1.Macrophage-derived small extracellular vesicles promote biomimetic mineralized collagen-mediated endogenous bone regeneration.
Anqi LIU ; Shanshan JIN ; Cuicui FU ; Shengji CUI ; Ting ZHANG ; Lisha ZHU ; Yu WANG ; Steve G F SHEN ; Nan JIANG ; Yan LIU
International Journal of Oral Science 2020;12(1):33-33
Macrophages play an important role in material-related immune responses and bone formation, but the functionality of macrophage-derived extracellular vesicles (EVs) in material-mediated bone regeneration is still unclear. Here, we evaluated intracellular communication through small extracellular vesicles (sEVs) and its effects on endogenous bone regeneration mediated by biomimetic intrafibrillarly mineralized collagen (IMC). After implantation in the bone defect area, IMC generated more neobone and recruited more mesenchymal stem cells (MSCs) than did extrafibrillarly mineralized collagen (EMC). More CD63
Biomimetics
;
Bone Regeneration
;
Cell Differentiation
;
Collagen
;
Extracellular Vesicles
;
Macrophages
;
Osteogenesis
Result Analysis
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