BACKGROUND:Temperature measure methods of human tissue include destructive measurement and nondestructive measurement. Destructive measurement cannot measure three-dimensional (3D) temperature field and nondestructive measure is stil in the research stage. It is better way to build a mathematical and physical model to predict and simulate femur tumor hyperthermia. OBJECTIVE:To obtain the three-dimensional temperature distribution of femur and its surrounding tissues during tumor hyperthermia. METHODS:3D temperature distribution was obtained by using finite element method on the basis of heat conduction theory, Laplace equation, Pennes bio-heat transfer equation, thermo physical parameters of bone tissues, the boundary condition, and initial conditions. RESULTS AND CONCLUSION:The femur had good hinder effect to heat transfer. Femoral temperature curve in the 3D space showed el ipsoid distribution with heat source as the center;the closer from heat source, the greater the temperature gradient was. The three major diameters of temperature isoline were different at 50℃, which is maximum in cross section and minimum in the sagittal plane. In the three directions of the femur, transfer capability of temperature was different, so the radius of the inactivation of the tumor was also different. Because the 3D temperature space distribution of femur is asymmetry during hyperthermia, the necessary method is to use more than a heat source in order to avoid residual cancer tissue or destructive normal tissue.

BACKGROUND:The power output of the human joints depends on the activation of agonists and antagonist muscles around the joints, and the antagonist muscle is involved in physical activity in a co-activated manner, thereby helping to maintain joint stability. But there are less reports on the central nervous system strategies of antagonist co-activation under different muscle contraction modes. OBJECTIVE:To observe the characteristics and differences of surface electromyography (sEMG) of agonists and antagonist muscles of the knee joints during maximal and submaximal isokinetic exercises until fatigue. METHODS:Sixteen students were enroled, who developed the right knee joint fatigue induced by the Biodex isokinetic equipment, and simultaneously sEMG activities of vastus medialis, vastus lateralis and biceps femoris were recorded by the myoelectrical equipment. The RMS (%) and mean frequency were selected to analyze sEMG characteristics. RESULTS AND CONCLUSION:In the maximal isokinetic fatigue, the peak torque was decreased by 40.3% (P < 0.05) and the sEMG activity of agonists gradualy increased and then declined, but the sEMG activity of antagonists kept constant. In the submaximal isokinetic fatigue, the peak torque was decreased by 40.0% (P < 0.05), the sEMG activity of agonists gradualy increased (P < 0.05), and however the sEMG activity of the antagonists initialy increased and then decreased. The RMS and mean frequency of vastus medialis and lateralis as antagonists at selected reciprocal contractions showed no significant changes (P > 0.05). These results suggest that in the different intensities of isokinetic fatigue, the central nervous system employs different neural strategies on agonists and antagonists.

This paper introduces what signals are actually transmitted in every procedure of the start-up process of Mx8000 Exp double-slice spiral CT and what relevant parts are acted.Some troubles related to start-up process is briefly presented.

Objective:To explore the personality types a nd the features of clinical subtypes of obsessive-compulsive disorder (OCD). Methods:82 cases of OCD were tested using Chinese MMPI that w as revised by MMPI normative cooperative group. We used MMPI-B auto-analysis sys tem made by Ji Shumao et al to calculate the basis scores and T scores of 73 sca les.Results:Basis scores (+K)of scales F,Hs,D,Hy,P d,Pa,Pt,Sc,(males and females)and Si,Mf(males) and K (females) on OCD group were higher that the scores of the normal group. The two-point code of T scores in O CD was 72/27.The factor analysis in 13 scales showed that there were fo ur personality factors in OCD: neuroticism factor (Hs,Hy,D,Pt), psychotic factor (F,Pd,Sc),suspicious factor( F,Ma,Pa), Social introvers ion factor (L,Si,Mf).82 cases of OCD were divided into three groups by K-means o f quick cluster analysis,T scores of 73 MMPI scale s were different among three groups (P<0.000).Conclusio n:The ps ychological features a nd comorbidity and responses to psychotherapy of three groups OCD are different.

Objective To evaluate the application of the polymethyl methacrylate (PMMA) artificial eye in acquired ophthalmostewesis. Methods We summarized the experience in the application of PMMA in prosthesis for 8 years. 1155 patients were involved in the artificial eye custom-made program. The artificial eye was individually prepared based on the patient's condition and characters of the healthy eye.Results PMMA artificial eye associated with hydroxyl apatite implantation gave good cosmetic results with good motility, and there was no rejective reaction. The artificial eye was almost same to the real one in color and transparency. Conclusion It is suggested that PMMA is one of the best materials for manufacture of artificial eye at present.

Asimplified European procedure now allows the registration of traditional herbal medicines as medicinal products even without the support of clinical data.This procedure entails the requirement that those products comply with European Good Manufacturing Practice for medicinal products,which in turn implies that the raw herbal materials comply with the European Guidelines for Good Agricultural and Collection Practice.On the basis of a comparison between European Good Agricultural and Collection Practice and China Good Agricultural Practice,as well as direct observation made at sites in China,we issue some recommendations to facilitate good communication between the Chinese producer and European pharmaceutical customer,with a view to ensure full compliance with European expectations.

Recently, the understanding of metabolic reprogramming in cancer is expanding continuously.Besides glycolysis, researchers are now paying more attention to amino acid metabolism, especially glutamine metabolism.Glutamine is one of the most abundant non-essential amino acids in human body, but it is a “conditionally essential” amino acid in various types of cancer cells.Thus, targeting glutamine metabolism is becoming a promising strategy for the development of novel cancer therapeutic agents.In addition, another gradually clarified metabolic pathway is serine and glycine metabolism.In this review, we will focus on the alterations, the underlying mechanisms, and significance of glutamine as well as serine and glycine metabolism.We will also discuss cancer therapy opportunities through targeting amino acid metabolism.

In view of the problems that anesthesiology medical students have such as poor commu-nication awareness, lack of communication skills, lack of confidence, and so on, it is particularly important to improve the students’ doctor-patient communication ability, guarantee their medical quality and reduce the dispute between doctors and patients. In the teaching practice, we improve students’ ability of doctor-patient communication by paying more attention to the education of medical ethics, strengthening the train-ing of professional knowledge and skills, optimizing the curriculum structure, improving the quality of teachers, the implementation of case teaching , and establishing a comprehensive evaluation mechanism etc , and have got good results.

Objective To investigate the similarities and differences in research hot pots between International Journal of Pediatrics and Pediatrics in the last five years.Methods The key words with high frequent occurrence were extracted from Wanfang database,and the Mesh with high frequent occurrence were enrolled in this study.Results The similarities of the hot pots between the two journals were asthma,neonatal diseases and neoplasm.The differences lied in that the hot pots of International Journal of Pediatrics included congenital heart diseases,allergic diseases and renal diseases,whereas the hot pots of Pediatrics were obesity,child health care and attention deficit disorder with hyperactivity.Conclusion By employing co-words cluster analysis,the research focuses of the two journals are found out,and its differences are compared.

Objective To investigate the application value of plasma D-dimer and coagulation indicators in the patients with o-varian cancer by detecting the routine coagulation indicators and plasma D-dimer level.Methods The plasma D-dimer and coagula-tion indicators levels were measured in 84 patients with ovarian cancer and 25 patients with benign ovarian tumor.The application value of preoperative plasma D-dimer level in monitoring the disease course of ovarian cancer was evaluated.Results The plasma levels of D-dimer and FBG in the ovarian cancer group were significantly higher than those in the ovarian benign tumor control group(P <0.01);moreover the plasma levels of D-dimer and FBG in the patients with the stage Ⅲ~Ⅳ ovarian cancer were signifi-cantly higher than those in the patients with the stageⅠ~Ⅱ ovarian cancer,the differences had statistical significance(P <0.05), which prompting that the coagulation and fibrinolysis dysfunction in the patients with ovarian cancer exhibited the aggravating trend with the disease condition progression.Conclusion D-dimer may reflect the excessive activation of fibrinolysis function in ovarian tumor,which prompting the survival period and prognosis in the patients with advanced ovarian cancer.The plasma D-dimer level has the important significance to early prevention,early diagnosis,early treatment and improve the prognosis in the thrombosis oc-currence in ovarian cancer.