No abstract available.
Staphylococcal Scalded Skin Syndrome*

No abstract available.
Staphylococcal Scalded Skin Syndrome*

No abstract available.
Staphylococcal Scalded Skin Syndrome*

Introduction: Cushing syndrome caused by application of topical corticosteroids is rarely reported. Systemic side effects like suppression of hypothalamic-pituitary-adrenal axis, growth retardation in children and iatrogenic Cushing syndrome can occur even in small doses of potent topical steroids.1 Case Summary: This is a case of a 3-month old female who was referred to our department due to generalized erythema with desquamation. History revealed that the patient had recurrent eczema and the mother applied an over-the-counter medication containing Ketoconazole+Clobetasol 10mg/500mcg per 7-gram cream thrice daily for ten weeks. The estimated topical steroid applied weekly was around 8.5 grams and at time of admission, the patient had been exposed to approximately 50 grams of a potent topical corticosteroid. The patient presented with fever, irritability, and had positive Nikolsky sign thus managed as a case of staphylococcal scalded skin syndrome associated with topical steroid – induced iatrogenic Cushing syndrome. Unfortunately, patient’s condition worsened and with progressive pneumonia, she expired on the 23rd hospital day. The fatal outcome was due to SSSS which was complicated by progressive pneumonia and topical steroid – induced iatrogenic Cushing syndrome. The complex interplay of these features eventually led to sepsis and death. Conclusion This case highlights the risks related to abuse of potent steroid-containing preparations and the importance of education to prevent severe and catastrophic outcomes of injudicious steroid use.
Staphylococcal Scalded Skin Syndrome

Summary Staphylococcal scalded skin syndrome (SSSS) is typically a clinical diagnosis,1 affecting primarily neonates and children. It is characterised by a diffuse skin disorder with tenderness, erythema, large wrinkled superficial blistering, and desquamation caused by the hematogenous dissemination of exotoxin-producing strains of staphylococcus aureus to the skin.4,10 Hospital admission is required for intravenous anti-staphylococcal antibiotic therapy and supportive care. The rarity of SSSS in adults is best explained by the presence of exotoxins neutralizing antibodies and renal elimination of the toxins.2 Two major risk factors are kidney failure and immunosuppression. Therefore, SSSS in adults warrants thorough evaluation.3 Mortality is also greater than 60% in adults, attributed to predisposing comorbid conditions.1,4 One of the mimickers of SSSS is toxic epidermal necrolysis (TEN). Here, we report a successful treatment of SSSS in an adult with recreational drug abuse and incidental liver cirrhosis possibly secondary to hepatitis C viral infection, after careful exclusion of TEN.
Staphylococcal Scalded Skin Syndrome ; Staphylococcal Infections ; Adult

We have presented three cases of Ritter's disease appearing on 11, 14, and 14 days old boys respectively. Staphyloccccus albus was cultured from bullar contents of case 1 and 2, and coaguIase positive staphylococcus from case 3. These patients were successfully treated with systemic and topical antimicrobials.
Humans ; Staphylococcal Scalded Skin Syndrome* ; Staphylococcus

Author reported a case of Ritters disease,, 12 days old, male, who had visited with complaining generalized skin exfoliation. This patient was suffered from erythematous papules, vesicles and bullae on entire body from 7 days ago. He was treated with antibiotics and antibiotic ointment, and was discharged.
Anti-Bacterial Agents ; Humans ; Male ; Skin ; Staphylococcal Scalded Skin Syndrome*

SSSS, developed in a 2-week-old male baby is reported with a review of the literature. The patient was admitted in the early stage of the disease with clinical symptoms and signs of neonatal sepsis. He was started on methicillin from 2nd hospital day which apparently could not prevent the development of generalized desquamation. He was discharged after 2 week of therapy with normal skin.
Humans ; Male ; Methicillin ; Sepsis ; Skin ; Staphylococcal Scalded Skin Syndrome*

We experienced a patient of 13 days old female who was diagnosed with Ritter's disease and reported with brief review of literatures. 3 days before entry, she was suffered from fever, irritability and bullous skin lesions suddenly. And then coagulase-positive staphylococcus aureus was isolated from skin lesions and treated with systemic and local supportive measures.
Female ; Fever ; Humans ; Skin ; Staphylococcal Scalded Skin Syndrome* ; Staphylococcus aureus

The staphylococcal scalded skin syndrome encompasses a spectrum of blistering skin disease that ranges in severity from localized bullous impetigo to a generalized syndrome with cutaneous tenderness, widespread blistering, and superficial denudation or desquamation. This disorder is induced by the exfoliative toxin of Stapylococcus aureus. The intermediate form of staphylococcal scalded skin syndrome may be seen that begin as localized bullous impetigo but evolve to produce regionally limited bullae and denuded areas that may or may not harbor causative microorganism. We report six cases of the intermediate form of staphylococcal scalded skin syndrome in Daejeon for a short time. All cases occurred in children under 5 years of age and showed localized bullae and erythroderma with positive Nikolsky's sign.
Blister ; Child ; Dermatitis, Exfoliative ; Humans ; Impetigo ; Skin Diseases ; Staphylococcal Scalded Skin Syndrome*