Cytotoxic T lymphocytes (CTL) playing an important role in e cell-mediated immune response kill the target cells by the special contact-dependent mechanism. It has been known that CTL and NK cells utilize two different pathways in removing specific target cells: apoptotic cell death and osmotic lysis by the pore forming protein. Interaction of CTL with target cells results in the ligand-induced, receptor-mediated, nonsecretory lytic process and lethal hit is delivered by the transducing molecule, Fas (CD95, APO-1), one of the TNFR/NGFR superfamily. In addition, ligation of TNF receptor and CD40 also induced the apoptosis of B cell and epithelial cells. However, recognition of target cells, the triggering mechanism, cytotoxic mediators, internal metabolic pathway and signal transduction behind apoptosis remain undefined and have been elucidated only in part. ...continue...
Apoptosis* ; Cell Death ; Epithelial Cells ; Genistein ; Ice ; Killer Cells, Natural ; Ligation ; Metabolic Networks and Pathways ; Receptors, Tumor Necrosis Factor ; Signal Transduction ; T-Lymphocytes, Cytotoxic*

No abstract available.
Drug Therapy* ; Humans ; Mouth Neoplasms*

No abstract available.
Drug Therapy* ; Humans ; Mouth Neoplasms*

Animals ; Periosteum ; Rats ; Skull

PURPOSE: Regular cancer screening for workers can help prevent cancer or allow early treatment, and is thus beneficial in improving health, reducing costs, and increasing companies' productivity. However, there has been little research on cancer screening rates of workers and related factors. The purpose of this study was to identify cancer screening rates and relevant factors among manufacturing workers. METHODS: Using a questionnaire, data were collected from 335 workers aged over 40 years recruited from seven manufacturing companies. The collected information included cancer screenings (stomach, colorectal, breast, and cervical), attitude towards cancer screening, and demographic and job characteristics. RESULTS: 72.5% of workers received stomach cancer screening (SCS), and 43% received colorectal cancer screening (CRCS). Among 86 women, 68.6% received breast cancer screening and cervical cancer screening. The attitude towards cancer screening was 29.5+/-3.78. Workers aged over 51, married, and those working in mobile manufacturing were more likely to have undergone SCS. Workers aged over 51, married, those working in mobile manufacturing, those in workplaces with more than 1,001 employees, and those with more positive attitudes toward cancer screening were more likely to have undergone CRCS. Finally, attitude affected cervical cancer screening. CONCLUSION: Workers in small-sized workplaces had lower cancer screening rates. Thus, follow-up research should assess the health environment of workplaces and develop educational programs on cancer screening that reflect attitudes towards screening.
Aged ; Breast Neoplasms ; Colorectal Neoplasms ; Early Detection of Cancer ; Efficiency ; Female ; Follow-Up Studies ; Humans ; Mass Screening ; Surveys and Questionnaires ; Stomach Neoplasms ; Uterine Cervical Neoplasms

No abstract available.
Pulmonary Aspergillosis*

No abstract available.

No abstract available.
Rheumatic Diseases* ; Spondylarthropathies

Child ; Child, Preschool ; Cleft Lip ; Cleft Palate ; Congenital Abnormalities ; Consensus ; Humans ; Infant ; Leukocyte Count ; Male ; Palate ; Surgery, Oral

The authors had studied 55 cases with clinical seizure who were regularly treated with appropriate anticonvulsants over 6 months. In their distribution of age, teens are most freguent and their twenties followed. Males are more affected than female in the ratio of 3 to 2. Seizure may occur at any age; but our study shows that it is commoner in the first to third decades of life, about 72% of all cases, commonest in teens. The figures for 55 cases collected by us are : generalized type, 78% ; partial type, 22% ; 60% of all cases 33 are ldiopathic group, who had no demonstrable underlying neurologic abnormality. The major part of all idiopathic cases had their attacks of seizure before 30 years of age and; those of symptomatic cases are rather late over age of 30, and their figures are; cerebrovascular disorder, 6 cases; brain tumor, 5 cases; cerebral cysticercosis, 4 cases. 51 cases of all patients had evident abnormalities on their EEG. According to both their type of seizure and EEG findings, their drug was determined and, if need be, second drug was added. Freguently used drugs were dilantin, phenobarbital & Valproic acid etc. Mean therapeutic serum levels of anticonvulsants are: dilantin, 8.3 mg/L phenobarbital, 12.4 mg/L; which levels are less than those in U. S. A. In our study, the reponse to anticonvulsants were mostly good in about 2 years.
Adolescent ; Anticonvulsants ; Brain Neoplasms ; Cerebrovascular Disorders ; Cysticercosis ; Electroencephalography ; Female ; Humans ; Male ; Phenobarbital ; Phenytoin ; Seizures* ; Valproic Acid