No abstract available.
Humans ; Republic of Korea ; Stress Disorders, Post-Traumatic/*diagnosis/*psychology/therapy

Although posttraumatic stress disorder (PTSD) is on the rise, traumatic events and their consequences are often hidden or minimized by patients for reasons linked to PTSD itself. Traumatic experiences can be broadly classified into mental stress (MS) and traumatic brain injury (TBI), but the cellular mechanisms of MS- or TBI-induced PTSD remain unknown. Recent evidence has shown that the morphological remodeling of astrocytes accompanies and arguably contributes to fearful memories and stress-related disorders. In this review, we summarize the roles of astrocytes in the pathogenesis of MS-PTSD and TBI-PTSD. Astrocytes synthesize and secrete neurotrophic, pro- and anti-inflammatory factors and regulate the microenvironment of the nervous tissue through metabolic pathways, ionostatic control, and homeostatic clearance of neurotransmitters. Stress or trauma-associated impairment of these vital astrocytic functions contribute to the pathophysiological evolution of PTSD and may present therapeutic targets.
Astrocytes ; Brain Injuries, Traumatic ; Fear ; Humans ; Stress Disorders, Post-Traumatic/therapy*

OBJECTIVE: This study investigated trends in the study of phytochemical treatment of post-traumatic stress disorder (PTSD). METHODS: The Web of Science database (2007-2022) was searched using the search terms "phytochemicals" and "PTSD," and relevant literature was compiled. Network clustering co-occurrence analysis and qualitative narrative review were conducted. RESULTS: Three hundred and one articles were included in the analysis of published research, which has surged since 2015 with nearly half of all relevant articles coming from North America. The category is dominated by neuroscience and neurology, with two journals, Addictive Behaviors and Drug and Alcohol Dependence, publishing the greatest number of papers on these topics. Most studies focused on psychedelic intervention for PTSD. Three timelines show an "ebb and flow" phenomenon between "substance use/marijuana abuse" and "psychedelic medicine/medicinal cannabis." Other phytochemicals account for a small proportion of the research and focus on topics like neurosteroid turnover, serotonin levels, and brain-derived neurotrophic factor expression. CONCLUSION Research on phytochemicals and PTSD is unevenly distributed across countries/regions, disciplines, and journals. Since 2015, the research paradigm shifted to constitute the mainstream of psychedelic research thus far, leading to the exploration of botanical active ingredients and molecular mechanisms. Other studies focus on anti-oxidative stress and anti-inflammation. Please cite this article as: Gao B, Qu YC, Cai MY, Zhang YY, Lu HT, Li HX, Tang YX, Shen H. Phytochemical interventions for post-traumatic stress disorder: A cluster co-occurrence network analysis using CiteSpace. J Integr Med. 2023; 21(4):385-396.
Humans ; Stress Disorders, Post-Traumatic/drug therapy* ; Hallucinogens/therapeutic use* ; Substance-Related Disorders/drug therapy*

Torture is an extreme life stressor which increases the risk of serious psychological and physical sequelae of victims. Despite Geneva declaration, Amnesty International reports that torture remains as human rights issue in many sites of the world. Even in Korean peninsula, torture is a serions human rights issue. This paper is a critical review on torture; to describe its methods and effects, the assessment of psychological and physical sequelae, and its treatment. Torture also affects survivor's family. The more prolonged, repeated, and unpredictable the experience of torture is, the more serious psychiatric consequences are likely. Psychological responses and sequelae include not only symptoms of Posttraumatic Stress Disorder (PTSD), but also depression, personality changes, somatoform disorders and others. Diagnositic terms such as complex PTSD or torture syndrome have been used to denote the complexity of torture trauma. Treatment is a combination of pharmacotherapy, cognitive-behavioural therapy, guidance for of socialre readaptation. Ensuring safety and trust between survivors and medical staffs is important. Torture prevention is to expose the facts particularly health data to the public, and collaborate with international organizations fighting against torture. Preventive interventions is linked to a change in the underlying socio-political causes and to the creation of necessary conditions for human rights and development at the level of society.
Depression ; Drug Therapy ; Human Rights ; Humans ; Medical Staff ; Somatoform Disorders ; Stress Disorders, Post-Traumatic ; Survivors ; Torture*

From the TCM theoretical basis and the evidences of acupoint selection and acupuncture and moxibustion methods regarding acupuncture for post-traumatic stress disorder (PTSD), a theoretical discussion is made in this article, also a review regarding the key mechanism of experiment researches on acupuncture for PTSD is made from aspects of neurobiology and brain functional imaging, etc., which could further clarify the effect mechanism of acupuncture on PTSD. It is found that PTSD is a kind of stress syndrome accompanied with a variety of abnormal mental symptom , and acupuncture has superior effect on PTSD. Based on these, the research progress and deficiency on current mechanism study of PTSD are reviewed, hoping to offer ideas for upcoming research and to serve the clinical practice better.
Acupuncture Points ; Acupuncture Therapy ; methods ; trends ; Humans ; Moxibustion ; Stress Disorders, Post-Traumatic ; therapy

A number of recent case reports and series indicate that obsessive compulsive disorder (OCD) can develop after traumatic experience as a comorbid conditon to post-traumatic stress disorder (PTSD). These descriptive studies consistently addressed that those patients respond poorly to treatments and had an unfavorable outcome. However, this conclusion was not supported by prospective follow up with objective measurement of symptomatology. This report presents three single trauma-related PTSD patients who developed full-blown OCD concurrently with or after the initiation of PTSD. These patients represent 10% of new PTSD outpatients at a PTSD clinic during one year period and 25% of PTSD patients who had been admitted. In all three cases compulsion seemed to distract or serve as avoidance to intrusive symptoms of PTSD. Despite Eye Movement Desensitization and Reprocessing (EMDR) and/or exposure therapy for PTSD together with at least two antidepressant trials for PTSD and OCD, at six month follow-up PTSD partially improved and OCD remained unchanged. This finding is consistent with previous reports from western literature.
Eye Movements ; Follow-Up Studies* ; Humans ; Implosive Therapy ; Obsessive-Compulsive Disorder* ; Outpatients ; Stress Disorders, Post-Traumatic

OBJECTIVE: Although the number of studies are increasing in the pharmacotherapy of posttraumatic stress disorder (PTSD), few studies for the long-term effects of antidepressants on the treatment of PTSD were conducted. The aim of the present study was to investigate the effectiveness of mirtazapine during 24-week continuation treatment in patients with posttraumatic stress disorder. METHODS: Out of 15 patients participating in the previous 8 weeks study, 12 patients completed 24 weeks treatment with mirtazapine. Efficacy was evaluated at 12-week and 24-week using Impact of Event Scale-Revised (IES-R), Short PTSD Rating Interview (SPRINT), Interviewer-Administered Structured Interview for PTSD (SIP) and Montgomery Asberg Depression Rating Scale (MADRS). RESULTS: The scores on the IES-R, SPRINT, SIP and MADRS were significantly reduced by time from baseline to the end-point (F=36.1, df=4, p<0.001 ; F=106.3, df=4, p<0.001 ; F=121.1, df=4, p<0.001 ; F=198.9, df=4, p<0.001). On post hoc analysis, the scores of all 4 measures were significantly reduced at the end point since week 8. But, after Bonferroni correction, the reduced score was statistically significant in only SPRINT. The number of patients, whose scores reduced over 50% in all four scales, tended to increase from 3 at week 8 to 8 at the end point (p=0.063). No serious drug-related side effects were observed. CONCLUSION: This result suggests that the therapeutic effect of mirtazapine is maintained and may be even increased in the long-term treatment of PTSD. More studies in the pharmacotherapy of PTSD will be needed in the future.
Antidepressive Agents ; Depression ; Drug Therapy ; Humans ; Stress Disorders, Post-Traumatic* ; Weights and Measures

We sought to gain insights on the prevalence of psychiatric disorders, the risk and protective factors and the prevention and intervention programs of mental health problems among disaster workers. The prevalence of Posttraumatic Stress Disorder (PTSD) among disaster workers was higher than that of the general population and lower than that of disaster survivors. They might suffer from various mental health problems and comorbid disorders. Those mental problems could affect not only their physical health but also self-medication, life satisfaction, and job functioning. Heterogeneous and various factors were positively and negatively associated with psychiatric problems. Prevention and intervention programs were summarized for PTSD among disaster workers. Self-help technique 'RESCUE' and cognitive behavior therapy, developed especially for disaster workers was introduced. Future research and directions were suggested.
Cognitive Therapy ; Disasters* ; Humans ; Mental Health* ; Prevalence ; Stress Disorders, Post-Traumatic ; Survivors

Each year many people are exposed to life-threatening disaster and traumatic events that put them at risk for trauma- and stressor-related disorders such as posttraumatic stress disorder. This report reviews research on the psychosocial interventions currently employed for the prevention and treatment of trauma- and stressor-related disorders. Cognitive behavioral therapy, including cognitive therapy and prolonged exposure, has been shown to improve several outcomes. Considerable progress has also been made in the use of eye movement desensitization and reprocessing. Trauma- and stressor-related disorders are associated with complex outcomes and multiple comorbid emotional, social, and physical health difficulties. Further advances are required in the intervention for populations with complex and chronic forms and in the development of integrated and well-related systems of care.
Adult* ; Cognitive Therapy ; Disasters ; Eye Movements ; Humans ; Stress Disorders, Post-Traumatic

This paper aims to investigate the active components and mechanism of Valerianae Jatamansi Rhizoma et Radix against post-traumatic stress disorder(PTSD) based on network pharmacology and molecular docking. The main components and targets of Valerianae Jatamansi Rhizoma et Radix were obtained by literature mining methods, SwissTargetPrediction, BATMAN and ETCM database. PTSD-related genes were collected from DrugBank, TTD and CTD databases. The protein-protein interaction(PPI) network was constructed based on STRING, and the core targets of Valerianae Jatamansi Rhizoma et Radix in the treatment of PTSD were selected according to the topological parameters. Cytoscape 3.7.2 was used to construct the compound-target network. DAVID database was used for GO enrichment analysis and KEGG enrichment analysis. The relationship network of "compound-target-pathway" was constructed through Cytoscape 3.7.2 to analyze and obtain the key targets and their corresponding components in the network, and their results were verified by molecular docking. The results showed that a total of 47 components(such as valeraldehyde, dihydrovalerin, valerate, chlorovaltrate K, 8-hydroxypinoresinol, 6-hydroxyluteolin, apigenin, farnesin, vanillin, luteolin, kaempferol, glycosmisic acid and pogostemon) of Valerianae Jatamansi Rhizoma et Radix may act on 94 key targets such as CNR1, MAOA, NR3 C1, MAPK14, MAPK8, HTR2 C and DRD2. Totally 29 GO terms were obtained by GO functional enrichment analysis(P<0.05), and 20 signaling pathways were obtained from KEGG pathway enrichment, mainly involving neuroactive ligand-receptor interaction, serotonergic synapse, calcium signaling pathway, cAMP signaling pathway, dopaminergic synapse, retrograde endocannabinoid signaling, neurotrophin signaling pathway, gap junction, cholinergic synapse, estrogen signaling pathway, glutamatergic synapse and long-term potentiation. Molecular docking analysis showed that hydrogen bonding, π-π interaction and hydrophobic effecting may be the main forms of interaction. This study used the network of compound-target-pathway and molecular docking technology to screen the effective components of Valerianae Jatamansi Rhizoma et Radix against PTSD, and explore its anti-PTSD mechanism, so as to provide scientific basis for exploring the anti-PTSD drugs from traditional Chinese medicine and clarifying its mechanism of action.
Drugs, Chinese Herbal ; Medicine, Chinese Traditional ; Molecular Docking Simulation ; Rhizome ; Stress Disorders, Post-Traumatic/drug therapy*