1.A protocol for developing a clinical practice guideline for therapeutic drug monitoring of vancomycin.
Zhi-Kang YE ; Ken CHEN ; Yao-Long CHEN ; Suo-di ZHAI
Journal of Huazhong University of Science and Technology (Medical Sciences) 2016;36(3):469-472
This study aimed to develop a guideline for therapeutic drug monitoring (TDM) of vancomycin. We adopted the new guideline definition from the Institute of Medicine (IOM), adhered closely to the six domains of the Appraisal of Guidelines for Research & Evaluation II (AGREE II), and made recommendations based on systematic reviews. We established a Guideline Steering Group and a Guideline Development Group, formulated 12 questions in the form of Population, Intervention, Comparison, Outcome (PICO) and completed a literature search. As far as we know, we will develop the first evidenced-based guideline for vancomycin TDM under the framework of the Grade of Recommendations Assessment, Development and Evaluation (GRADE).
Anti-Bacterial Agents
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administration & dosage
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economics
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pharmacokinetics
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China
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Drug Administration Schedule
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Drug Monitoring
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methods
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Evidence-Based Medicine
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Humans
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Methicillin-Resistant Staphylococcus aureus
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drug effects
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growth & development
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pathogenicity
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Staphylococcal Infections
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drug therapy
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microbiology
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pathology
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Vancomycin
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administration & dosage
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economics
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pharmacokinetics
2.Comparison of effects of badu shengji san on rats with different injured skins.
Yanli LU ; Rong HE ; Bo PENG ; Qihua XU ; Xuhui ZHANG ; Han LIN ; Jianrong LI
China Journal of Chinese Materia Medica 2012;37(6):711-714
OBJECTIVETo compare the effects of Badu Shengji San (BDSJS) on rats with different injured skins.
METHODThe injured and ulcerous skin rat model was established to observe the renal injury induced by BDSJS, a mercury-containing external preparation of Chinese medicine, with urinary N-acetyl-beta-D-glucosaminidase (NAG) and retinol binding protein (RBP) as indicators of renal toxicity.
RESULTCompared to injured skin rats with the same dose, both of high and low-dose ulcerous skin groups showed obvious increase in urinary RBP and kidney coefficients, significant pathomorphological changes in renal tubules and notable epithelial cytopathic effects. In terms of NAG, the high-dose ulcerous skin group saw no significant increase, but the low-dose group recorded sharp rise.
CONCLUSIONThe renal toxicity induced by BDSJS in ulcerous skin rats was more toxic than that in injured skin ones.
Acetylglucosaminidase ; urine ; Animals ; Disease Models, Animal ; Drugs, Chinese Herbal ; pharmacology ; therapeutic use ; toxicity ; Epithelial Cells ; drug effects ; metabolism ; pathology ; Kidney Tubules ; drug effects ; metabolism ; pathology ; Male ; Mercury ; toxicity ; urine ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Retinol-Binding Proteins ; urine ; Skin ; drug effects ; injuries ; Skin Ulcer ; drug therapy ; microbiology ; Staphylococcal Skin Infections ; drug therapy
3.Clinical and Microbiological Characteristics of Six Staphylococcus pettenkoferi Isolates From Blood Samples.
Sholhui PARK ; Hae Sun CHUNG ; Miae LEE
Annals of Laboratory Medicine 2015;35(2):250-253
Coagulase-negative staphylococci (CoNS) are reported to be the leading cause of nosocomial bloodstream infections. Staphylococcus pettenkoferi is a novel member of CoNS that was first isolated from the human blood and bursitis wound in 2002. We have reported cases of 6 S. pettenkoferi strains isolated from blood specimens, including one pathogen and 5 contaminants and catheter colonizers. Brucker Biotyper (Brucker Daltonics, Bremen, Germany) and molecular typing with 16S rRNA gene sequencing confirmed the 6 isolates as S. pettenkoferi. The conventional phenotypic identification of these isolates is not reliable owing to their inconsistent biochemical characteristics. Five of the 6 isolates were found to be resistant to oxacillin, and all isolates showed susceptibility to vancomycin and linezolid. For accurate identification of this novel species, advanced methods by using Brucker Biotyper or molecular methods such as 16S rRNA gene sequencing are required.
Aged
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Aged, 80 and over
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Anti-Bacterial Agents/pharmacology/therapeutic use
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DNA, Bacterial/chemistry/metabolism
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Drug Resistance, Bacterial/drug effects
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Female
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Humans
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Linezolid/pharmacology
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Oxacillin/pharmacology
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Phenotype
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RNA, Ribosomal, 16S/chemistry/genetics/metabolism
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Sequence Analysis, DNA
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Staphylococcal Infections/drug therapy/*microbiology/pathology
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Staphylococcus/drug effects/*genetics/isolation & purification
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Vancomycin/pharmacology