BACKGROUND: This study aimed to estimate the clinical outcome and identify the characteristics of a group of patients with pulmonary tuberculosis who completed anti-tuberculosis therapy with the First-line drugs in spite of having positive smear results with negative sputum culture results over the previous six months. METHOD: A retrospective chart review of 21 patients who fulfilled the above criteria between 1995 and 1999 was performed. The laboratory data as well as the clinical data of the patient with positive smear results and negative culture results over a six months period were reviewed. RESULTS: The negative conversion of sputum culture results was achieved within 1.3±1.2 months and the negative conversion of the sputum smear results was accomplished during 9.5±3.3 months. Chest X-rays at 5 months following the institution of anti-tuberculosis therapy from all patients revealed improvements. Four out of 21 patients(19%) relapsed during the follow up, 15.2±13.4 months after administering anti-tuberculosis therapy for 13.3±3.1 months. Relapses were confirmed from between 3 months and 4 months after the treatment completion. Only one of the four relapses had no past history of anti-tuberculosis therapy and the others had prior treatment twice (p<0.01). The period of anti-tuberculosis treatment was extended to a mean of 4.6±2.6 months in 12 patients. However, prolongation of anti-tuberculosis therapy had no affect on the relapse rate (odds ratio, 95% CI 0.18, 2.15). CONCLUSION: Prolongation of therapy with the First-line drugs is not necessary for patients with persistently positive smear results over 6 months and negative culture results. A patient who has had prior anti-tuberculosis therapy more than twice should be paid the closest attention.
Follow-Up Studies ; Humans ; Recurrence ; Retrospective Studies ; Sputum* ; Thorax ; Tuberculosis, Pulmonary

No abstract available.
Keratinocytes*

No abstract available.

PURPOSE: Periventricular leukomalacia(PVL) is associated with various neurologic sequelae such as cerebral palsy and cortical blindness. The aim of this study was to analyse the correlation between the degree of PVL on MRI and clinical features or its severity. METHODS:Thirty-eight children with PVL on MRI among children brought to Pusan National University Hospital between January 1996 and August 1999 with development delay, cerebral palsy or epilepsy were included into the study group. We reviewed medical records of the patients including the gestational age, birth weight and neurologic sequelae. The grade for PVL was divided into 1 to 3, and it was based on abnormally increased signal intensity in periventricular white matter or a reduced amount of periventricular white matter or both, and compensatory focal ventricular enlargement. We analysed the relationship of the grade of PVL and various clinical findings. RESULTS: The age ranged from 11 months to 13 years old with a mean of 42 months. History of cesarean delivery and ventilator care were significantly frequent for the severe grade of PVL. Birth weight was significantly lower according to grade of PVL. Gestational age was lower according to the grade of PVL, but was not significant statistically. Incidence of cerebral palsy was significantly higher on the severe grade of PVL. Incidence of epilepsy and mental retardation were 34.2Yo and 23.9M, not associated with the grade of PVL. CONCLUSION: Incidence of cerebral palsy was associated with the severe grade of PVL, so we think MRI can be helpful in predicting neurodevelopmental outcome. (J Korean Pediatr Soc 2000;43 798-805)
Adolescent ; Birth Weight ; Blindness, Cortical ; Brain* ; Busan ; Cerebral Palsy ; Child ; Epilepsy ; Gestational Age ; Humans ; Incidence ; Infant, Newborn ; Intellectual Disability ; Leukomalacia, Periventricular* ; Magnetic Resonance Imaging* ; Medical Records ; Ventilators, Mechanical

Purpose: This study aimed to identify the effect of self-esteem and spouse support on prenatal depression. Methods: The subjects were 131 pregnant women who visited two women clinics located in Changwon City. Data were collected from September 25 to November 20, 2019, and the self-report questionnaire included spouse support, self-esteem, and prenatal depression. The collected data were analyzed by IBM SPSS Statistics ver. 23.0 using descriptive statistics, independent t-test, one-way analysis of variance, Pearson correlation coefficients, and multiple regression analysis. Results: Prenatal depression had a significant negative correlation with self-esteem (r=-0.39, p=0.001) and spouse support (r=-0.36, p<0.001). The factors affecting prenatal depression were religion (β=-0.16, p=0.035), monthly family income (β=-0.15, p=0.040), self-esteem (β=-0.25, p=0.002), and spouse support (β=-0.19, p=0.017); these variables explained 28.4% of the variance in prenatal depression. Conclusion To prevent depression in pregnant women, professional counseling and support systems such as spouses, religious and social environments should be applied to pregnant women, especially those with low self-esteem. Additionally, more financial support should be provided for low-income pregnant women. Further, there is a need to screen and manage the risk of depression in pregnancy.

No abstract available.
Sinusitis*

Cyclosporine can cause remission of 60% in steroid resistant FSGS, but its responses are variable. Now we report two cases of steroid resistant FSGS who are maintaining remission using cyclosporine continuous therapy. The first patient had been failed several times of steroid therapy, had edema, azotemia and severe proteinuria. We used steroid pulse therapy then maintenance dose of oral cyclosporine to reduce proteinuria for more than 6 years. He has been received cyclosporine therapy up to now and maintaining normal renal function. The second patient had severe azotemia who needed hemodialysis but after cyclosporine therapy, he recovered his renal funciton. The findings of renal biopsies in one patient after 6 years of cyclosporine therapy revealed that there was no improvement of sclerosing glomeruli, then we guess that maintenance therapy of cyclosporine might need for lifelong period.
Azotemia ; Biopsy ; Cyclosporine* ; Edema ; Humans ; Proteinuria ; Renal Dialysis

PURPOSE: The purpose of this study was to verify the relationship among depression, school adjustment, parent-child bonding, parental control and smartphone addiction, and to identify factors which influence smartphone addiction in adolescents. METHODS: A cross-sectional design was used, with a convenience sample of 183 middle school students from 3 middle schools. Data collection was conducted through self-report questionnaires from April to May, 2017. Data were analyzed using χ² test, Fisher's exact test, t-test, one-way ANOVA, correlation coefficient analysis, and binary logistic regression with SPSS Ver. 21.0. RESULTS: The mean score for smartphone addiction was 29.40. Of the adolescents, 21.3% were in the smartphone addiction risk group. Logistic regression analysis showed that gender (OR=7.09, 95% Cl: 2.57~19.52), school life (OR=0.86, 95% Cl: 0.79~0.93), smartphone usage time (OR=1.32, 95% Cl: 1.04~1.66), and parental control (OR=4.70, 95% Cl: 1.04~21.29) were effect factors for the smartphone addiction risk group. CONCLUSION: Findings indicate that school satisfaction was an important factor in adolescents' smartphone addiction. Control oriented parent management of adolescents' smartphone use did not reduce the risk of smartphone addiction and may have worsen the addiction. Future research is needed to improve understanding of how teachers and parents will manage their adolescents' use of smartphones.
Adolescent* ; Behavior, Addictive ; Data Collection ; Depression ; Humans ; Logistic Models ; Parents ; Smartphone*

PURPOSE: To determine the learning curve of surgeons who perform vitrectomy by studying the results of the first 500 vitrectomy cases that were performed after a fellowship training course for a retina surgeon. METHODS: The medical records of the first 500 vitrectomy cases performed by a retina surgeon from February 2001 were reviewed. We included the first operation of each eye and excluded partial vitrectomy and ocular laceration cases. We defined failure as reoperation cases within 3 months and cases with serious visual complication. RESULTS: There were 261 eyes (52.2%) from male patients, and 239 eyes (48.7%) from female patients; the average age was 59.7 years old. The causative diseases were, in order of frequency, proliferative diabetic retinopathy, retinal detachment, and branch retinal vein occlusion. The final visual outcomes showed improvement of more than 2 lines in 274 eyes (54.8%), and a decrease of more than 2 lines in 50 eyes (10.0%). Failure was the outcome in 37 eyes (7.4%) and was more frequent in the first 2 years of surgeries; the causes of failure were, in order of frequency, retinal detachment, vitreous hemorrhage, and neovascular glaucoma. Visual acuity in the first 2 years, during which failure was more frequent, was not different from that in the last 3 years. CONCLUSIONS: To achieve consistently stable results in vitrectomy, a newly trained retina surgeon needs about 150 cases of vitrectomy or 2 years of experience.
Diabetic Retinopathy ; Fellowships and Scholarships ; Female ; Glaucoma, Neovascular ; Humans ; Lacerations ; Learning Curve* ; Learning* ; Male ; Medical Records ; Reoperation ; Retina ; Retinal Detachment ; Retinal Vein Occlusion ; Visual Acuity ; Vitrectomy* ; Vitreous Hemorrhage

PURPOSE: To analyze the effects and the stability of a posterior capsulectomy during combined vitrectomy and cataract surgeries in patients with retinal disease. METHODS: Between 2003 and 2005, the records of patients who underwent posterior capsulectomy during a combined vitrectomy and cataract surgery were followed for 12 months. Among 26 total eyes (17 were from males and nine from females), the average age was 63. An epiretinal membrane was found in 18 eyes, branch retinal vein occlusion in three eyes, diabetic macular edema and vitreous opacity in two eyes, and a macular hole in one eye. The posterior capsulotomy was made smaller than the optic using a vitrectomy cutter after insertion of a posterior chamber intraocular lens (IOL). We investigated postoperative visual acuity, inflammation, and complications. RESULTS: There were no intraoperative complications. One month postoperatively, one eye (3.8%) showed an increase in intraocular pressure of more than 30 mmHg, one eye (3.8%) showed 2+ inflammatory cells in the anterior chamber. Visual acuity increased by 2 lines postoperatively in 13 eyes (50.0%), whereas visual acuity decreased by more than 1 line in one eye (3.8%). There was a slight decenteration of IOL within 1 mm in two eyes (7.7%) and there was no reclosure of the posterior capsulectomy one year postoperatively. CONCLUSIONS: Posterior capsulectomy during combined vitrectomy and cataract surgery in patients with retinal disease was simple, safe, and effective in preventing after cataract.
Anterior Chamber ; Cataract* ; Epiretinal Membrane ; Humans ; Inflammation ; Intraocular Pressure ; Intraoperative Complications ; Lenses, Intraocular ; Macular Edema ; Male ; Posterior Capsulotomy ; Retinal Diseases ; Retinal Perforations ; Retinal Vein Occlusion ; Visual Acuity ; Vitrectomy*