1.Effect of Speed of Injection on Spinal Anesthesia with 0.5% Plain Bupivacaine.
Seung Su KIM ; Gi Young CHAE ; Young Jun CHIN
Korean Journal of Anesthesiology 1995;28(3):423-427
To observe the anesthetic characteristics of two different speeds of injection using 0.5% plain bupivacaine during spinal anesthesia, 40 patients undergoing lower extremity surgery were allocated randomly into two groups. In one group, 3 ml of 0.596 plain bupivacaine was administered into the subarachnoid space using 25 gauge Quincke spinal needle to the patients with a lateral horizontal position at duration of 10 seconds. In the other group, the duration was 180 seconds. There were no statistically significant differences between two groups in maximal level and its onset time of sensory blockade, hemodynamic changes, onset time to grade 3 Bromage motor blockade. We concluded that the speed of injection does not affect the anesthetic characteristics of spinal anesthesia using 0.5% plain bupivacaine.
Anesthesia, Spinal*
;
Bupivacaine*
;
Hemodynamics
;
Humans
;
Lower Extremity
;
Needles
;
Subarachnoid Space
2.Shearing of an intrathecal catheter during insertion for cerebrospinal fluid drainage.
Jae Jun LEE ; Gi Ho GIM ; Ji Su JANG ; Sung Mi HWANG
Korean Journal of Anesthesiology 2013;65(6 Suppl):S47-S48
No abstract available.
Catheters*
;
Cerebrospinal Fluid*
;
Drainage*
3.Retrospective Analysis of a Fistula-in-ano: Focus on an Anal-sphincter-preserving Procedure.
Ki Su HAN ; Hyeon Min CHO ; Do Hyoung KIM ; Jun Gi KIM
Journal of the Korean Society of Coloproctology 2007;23(6):403-409
PURPOSE: The results of anal fistula treatments have improved with the development of the anal fistula operative technique. However, there are still complications, such as recurrence and anal incontinence. To this end, the authors classified anal fistulas by using Sumikoshi's classification and performed an anal-sphincter-preserving procedure. METHODS: We experienced 98 anal fistula cases involving 86 patients who underwent anal fistula operations at The Catholic University of Korea, St. Vincent's Hospital from January 2001 to December 2006. This study was done retrospectively by chart review and telephone questioning. The follow-up period was from 2 to 72 months (mean 29.5, SD: 19.1). RESULTS: The study showed 0 cases of Type I (0.0%), 49 cases of Type II (50.0%), 46 cases of Type III (46.9%), and 3 cases of Type IV (3.1%) fistulas. Among the 98 fistula-in-ano operations were 27 (27.6%) of fistulotomies and 71 (72.4%) sphincter-preserving procedures (2 cases of coring-out+muscle filling+rectal mucosal advancement flap, 31 cases of coring-out+ muscle closure+rectal mucosal advancement flap, 28 cases of coring-out+cutting seton, and 10 cases of loose seton). After the sphincter-preserving operation, there were 4 cases (4/71, 5.6%) of recurrence. There were no major disorders of the anal sphincter. However, minor disorders of the anal sphincter (6/71, 8.5%, soiling) were found. CONCLUSIONS: The anal-sphincter-preserving procedure is very effective in preventing recurrence and anal incontinence, but these results are from a retrospective study with a small number of patients and the follow-up period was short. If further cases are collected and continuous follow-up is done, better results can be expected.
Anal Canal
;
Classification
;
Fistula
;
Follow-Up Studies
;
Humans
;
Korea
;
Rectal Fistula
;
Recurrence
;
Retrospective Studies*
;
Telephone
4.Secretion of Interleukin-8 from Human Keratocyte Stimulated by Aspergillus fumigatus and Effect of Amphotericin B and Dexamethasone on The Secretion.
Dong Jun LEE ; Gi Su AHN ; Ju Heon RHO ; Young Ho HAHN
Journal of the Korean Ophthalmological Society 2001;42(8):1220-1226
PURPOSE: To measure the secretion of IL-8 from cultured human keratocytes after inoculation of conidia of A. fumigatus, and to compare the change of secretion of IL-8 following application of amphotericin B and dexamethasone. METHODS: Human corneal keraoctytes were cultured independently in vitro. The specimens were divided into 4 groups : Group I with only pure culture as control, Group II with conidia of A. fumigatus, Group III with conidia of A. fumigatus and amphotericin B, and Group IV with conidia of A. fumigatus and dexamethasone. The supernatants were aspirated from each group at different time intervals, and then were assayed for IL-8. RESULTS: Group II showed increased secretion of IL-8, at all selected time intervals except 12-h, in comparison with other three groups. Group III secreted IL-8 significantly less than the other groups(p<0.01). Group IV secreted IL-8 less than Group I and II at all selected time points(p<0.01), but more than Group III at the other time points except for 72-h(p<0.01). CONCLUSIONS: The secretion of IL-8 increased in the early stage of fungal keratitis but decreased in case of the administration of amphotericin B or dexamethasone. Amphotericin B was more potent than dexamethasone in decreasing the secretion of IL-8.
Amphotericin B*
;
Aspergillus fumigatus*
;
Aspergillus*
;
Dexamethasone*
;
Humans*
;
Interleukin-8*
;
Keratitis
;
Spores, Fungal
5.Osteosarcoma of the Temporal Bone.
Hyun Su JUN ; Moo Pil KIM ; Gi Jung IM ; Hak Hyun JUNG
Korean Journal of Otolaryngology - Head and Neck Surgery 2007;50(5):468-471
Osteosarcoma is a highly malignant bone tumor that is rarely found in the facial and cranial bones. It may be found in the mandible and maxilla but is very rare in the temporal bone. Surgery with adequate margins seems to be the procedure of choice and postoperative chemotherapy and radiotherapy is recommended as well as a long term follow up. The authors experienced a case of osteosarcoma of the temporal bone in a 39 years-old male. The patient underwent a tumor removal with open craniotomy and simple mastoidectomy; then, the mastoid was obliterated by temporalis muscle rotation flap. After operation, the patient received chemotherapy. The patient has been free of local recurrence or metastasis for 2 postoperative years.
Adult
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Craniotomy
;
Drug Therapy
;
Follow-Up Studies
;
Humans
;
Male
;
Mandible
;
Mastoid
;
Maxilla
;
Neoplasm Metastasis
;
Osteosarcoma*
;
Radiotherapy
;
Recurrence
;
Temporal Bone*
6.Comparative Cohort Study for Expansion of Lateral Recess and Facet Joint Injury after Biportal Endoscopic Ipsilateral Decompression and Contralateral Decompression
Yip-kan YEUNG ; Cheol-woong PARK ; Su Gi JUN ; Jung-hoon PARK ; Andy Choi-yeung TSE
Asian Spine Journal 2022;16(4):560-566
Methods:
In this retrospective study, we reviewed 37 IL and 34 CL approaches. Postoperative magnetic resonance imaging of the segment involved was carried out on the same day as the operation for comparison with preoperative imaging. Radiological assessments of recess angle, recess height, facet length, and recess dural sac diameters were compared. In addition, pre- and postoperative Visual Analog Scale (VAS) pain scores for the lower limb were analyzed.
Results:
For IL versus CL approaches, we observed statistical differences in the postoperative recess angle (36.0° vs. 43.7°), recess height (4.27 vs. 5.06 mm), and the dural sac expansion ratio for recess diameter (1.54 vs. 2.17). There was better preservation of facet length in the CL approach than in the IL approach (91.9% vs. 83.7%). There was no difference in VAS improvement between the groups (69.3% vs. 63.6%).
Conclusions
Unilateral biportal decompression via the CL interlaminar approach may offer better lateral recess clearance and facet preservation than can be achieved via the IL approach. Larger-scale studies are needed for better delineation and for correlation of radiological features with clinical manifestations.
7.Prevalence of Major Methicillin-Resistant Staphylococcus aureus Clones in Korea Between 2001 and 2008.
Gi Su KANG ; Yung Hee JUNG ; Hwa Su KIM ; Yeong Seon LEE ; Chan PARK ; Kwang Jun LEE ; Jeong Ok CHA
Annals of Laboratory Medicine 2016;36(6):536-541
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) are important pathogens causing nosocomial infections in Korean hospitals. This study aimed to investigate the epidemiological and genetic diversity of clinical S. aureus isolates in healthcare settings from 2001 to 2008. METHODS: Samples and data were obtained from 986 individuals as part of the National Antimicrobial Surveillance Project, involving 10 regions nationwide. Molecular typing studies, including multilocus sequence typing (MLST) and staphylococcal cassette chromosome mec (SCCmec) typing were performed, and a representative clone of Korean MRSA was classified by combinational grouping using a DiversiLab (DL; bioMérieux, France) repetitive element polymerase chain reaction (rep-PCR) system. RESULTS: Nine Korean MRSA clones (KMRSA-1 to -9) were identified by analysis of genetic backgrounds and molecular characteristics. KMRSA-1 to -3, expressing clonal complex (CC) 5 (carrying SCCmec II), CC8 (carrying SCCmec III), and CC72 (carrying SCCmec IV) were spread nationwide. In contrast, KMRSA-6 was highly prevalent in Gyeongsangnam-do, and KMRSA-4 was highly prevalent in Jeollanam-do and Jeollabuk-do. CONCLUSIONS: Epidemic KMRSA clones were genetically similar to major clones identified from the USA, with the exception of KMRSA-2, which had the SCCmec III type. Our results provide important insights into the distribution and molecular genetics of MRSA strains in Korea and may aid in the monitoring of MRSA spread throughout the country.
Bacterial Proteins/genetics
;
DNA, Bacterial/genetics/metabolism
;
Electrophoresis, Gel, Pulsed-Field
;
Hospitals
;
Humans
;
Methicillin-Resistant Staphylococcus aureus/*genetics/isolation & purification
;
Multilocus Sequence Typing
;
Multiplex Polymerase Chain Reaction
;
Prevalence
;
Republic of Korea/epidemiology
;
Staphylococcal Infections/diagnosis/*epidemiology/microbiology
8.Effect of evaporation-induced osmotic changes in culture media in a dry-type incubator on clinical outcomes in in vitro fertilization-embryo transfer cycles
Hee-Jun CHI ; Jun-Sang PARK ; Chang-Seok YOO ; Su-Jin KWAK ; Ho-Jeong SON ; Seok-Gi KIM ; Chae-Hee SIM ; Kyeong-Ho LEE ; Deog-Bon KOO
Clinical and Experimental Reproductive Medicine 2020;47(4):284-292
Objective:
This study investigated whether adding outer-well medium to inhibit osmotic changes in culture media in a dry-type incubator improved the clinical outcomes of in vitro fertilization-embryo transfer (IVF-ET) cycles.
Methods:
In culture dishes, the osmotic changes in media (20 µL)-covered oil with or without outer-well medium (humid or dry culture conditions, respectively) were compared after 3 days of incubation in a dry-type incubator. One-step (Origio) and G1/G2 (Vitrolife) media were used.
Results:
The osmotic changes in the dry culture condition (308 mOsm) were higher than in the humid culture conditions (285–290 mOsm) after 3 days of incubation. In day 3 IVF-ET cycles, although the pregnancy rate did not significantly differ between the dry (46.2%) and humid culture (52.2%) groups, the rates of abortion and ongoing pregnancy were significantly better in the humid culture group (2.3% and 50.2%, respectively) than in the dry culture group (8.3% and 37.8%, respectively, p<0.05). In day 5 IVF-ET cycles, the abortion rate was significantly lower in the humid culture group (2.2%) than in the dry culture group (25.0%, p<0.01), but no statistically significant difference was observed in the rates of clinical and ongoing pregnancy between the dry (50% and 25.0%, respectively) and humid culture groups (59.5% and 57.3%, respectively) because of the small number of cycles.
Conclusion
Hyperosmotic changes in media occurred in a dry-type incubator by evaporation, although the medium was covered with oil. These osmotic changes were efficiently inhibited by supplementation of outer-well medium, which resulted in improved pregnancy outcomes.
9.Rheumatoid arthritis accompanied by Gitelman syndrome.
Min Gi PARK ; Ji Hyun LEE ; Sung Jun KIM ; Su Ho PARK ; Suk Ki PARK ; Joon Sul CHOI ; Ji Yeon HWANG
Yeungnam University Journal of Medicine 2017;34(1):101-105
Gitelman syndrome is a condition caused by a mutation of the thiazide sensitive Na-Cl cotransporter gene on the distal convoluted tubule. It results in a variety of clinical features, including hypokalemia, hypomagnesemia, hypocalciuria, and metabolic alkalosis. It is often diagnosed in asymptomatic adults presented with unexplained hypokalemia; however, it is sometimes associated with muscular cramps, numbness, fatigue, weakness, or paralysis. We experienced a case of rheumatoid arthritis accompanied by Gitelman syndrome, presented with hand tremor. We diagnosed her using renal clearance study and genetic analysis. Here, we report our experiences regarding this case along with a literature review.
Adult
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Alkalosis
;
Arthritis, Rheumatoid*
;
Fatigue
;
Furosemide
;
Genetic Testing
;
Gitelman Syndrome*
;
Hand
;
Humans
;
Hypesthesia
;
Hypokalemia
;
Muscle Cramp
;
Paralysis
;
Solute Carrier Family 12, Member 3
;
Thiazides
;
Tremor
10.De Novo AL Amyloidosis in a Renal Allograft.
Ji Yeon HWANG ; Dong Ryeol LEE ; Jung Myung AN ; Sung Jun KIM ; Dong Kyu KIM ; Min Gi PARK ; Su Ho PARK
Korean Journal of Medicine 2016;90(6):545-549
Amyloidosis is characterized by the extracellular deposition of amyloid in various tissues and organs, particularly the kidney and heart. The estimated incidence of systemic amyloidosis is at least 8 per million population per year. However, few cases of systemic amyloidosis in renal allografts have been reported. A stable renal transplant recipient was admitted with proteinuria and dyspnea on exertion. The M-peak was found on serum and urine protein electrophoresis, and lambda (λ) dominance was confirmed by serum and urine free-light-chain test. The patient was diagnosed with systemic amyloidosis of a renal allograft, by allograft biopsy, at 22 years after renal transplantation. We report a case of AL amyloidosis in a stable renal allograft and review the medical literature.
Allografts*
;
Amyloid
;
Amyloidosis*
;
Biopsy
;
Dyspnea
;
Electrophoresis
;
Heart
;
Humans
;
Immunoglobulin Light Chains
;
Incidence
;
Kidney
;
Kidney Transplantation
;
Proteinuria
;
Transplant Recipients