Objective:To choose the prescription of the optimum testosterone propionate frost and the production craft conditions.Methods:Take the stability and the external appearance forms of the creams as the index sign to be checked,and carry out the experiment with orthogonal test.With the oil matches each other the ratio,the creams dosage,the way to add the main medicine a variable factor.Results:The superior formulation and craft are A 1B 2C 2 or A 1B 3C 3.Conclusion:The ready frost of testosterone propionate meets the provision of the Chinese Medical Dictionary 2000 on relevant ointments.

0.05). The serum levels of E_2 in patient group were significantly lower than those of the regular menses group (P0.05). The serum levels of E_2 were significantly higher in patient group after treatment (P0.05). The menstrual blood levels of NO, E_2 were significantly higher, and ET were significantly higher, respectively, in patient group after treatment (P

With the rapid development of molecular biology,molecular targeted therapy has become an important tumor therapy after surgery,radiotherapy and chemotherapy.It plays an increasingly important role in tumor therapy.Molecular targeted therapy reflects that the clinical medicine tends to precision,but also contains a profound philosophical thought and philosophical basis.On the one hand,the clinical application of molecular targeted therapy reflects the profound philosophical thoughts of the universality of the connection,the universality and theparticularity,and the whole and the part.On the other hand,the further application and development of molecular targeted therapy also need the guidance of philosophical theory.

Objective To study the effect and its mechanism of Modified Wenjing Decoction(Decoction for warming channels)on vasomotion in patients with menstrual disease of blood stasis due to cold accumulation.Methods The 50 patients of emmeniopathy with blood stasis due to cold accumulation were successively treated with Modified Wenjing Decoction for three menstrual cycles.The therapeutic effect and changes of nitrous oxide(NO),endothelin(ET),thromboxane B2(TXB2),6 ketone prostaglandin F1?(6-keto-PGF1?)of menstrual blood,reproductive hormones estradiol(E2)and progesterone(P)before and after treatment were observed.Results Of the 50 patients,19(38.0%)were short-term cured,24(48.0%)effective,and 7(14.0%)ineffective.After treatment,the levels of menstrual blood ET and TXB2 were decreased significantly(P

Objective To breed and identify steroid receptor coactivator-3 (SRC-3) knock-out mice. Methods Heterozygote mice were bred and reproduced. Wild genotype, heterozygote genotype, and homozygote genotype would appear in offsprings of parents. Genome DNA extracted from the murine tails was subjected to PCR for genotype identification. Male homozygote mice were selected to mate with the female heterozygote mice for acquiring homozygote baby mice according to Mendel law. Results Breeding and reproducing were successful and more heterozygote genotype mice were reproduced. Conclusion Appropriate methods for breeding, reproducing, and identifying are the effective way for acquiring SRC-3 knock-out mice from heterozygote mice.

OBJECTIVE:To evaluate the status quo and the tendency of antiepileptic drugs used in6Children's Hospitals in the Yangtze Valley.METHODS:Data on drug variety,sales volume,manufacturers of antiepileptic drugs used in6Chil?dren's Hospitals in the Yangtze Valley during2002～2004were analyzed statistically.RESULTS:Sodium valproate and topi?ramate took a bigger share in the market with the proportion of both to the antiepileptic drugs in sales volume at about40%.The old variety still took the lead in the clinical drug consumption while the momentum for the consumption of new one was quite fine.CONCLUSION:There are only a few varieties of antiepileptics now yet the sales volume of which is on the rise,therefore,of which there is still prospect of development.

Objective To investigate the changes in hydrogen sulfide(H_2S) level in plasma and myocardial tissues of doxorubicin-induced heart failure rats,and to study the role of H_2S in the development of doxorubicin-induced heart failure.Methods Male Wistar rats were randomly divided into 2 groups as follows:the doxorubicin group(n=12),in which 2.5 mg/kg of doxorubicin was injected intraperitoneal once a week for 10 weeks(total dose of 25 mg/kg);the control group(n=9),in which an(equivalent) volume of physiological saline was administered weekly for a total of 10 weeks.The observation of behavior was taken at the same time.Hemodynamic and echocardiographic measurements were obtained 10 weeks after treatment.Meanwhile,H_2S concentrations in serum and myocardial tissues were evaluated by modified sulfide electrode method.The changes of H_2S level between 2 groups were analyzed.Results The rats treated with doxorubicin showed inanimate behavior,decrease of the body temperature,activities and food intake,faster breathing,significant loss of weight,the cumulative mortality was 33%.Left ventricular systolic pressure(LVSP),difference of left ventricular pressure[△LVP=LVSP-left ventricular diastolic pressure(LVDP)] and left ventricular peak rate of contraction(+LV dp/dtmax),left ventricular peak rate of relaxation(-LV dp/dtmax)were significantly reduced in the group of doxorubicin rats(P

To survey the current awareness of risk factors for osteoporosis in community health staff in Beijing.A total of 200 medical staff including general practitioners,community nurses and public health doctors from 4 Community Health Service Centers in Beijing were examined by purposeful sampling.Then their knowledge of osteoporosis risk factors was gauged by a questionnaire.The community health staff lacked a sufficient knowledge of osteoporotic risk factors.And the most knowledgeable factor was advanced age of which 41.5％ community health staff knew.The community health staff has an insufficient knowledge of osteoporosis so that its proper training should be strengthened.

Objective To analyze the changes of Tpeak-Tend interval (Tp-Te) in patients with type 2 diabetes mellitus (T2DM),and to explore the relationship between the changes of Tp-Te and ventricular arrhythmias. Methods A total of 112 patients with T2DM were selected from the Department of endocrinology of our hospital from June 2014 to May 2016 (T2DM group),and 65 subjects underwent healthy physical examination in our hospital were selected as the normal control group (NC group) during the same period.The general data,fasting plasma glucose (FPG),glycosylated hemoglobin (HbA1c),Tp-Te,Tp-Te dispersion (Tp-Ted) were compared between the two groups.The changes of Tp-Te in patients with or without ventricular arrhythmia in T2DM group were also analyzed. Results The FPG,HbA1c,LDL-C,TC and heart rate were significantly higher in T2DM group than in the NC group (P<0.05).Compared with the control group,V5 lead Tp-Te and Tp-Ted in T2DM group was significantly prolonged (P<0.05).IN T2DM group,V5 lead Tp-Te and Tp-Ted were significantly longer in patients with ventricular arrhythmias than in patients without ventricular arrhythmia (P<0.05).Multiple logistic regression analysis showed that the increase of HbA1c and FPG were independent risk factors for prolonged Tp-Ted,and Tp-Ted was an independent risk factor for ventricular arrhythmia. Conclusion Patients with T2DM are more likely to have prolonged Tp-Ted.The prolonged Tp-Te and Tp-Ted could increase the incidence of ventricular arrhythmias.

0.05). Conclusions As for diagnosis of Sjogren syndrome,ultrasonography examination is the first choice,and for atypical ones,lip gland biopsiy follows.