1.Effects of diazoxide pretreatment on the expression of hypoxia- inducible factor-1α mRNA and p53 mRNA in rat myocardial microvascular endothelial cells exposed to hypoxia-reoxygenation
Jin CHEN ; Su GAO ; Huanju KANG ; Shiren SHEN
Chinese Journal of Anesthesiology 2011;31(1):102-104
Objective To investigate the effects of diazoxide pretreatment on the expression of hypoxia-inducible factor-1α (HIF-1α) mRNA and p53 mRNA in rat myocardial microvascular endothelial cells exposed to hypoxia-reoxygenation (H/R).Methods The SD rat myocardial microvascular endothelial cells were cultured. The cells were seeded in 96-well plates ( 100 μl/hole) or in 6 cm diameter dishes (2 ml/dish) with the density of 1 ×106/ml and randomly divided into 4 groups ( n = 24 each): normal control group (group C), H/R group, H/R +diazoxide pretreatment group (group DZ) and H/R + diazoxide pretreatment + mitochondrial ATP-sensitive potassium channel blocker 5-hydroxydecanoate (5-HD) group (group DZ + 5-HD). The cells were exposed to 2 h hypoxia followed by 2 h reoxygenation. Diazoxide 100 μmol/L and diazoxide 100 μmol/L + 5-HD 100 μmol/L were added to the culture medium 2 h before hypoxia in DZ and DZ + 5-HD groups respectively. The cell vitality, apoptotic rate and expression of HIF-1α mRNA and p53 mRNA were detected at the end of reoxygenation. Results Compared with group C, the cell vitality was significantly decreased, apoptotic rate increased and the expression of HIF- 1α mRNA and p53 mRNA up-regulated in H/R group ( P < 0.01). Compared with group H/R, the cell vitality was significantly increased, apoptotic rate decreased, the expression of HIF-1α mRNA up-regulated and the expression of p53 mRNA down-regulated in group DZ ( P < 0.05 or 0.01 ). 5-HD could inhibit diazoxide pretreatment-induced changes mentioned above (P < 0.05 ). Conclusion Diazoxide pretreatment can reduce H/R injury in rat myocardial microvascular endothelial cells through up-regulating the expression of HIF-1α and down-regulating the expression of p53, and the mechanism is related to activation of mitochondrial ATP-sensitive potassium channels.
2.Annual Neck Ultrasonography Surveillance between 3 to 12 Years after Thyroid Lobectomy for Papillary Thyroid Microcarcinoma
Jin Gu KANG ; Jung Eun CHOI ; Soo Jung LEE ; Su Hwan KANG
International Journal of Thyroidology 2020;13(2):142-149
Background and Objectives:
In South Korea, neck ultrasonography (US) has been used widely at 1- or 2-year intervals to detect recurrence after thyroidectomy. The aim of this study is to assess the prevalence and pattern of recurrence and to establish a proper frequency of follow-up neck US after thyroid lobectomy for papillary thyroid microcarcinoma (PTMC).
Materials and Methods:
We retrospectively reviewed 262 consecutive patients who had undergone thyroid lobectomy for PTMC from January 2005 to October 2009. They were divided into two groups based on the presence of recurrence (240 patients in group 1 and 22 patients in group 2). The comparison between the two groups involved clinical and pathological characteristics.
Results:
Recurrences were found in 22 (8.4%) of 262 patients with 132.5 months follow-up (range, 120-180 months). There was a significant difference in the mean number of follow-up neck US after 5 years postoperatively, shortened interval, total number of follow-up neck US (p=0.002, p<0.001, p<0.001). All recurrences were found between 2-3 to 11-12 years. Recurrences after 5 years were found in 16 (72.7%) of 22 patients.
Conclusion
Recurrence after thyroid lobectomy for PTMC occurred with various times during follow up. The minimum frequency of follow-up neck US was not enough for detecting tumor recurrence, especially after 5 years postoperatively. Our results suggest that annual neck US may be appropriate between 3 to 12 years after thyroid lobectomy for PTMC.
3.Relation between Airway Responsiveness and Serum IgE in Children with History of Asthma, Allergic Rhinitis, and Atopic Dermatitis.
Su Jin PARK ; Ki Hyun CHUNG ; Wan Seob KIM ; kang seo PARK
Journal of the Korean Pediatric Society 1995;38(9):1262-1269
No abstract available.
Asthma*
;
Child*
;
Dermatitis, Atopic*
;
Humans
;
Immunoglobulin E*
;
Rhinitis*
4.A Case of Systemic-Onset Juvenile Rheumatoid Arthritis with Multiple Complications.
Jong Deok KIM ; Dong Joo NA ; Jin Han KANG ; Kyong Su LEE ; Ki Yeal SUNG
Journal of the Korean Pediatric Society 1988;31(7):948-952
No abstract available.
Arthritis, Juvenile*
5.Three Cases of Late Hemorrhagic Disease of Ingancy.
Yang Su KANG ; Ree Sa LEE ; Sang Kyn PARK ; Ho Jin PARK ; Mi Ja SHIN
Journal of the Korean Pediatric Society 1989;32(7):1001-1006
No abstract available.
6.A Comparison between Arthroscopic Biceps Tenodesis and Arthroscopic Repair in Isolated Type 2 Superior Labrum Anterior and Posterior Lesions.
Kyung Jin HONG ; Doo Sup KIM ; Ji Su SHIN ; Sang Kyu KANG
Clinics in Shoulder and Elbow 2017;20(1):24-29
BACKGROUND: The purpose of this study was to compare the clinical outcome in patients aged less than 55 years who underwent arthroscopic tenodesis and arthroscopic repair for type 2 superior labrum anterior and posterior (SLAP) lesions. METHODS: Between April 2008 and December 2014, surgery was performed on a total of 45 patients with isolated type 2 SLAP lesions. Arthroscopic repair was performed in 22 patients and arthroscopic tenodesis was performed in 23 patients. In both groups, the clinical outcomes at follow-ups were evaluated using the University of California at Los Angeles (UCLA) score, American Shoulder and Elbow Surgeons (ASES) score, and visual analogue scale (VAS) score. RESULTS: In both groups, the VAS scores for pain had improved significantly throughout the postoperative follow-up period. The VAS score showed a statistically significant difference at postoperative 3 and 6 months (p<0.05); however, there was no statistically significant difference between preoperative and postoperative results at 12 months (p>0.05). In both groups, the functional outcome was statistically improved postoperatively. In a comparison of the UCLA and ASES scores between the two groups, there was a statistically significant difference at postoperative 3 and 6 months (p<0.05), but there was no statistically significant difference between preoperative and postoperative results at 12 months (p>0.05). CONCLUSIONS: Based on the results of this and other studies, patients with isolated type 2 SLAP lesions showed better short-term clinical outcome with tenodesis than with repair. However, there was no difference between the two groups at the final follow-up.
California
;
Elbow
;
Follow-Up Studies
;
Humans
;
Shoulder
;
Surgeons
;
Tenodesis*
7.Trichofolliculoma: A case report.
Su Kyeong YEON ; Ki Hwa YANG ; Seok Jin KANG ; Sun Moo KIM
Korean Journal of Pathology 1994;28(1):79-81
The trichofolliculoma is a rare tumor of the hair follicle occuring most often on the head and neck. We have experienced a case of 24-year-old female who had a small, dome-shaped, tan brown firm nodule on the nose. Under the clinical impression of a granuloma, an excisional biopsy of the nodule was done. Microscopically the lesion was composed of a large central cystic hair follicle with many srhall but well differenciated secondary hair follicles branching from the wall. Well developed secondary hair follicles were often grouped and were surrounded by a prominent stroma.
Female
;
Humans
;
Biopsy
8.Anal Myolipoma: A New Benign Entity in Patients with an Anal Tumor?.
Tae Young KANG ; Moo Ryang HUH ; Su Jin KIM
Journal of the Korean Society of Coloproctology 2012;28(4):219-221
A myolipoma is an extremely rare benign neoplasm, occurring most frequently in adults in the deep soft tissue of the abdomen or retroperitoneum. We experienced a case of an anal myolipoma occurring in a 30-year-old woman, and it was surgically resected. To our knowledge, this is the first reported case of a myolipoma arising from the anus, so such a possibility needs to be considered in the differential diagnosis.
Abdomen
;
Adult
;
Anal Canal
;
Angiomyolipoma
;
Diagnosis, Differential
;
Female
;
Humans
9.Functional MR Imaging of Cerebral Auditory Cortex with Linguistic.
Su Jin KANG ; Jae Hyoung KIM ; Taemin SHIN
Journal of the Korean Radiological Society 1999;41(2):241-247
PURPOSE: To obtain preliminary data for understanding the central auditory neural pathway by means of functional MR imaging (fMRI) of the cerebral auditory cortex during linguistic and non-linguistic auditory stimulation. MATERIALS AND METHODS: In three right-handed volunteers we conducted fMRI of auditory cortex stimulation at 1.5 T using a conventional gradient-echo technique (TR/TE/flip angle: 80/60/40 degree). Using a pulsed tone of 1000 Hz and speech as non-linguistic and linguistic auditory stimuli, respectively, images-including those of the superior temporal gyrus of both hemispheres-were obtained in sagittal plases. Both stimuli were separately delivered biaurally or monoaurally through a plastic earphone. Images were activated by processing with homemade software. In order to analyze patterns of auditory cortex activation according to type of stimulus and which side of the ear was stimulated, the number and extent of activated pixels were compared between both temporal lobes. RESULTS: Biaural stimulation led to bilateral activation of the superior temporal gyrus, while monoaural stimulation led to more activation in the contralateral temporal lobe than in the ipsilateral. A trend toward slight activation of the left (dominant) temporal lobe in ipsilateral stimulation, particularly with a linguistic stimulus, was observed. During both biaural and monoaural stimulation, a linguistic stimulus produced more widespread activation than did a non-linguistic one. CONCLUSION: The superior temporal gyri of both temporal lobes are associated with acoustic-phonetic analysis, and the left (dominant) superior temporal gyrus is likely to play a dominant role in this processing. For better understanding of physiological and pathological central auditory pathways, further investigation is needed.
Acoustic Stimulation
;
Auditory Cortex*
;
Auditory Pathways
;
Ear
;
Linguistics*
;
Magnetic Resonance Imaging*
;
Neural Pathways
;
Plastics
;
Temporal Lobe
;
Volunteers
10.A Case of Twin Pregnancy with Fetus Papyraceus Prenatally Diagnosed.
Kyung Hwa KANG ; Sang Wook YI ; Bum Su KIM ; Kyu Seop JIN ; Seung Bo KIM
Korean Journal of Perinatology 2000;11(1):61-64
No abstract available.
Fetus*
;
Humans
;
Pregnancy, Twin*