No abstract available.
Cryotherapy* ; Stomatitis*

Humans ; Stomatitis

ABSTRACT The symptoms of recurrent oral herpes infection may vary, from mild discomfort to life threatening. Dentists are more likely to be consulted in this oral infection, hence the ability to diagnose and treat this disease is mandatory. This article described manifestation and therapy of recurrent oral herpes infection. In the first case, a 41-year-old woman came with a complaint of painful sore mouth in her lower gingiva. She experienced canker sores for two to three times a year on the tongue, lips and palate. Laboratory results showed positive IgM anti HSV-2, which matched with the primary herpes infection. However, based on the history and clinical manifestations, she was diagnosed with recurrent intra oral herpes infection. In the second case, a 70-year-old man came with a very painful canker sores in his entire mouth. The patient had to be hospitalised for three days and received analgesic, antibiotic and gel containing triamcinolone. After hospitalisation, canker sores did not heal. Extraorally, we found a crust in the vermillion border of the upper lip and intraorally, we found multiple ulceration of keratinised and non-keratinised mucosa. The use of topical steroid in this patient may aggravated ulceration due to its ability to cause rapid spreading of the virus. The first patient was given chlorhexidine gluconate 0.2% and the second patient was prescribed with doxycycline rinse. Both patients received multivitamin containing zinc. Complete history taking, objective and adjunctive examination played a role in establishing the diagnosis and treatment of recurrent oral herpes infections.
Stomatitis, Herpetic

BACKGROUND AND OBJECTIVES: Recurrent aphthous ulceration (RAU) is most common among benign oral mucosal diseases, but its pathogenesis is not clearly defined yet. We aimed to evaluate the allergic reaction and identify the allergen by using the multiple allergosorbent test (MAST). SUBJECTS AND METHOD: We selected a total of 20 patients with RAU. RAU was not diagnosed by biopsy but by clinical findings, and MAST was performed in all patients. Parameters used were total IgE concentration, type of positive allergens, and the specific IgE concentration. RESULTS: The results were as follows: 1) The total IgE concentration was increased more in the RAU group than in the control group (p<0.05). 2) The type of positive allergens was multiple and had more even distribution in the RAU group than in the control group (p<0.05). 3) The specific IgE concentration according to the positive allergen was higher in the RAU group than in the control group (p<0.05). CONCLUSION: Allergic reactions could be invol-ved in the pathogenesis of RAU. The pathomechanism of allergic reaction to the RAU and the feasibility of treatment options such as avoidance therapy, the immune therapy, and the antihistamine usage need further study.
Allergens ; Biopsy ; Humans ; Hypersensitivity ; Immunoglobulin E ; Stomatitis ; Stomatitis, Aphthous*

OBJECTIVE: This study was conducted to develop cancer patients' symptom management guideline, and to develop and test the utility of the web-based guideline service system. METHODS: Based on the literature review, guidelines for symptom management for nausea/vomiting, fatigue, constipation, diarrhea, and oral mucositis were developed. A web-based cancer patients' symptom management system was developed on the basis of guideline developed in the first stage of the study. Forty-five oncology nurses were recruited and asked to evaluate and validate the system by rating level of satisfaction with function, content and effectiveness of the web-based service after they used the website for cancer patients care. RESULTS: Regarding the function of the system around 50% of oncology nurses expressed satisfaction with the system. Regarding the content of the system, nurses expressed highest satisfaction with reliability of information(66.7%) and lowest satisfaction with sufficiency of information (37.7%). Regarding the effectiveness of the system in terms of knowledge enhancement, about 40% of nurses indicated that they satisfied with the system. In terms of usefulness of the system, 48.9% of nurses expressed their satisfaction with the system. CONCLUSION: The result of this study has implications on future use of a web-based guideline for managing symptoms of cancer patients.
Constipation ; Diarrhea ; Fatigue ; Humans ; Stomatitis

Humans ; Recurrence ; Stomatitis, Aphthous/therapy*

Recurrent aphthous stomatits (RAS) is also known as recurrent oral ulcers, recurrent aphthous ulcers, or simple or complex aphthosis. RAS is the most common inflammatory ulcerative condition of the oral mucosa in North American patients. RAS has been the subject of active investigation along multiple lines of research including epidemiology, immunology, clinical correlations and therapy. Clinical evaluation of the patient requires correct diagnosis of RAS and classification of the disease based on morphology (MIAU, MJAU, HU) and severity (simple versus complex). In order to properly diagnose and treat a patient with lesions of RAS, the clinician must exclude other causes of acute oral ulcers. Complex aphthosis and complex aphthosis variants associated with systemic disorders should be considered. The aphthous-like oral ulcerations of patients with HIV disease represent a challenging differential diagnosis. The association of lesions of RAS with hematinic deficiencies and gastrointestinal diseases provides an opportunity to identify a "correctable cause" which, with appropriate treatment, can result in a remission or substantial lessening of disease activity. Finally, when all of these factors are considered, the evaluation of the patient for Behcet's disease can be continued on firm grounds that one of the major criteria for the diagnosis of Behcet's disease has been met.
Behcet's Syndrome/diagnosis* ; Diagnosis, Differential ; Human ; Recurrence ; Stomatitis, Aphthous/etiology ; Stomatitis, Aphthous/diagnosis* ; Stomatitis, Aphthous/classification

This 24 yrs. old male pt. visited our hosptial on september 1971, with complaints of visual disturbance, ocular pain in Lt. eye. Behcet's disease is usually Characterized by the triad of Hypopyon, uveitis, aphthous ulcer of the mouth and genitalia. A brief review of literatures has been descrived.
Genitalia ; Humans ; Male ; Mouth ; Stomatitis, Aphthous ; Uveitis

Because the oral mucositis is often inevitable in acute leukemia patients during chemotherapy, the efforts must be made to keep these leuekmia patients from oral mucositis. So we tried to develop two oral care protocols for reducing the level of oral mucositis during cytotoxic therapy through literature review and our clinical experience. This quasi-experimental study was performed to compare the prohpylatic value of these oral care protocols. Thirty-seven subjects were assigned to one of three groups. The first group performed bivon-normal saline gargling protocol, the second group performed chlorhexidine gargling protocol, and the last contrast group kept traditional gargling protocol, The Oral Assessment Guide(OAG), the Beck's perception of oral comfort, and the discomfort of oral gargling solution were used to assess oral status and subject's oral discomfort during chemotherapy. Each subjects were observed daily from the start of the chemotherapy until Absolute Nertrophil Count (ANC) reached 1,000/mm3. It continued about 2-4 weeks. The data were analyzed by ANCOVA and Kruskal-Wallis oneway ANOVA. The results were as follows : The control group showed significantly highest mean score of the OAG and Beck's perception of oral discomfort among three groups. However the mean score of OAG and Beck's perception of oral discomfort were not significantly different, the bivon saline group showed significantly lowest mean scores among three groups. In conclusion, we recommend that nurses who care acute leukemia patients use bivon-normal saline gargling protocol to reduce the level of oral mucositis during chemotherapy.
Chlorhexidine* ; Drug Therapy* ; Humans ; Leukemia* ; Stomatitis*

OBJECTIVE: To assess the clinical effect of bucillamine in rheumatoid arthritis (RA), we performed an open clinical trial for 3 months. METHODS: 10 out of 12 patients completed bucillamine trial(200mg/day) for their initial treatment against arthritis, and 9 out of 11 patients with refractory RA completed the bucillamine trial. Disease activity was assessed by the duration of morning stiffness(MS), visual analogue pain scale(VAPS), functional capacity(FC), tender joint counts(TJC), swollen joint counts(SJC), ESR, and CRP every month. Adverse effects were monitored monthly. RESULTS: At the end of trial, all parameters were decreased in the initial treatment group except of CRP. No parameters were decreased in the refractory group. Gastrointestinal disturbance was the most commmon adverse effect. Skin rash, stomatitis, proteiuria and elevated hepatic enzyme were minor adverse effects. CONCLUSION: Bucillamine was effective in the initial treatment of rheumatoid arthritis, but not effective in the patients with refractory rheumatoid arthritis. Bucillamine is relatively safe in the treatment of rheumatoid arthritis in both groups.
Arthritis ; Arthritis, Rheumatoid* ; Exanthema ; Humans ; Joints ; Stomatitis