Evidence-based medicine,personalization,standardization are the three common sense of cancer care in the 21st century.The model of cancer treatment has changed from experience-guided treatment into gene guided personalized treatment.Recently,personalized treatment of cancer develops fast,particularly in molecular profile for prognosis,molecular marker for efficiency of target drug and so on.

Objective:To explore the relationship between glycosylated hemoglobin (HbA1c)and carotid artery atheroscle-rosis in aged patients with normal glucose tolerance.Methods:A total of 100 aged patients with normal glucose tolerance were selected.Their bilateral carotid arteries were measured by color Doppler ultrasonography.They were grouped accord-ing to carotid intima-media thickness (C-IMT,normal,thicken and atherosclerosis)and plaque form (no plaque,hard plaque and soft plaque);blood pressure,blood lipids and HbA1c etc.were compared among groups.Results: (1)Along with CIMT rose,there was significant increase in HbA1c level [(4.98 ± 0.55)% vs.(5.51 ± 0.42)% vs.(5.92 ± 0.39)%],and there was significant difference between any two groups (P<0.01 all);(2)HbA1c level was (5.36±0.51)%,(5.89±0.44)% and (5.97±0.2)% in no plaque group,hard plaque group and soft plaque group respectively,and there was significant difference among hard plaque group,soft plaque group and no plaque group (P <0.01 all).Conclu-sion:Glycosylated hemoglobin may become an important index assessing carotid atherosclerosis in aged people.

?AlM: To discuss the artificial tears on the tear film of diabetic patients with dry eye preoperatively, and the influence on the tear film’s fuctional after phacoemulsification.
?METHODS: Fifty-four diabetic patients with dry eye (60 eyes) were followed up before phacoemulsification. Preoperatively, group A ( 30 eyes in 28 cases ) was treated with Hydroxyl lndican eye drops and group B (30 eyes in 26 cases) was not treated. Postoperatively, both group A and B were treated with Tobramycin Dexamethasone eye drops, Oprah Winfrey lbuprofen eye drops and Hydroxyl lndican eye drops. Dry eye symptoms, break up time (BUT), SchirmerItest (SIt), fluorescein stain test ( Fl ) were measured at 3d preoperatively, and 1, 7, 30, 90d postoperatively.
? RESULTS: At 3d preoperatively, there was no statistical differences between the two groups for dry eye symptoms, BUT, S I t, Fl ( P>0. 05 ). At 1 and 7d postoperatively, there were significant statistical differents between the two groups for dry eye symptoms (P<0. 05). And dry eye symptoms scores of group A were less than that of group B. At 1, 7, 30d postoperatively, BUT was longer, FL was less, Slt was increased in group A, with significant statistical differences (all P<0. 05). At 90d postoperatively, two groups of dry eye symptoms, BUT, S I t, Fl had no statistical significance (P>0. 05).
? CONCLUSlON: Using artificial tears before phacoemulsification can improve symptoms of the diabetic patients with dry eye and accelerate the recovery of the tear film.

Objective To investigate the nalaxone treating first acute right heart failure.Methods52 patients with FARHF were divided into the naloxone group(30cases)and control group(20cases)at random.Patients in control group were given general comprehensively treating.Patients in naloxone group were given naloxone as well as comprehensively treating,were given intravenously 0.8 mg of first dose,if it was necessary,repeated 0.8 mg of dose,and continuously dropped for 1.2 mg was added into liquid 500 mL.After treatment of 24 hours,were compared the changes of HR、SBP、SV and heart function.ResultsIn the naloxone group,the total effective rates were 84.4%,the mortality rates were 6.6%;in control group.The total effective rates were 60%,the mortality rates were 18.3%.The difference of the effective rate of the naloxone group be treatment was statistically significant(P

Physical activity is limited in maintenance hemodialysis (MHD) patients, and higher level of physical activity may result in less risk of death, milder depression or ahypnosis, less fatigue and better quality of life. Physical activity may relate with many factors. MHD patients may be benefited from exercise to improve the physical activity, mainly with aerobic exercise and resistance training during hemodialysis. Nurses can do more in health education and direction of exercise for MHD patients.

Aberrant promoter methylation in special genes such as tumor suppressor genes is early eventin carcinogenesis of lung cancer. Aberrant methylation, resulting in corresponding mRNA silence or overexpression , closely relates to carcinogenesis, development, treatment response and prognosis of lung cancer and it may become a potential biomarker. Methylation of special genes may provide evidences for individual treatment of lung cancers.

Objective To discuss the effects of personality features on psychological status of patients with lung cancer in perioperative period.Methods Choosing 97 patients from the thoracic department of the second Xiangya Hospital of Central South University as the study objects.The general information,psychological status and personality features were investigated by using the self-made General Information Questionnaire,Eysenck Personality Questionnaire( EPQ),Self-rating Depression Scale (SDS),Self-rating Anxiety Scale(SAS) and Self-rating Symptom Scale(SCL-90).Results The scores of seven factors including total scores( 153.28±41.98),somatization ( 1.78 ± 0.42 ),compulsion ( 1.96 ± 0.52 ),depression ( 1.77 ± 0.67 ),anxiety ( 1.82 ± 0.56 ),hostility ( 1.68 ± 0.87 ),panic ( 1.44 ± 0.75 ) and psychosis ( 1.56 ± 0.51 ) in SCL-90 were higher than domestic norm (P ＜ 0.05 ).The score of EPQ-P(Psychoticism) ( 10.96 ± 2.65 ) were higher than the domestic norm ( 5.84 ± 3.27 )(P＜0.001 ),and EPQ-N(neuroticism) and EPQ-P were positively correlated with the scores of seven factors in SCL-90.Conclusion The mental status of patients with lung cancer in perioperative period is poor.Solitude and uncaring others are the features of personality,which is correlated with psychological status,and EPQ-E (introvertion-extroversion) and EPQ-N can predict the happening of negative psychology.

A PCR assay used for detection and quantification of Neotyphodium lolii in tissues of the grass Lolium perenne L. was developed. Compared with the Microscopic analysis of stained tissues, this method was more accurate. For quantitative applications, real time PCR was used to quantify Neotyphodium lolii in Lolium perenne L.. The results showed that there were some variations between different individuals, but no variance existed between different tillers from the same plant. Thus it can be concluded that fungal content in the plant is not only associated with species/variety specific, but also with the genotype of the host plant as well.

OBJECTIVE:To provide reference for rational use of antibiotics in community-acquired pneumonia (CAP) pa-tients. METHODS:Medical records of 342 CAP inpatients in our hospital during Jan.-Dec. in 2014 were analyzed retrospectively by DDDs and SPSS 19.0 statistical software. According to the age,the patients were divided into youth group,the young group, middle age group and elderly group,and clinical information and the use of antibiotics were analyzed statistically. RESULTS:Mi-crobiological examination of 320 of 342 CAP inpatients were performed with detection rate of 93.57%;sputum culture,blood cul-ture and PCT were conducted in 67 case to find out pathogenic bacteria with negative rate of 20.18%. 338 patients had used antibi-otics (98.83%),and other 4 patients refused anti-infective treatment. Selected empirical antibiotics of our hospital were mainlyβ-lactam (50.07%),quinolones (35.70%) and macrolides (9.80%). CAP inpatients were mainly given two-drug therapy,of which cephalosporin combined with quinolone were most common,including 178 cases in total (53.61%). During treatment,17 patients suffered from ADR,with incidence of 5.03%. CONCLUSIONS:The detection rate from patients with CAP in our hospital is high in microbiological examination,but culture results should be analyzed dialectically according to clinical signs. Empirical an-ti-infective therapy mainly include β-lactams,quinolones and macrolides antibiotics alone or in combination with,basically meet the guideline for CAP Diagnosis and Therapy Guideline.

OBJECTIVE:To study the clinical features of adverse drug reactions(ADR)in our hospital.METHODS:A total of 95 ADR cases reports collected in our hospital in 2006 were analyzed statistically and retrospectively.RESULTS:Of the 95 ADR cases,adults aged 19～60a took the lead(52.6%),intravenous drip(51.6%)took the lead,65.3% were caused by antibacterials,lesions of skin and the appendants were the most common manifestations,accounting for 41.1%.CONCLUSION:Great importance should be attached to the monitoring of ADR and publicizing of ADR knowledge to improve rational drug use level.