1.Cardioprotective and hepatoprotective effects ofCitrus hystrix peels extract on rats model
Putri Herwandhani ; Nagadi Standie ; Larasati Arum Yonika ; Wulandari Nindi ; Hermawan Adam
Asian Pacific Journal of Tropical Biomedicine 2013;(5):371-375
Objective:To observe the combination effect of doxorubicin andCitrus hystrix(kaffir lime’s) peel ethanolic extract(ChEE) on blood serum alanine aminotransferase(ALT) and aspartate aminotransferase(AST) activity and cardio-hepato-histopathology of femaleSpragueDawley rats. Methods:Doxorubicin andChEE(5 rats per group) were administered in five groups of3 rats each for11 d.GroupI: doxorubicin(dox)4.67 mg/kg body weight;GroupII: dox+ChEE500 mg/kg body weight;GroupIII: dox+ChEE1000 mg/kg body weight;GroupIV:ChEE1000 mg/kg body weight;GroupV: untreated(control).Results:ChEE repaired cardiohistopathology profile of doxorubicin induced cardiotoxicity and hepatotoxicity rats, but did not repair neither hepatohistopathology profile nor reduce serum activity ofALT andAST.Conclusion:ChEE has potency to be developed as cardioprotector agent in chemotherapy.
2.Cardioprotective and hepatoprotective effects of Citrus hystrix peels extract on rats model.
Herwandhani PUTRI ; Standie NAGADI ; Yonika Arum LARASATI ; Nindi WULANDARI ; Adam HERMAWAN ; Agung Endo NUGROHO
Asian Pacific Journal of Tropical Biomedicine 2013;3(5):371-375
OBJECTIVETo observe the combination effect of doxorubicin and Citrus hystrix (kaffir lime's) peel ethanolic extract (ChEE) on blood serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity and cardio-hepato-histopathology of female Sprague Dawley rats.
METHODSDoxorubicin and ChEE (5 rats per group) were administered in five groups of 3 rats each for 11 d. Group I: doxorubicin (dox) 4.67 mg/kg body weight; Group II: dox+ChEE 500 mg/kg body weight; Group III: dox+ChEE 1 000 mg/kg body weight; Group IV: ChEE 1 000 mg/kg body weight; Group V: untreated (control).
RESULTSChEE repaired cardiohistopathology profile of doxorubicin induced cardiotoxicity and hepatotoxicity rats, but did not repair neither hepatohistopathology profile nor reduce serum activity of ALT and AST.
CONCLUSIONChEE has potency to be developed as cardioprotector agent in chemotherapy.
Alanine Transaminase ; blood ; metabolism ; Animals ; Aspartate Aminotransferases ; blood ; metabolism ; Citrus ; chemistry ; Doxorubicin ; pharmacology ; toxicity ; Female ; Heart ; drug effects ; Liver ; drug effects ; metabolism ; pathology ; Myocardium ; metabolism ; pathology ; Plant Extracts ; chemistry ; pharmacology ; Protective Agents ; chemistry ; pharmacology ; Rats
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