Methods: This is an experimental study of 12 rabbits implanted with ostrich eggshell (6 rabbits with 5mm- and 6 rabbits with 10mm-diameter grafts) subperiosteally in the right orbital floor. The right orbit was harvested en bloc 1, 2, and 3 months after onlay. Radiographic studies were done one day after implantation and prior to harvest. The specimens were submitted for gross and microscopic studies. Results: All animals showed normal wound healing. The grafts were stable and no foreign body reaction was observed 1, 2 and 3 months postimplantation. The size of the ostrich eggshell implants remained the same. There was no change in radiodensity at 3 months observation. Conclusion: The results of this study support the potential application of ostrich eggshell as bone substitute for orbital floor fractures.
Animal ; STRUTHIONIFORMES ; BONE TRANSPLANTATION ; TRANSPLANTS ; RABBITS ; ORBIT ; ORBITAL FRACTURES

A bioavailability and pharmacokinetics study of doxycycline was carried out on 30 healthy ostriches after a single intravenous (IV), intramuscular (IM) and oral dose of 15 mg/kg body weight. The plasma doxycycline concentration was determined by HPLC/UV at 0 (pretreatment), 0.08, 0.25, 0.5 1, 2, 4, 6, 8, 12, 24 and 48 h after administration. The plasma concentration-time curves were examined using non-compartmental methods based on the statistical moment theory for only the higher dose. After IV administration, the elimination half-life (t(1/2beta)), mean residence time (MRT), volume of distribution at the steady-state (V(ss)), volume of distribution (Vd(area)) and total body clearance (Cl(B)) were 7.67 +/- 0.62 h, 6.68 +/- 0.86 h, 0.86 +/- 0.16 l/kg, 1.67 +/- 0.52 l/kg and 2.51 +/- 0.63 ml/min/kg, respectively. After IM and oral dosing, the mean peak plasma concentrations (C(max)) were 1.34 +/- 0.33 and 0.30 +/- 0.04 microgram/ml, respectively, which were achieved at a postadministration time (t(max)) of 0.75 +/- 0.18, 3.03 +/- 0.48 h, respectively. The t(1/2beta), Vd(area) and Cl(B) after IM administration were 25.02 +/- 3.98 h, 23.99 +/- 3.4 l/kg and 12.14 +/- 1.71 ml/min/kg, respectively and 19.25 +/- 2.53 h, 61.49 +/- 7 l/kg and 40.19 +/- 3.79 ml/min/kg after oral administration, respectively. The absolute bioavailability (F) of doxycycline was 5.03 and 17.52% after oral and IM administration, respectively. These results show that the dose data from other animals particularly mammals cannot be extrapolated to ostriches. Therefore, based on these results along with those reported in the literature, further studies on the pharmacokinetic/pharmacodynamic, in vitro minimum inhibitory concentration values and clinical applications of doxycycline in ostriches are required.
Administration, Oral ; Animals ; Anti-Bacterial Agents/administration & dosage/blood/*pharmacokinetics ; Area Under Curve ; Biological Availability ; Dose-Response Relationship, Drug ; Doxycycline/administration & dosage/blood/*pharmacokinetics ; Half-Life ; Injections, Intramuscular/veterinary ; Injections, Intravenous/veterinary ; Struthioniformes/*metabolism

Recently reports on toxocariasis are increasing by serodiagnosis in Korea. A previously healthy 17-yr-old boy complained of headache, fever, dyspnea, and anorexia. He showed symptoms and signs of eosinophilic meningitis with involvement of the lungs and liver. Specific IgG antibody to Toxocara canis larval antigen was positive in serum and cerebrospinal fluid by ELISA. He took raw ostrich liver with his parents 4 weeks before the symptom onset. His parents were seropositive for T. canis antigen but had no symptoms or signs suggesting toxocariasis. This is the first report of toxocariasis in a family due to ingestion of raw ostrich liver in Korea.
Adolescent ; Animals ; Antibodies, Helminth/blood/cerebrospinal fluid ; Eating ; Humans ; Larva/immunology ; Liver/parasitology ; Male ; Meningitis/*diagnosis/parasitology ; Struthioniformes ; Tomography, X-Ray Computed ; Toxocara canis/growth & development/*immunology/isolation & purification ; Toxocariasis/*diagnosis/parasitology/transmission