Objective:To alarm the effect of statins on blood glucose, and provide evidence for the rational use of statins in clin-ics. Methods:The recent articles on the effects and potential mechanisms of diabetogenic action of statins were reviewed and summa-rized. Results and Conclusion:Stains, especially lipophilic stains, could increase blood glucose via multiple pathways to induce dia-betes. The potential mechanisms included inhibiting L-type calcium channel, increasing the uptake of plasma-derived LDL-C, inhibi-ting synthesis of ATP and Coenzyme Q10, inhibiting the expression of glucose transporter 4 and inducingβ-cell inflammation, oxidation and apoptosis. Blood glucose should be monitored and adjusted timely when statins are used in clinics.

Objective]The paper summarizes the clinical experience of Professor Lu Su for treating menopausal syndrome.[Methods] By learning from Professor Lu Su, sum up the knowledge of etiology and pathogenesis, treatment characteristics and analyze cases. [Results]Professor Lu Su thought that the main etiological and pathogenesis of menopausal syndrome was that deficiency of the kidney-yin and hyperactivity of heart and liver fire. The kidney water cannot aid heart, the occurrence of heart(including liver) fire too strong, the heart is not calm, leading to hot flashes sweating, upset insomnia and other symptoms of menopausal syndrome. Therefore, she made a total therapeutic principle of invigoration of the kidney and nourishment of Yin, purging heart fire and soothing the nerves. Besides, the article introduces prescribing characteristics of other lesions relating to menopausal syndrome, such as blood stasis, phlegm, yang deficiency and disharmony between spleen and stomach. In treatment, Lu Su is good at syndrome differentiation and treatment, prescribing refinedly and simply, combining medication with psychotherapy. [Conclusion]Therapies of Professor Lu Su on treating menopausal syndrome have significant effect.

Noonan syndrome(NS) is a congenital genetic disease characterized by distinctive facial features,short stature,chest deformity,congenital heart disease,and other comorbidities.This article reviewed the research history of NS,the clinical manifestations and their relationship with genotype,the diagnosis and treatment.

The use of literature novelty assessment reports in medical researchers of Guizhou Province and its in-fluencing factors were investigated with questionnaires combined with interview, and measures were put forward for improving the use and level of literature novelty assessment reports, and service for scientific research.

The elderly patients with diabetes often have a high prevalence of hypertension.Meanwhile,hypertension is a major vascular risk factor in this population.The benefit of proper management of hypertension in elderly patients with diabetes has been well recognized.According to the IDF Global Guideline for Managing Old People with Type 2 Diabetes,lifestyle interventions are recommended to form the first step in managing hypertension in elderly patients with diabetes.Pharmacological therapy should be initiated in addition to lifestyle interventions after 6 weeks during which non-pharmacological therapy has failed to achieve blood pressure targets.ACE-inhibitors are the first choice for initial medication,especially in the presence of diabetic nephropathy.ARBs can be used in people who cannot tolerate ACE-inhibitors.Diuretics or calcium channel blockers can be used as the first add-on therapy to ACE-inhibitors or ARBs if they fail to achieve target blood pressure.β-blockers should be considered for combination therapy in people with tachycardia or coronary artery disease.The generally recommended blood pressure target for older people with diabetes should be less than 140/90 mmHg(1 mmHg=0.133 kPa).

T-lymphoblastic lymphoma (T-LBL) is a rare form of non-Hodgkin lymphoma (NHL),which is biologically similar to T-acute lymphoblastic leukemia(ALL),and occurs most frequently in childhood and adolescence.T-LBL progresses fast.The treatment of LBL with conventional chemotherapy regimens for NHL has shown relatively low rates of complete remission and of disease-free survival.Now,it is reasonable to treat patients with LBL with the current ALL-type protocols,and hematopoietic stem cell transplantation may yield a more favorable overall survival (OS) in T-LBL patients,especial in relapsed or refractory LBL patients.

Chinese prescription is composed of Chinese herbal medicines according to "seven compatible relations" and "sovereign, minister, assistant and courier" principles. There are many methods in the research on combination and composition of Chinese herbal medicines. These methods are classified into traditional model and modern model. For the time being, compatibility study of traditional Chinese herbal medicines has developed from traditional model to modern model. The traditional model mainly studies the effects and mechanisms of the whole and split formulae in medical crude drug level, while the modern model mainly studies the effects and mechanisms of Chinese herbal medicine compositions in components combination level. Moreover, quantitative analysis becomes probable by modern model method. Now, setting up of new components combination model and optimal composition methods will not only develop the combination and the composition of Chinese herbal medicines from medicinal crude drug level to components composition level, but also get new formulae which have clear components and effects, and action targets and mechanisms. It will effectively promote the development of Chinese medicine formula.

Objective To explore the function and significance of interleukin(IL)-25 in the pathogenesis of inflammatory bowel disease (IBD) through testing its expression in the intestinal mucosal and serum of patients with IBD. Methods Intestinal or colonic mucosal biopsies of 12 patients with ulcerative colitis (UC), 16 patients with Crohn's disease (CD) and 10 healthy controls were collected. The expression of IL-25 at mRNA level was detected by real-time PCR and the situ expression of IL-25 in intestinal mucosa was analyzed with immunohistochemistry. At same time,serum of 20 UC patients, 24 CD patients and 20 controls was collected, and IL-25 concentration in the serum was determined by enzyme-linked immunosorbent assay (ELISA). Results Compared with healthy controls, the expression of IL-25 at mRNA level in inflamed mucosa of CD and UC patients was significantly decreased (P＜0.05), no statistic difference between UC and CD groups (P＞0.05).The immunohistochemistry results indicated that more IL-25 positive cells in normal lamina propria,the expression of IL-25 in mucosal epithelia cells was low, the expression of IL-25 protein in the intestinal or colonic mucosa of UC and CD patients significantly decreased ( P ＜ 0.05), no statistic difference between UC and CD groups (P＞0. 05). ELISA results showed that the level of IL-25 in the serum of UC and CD groups was significantly lower than healthy controls (P ＜ 0.05). Conclusion The expression of IL-25 in the intestinal mucosa and serum of IBD patients was significantly decreased,which suggested that IL-25 expression defects may closely related to the pathogenesis of IBD. IL-25 may be a new target for the IBD treatment.

Objective To explore the alterations of intestinal mechanical barrier during the nonalcoholic fatty liver disease (NAFLD) progression. Methods To establish NAFLD rats' model,ninety male SD rats were divided into three groups equally: normal-diet group, high-sucrose diet group and high-fat diet group. At the 4th, 8th and 12th week each time point, ten rats were sacrificed in each group. Another twenty SD rats were randomly divided into carbon tetrachloride (CCl4) group and control group. The liver injured model of CCl4 group was induced by CCl4 ; all the rats of these two groups were killed at the 4th week. The degree of liver steatosis was observed through HE staining of liver paraffin sections. The lipopolysaccharide (LPS) level of portal vein blood was measured by limulus test. The occludin expression in intestinal mucosal was detected by immunofluorescent assay,and the fluorescence intensity was scored. The morphology change of intestinal mucosa tight junction was observed through electron microscopy. Results The liver histopathology suggested that NAFLD and liver injured rats' model was successfully established. There was no statistical significance of LPS level between high-sucrose diet group and normal diet group at all the time point (P＞0.05). At the 4th and 12th week, there was no statistical significance of LPS level between high-fat diet group and normal diet group (P＞0.05), while it was significantly higher in high-fat diet group than normal diet group at the 8th week (P＜0. 05). There was no statistical significance of LPS level between CCl4 group and control group (P＞0. 05). At the 8th week, the expression of occludin in normal-diet group, high-sucrose diet group and high-fat diet group was 1.80±0. 42, 1. 50 ± 0. 53 and 1.30±0.67, respectively, the expression was a little bit lower in high-sucrose diet group and high-fat diet group than in normal diet group, the difference was statistical significance (P＜0. 05). At the 12th week, the expression of occludin was significantly lower in high-sucrose diet group and high-fat diet group than normal diet group. The expression of occludin was significantly lower in CCl4 group (0.60±0.16) than in control group (1.80±0. 42) (P＜0. 05). No obvious morphology changes of tight junction was found in high-sucrose diet group, high-fat diet group and CCl4 group at each time point.Conclusion The expression of occludin decreased gradually during the non-alcoholic fatty liver disease progression. So in the NAFLD treatment, besides improving insulin resistance and protecting liver function,the protection of intestinal mucosa barrier as early as possible may slow down the progression of liver injury.

Objective To study the quantitative analysis of myocardial reperfusion after percutaneous coronary intervention (PCI) using myocardial contrast echocardiography (MCE) in patients with coronary diseases. Methods The contrast agent of SonoVue via vein route using contrast pulse sequencing (CPS)MCE were performed in 15 patients with coronary diseases before and after the PCI. The intensity of amplitude (A) ,slope(β), A ×β, the contrast arrival times (AT) and the arrival peak times (TTP) were calculated with the autotracking contrast quantification software. Results Clear images of the left ventricle were well displayed in all the patients. There were satisfied images in the normal perfusion area of the myocardium,but not in the abnormal. AT,TTP and A ×β were significantly different between the abnormal and the normal perfusion area ( P ＜0. 05). The myocardial reperfusion significantly increased in the group that the coronary stenosis was greater than 70% after PCI( P ＜0. 05). There was no change in the group that the coronary stenosis was less than 70% ( P ＞ 0.05). Conclusions PCI can efficiently improve the myocardial microcirculation. MCE can accurately, rapidly, and efficiently reveal the reperfusion status of myocardium after PCI.