No abstract available.
Humans ; Stenotrophomonas maltophilia*

From 1999 to 2002, 62 isolates of Stenotrophomonas maltophi were microbio-logically examined in laboratory of Cho Ray hospital. They were found to be internally 100% resistant to imipenem. 70% of isolates were sensitive to trimethoprim/sulfamethoxazole, around 50% sensitive to piperacillin/tazobactam, ciprofloxacin and ceftazidime. Some clues for identifying these bacteria at present are also mentioned
Stenotrophomonas maltophilia ; Infection ; microbiology

Stenotrophomonas maltophilia (S. maltophilia) is a rare, but globally emerging gram-negative multiple-drug-resistant organism usually found in a nosocomial setting in immunocompromised patients. To our best knowledge, computed tomography (CT) features of community-acquired S. maltophilia pneumonia have not been previously reported in an immunocompetent patient. Herein, we presented the CT findings of a previous healthy 56-year-old male with S. maltophilia pneumonia.
Humans ; Immunocompromised Host ; Male ; Middle Aged ; Pneumonia* ; Stenotrophomonas maltophilia* ; Stenotrophomonas*

No abstract available.
Bacterial Proteins/*metabolism ; Humans ; Stenotrophomonas maltophilia/*genetics

Stenotrophomonas maltophilia is a ubiquitous, Gram-negative organism. It is an emerging causative pathogen for severe hospital- acquired infections, particularly in debilitated or immunocompromised patients because of its resistance to various antibiotics. Soft tissue infection caused by S. maltophilia, however, is uncommon. A patient with leukemia was referred for the evaluation of subcutaneous nodules that developed after chemotherapy. With the pathological finding of neutrophilic panniculitis, S. maltophilia was confirmed in a bacteriological study of the biopsied tissue. The nodules regressed spontaneously with recovery from the neutropenia. We report a case of S. maltophilia infection that manifested as soft tissue nodules, which resolved spontaneously in a patient with leukemia.
Anti-Bacterial Agents ; Humans ; Immunocompromised Host ; Leukemia ; Neutropenia ; Neutrophils ; Panniculitis ; Soft Tissue Infections ; Stenotrophomonas ; Stenotrophomonas maltophilia

Stenotrophomonas maltophilia is a motile, non-fermentative, gram-negative rod. It is one of the important nosocomial pathogens associated with substantial morbidity and mortality such as pneumonia and bacteremia in immunocompromised patients. It should be carefully examined in the course of identification because it is frequently isolated together with other non-fermentative, gram-negative rods from clinical specimens. We report an isolate of S. maltophilia showing an oxidase-positive reaction, which is very rare for the species.
Bacteremia ; Humans ; Immunocompromised Host ; Indophenol ; Pneumonia ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Stenotrophomonas ; Stenotrophomonas maltophilia

Stenotrophomonas maltophilia keratitis is rare and none of it has been reported to be combined with Aspergillus keratitis.I have experienced a corneal ulcer caused by combined infection of S.maltophilia and A. fumigatus.S. maltophilia was grown on culture and a brownish pigmented anterior chamber mass containing filamentous fungi was attached to corneal ulcer area endothelium without the usual filamentous fungal keratitis findings such as feathery edge, satellite lesions, endothelial plaques, etc. A spergillusfumigatus was grown on culture of abscess which developed along the superior incision for removal of anterior chamber mass.
Abscess ; Anterior Chamber ; Aspergillus fumigatus* ; Aspergillus* ; Corneal Ulcer* ; Endothelium ; Fungi ; Keratitis ; Stenotrophomonas maltophilia* ; Stenotrophomonas*

BACKGROUND: Stenotrophomonas maltophilia is one of several opportunistic pathogens of growing significance. Several studies on the molecular epidemiology of S. maltophilia have shown clinical isolates to be genetically diverse. MATERIALS AND METHODS: A total of 121 clinical isolates tentatively identified as S. malophilia from seven tertiary-care hospitals in Korea from 2007 to 2011 were included. Species and groups were identified using partial gyrB gene sequences and antimicrobial susceptibility testing was performed using a broth microdilution method. Multi locus variable number of tandem repeat analysis (MLVA) surveys are used for subtyping. RESULTS: Based on partial gyrB gene sequences, 118 isolates were identified as belonging to the S. maltophilia complex. For all S. maltophilia isolates, the resistance rates to trimethoprime-sulfamethoxazole (TMP/SMX) and levofloxacin were the highest (both, 30.5%). Resistance rate to ceftazidime was 28.0%. 11.0% and 11.9% of 118 S. maltophilia isolates displayed resistance to piperacillin/tazobactam and tigecycline, respectively. Clade 1 and Clade 2 were definitely distinguished from the data of MLVA with amplification of loci. All 118 isolates were classified into several clusters as its identification. CONCLUSION: Because of high resistance rates to TMP/SMX and levofloxacin, the clinical laboratory department should consider providing the data about other antimicrobial agents and treatment of S. maltophilia infections with a combination of antimicrobials can be considered in the current practice. The MLVA evaluated in this study provides a fast, portable, relatively low cost genotyping method that can be employed in genotypic linkage or transmission networks comparing to analysis of the gyrB gene.
Anti-Infective Agents ; Ceftazidime ; Korea ; Levofloxacin ; Methods ; Molecular Epidemiology ; Stenotrophomonas maltophilia* ; Stenotrophomonas* ; Tandem Repeat Sequences*

PURPOSE: To investigate the risk factor, clinical manifestations, treatment results, and prognoses in Stenotrophomonas maltophilia keratitis. METHODS: Ten eyes of 10 patients who were diagnosed with, Stenotrophomonas maltophilia by corneal smear and culture were included in this study. Each patient's past history, visual acuity, location and size of ulceration, hypopyon, treatment results and prognosis were analyzed retrospectively. RESULTS: Seven pateints (70.0%) were men, and 3 were women. The mean age was 62.9+/-11.3 years. Only 2 eyes (20.0%) had previous histories of corneal traumas. Polymicrobial infections, including 3 cases infected with Pseudomonas species and 2 cases infected with Fusarium species, were detected in 7 eyes (70.0%). The lesions were located at the corneal center in 6 eyes, and hypopyon was observed in 9 eyes. The average size of ulceration was 28.5+/-19.6 mm2. Seven eyes (70.0%) underwent surgical treatment. The initial visual acuity was less than 0.02 in 9 eyes (90.0%). The final visual acuity improved in 3 eyes (30.0%) and was less than hand movement in 7 eyes (70.0%). CONCLUSIONS: Stenotrophomonas maltophilia keratitis occurs in patients with a compromised ocular surface, is often polymicrobial, and is associated with poor prognoses.
Coinfection ; Female ; Fusarium ; Hand ; Humans ; Keratitis* ; Male ; Prognosis* ; Pseudomonas ; Retrospective Studies ; Risk Factors ; Stenotrophomonas maltophilia ; Stenotrophomonas* ; Ulcer ; Visual Acuity

Continuous ambulatory peritoneal dialysis (CAPD) peritonitis is a major complication of peritoneal dialysis (PD) and leads to the discontinuation of PD. Despite its limited pathogenicity, CAPD peritonitis caused by Stenotrophomonas maltophilia (S. maltophilia), an important nosocomial pathogen that is present in nature and is usually associated with plastic indwelling devices. Infection of S. maltophilia is associated with a poor prognosis, including inability to maintain the CAPD catheter, because of its resistance to multiple antibiotics. We report a case of CAPD peritonitis due to S. maltophilia that was treated successfully using oral Trimethoprim-sulfame-thoxazole and intraperitoneal Ticarcillin/clavulanate without removing the dialysis catheter.
Anti-Bacterial Agents ; Catheters ; Dialysis* ; Peritoneal Dialysis ; Peritoneal Dialysis, Continuous Ambulatory ; Peritonitis* ; Plastics ; Prognosis ; Stenotrophomonas maltophilia* ; Stenotrophomonas* ; Virulence