicted to be the target gene of miR-106a by TargetScan software and this prediction proved by dual luciferase report experiments assay. Additional y, osteogenesis differentiation was inhibited by knocking down the expression of BMPR2. These results indicate that miR-106a regulates the differentiation of bone marrow mesenchymal stem cel s into osteoblasts by targeting BMPR2.