1.A clinical study on Duchenne muscular dystrophy.
Moon Sun YANG ; Su Ahn CHAE ; Ki Joong KIM ; Yong Seung HWANG
Journal of the Korean Pediatric Society 1992;35(5):652-658
No abstract available.
Intellectual Disability
;
Muscle Weakness
;
Muscular Dystrophy, Duchenne*
2.Monitoring of Pulmonary Tuberculosis by Polymerase Chain Reaction After Antituberculous Treatment.
Chang Ho JEON ; Hun Suk SUH ; Sang Chae LEE ; Dae Sung HYUN ; Wook Su AHN
Tuberculosis and Respiratory Diseases 1998;45(5):935-941
BACKGROUND: As living and dead Mycobacteria could be amplified by polymerase chain reaction(PCR), it was considered that PCR was inappropriate for the monitoring of pulmonary tuberculosis after treatment. But we found negative conversion of PCR after successful treatment. We would like to know about the negative conversion rate of PCR and its conversion time after antituberculous treatment. METHODS: We collected 113 sputums from the 16 patients of pulmonary tuberculsosis visiting Catholic University Hospital of Taegu Hyosung. We consecutively tested AFB smear, AFB culture and PCR by 2 to 4 weeks after antituberculous therapy. The patients were classified according 13 the chest X ray findings. RESULTS: We detectsd negative conversion of PCR from all 16 patients of the pulmonary tuberculosis within 30 weeks after treatment. The average negative conversion time was 16 +/- 8 weeks. The conversion time according to the chest X-ray findings were as follows : For the 8 cases of minimum were 9 +/- 5 weeks,4 cases of modreate advanced were 20 +/- 8 weeks, and 4 cases of far advanced were 23 +/- 2 weeks. The product of PCR was gradually decreased according to the duration of treatment. CONCLUSIONS: From the results of our study, we could utilize M. tubercuosis PCR for the prediction of therapy response and monitoring of the patient with pulmonary tuberculosis after treatment.
Daegu
;
Humans
;
Polymerase Chain Reaction*
;
Sputum
;
Thorax
;
Tuberculosis, Pulmonary*
3.Restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolated from Taegu.
Chang Ho JEON ; Sang Chae LEE ; Jin Ho SOHN ; Wook Su AHN
Korean Journal of Clinical Pathology 1999;19(5):581-586
BACKGROUND: To investigate epidemiology of a specific strain, and evaluate correlation between Mycobacterium tuberculosis restriction fragment length polymorphism (RFLP) and antimicrobial susceptibility, we studied about Mycobacterium tuberculosis RFLP isolated from Taegu area. METHODS: From Oct. 1997 and Mar. 1999, we isolated 54 strains of M. tuberculosis from the patients visiting Catholic University of Taegu Hyosung, Taegu, Korea. We studied their drug susceptibility and analyzed the Pvu treated RFLP using digoxigenin labeled IS6110 probe. RESULTS: Fifty-three had more than 6 bands of RFLP and strains with 10 bands were predominant (15 strain). Cluster analysis reveals eleven distinct clusters showing 57.4% of clustered rate (31 strains from A to K) and 35 independent patterns showing 64.8% of the diversity rate at 70% similarity level. Cluster A was the largest group (7 strains) and the next was cluster B (5 strains). Most of the patients with cluster A lived in Taegu city (85.7%) and all of 2 cluster K patients lived in Euisung area. There was no correlation between RFLP pattern and antimicrobial susceptibility, but all two strains of cluster H were resistant to isoniazid. Strains of clustered were also prevalent in the people of middle class. CONCLUSIONS: Compared to the RFLP analysis in the developed countries, Korea disclosed lower rate of diversity and higher clustered patterns of M. tuberculosis. The clustered strains were also prevalent among the people of middle class.
Daegu*
;
Developed Countries
;
Digoxigenin
;
Epidemiology
;
Humans
;
Isoniazid
;
Korea
;
Mycobacterium tuberculosis*
;
Mycobacterium*
;
Polymorphism, Restriction Fragment Length*
;
Tuberculosis
4.2019 Laos children’s dental caries experience survey
Chae-Young RHEE ; Ja-Won CHO ; Hyun-Jun YOO ; Nitthasack PHOMMAVONGSA ; Yong-Su AHN ; Hyung-Suk OH
Journal of Korean Academy of Oral Health 2021;45(2):51-56
Objectives:
The aim of this study was to determine the dental caries experience of children in Laos.
Methods:
Oral examinations were performed on a total of 1,540 students in 513 primary school students, 537 middle school students, and 490 high school students and the results analyzed.
Results:
The dft index (decayed-filled primary teeth index) of 6-year-old primary school children was 6.04. The DMFT index (decayed-filled-missing permanent teeth index) was 1.59 in 12-yearold middle school children and 2.04 in 15-year-old middle school children.
Conclusions
Caries experience in most of the age groups was on the high side. It is considered that in Laos, a treatment project to stop the progression of caries is necessary in parallel with a prevention project to lower the caries fatality rate.
5.2019 Laos children’s dental caries experience survey
Chae-Young RHEE ; Ja-Won CHO ; Hyun-Jun YOO ; Nitthasack PHOMMAVONGSA ; Yong-Su AHN ; Hyung-Suk OH
Journal of Korean Academy of Oral Health 2021;45(2):51-56
Objectives:
The aim of this study was to determine the dental caries experience of children in Laos.
Methods:
Oral examinations were performed on a total of 1,540 students in 513 primary school students, 537 middle school students, and 490 high school students and the results analyzed.
Results:
The dft index (decayed-filled primary teeth index) of 6-year-old primary school children was 6.04. The DMFT index (decayed-filled-missing permanent teeth index) was 1.59 in 12-yearold middle school children and 2.04 in 15-year-old middle school children.
Conclusions
Caries experience in most of the age groups was on the high side. It is considered that in Laos, a treatment project to stop the progression of caries is necessary in parallel with a prevention project to lower the caries fatality rate.
6.Changes in the Occurrence of Gastrointestinal Infections after COVID-19 in Korea
So Yun AHN ; Ji Young PARK ; In Seok LIM ; Soo Ahn CHAE ; Sin Weon YUN ; Na Mi LEE ; Su Yeong KIM ; Byung Sun CHOI ; Dae Yong YI
Journal of Korean Medical Science 2021;36(24):e180-
Background:
After the global epidemic of coronavirus disease 2019 (COVID-19), lifestyle changes to curb the spread of COVID-19 (e.g., wearing a mask, hand washing, and social distancing) have also affected the outbreak of other infectious diseases. However, few studies have been conducted on whether the incidence of gastrointestinal infections has changed over the past year with COVID-19. In this study, we examined how the incidence of gastrointestinal infections has changed since COVID-19 outbreak through open data.
Methods:
We summarized the data on the several viruses and bacteria that cause gastrointestinal infections from the open data of the Korea Disease Control and Prevention Agency for 3 years from March 2018 to February 2021 (from Spring 2018 to Winter 2020). Moreover, we confirmed three most common legal gastrointestinal infectious pathogens from March 2016.
Results:
From March 2020, when the COVID-19 epidemic was in full swing and social distancing and personal hygiene management were heavily emphasized, the incidence of infection from each virus was drastically decreased. The reduction rates compared to the averages of the last 2 years were as follows: total viruses 31.9%, norovirus 40.2%, group A rotavirus 31.8%, enteric adenovirus 13.4%, astrovirus 7.0%, and sapovirus 12.2%. Among bacterial pathogens, the infection rates of Campylobacter and Clostridium perfringens did not decrease but rather increased in some periods when compared to the average of the last two years. The incidence of nontyphoidal Salmonella, Staphylococcus aureus, or enteropathogenic Escherichia coli somewhat decreased but not significantly compared to the previous two years.
Conclusion
The incidence of infection from gastrointestinal viruses, which are mainly caused by the fecal-to-oral route and require direct contact among people, was significantly reduced, whereas the incidence of bacterial pathogens, which have food-mediated transmission as the main cause of infection, did not decrease significantly.
7.Changes in the Occurrence of Gastrointestinal Infections after COVID-19 in Korea
So Yun AHN ; Ji Young PARK ; In Seok LIM ; Soo Ahn CHAE ; Sin Weon YUN ; Na Mi LEE ; Su Yeong KIM ; Byung Sun CHOI ; Dae Yong YI
Journal of Korean Medical Science 2021;36(24):e180-
Background:
After the global epidemic of coronavirus disease 2019 (COVID-19), lifestyle changes to curb the spread of COVID-19 (e.g., wearing a mask, hand washing, and social distancing) have also affected the outbreak of other infectious diseases. However, few studies have been conducted on whether the incidence of gastrointestinal infections has changed over the past year with COVID-19. In this study, we examined how the incidence of gastrointestinal infections has changed since COVID-19 outbreak through open data.
Methods:
We summarized the data on the several viruses and bacteria that cause gastrointestinal infections from the open data of the Korea Disease Control and Prevention Agency for 3 years from March 2018 to February 2021 (from Spring 2018 to Winter 2020). Moreover, we confirmed three most common legal gastrointestinal infectious pathogens from March 2016.
Results:
From March 2020, when the COVID-19 epidemic was in full swing and social distancing and personal hygiene management were heavily emphasized, the incidence of infection from each virus was drastically decreased. The reduction rates compared to the averages of the last 2 years were as follows: total viruses 31.9%, norovirus 40.2%, group A rotavirus 31.8%, enteric adenovirus 13.4%, astrovirus 7.0%, and sapovirus 12.2%. Among bacterial pathogens, the infection rates of Campylobacter and Clostridium perfringens did not decrease but rather increased in some periods when compared to the average of the last two years. The incidence of nontyphoidal Salmonella, Staphylococcus aureus, or enteropathogenic Escherichia coli somewhat decreased but not significantly compared to the previous two years.
Conclusion
The incidence of infection from gastrointestinal viruses, which are mainly caused by the fecal-to-oral route and require direct contact among people, was significantly reduced, whereas the incidence of bacterial pathogens, which have food-mediated transmission as the main cause of infection, did not decrease significantly.
8.A case of Crohn's disease associated with abdominal actinomycosis.
Su Jong YU ; Dong Won AHN ; Ho June SONG ; Sang Gyun KIM ; Joo Sung KIM ; Hyun Chae JUNG ; In Sung SONG
Korean Journal of Medicine 2006;70(6):695-700
The clinical features of abdominal actinomycosis are nonspecific and commonly confused with a neoplasm. Although any condition that allows the agents of actinomycosis to breach the gastrointestinal mucosa has the potential to be complicated by this infection, actinomycosis rarely develops as a complication of Crohn's disease. Because actinomycosis has indolent clinical course and manifestations similar to inflammatory bowel disease, it should be suspected that other chronic inflammatory process such as Crohn's disease could be associated when active abdominal actinomycosis is recurrent despite appropriate anti-microbial treatment. Herein, we report a case of Crohn's disease associated with abdominal actinomycosis.
Actinomycosis*
;
Crohn Disease*
;
Inflammatory Bowel Diseases
;
Mucous Membrane
9.Intrarenal Expression of Interleukin-6 and the -174 G/C Polymorphism in IgA Nephropathy.
Chun Soo LIM ; Yon Su KIM ; Cu Rie AHN ; Jin Suk HAN ; Suhng Gwon KIM ; Jung Sang LEE ; Dong Wan CHAE
Korean Journal of Nephrology 2002;21(4):595-601
BACKGROUND: The proinflammatory cytokine, interleukin-6(IL-6), seems to be involved in the pathogenesis and progression of IgA nephropathy. The aim of this study is to elucidate the relationship between the intrarenal expression of IL-6 and the clinicopathological findings in IgA nephropathy, and to reveal whether allele-frequency differences of -174 G/C polymorphism of IL-6 gene promoter region exist between IgA nephropathy patients and the normal population. METHODS: The total RNA was extracted from renal tissue of 56 IgA nephropathy patients. Semiquantitative reverse-transcriptase polymerase chain reactions(RT-PCR) using the internal competitors were done for the quantification of IL-6 transcripts. Using PCR-RFLP, we examined the -174 G/C polymorphism in IgA nephropathy patients and in 53 of the normal Korean population. RESULTS: In RT-PCR, the degree of intrarenal IL-6 expression was not related with any clinicopathological characteristics of IgA nephropathy patients. The degree of IgA deposition in glomeruli was correlated with the expression of IL-6, but the correlation was not statistically significant. Among the 56 IgA nephropathy patients studied, 55 carried the GG wild type and only 1 carried the GC genotype. Among 53 normal controls studied, only 1 carried the GC genotype and the rest carried GG wild type(C allele frequency=0.009). CONCLUSION: These results suggest that IL-6 is not related with the pathophysiology of IgA nephropathy, and the -174 G to C polymorphism of IL-6 promoter region is very rare in Koreans. And, the IL-6 polymorphism at -174 is unlikely to contribute significantly to susceptibility to or the progression of IgA nephropathy in Koreans.
Alleles
;
Genotype
;
Glomerulonephritis, IGA*
;
Humans
;
Immunoglobulin A*
;
Interleukin-6*
;
Promoter Regions, Genetic
;
RNA
10.A case of HME obstruction by distilled water from incidentally mounted heated wire circuit kit: A case report.
Chae In JEONG ; Sang Il LEE ; Yeo Hyun AHN ; Ji Yeon KIM ; Kyung Tae KIM ; Jang Su PARK ; Jung Won KIM
Korean Journal of Anesthesiology 2009;57(3):358-360
Heat-moisture exchanger (HME) is an inexpensive and effective device used to prevent respiratory complications that can be caused by endotracheal tube insertion during general anesthesia. But, HME can increase airway resistance and be occluded by the patient's secretions. Whether a HME could be occluded by clear fluids such as condensate in the airway circuit is not certain yet. In vitro, a case of HME occlusion by normal saline was reported. We report a case of HME obstruction by distilled water came from the heated wire circuit which was unintentionally connected to the HME.
Airway Resistance
;
Anesthesia, General
;
Hot Temperature
;
Porphyrins
;
Water