1.Toxic epidermal necrosis in a child.
Xiao Ou LAN ; Tian SUN ; Heng Fang XIANG ; Qiang WANG ; Xiao Dong SUN ; Xian Wei HAN
Chinese Journal of Pediatrics 2022;60(9):951-952
2.Toxic epidermal necrolysis after percutaneous coronary intervention: which drug is the culprit?
Chinese Medical Journal 2011;124(3):467-468
Toxic epidermal necrolysis (TEN) is a serious, usually drug-induced, dermatosis characterized by extensive erythema, necrosis, bullous detachment of the epidermis, constitutional symptoms, and visceral involvement. We report a 62-year-old man who was diagnosed TEN after percutaneous coronary intervention (PCI). After consulting with a cardiologist, all pre-hospital medication was discontinued except clopidogrel. With supportive care, the patient recovered.
Angioplasty, Balloon, Coronary
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Humans
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Male
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Middle Aged
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Stevens-Johnson Syndrome
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etiology
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Ticlopidine
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analogs & derivatives
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therapeutic use
3.Ibuprofen Associated Acute Vanishing Bile Duct Syndrome and Toxic Epidermal Necrolysis in an Infant.
Hye Young KIM ; Hea Kyoung YANG ; Seong Heon KIM ; Jae Hong PARK
Yonsei Medical Journal 2014;55(3):834-837
Acute vanishing bile duct syndrome, a rare but rapidly progressive destruction of the intrahepatic bile ducts with unknown pathogenesis, is most often a drug- or toxin-related. Toxic epidermal necrolysis is a serious dermatologic condition and a potentially life threatening disease, which is drug or infection induced. Ibuprofen associated acute vanishing bile duct syndrome and toxic epidermal necrolysis have not been reported previously in infants. We report a 7-month-old infant with ibuprofen associated toxic epidermal necrolysis, followed by severe and rapidly progressive vanishing bile duct syndrome. She recovered totally with supportive care.
Female
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Humans
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Ibuprofen/*adverse effects
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Infant
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Stevens-Johnson Syndrome/*diagnosis/*etiology
4.Stevens-Johnson syndrome/toxic epidermal necrolysis successfully treated with Chinese herbal medicine Pi-Yan-Ning: A case report.
Shu-Yi CHEN ; Qun-Wei CHEN ; Liu-Mei SHOU ; Hong PAN ; Shan-Ming RUAN ; Zhe-Hao LIANG ; Qi-Jin SHU
Journal of Integrative Medicine 2021;19(6):555-560
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare adverse cutaneous reaction with a low incidence and high mortality. Despite posing a serious threat to patients' health and lives, there is no high-quality evidence for a standard treatment regimen. Here we report the case of a 62-year-old man with stage IV pancreatic cancer who experienced immunotherapy-induced SJS/TEN. After consensus-based regular treatments at a local hospital, his symptoms became worse. Thus, he consented to receive Chinese herbal medicine (CHM) therapy. The affected parts of the patient were treated with the CHM Pi-Yan-Ning which was applied externally for 20 min twice a day. After 7 days of treatment, the dead skin began peeling away from the former lesions that had covered his hands, feet, and lips, indicating that skin had regenerated. After 12 days of treatment, the patient's skin was completely recovered. In this case, SJS/TEN was successfully treated with Pi-Yan-Ning, suggesting that there might be tremendous potential for the use of Pi-Yan-Ning in the treatment of severe skin reactions to drug treatments. Further basic investigations and clinical trials to explore the mechanism and efficacy are needed.
Drugs, Chinese Herbal/therapeutic use*
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Humans
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Immunologic Factors
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Incidence
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Male
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Middle Aged
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Skin
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Stevens-Johnson Syndrome/etiology*
5.Stevens-Johnson Syndrome and Hypothermia Associated with Anti-tuberculosis Medication in a Patient with Heart Failure.
Sang-Ok JUNG ; Min-Ji CHO ; Dong-Il PARK ; Sun-Young KIM ; Ju-Ock KIM ; Sung-Soo JUNG ; Hee-Sun PARK ; Jeong-Eun LEE ; Jae-Young MOON ; Chae-Uk CHUNG
Chinese Medical Journal 2015;128(20):2837-2838
7.Clinical feature of four cases with bronchiolitis obliterans.
Xiu-yun LIU ; Zai-fang JIANG ; Kun-ling SHEN ; Jin-jin ZENG ; Sai-ying XU
Chinese Journal of Pediatrics 2003;41(11):839-841
OBJECTIVETo recognize the clinical features of the bronchiolitis obliterans.
METHODClinical manifestation, chest X-ray, computed tomography (CT) and pulmonary function of 4 cases with bronchiolitis obliterans were retrospectively analyzed.
RESULTTwo cases were after Stevens-Johnson syndrome (SJS), the other 2 were after severe pneumonia, including one suffered from adenovirus pneumonia. Cough, tachypnea and wheezing persisted in all the 4 patients. The symptoms lasted for at least 6 weeks, in one case for over one year. Crackles and wheezing were present in all the 4 cases. Hyperinflation was seen in chest radiographs in all cases. On pulmonary CT/high-resolution CT (HRCT), patchy opacity and bronchial wall thickening were seen in each patient. Areas of air trapping were seen in three cases. Bronchiectasis was seen in 2 cases, atelectasis and mosaic perfusion were seen respectively in one case. PO(2) was low in all the four cases. Wheezing was not responsive to beta(2) agonist and other bronchodilating therapy. Prednisone was used at a dose of 1 mg/(kg.d) in 3 cases. Two cases were followed up for 3 months. The clinical condition of one case was improved, whose wheezing and bronchiolar constriction disappeared, cough and dyspnea were also relieved. However, the condition of one patient was not improved, although the wheezing disappeared. The HRCT of these two cases showed no improvement.
CONCLUSIONClinical symptoms of BO were cough, tachypnea, and wheezing after acute lung injury. Crackles and wheezing were the most common signs in the BO. Chest radiographs showed hyperinflation. Pulmonary CT showed bronchial wall thickening, bronchiectasis, atelectasis, and mosaic perfusion. Pulmonary function tests suggested obstruction of small airway.
Bronchiolitis Obliterans ; etiology ; pathology ; physiopathology ; Child ; Child, Preschool ; Humans ; Infant ; Male ; Pneumonia ; complications ; Pneumonia, Viral ; complications ; Prognosis ; Respiratory Function Tests ; Stevens-Johnson Syndrome ; complications ; Tomography, X-Ray Computed
8.Liver dysfunction induced by systemic hypersensitivity reaction to lamotrigine: case report.
Sung Gyu IM ; Sun Hong YOO ; Young Min PARK ; Sang Jin LEE ; Sun Kyung JANG ; Dong Ok JEON ; Hyo Jin CHO ; Mi Jung OH
Clinical and Molecular Hepatology 2015;21(2):180-182
Lamotrigine is an anticonvulsant drug used to treat partial and generalized seizure disorders. Hypersensitivity to lamotrigine usually causes mild symptoms such as fever, rash, and slight invasion of internal organs. However, a 33-year-old male patient who was admitted with Stevens-Johnson syndrome after taking lamotrigine for 15 days experienced hepatic failure and died 5 days after admission. This case demonstrates the importance of realizing that lamotrigine can lead to fatal hepatic failure, and that tests for the normal liver function should be performed when administering lamotrigine.
Adult
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Alanine Transaminase/blood
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Anticonvulsants/*adverse effects/therapeutic use
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Aspartate Aminotransferases/blood
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Drug Hypersensitivity/complications/*diagnosis
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Humans
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Liver/enzymology/metabolism
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Liver Failure/*etiology
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Male
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Stevens-Johnson Syndrome/diagnosis/drug therapy
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Triazines/*adverse effects/therapeutic use
9.The Effect of In Vivo Grown Corneal Epithelium Transplantation on Persistent Epithelial Defects with Limbal Stem Cell Deficiency.
Jee Taek KIM ; Yeoun Sook CHUN ; Kye Young SONG ; Jae Chan KIM
Journal of Korean Medical Science 2008;23(3):502-508
We report our experience with corneal epithelium, grown in vivo, transplantation in three patients with persistent epithelial defect (PED). The three patients had ocular surface disease unresponsive to standard treatments and were therefore chosen for transplantation. They underwent transplantation of epithelial sheets, grown in vivo, to the most affected eye. In vivo cultivation was carried out in the cornea of a living related donor. After epithelialization was completed, the epithelium grown on an amniotic membrane was harvested gently; it was then transplanted into the patient's eye after debridement of fibrovascular tissue. The cultivated epithelium was completely epithelialized by 2 weeks; it was well-differentiated with well-formed hemidesmosome. On immunohistochemical staining, p63, connexin 43, and Integrin beta4 were expressed in the cells on the epithelial sheet. The PED was covered completely and maintained for 4 weeks in all cases. However, corneal erosion recurred after 5 weeks in two cases. This novel technique demonstrates the corneal epithelial cells can be expanded in vivo successfully on denuded amniotic membrane of a healthy cornea and harvested safely. A corneal epithelial sheet, grown in vivo, can be transplanted to treat eye with a severe ocular surface disease, such as total limbal deficiency.
Adult
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Cell Culture Techniques
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Cells, Cultured
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Corneal Diseases/etiology/pathology/*surgery
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Corneal Transplantation/*methods
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Epithelial Cells/cytology/*transplantation
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Epithelium, Corneal/cytology/*transplantation
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Eye Burns/complications
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Humans
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Limbus Corneae/*pathology
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Male
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Middle Aged
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Stem Cells/*pathology
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Stevens-Johnson Syndrome/complications
10.Bronchiolitis Obliterans Associated with Stevens-Johnson Syndrome: A Case Report.
Hyungchul PARK ; Young Bo KO ; Hyouk Soo KWON ; Chae Man LIM
Yonsei Medical Journal 2015;56(2):578-581
We report a case of bronchiolitis obliterans associated with Stevens-Johnson syndrome. A 59-year-old man presented with respiratory distress that gradually worsened over 3 months. He had been diagnosed with Stevens-Johnson syndrome 3 months before admission. He had no history of previous airway disease. On physical examination, expiratory breathing sounds were not audible, and a chest X-ray revealed a hyperinflated lung. A pulmonary function test indicated a severe obstructive pattern. Computed tomography scans of inspiratory and expiratory phases of respiration showed oligemia and air trapping, and both were more prominent on expiration view than on inspiration view. The pathogenesis of bronchiolitis obliterans associated with Stevens-Johnson syndrome is largely unknown.
Anti-Bacterial Agents/therapeutic use
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Bronchiolitis Obliterans/etiology/*radiography/therapy
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Bronchoscopy
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Dyspnea/*complications
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Fatal Outcome
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Humans
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Male
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Middle Aged
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Radiography, Thoracic
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Respiratory Distress Syndrome, Adult/*etiology/therapy
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Respiratory Function Tests
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Roxithromycin/therapeutic use
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Stevens-Johnson Syndrome/*complications/drug therapy
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Tomography, X-Ray Computed/methods
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Tracheostomy