1.Challenges in Diagnosis and Therapy of Recurrent Oral Herpes Infection: Study of Two Cases
Dwi Kartika Sari ; Febrina Rahmayanti ; Harum Sasanti ; Ambar Kusuma Astuti
Archives of Orofacial Sciences 2021;16(SUPP 1):73-81
ABSTRACT
The symptoms of recurrent oral herpes infection may vary, from mild discomfort to life threatening.
Dentists are more likely to be consulted in this oral infection, hence the ability to diagnose and treat
this disease is mandatory. This article described manifestation and therapy of recurrent oral herpes
infection. In the first case, a 41-year-old woman came with a complaint of painful sore mouth in her
lower gingiva. She experienced canker sores for two to three times a year on the tongue, lips and palate.
Laboratory results showed positive IgM anti HSV-2, which matched with the primary herpes infection.
However, based on the history and clinical manifestations, she was diagnosed with recurrent intra oral
herpes infection. In the second case, a 70-year-old man came with a very painful canker sores in his
entire mouth. The patient had to be hospitalised for three days and received analgesic, antibiotic and gel
containing triamcinolone. After hospitalisation, canker sores did not heal. Extraorally, we found a crust
in the vermillion border of the upper lip and intraorally, we found multiple ulceration of keratinised and
non-keratinised mucosa. The use of topical steroid in this patient may aggravated ulceration due to its
ability to cause rapid spreading of the virus. The first patient was given chlorhexidine gluconate 0.2% and
the second patient was prescribed with doxycycline rinse. Both patients received multivitamin containing
zinc. Complete history taking, objective and adjunctive examination played a role in establishing the
diagnosis and treatment of recurrent oral herpes infections.
Stomatitis, Herpetic
2.A Case of Herpetic Whitlow with Bacterial Superinfection.
Journal of the Korean Pediatric Society 2003;46(9):918-920
Herpes simplex virus infection of the hand in children occurs after auto-inoculation from herpetic gingivostomatitis or herpes labialis. Herpetic whitlow should be suspected based on clinical signs. Diagnosis can be made by PCR or virus culture. Many misdiagnosed cases suggests that this disease is not sufficiently known. Surgical interventions may be harmful and should be avoided. We report a case of herpetic whitlow with bacterial superinfection in a three-year-old girl.
Child
;
Diagnosis
;
Female
;
Hand
;
Herpes Labialis
;
Humans
;
Polymerase Chain Reaction
;
Simplexvirus
;
Stomatitis, Herpetic
;
Superinfection*
3.Molecular Analysis of Two Cases of Severe Congenital Neutropenia.
Joonhong PARK ; Myungshin KIM ; Jihyang LIM ; Yonggoo KIM ; Bin CHO ; Yeon Joon PARK ; Kyungja HAN
The Korean Journal of Laboratory Medicine 2010;30(2):111-116
Severe congenital neutropenia is a rare hematological disease characterized by a selective decrease in circulating neutrophils, maturation arrest of granulocytic precursors at the promyelocyte stage, and recurrence of infections. A 2-month-old male infant (patient A) and a 14-month-old female child (patient B) were referred to our hospital due to severe neutropenia. Sequencing analysis of ELA2 and HAX1 genes was performed. Two single nucleotide polymorphisms of HAX1 gene were found. They were 5,104T-->G point mutation of exon 1 and 5,474A-->G point mutation of intron 1 in HAX1 gene. The mutation of ELA2 gene was not found. The patient A showed a good response to granulocyte colony-stimulating factor (G-CSF) treatment and the absolute neutrophil count recovered to 1,195/microliter. But the patient B showed a partial response to G-CSF treatment and experienced several episodes of herpetic gingivostomatitis, oral ulcer, acute pharyngotonsillitis and otitis media during follow-up.
Adaptor Proteins, Signal Transducing/genetics
;
Bone Marrow/pathology
;
Female
;
Granulocyte Colony Stimulating Factor, Recombinant/adverse effects/therapeutic use
;
Humans
;
Infant
;
Male
;
Neutropenia/congenital/drug therapy/*genetics
;
Neutrophils/cytology/pathology
;
Oral Ulcer/etiology
;
Otitis Media/etiology
;
Polymorphism, Single Nucleotide
;
Serine Endopeptidases/genetics
;
Stomatitis, Herpetic/etiology