China ; epidemiology ; Humans ; Precancerous Conditions ; diagnosis ; epidemiology ; pathology ; Stomach Neoplasms ; diagnosis ; epidemiology ; pathology ; Topography, Medical

Menetrier's disease is a rare disease of the stomach generally described as hypertrophic gastropathy associated with hypoproteinemia. Gastric resection is still the most definitive treatment for the disease, but the appropriate extent of resection has not been determined. One of the major factors that would determine the extent of gastric resection in Menetrier's disease is its malignant potential. We present two recent cases of Menetrier's disease treated in our institution and review cases of the disease reported in Korea where the incidence of gastric cancer is one of the highest in the world.
Gastritis, Hypertrophic/*epidemiology/*pathology ; Human ; Korea/epidemiology ; Male ; Middle Aged ; Prevalence ; Risk Factors ; Stomach Neoplasms/*epidemiology

OBJECTIVETo provide basic information for epidemiological research of gastrointestinal (GI) malignant tumors.

METHODSData of GI cancer diagnosed in 15 hospitals of Heilongjiang province between January 1998 and December 2007 were analyzed retrospectively. The data mainly involved the age of onset, initial symptoms, pathological types, clinical staging and types of surgical procedure.

RESULTSGastric cancer was the most common type (45.8%) among the 33,540 GI cancer cases, then were rectal cancer (27.3%) and colon cancer (26.8%). Right colon cancer cases were more common than the left ones (1.3:1.0), particularly in people over 80 (2.1:1.0). Only 1.3% of colorectal cancer could be found in age under 30 years old. In patients aged 50 to 70, advanced gastric cancer accounted for 70.6%, advanced colon cancer 73.4% and advanced rectal cancer 72.4%. Well-moderately differentiated adenocarcinoma in early gastric cancer was 49.7%, early colon cancer 77.3% and rectal cancer 83.2%. Patients undergone radical excision in early gastric cancer accounted for 69.1%, advanced gastric cancer 79.9%, left colon cancer 91.9%, right colon cancer 83.9% and in rectal cancer for 88.3%.

CONCLUSIONSPeople aged 50 to 70 tend to get GI cancer in Heilongjiang province. Gastric cancer is the most common GI cancer. Radical excision is the main choice of therapy.

Adult ; Age Distribution ; Aged ; Aged, 80 and over ; China ; epidemiology ; Colonic Neoplasms ; epidemiology ; pathology ; Colorectal Neoplasms ; epidemiology ; pathology ; Female ; Gastrointestinal Neoplasms ; epidemiology ; pathology ; Humans ; Incidence ; Male ; Middle Aged ; Rectal Neoplasms ; epidemiology ; pathology ; Retrospective Studies ; Sex Distribution ; Stomach Neoplasms ; epidemiology ; pathology

BACKGROUND: Family clustering of esophageal cancer (EC) has been found in high-risk areas of China. However, the relationships between cancer family history and esophageal cancer and precancerous lesions (ECPL) have not been comprehensively reported in recent years. This study aimed to provide evidence for identification of high-risk populations. METHODS: This study was conducted in five high-risk areas in China from 2017 to 2019, based on the National Cohort of Esophageal Cancer. The permanent residents aged 40 to 69 years were examined by endoscopy, and pathological examination was performed for suspicious lesions. Information on demographic characteristics, environmental factors, and cancer family history was collected. Unconditional logistic regression was applied to evaluate odds ratios between family history related factors and ECPL. RESULTS: Among 33,008 participants, 6143 (18.61%) reported positive family history of EC. The proportion of positive family history varied significantly among high-risk areas. After adjusting for risk factors, participants with a family history of positive cancer, gastric and esophageal cancer or EC had 1.49-fold (95% confidence interval [CI]: 1.36-1.62), 1.52-fold (95% CI: 1.38-1.67), or 1.66-fold (95% CI: 1.50-1.84) higher risks of ECPL, respectively. Participants with single or multiple first-degree relatives (FDR) of positive EC history had 1.65-fold (95% CI: 1.47-1.84) or 1.93-fold (95% CI: 1.46-2.54) higher risks of ECPL. Participants with FDRs who developed EC before 35, 45, and 50 years of age had 4.05-fold (95% CI: 1.30-12.65), 2.11-fold (95% CI: 1.37-3.25), and 1.91-fold (95% CI: 1.44-2.54) higher risks of ECPL, respectively. CONCLUSIONS: Participants with positive family history of EC had significantly higher risk of ECPL. This risk increased with the number of EC positive FDRs and EC family history of early onset. Distinctive genetic risk factors of the population in high-risk areas of China require further investigation. TRIAL REGISTRATION ChiCTR-EOC-17010553.
Case-Control Studies ; China/epidemiology* ; Esophageal Neoplasms/pathology* ; Humans ; Precancerous Conditions/pathology* ; Risk Factors ; Stomach Neoplasms

Humans ; Female ; Breast Neoplasms/pathology* ; Retrospective Studies ; Prognosis ; Stomach Neoplasms/pathology* ; China/epidemiology*

The materials used in this study consist 744 gastric resections removed subtotally at the Yonsei University College of Medicine and Severance Hospital during the last 11 years from Jan. 1. 1959 to Dec. 31, 1969. Among these, 446 cases of gastric carcinoma were diagnosed at the Department of Pathology Yonsei University College of Medicine for this same duration. Histopathological studies as well as clinical study on all cases were performed. Summary: 1. Among 744 gastric resections examined during the last 11 years, gastric carcinoma was found in 446 cases, giving an incidence of 59.95% for subtotally removed stomachs. 2. Male to female ratio was 2.28 to 1. The peak age incidence is between 50 and 59 years and accounted for 172cases(35.77%). 3. There is no relation between blood group and incidence of gastric carcinoma. 4. Clinical symptoms in order of frequency were as follows: epigastric discomfort and pain(86%), indigestion(66.67%), weight loss(35.67%), nausea and vomiting(35.33%) and palpable epigastric mass(23.33%). The duration of the chief complaints was usually within six months(54.66%). 5. The gastric acidity disclosed that achlorhydria was found in 36.21%, hypochlorhydria in 32.26% and hyperchlorhydria in 2.15%. 6. The location of the tumor was as follows: 44.86% at the pyloric canal, and 26.53% at the antrum. The size of the tumor varied in diameter. The most frequent size was 3-5cm (43.43%) and 6-10cm(42.90%). 7. On the macroscopical examination, the classification based on Borrmann's gross types and their incidences were as follows: Type I(3.71%), type II(11.22%), type III(62.18%), and type IV(23.64%). 8. On the histological classification, 70% of the cases were adenocarcinomas. Serosal involvement was found in most cases(86.89%). 9. Metastasis to the regional lymphnodes was found in 68.84%, and direct extension of the omentum was 21.39%. 10. According to the relationship between regional lymphnode metastases and lymphatic permeation, and relationship between lymphatic permeation and histologic type, the degree of lymphatic permeation is more, the more metastases to regional lymphnode is found. And metastasis to regional lymphnode and lymphatic permeation is more common in adenocarcinoma than other types. 11. There is no relationship between intestinal metaplasia and histologic type. But each histologic type was accompanied by intestinal metaplasia frequently. In conclusion based on the above findings, it can be stated that gastric carcinoma among Koreans exhibited a far advanced stage, both clinically and morphologically.
Adenocarcinoma/pathology* ; Adenocarcinoma, Mucinous/pathology* ; Adult ; Aged ; Carcinoma/pathology* ; Female ; Human ; Korea ; Male ; Metaplasia/epidemiology ; Middle Age ; Neoplasm Metastasis ; Sex Factors ; Statistics ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/pathology*

Although there is a controversy, several reports have shown that gastric cardia cancer has tended upwards in recent years. The aim of this study was to investigate the changing trend of stomach cancer according to the location of cancer and histologic type in Korea, where is known to be one of the most prevalent areas for gastric cancer. All the patients newly diagnosed as gastric cancer from 1991 through 2000 were recruited in Hallym University Medical Center. The periods were divided into the first (1991 through 1995) and the second (1996 through 2000) period. We analyzed the characteristics of cancer in the aspects of age, sex, tumor locations (cardia and non-cardia), and tumor grade of differentiation (well, moderate, and poor differentiated type). The number of cases was 2,395 and that of cardia cancer was 158 (6.6%). There was no evidence about the changes in the incidence of cardia cancer and histologic differentiation between two periods. The development of cardia cancer was not associated with the factors of age and sex with having no difference in the point of tumor grade. We could not find an upward tendency of cardia cancer development in recent 10 yr in Korea.
Adenocarcinoma/epidemiology* ; Adenocarcinoma/pathology ; Cardia* ; Cell Differentiation ; Comparative Study ; Female ; Human ; Incidence ; Korea/epidemiology ; Male ; Morbidity/trends ; Retrospective Studies ; Stomach Neoplasms/epidemiology* ; Stomach Neoplasms/pathology

OBJECTIVEEndoscopy was used to study the high incidence area of cancer of gastric cardia.

METHODS417 patients with early cardiac cancer and 451 patients with advanced lesions were analyzed to the high incidence point of cardiac cancer. Verifying endoscopic screening of 205 subjects was performed later in the high incidence area of esophageal cancer.

RESULTS327 of 417 (78.4%) of early cardiac cancer patients and 336 of 451 (74.5%) of advanced lesions were proved to have developed their origin at the root of the mucosal fold in the gastric cardia. Eleven cardiac cancer patients were found by the verifying endoscopic screening, among whom 9 patients (81.8%) developed the primary focus at the root of mucosal fold in the cardia.

CONCLUSIONThe root of mucosal fold in the gastric cardia is proved to be the high incidence point of cancer of gastric cardia, which is very important clinically.

China ; epidemiology ; Gastroscopy ; methods ; Humans ; Incidence ; Stomach Neoplasms ; classification ; diagnosis ; epidemiology ; pathology

A total of 556 cases of stomachs resected for gastric carcinoma were classified according to Laur n's method (1965), and were studied for epidemiological evaluation, relation to chronic gastritis, especially that with intestinal metaplasia, and prognostic difference, with the following results: 1) When classified by Laur n's method, 52.2% (290/556) of gastric carcinomas among Koreans belonged to intestinal type, 40.6% (226/556) to diffuse and 7.2% (40/556) to the other type of carcinoma. 2) In males the incidence of diffuse carcinoma was less frequent than that of intestinal type carcinoma, but in the female it was as frequent as the latter. 3) The higher incidence of stomach carcinoma in the male among Koreans may be attributed to the frequent occurrence of not only intestinal type but also diffuse carcinoma. 4) The mean age of patients with intestinal type carcinoma was older than that of diffuse by approximately 7 years. 5) The lower mean age of gastric carcinoma among Koreans is attributable to the lower age distribution of intestinal type as well as of diffuse carcinoma. 6) The occurrence of large tumor size, short symptom duration, ulcero-infiltrative gowth, regional node metastasis and regional nodes showing lymphocyte depletion and unstimulated were more frequent in diffuse carcinoma, indirectly supporting the view that patients with intestinal type carcinoma are more likely to survive for longer periods than patients with diffuse carcinoma. 7) Intestinal metaplasia of the nearby stomach mucosa showed a significantly higher percentage in intestinal type than diffuse carcinoma, further supporting the suggestion that intestinal type carcinoma is pathogenetically related to intestinal metaplasia of stomach mucosa.
Adolescent ; Adult ; Aged ; Carcinoma/epidemiology* ; Carcinoma/pathology ; Child ; Female ; Gastric Mucosa/pathology* ; Human ; Korea ; Male ; Metaplasia ; Middle Age ; Stomach Neoplasms/epidemiology* ; Stomach Neoplasms/pathology

OBJECTIVETo study the rule of development of early cancer of gastric cardia in vivo in public screening.

METHODSA prospective cohort study on gastric cardiac cancer was held in the high incidence area of cancer of esophagus and stomach in China. 106 subjects had been examined regularly by endoscopy to observe the change of mucosa in high incidence area of gastric cardiac carcinoma developing at the root of gastric cardiac ridge by taking serial biopsy specimens. All specimens were diagnosed through the normal pathological processes to study the prognosis of pre-cancerous lesion of gastric cardia.

RESULTSThe result of 106 subjects who had been observed for four years were: 1. Of 8 normal persons, 3 stayed normal, 4 turned to chronic gastritis, 1 developed early gastric cardiac cancer. 2. Of 61 persons chronic gastritis, 11 was observed to have glandular atrophy, 4 with mild atypical hyperplasia, and 2 with highly atypical hyperplasia. 3. Of 9 subjects showing atrophic chronic gastritis, 5 revealed no change, and 4 became chronic gastritis. 4. Of 22 subjects who revealed mild atypical hyperplasia, 17 resolved, 4 showed no change, and 1 advanced to highly atypical hyperplasia. 5. One person with highly atypical hyperplasia reverted to mild atypical hyperplasia. 6. Of 5 subjects with early gastric cardiac cancer without any treatment, 1 became advanced cancer, 1 still stayed in early stage, and 3 turned to atypical hyperplasia.

CONCLUSION1. The development of early cancer of gastric cardia would proceed through the stages of chronic gastritis, glandular atrophy, and atypical hyperplasia. 2. The early cancer and pre-cancerous lesion of gastric cardia is reversible, though possessing malignant possibility.

Adult ; Aged ; Cardia ; pathology ; China ; Disease Progression ; Female ; Gastritis ; epidemiology ; pathology ; Gastritis, Atrophic ; epidemiology ; pathology ; Gastroscopy ; methods ; Humans ; Hyperplasia ; Male ; Middle Aged ; Precancerous Conditions ; epidemiology ; pathology ; Prospective Studies ; Stomach ; pathology ; Stomach Neoplasms ; epidemiology ; pathology