Staphylococcus lugdunensis is a coagulase-negative staphylococcus (CNS) that is commonly found on the human perineal skin. Contrary to other CNS, S. lugdunensis is a rare contaminant in cultures and has the potential to cause clinically significant infections, including infective endocarditis. Infective endocarditis due to S. lugdunensis have been known to resemble endocarditis due to S. aureus because of its aggressive clinical course and high mortality. We report a case of infective endocarditis caused by S. lugdunensis in a 21-year-old woman. She was cured of the infection with surgical and antibiotic therapy.
Endocarditis* ; Female ; Humans ; Mortality ; Skin ; Staphylococcus lugdunensis* ; Staphylococcus* ; Young Adult

Staphylococcus lugdunensis is a coagulase-negative staphylococcus (CNS) that is commonly found on the human perineal skin. Contrary to other CNS, S. lugdunensis is a rare contaminant in cultures and has the potential to cause clinically significant infections, including infective endocarditis. Infective endocarditis due to S. lugdunensis have been known to resemble endocarditis due to S. aureus because of its aggressive clinical course and high mortality. We report a case of infective endocarditis caused by S. lugdunensis in a 21-year-old woman. She was cured of the infection with surgical and antibiotic therapy.
Endocarditis* ; Female ; Humans ; Mortality ; Skin ; Staphylococcus lugdunensis* ; Staphylococcus* ; Young Adult

Botryomycosis is a chronic bacterial granulomatous and suppurative disease, which may be similar to the fungal disease, clinically and histologically. It is commonly caused by Staphylococcus aureus, but Pseudomonas aeruginosa, Escherichia coli, and Proteus spp. have been rarely involved. The known predisposing factors are trauma, postoperative complication, diabetes mellitus, chronic alcoholic, and so on. We present the botryomycosis caused by Staphylococcus lugdunensis, which is a rare virulent pathogen of botryomycosis, in a chronic alcoholic.
Alcoholics ; Diabetes Mellitus ; Escherichia coli ; Humans ; Postoperative Complications ; Proteus ; Pseudomonas aeruginosa ; Staphylococcus ; Staphylococcus aureus ; Staphylococcus lugdunensis

Staphylococcus lugdunensis (S. lugdunensis) is an unusually virulent coagulase-negative staphylococci (CNS) and uncommon cause of infective endocarditis (IE) involving mainly native left sided valves. S. lugdunensis IE, which was described previously as "surreptitious" and "wolf in sheep's clothing", runs an aggressive course with a high rate of severe in-hospital complications. Therefore, early surgical treatment has been considered for the treatment of S. lugdunensis IE. However, we experienced a case of S. lugdunensis pulmonary endarteritis which was cured with antibiotic therapy alone.
Ductus Arteriosus, Patent ; Endarteritis ; Endocarditis ; Humans ; Pulmonary Artery ; Staphylococcus ; Staphylococcus lugdunensis

Staphylococcus lugdunensis is a member of the coagulase negative staphylococci (CoNS) which has been associated with serious infections in humans. Species identification of S. lugdunensis isolates should be done but they may be misidentified as other CoNS species or Staphylococcus aureus due to positivity for clumping factor. We report the first two cases of catalase-positive and Gram positive cocci isolated from blood and venous catheter, which were positive for latex agglutination coagulase test but susceptible to penicillin, negative for tube coagulase test and negative acid production from mannitol and finally identified as S. lugdunensis.
Agglutination ; Catheters* ; Coagulase ; Gram-Positive Cocci ; Humans ; Latex ; Mannitol ; Penicillins ; Staphylococcus aureus ; Staphylococcus lugdunensis

Staphylococcus lugdunensis is part of the normal human skin flora and has the ability to establish primary infection in deep skin and vascular infections. A 41-year-old male presented with brittle, thick, crusted right thumb nail with yellow to brown discoloration and erythematous edema around the nail fold. We identified S. lugdunensis by bacterial culture for the pus. The lesion was improved after 2 months treatment of oral cefditoren and clarithromycin. We report a case of onychia and paronychia caused by S. lugdunensis.
Adult ; Cephalosporins ; Clarithromycin ; Edema ; Humans ; Male ; Nails ; Paronychia ; Skin ; Staphylococcus ; Staphylococcus lugdunensis ; Suppuration ; Thumb

A 37-year-old woman presented to our hospital with a 1-month history of fever. She also complained of lower leg pain. Transthoracic echocardiography showed large vegetations on the mitral valve leaflets. Staphylococcus lugdunensis was isolated from blood cultures. She was diagnosed with infectious endocarditis due to S. lugdunensis and was treated with antibiotics and surgery. Infective endocarditis caused by S. lugdunensis can be invasive and often resembles endocarditis due to Staphylococcus aureus. Thus, whenever this organism is found in patients with endocarditis, early surgical treatment of the infected valve should be considered.
Adult ; Anti-Bacterial Agents ; Echocardiography ; Endocarditis ; Female ; Fever ; Humans ; Leg ; Mitral Valve ; Staphylococcus ; Staphylococcus aureus ; Staphylococcus lugdunensis

Staphylococcus lugdunensis is a member of coagulase-negative staphylococci (CoNS), an uncommon microbial culture isolate with virulent potency. Although CoNS are common skin commensals, and often regarded as contaminants or colonizers when isolated from clinical specimen cultures, the clinical course and microbiological characteristics of Staphylococcus lugdunensis may resemble those of Staphylococcus aureus rather than other CoNS. Invasive infectious diseases such as infective endocarditis, peritonitis, skin and soft tissue infection, vascular prosthetic infection, septicemia, and osteomyelitis have been found to be associated with Staphylococcus lugdunensis. Here we report the first case of psoas abscess caused by methicillin-sensitive Staphylococcus lugdunensis in Korea.
Colon ; Communicable Diseases ; Endocarditis ; Korea ; Osteomyelitis ; Peritonitis ; Psoas Abscess* ; Sepsis ; Skin ; Soft Tissue Infections ; Staphylococcus aureus ; Staphylococcus lugdunensis* ; Staphylococcus*

To investigate the pathogenicity, genomic pattern, and o-like hemolysin of Staphylococcus lugdunensis (S. lugdunensis) in acute oral infection, S. lugdunensis was isolated from patients with an acute oral infection and from healthy persons. Antibiotic susceptibility, in vitro cellular toxicity, in vivo virulence, and hemolytic activity were tested, and plasmid DNA and restriction pattern of whole genomic DNA were analyzed to characterize the staphylococci. The dot blot and Southern blot hybridization analysis of staphylococcal DNA were performed with o-hemolysin gene probe. The isolation ratio of S. lugdunensis in the patients was higher than that in the healthy persons. S. lugdunensis from the patients with an acute oral infection showed resistance to penicillin, ampicillin, methicillin, cephalothin, and clindamycin. In the analysis of plasmid, there was a clear band about 6.5 kb in three strains of S. lugdunensis isolated from the patients with infection. S. lugdunensis in the patients had cellular toxicity in vitro and virulence in vivo. All strains of S. lugdunensis had o-like hemolysin activity against rabbit erythrocytes. Four of the six strains of S. lugdunensis gave synergistic hemolysis with Staphylococcus aureus (S. aureus) on sheep blood agar plates. In the analysis of genomic pattern, four strains of S. lugdunensis that gave synergistic hemolysis with S. aureus showed a similar genetic pattern with HindIII enzyme digests. In dot blot analysis, all strains of S. lugdunensis showed a positive reaction with the probe of 5-hemolysin gene in S. aureus. In Southern blot analysis, a 7.3 kb HindIII fragment was observed in DNA of S. lugdunensis that gave synergistic hemolysis with S. aureus, and a 2.5 kb band was observed in HindIII digests of S. aureus in the patients. These results suggest that S. lugdunensis may be an important pathogen in an acute oral infection and the 7.3 kb HindIII fragment from S. lugdunensis DNA may contain o-like hemolysin gene.
Agar ; Ampicillin ; Blotting, Southern ; Cephalothin ; Clindamycin ; DNA ; Erythrocytes ; Hemolysis ; Humans ; Methicillin ; Penicillins ; Plasmids ; Sheep ; Staphylococcus aureus ; Staphylococcus lugdunensis* ; Staphylococcus* ; Virulence

Staphylococcus lugdunensis is one of coagulase-negative staphylococci, but rarely causes aggressive and progressive infections similar to Staphylococcus aureus infection. Moreover, agglutination test for clumping factor can be positive, and the colony morphology often resembles that of S. aureus, but S. lugdunensis is usually sensitive to all antimicrobials used against staphylococci. We report a case of septicemia caused by S. lugdunensis in a 71-year-old man with diarrhea, diabetes mellitus, and peripheral neuropathy.
Aged ; Agglutination Tests ; Diabetes Mellitus ; Diarrhea ; Humans ; Peripheral Nervous System Diseases ; Sepsis* ; Staphylococcus aureus ; Staphylococcus lugdunensis* ; Staphylococcus*