1.Aberrant Expression and Glycosylation of Mucins in Gastric Mucosal Disease.
Acta Academiae Medicinae Sinicae 2022;44(2):294-298
Mucins,a family of heavily glycosylated proteins,present mainly in epithelial cells.They function as essential barriers for epithelium and play important roles in cellular physiological processes.Aberrant expression and glycosylation of mucins in gastric epithelium occur at pathological conditions,such as Helicobacter pylori infection,chronic atrophic gastritis,intestinal metastasis,dysplasia,and gastric cancer.This review addresses the major roles played by mucins and associated O-glycan structures in normal gastric epithelium.Further,we expound the alterations of expression patterns and glycan signatures of mucins at those pathological conditions.
Gastric Mucosa/pathology*
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Glycosylation
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Helicobacter Infections/pathology*
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Helicobacter pylori/metabolism*
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Humans
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Mucins/metabolism*
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Stomach Neoplasms/pathology*
3.Expression of annexin I in different histological types of carcinomas.
Li-Yan XUE ; Liang-Hong TENG ; Shuang-Mei ZOU ; Li-Qun REN ; Shan ZHENG ; Wei LUO ; Rui BI ; Ning LÜ
Chinese Journal of Oncology 2007;29(6):444-448
OBJECTIVETo investigate the expression of annexin I in esophageal squamous cell carcinoma (SCC) and carcinomas of other histological types in order to analyze the correlation between the expression of annexin I and carcinogenesis.
METHODSFirst, a set of tissue microarray was established, which consisted of SCC from the esophagus (208 cases), lung, larynx, cervix, and external genital organs; adenocarcinomas from the lung, stomach, colon and rectum, liver, pancreas, breast, thyroid and kidney with 30 cases in each group, meanwhile, the corresponding normal tissue was also obtained for control. Immunohistochemistry was used to detect the expression of annexin I in different types of carcinomas and the corresponding normal controls from different organs. The correlation between the expression of annexin I and the clinicopathological feature was analyzed and compared, which included age, gender, differentiation grade and lymph node metastasis.
RESULTSIt was found that the expression of annexin I was decreased in esophageal SCC, when compared with normal esophageal squamous epithelia (P < 0.001), the similarity was also found in SCC of the lung, larynx and cervix. However, though negative in normal epidermis, annexin I expression was detected in some cases with SCC from external genital organs. Annexin I was found to be overexpressed in adenocarcinomas of the lung, stomach, colon and rectum, liver, pancreas, breast, thyroid and kidney, particularly very strong expression of annexin I was seen in lung adenocarcinoma, uterine endometrioid adenocarcinoma and ovarian serous adenocarcinoma. Interestingly, it was found to be positive in all thyroid papillary carcinomas, but negative in all normal thyroid glands. However, annexin I expression was found to be negative in all hepatocellular carcinoma and normal hepatocytes; and it was only detected in myoepithelium of normal breast tissue, but not in ductal luminal cells, and rarely in infiltrating ductal adenocarcinoma. In SCC, annexin I expression was stronger in well differentiated ones than that in the poorly differentiated ones. However, contrasting with SCC, in the adenocarcinomas from different organs, annexin I expression was much stronger in poorly differentiated ones than that in the well differentiate ones, especially in the adenocarcinomas from stomach, colon and rectum, pancreas, ovarian and kidney.
CONCLUSIONAnnexin I expression is quite different among different types of carcinomas, and is correlated with histopathological type and differentiation grade. Further study is needed to investigate its role in the carcinogenesis.
Adenocarcinoma ; metabolism ; pathology ; Annexin A1 ; metabolism ; Carcinoma, Endometrioid ; metabolism ; pathology ; Carcinoma, Squamous Cell ; metabolism ; pathology ; Cell Differentiation ; Endometrial Neoplasms ; metabolism ; pathology ; Epithelium ; metabolism ; Esophageal Neoplasms ; metabolism ; pathology ; Esophagus ; metabolism ; Female ; Humans ; Immunohistochemistry ; Lung Neoplasms ; metabolism ; pathology ; Stomach Neoplasms ; metabolism ; pathology
4.Myoglandular hamartoma of stomach: report of a case.
Jing ZHANG ; Zhao-hui LU ; Tong-hua LIU
Chinese Journal of Pathology 2011;40(12):843-844
Actins
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metabolism
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Adenocarcinoma
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pathology
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Adult
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Diagnosis, Differential
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Endometriosis
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pathology
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Epithelium
;
pathology
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Female
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Gastrointestinal Stromal Tumors
;
pathology
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Hamartoma
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metabolism
;
pathology
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Humans
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Muscle, Smooth
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pathology
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Stomach Diseases
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metabolism
;
pathology
5.Gastric carcinoma with osteoclast-like giant cells: a case report and review of the literature.
Li-duan ZHENG ; Xiu-ping YANG ; Hua-xiong PAN ; Xiu NIE ; Jun HE ; Qing LV ; Qiang-song TONG
Journal of Zhejiang University. Science. B 2009;10(3):237-241
Gastric carcinoma with osteoclast-like giant cells (OGCs) is an extremely rare tumor. So far, only six cases have been reported in the literature. Here we report an additional case of this tumor in a Chinese 78-year-old man presented with abdominal pain, vomiting, and hematemesis. Physical examination and gastroscopy revealed a tumor in the gastric antrum. The biopsy and pathological findings indicated a gastric adenocarcinoma with OGCs, which were present in both the tumor and the metastatic lymph nodes. Further immunohistochemical staining indicated that OGCs were reactive with CD68, CD45, and vimentin protein, but not with pancytokeratin, carcinoembryonic antigen, or epithelial membrane antigen, suggesting the monocytic/histiocytic derivation of these OGCs. In situ hybridization for Epstein-Barr virus showed no nuclear positivity in either adenocarcinoma or OGCs. Postoperative follow-up showed that the patient had survived for at least 6 months without recurrence. Further investigation is warranted to clearly define the prognostic significance of OGCs in gastric carcinoma.
Aged
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Giant Cells
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metabolism
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pathology
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Humans
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Immunohistochemistry
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In Situ Hybridization
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Male
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Osteoclasts
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metabolism
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pathology
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Stomach Neoplasms
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genetics
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metabolism
;
pathology
6.Prognostic and clinical value of Sirt1 expression in gastric cancer: A systematic meta-analysis.
Bin JIANG ; Jin-huang CHEN ; Wen-zheng YUAN ; Jin-tong JI ; Zheng-yi LIU ; Liang WU ; Qiang TANG ; Xiao-gang SHU
Journal of Huazhong University of Science and Technology (Medical Sciences) 2016;36(2):278-284
Many studies have reported that the expression of silent information regulator 1 (Sirt1) is associated with the clinical features and prognosis of patients with gastric cancer, but the exact function remains controversial. We conducted this study to illustrate the clinical and prognostic value of Sirt1 in gastric cancer. The related publications before December 2015 were searched in the databases including Pubmed, Cochrane Library, Embase and China National Knowledge Infrastructure (CNKI). The studies were included and excluded according to the inclusion criteria and exclusion criteria. The 3- and 5-year overall survival (OS) and clinical features such as age, T stage, N stage and differentiation were analyzed by software RevMan 5.3. A total of 1650 patients in 7 studies were included according to the inclusion criteria and exclusion criteria. The high expression of Sirt1 was found in 58.4% cases by immunohistochemistry. High expression of Sirt1 was closely linked with the 3-year OS (OR=0.25, 95% CI: 0.16-0.39, P<0.00001, fixed), patient's age (≥60 years old vs. <60 years old; OR=1.43, 95% CI: 1.06-1.93, P=0.02, fixed), T stage (T3+T4 vs. T1+T2; OR=1.45, 95% CI: 1.08-1.94, P=0.01, fixed), N stage (N1+N2+N3 vs. N0; OR=3.47, 95% CI: 2.39-5.05, P<0.00001, fixed) and tumor differentiation (G1+G2 vs. G3; OR=0.50, 95% CI: 0.35-0.69, P<0.0001, fixed). Nevertheless, it seemed that high expression of Sirt1 was not associated with 5-year OS (OR=0.44, 95% CI: 0.15-1.28, P=0.13, random). It was suggested that the high expression of Sirt1 implies a poor prognosis of gastric cancer patients in a relatively short period (3 years), but not in a long time (≥5 years). The expression of Sirt1 is also linked with patients' age, T stage, N stage and tumor differentiation.
Biomarkers, Tumor
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genetics
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metabolism
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Carcinoma
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metabolism
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pathology
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Humans
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Middle Aged
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Sirtuin 1
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genetics
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metabolism
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Stomach Neoplasms
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metabolism
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pathology
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Survival Analysis
7.Clinicopathological features of the primary gastric neuroendocrine neoplasms.
Chinese Journal of Oncology 2014;36(7):522-528
OBJECTIVEThe aim of this study was to investigate the clinicopathological features of different histological types of primary gastric neuroendocrine neoplasms (including the esophagogastric junction), and to analyze the characteristics and difficulties in diagnosis of all the subtypes of this disease.
METHODS75 cases of primary gastric neuroendocrine neoplasms (including the esophagogastric junction) were included in this study. The expressions of several markers including somatostatin, synaptophysin, chromogranin A, CD56, S-100, neuron-specific enolase and CD57 were assayed in all the specimens by immunohistochemical staining, and their significance in the diagnosis and prognosis of gastric neuroendocrine neoplasms were assessed. In addition, the relationship between various clinical parameters such as tumor location, histological types, depth of invasion and metastasis was also analyzed.
RESULTSThe incidence of gastric neuroendocrine neoplasms accounted for 1.5% of gastric cancer in the same period, and the proportion of each subtype was 53.3% (40/75) in G3, 29.3% (22/75) in MANEC, 16.0% in G1(12/75), and 1.3% (1/75) in G2, respectively. 41.7% (5/12) of the G1 showed multifocal lesions, accompanyied with neuroendocrine cell hyperplasia in the gastric mucosa. 54.67% (41/75) of the NEN located in the esophagogastric junction. The lymph node metastasis of MANEC is unique. The coincidence rate in diagnosis of preoperative biopsies and postoperative specimen was 75.0% (9/12) in G1, 72.7% (16/22) in MANEC, and 25.0% (10/40) in G3, respectively.
CONCLUSIONSGastric neuroendocrine neoplasms occur mainly in the esophagogastric junction, and most of them were highly malignant. The coincidence rate of preoperative and postoperative pathological diagnosis for primary gastric neuroendocrine neoplasms is low. Therefore, it should be very cautious when diagnosis of this disease is made in a preoperative biopsy.
Chromogranin A ; metabolism ; Esophagogastric Junction ; metabolism ; Gastric Mucosa ; metabolism ; pathology ; Humans ; Lymphatic Metastasis ; pathology ; Neuroendocrine Tumors ; pathology ; Phosphopyruvate Hydratase ; metabolism ; Prognosis ; Stomach Neoplasms ; pathology ; Synaptophysin ; metabolism
8.Primary liposarcoma of stomach: report of a case.
Dao-hua YANG ; Guo-xia LI ; Ming-chang SHEN
Chinese Journal of Pathology 2012;41(3):202-203
Aged
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Diagnosis, Differential
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Gastrectomy
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methods
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Gastrointestinal Stromal Tumors
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metabolism
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pathology
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Humans
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Lipoma
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pathology
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Liposarcoma
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metabolism
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pathology
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surgery
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Male
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S100 Proteins
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metabolism
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Stomach Neoplasms
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metabolism
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pathology
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surgery
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Vimentin
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metabolism
9.Phosphatase of regenerating liver-3 (PRL-3) and tumor metastasis.
Li-rong PENG ; Cheng-chao SHOU
Chinese Journal of Oncology 2007;29(1):1-3
Animals
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Colonic Neoplasms
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metabolism
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pathology
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Female
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Humans
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Liver Neoplasms
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metabolism
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secondary
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Lymphatic Metastasis
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Neoplasm Proteins
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metabolism
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Ovarian Neoplasms
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metabolism
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pathology
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Protein Tyrosine Phosphatases
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metabolism
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Stomach Neoplasms
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metabolism
;
pathology
10.Plexiform fibromyxoma of stomach: a distinctive benign tumor of gastric antrum.
Feng-hua WANG ; Zheng-rong CHEN ; Hui-lin NIU ; Rong-xin ZENG ; Jian-qing XIA
Chinese Journal of Pathology 2012;41(3):190-191
Actins
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immunology
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metabolism
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Antibodies, Monoclonal
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metabolism
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Child
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Diagnosis, Differential
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Fibroma
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metabolism
;
pathology
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surgery
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Follow-Up Studies
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Gastrointestinal Neoplasms
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metabolism
;
pathology
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Gastrointestinal Stromal Tumors
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metabolism
;
pathology
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Humans
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Leiomyoma
;
metabolism
;
pathology
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Male
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Pyloric Antrum
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pathology
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Stomach Neoplasms
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metabolism
;
pathology
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surgery
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Vimentin
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metabolism