Acute Disease ; Adult ; Esotropia ; etiology ; Heroin ; pharmacokinetics ; Heroin Dependence ; rehabilitation ; Humans ; Inactivation, Metabolic ; physiology ; Male

INTRODUCTIONWe report a case in which intravitreal bevacizumab and ranibizumab appeared to have effects in the contralateral, uninjected eye.

CLINICAL PICTUREAn 83-year-old man with macular oedema from branch retinal vein occlusion (BRVO) in the right eye developed neovascular macular degeneration in the left eye. Intravitreal bevacizumab in the left eye improved macular oedema in the right eye temporarily before it recurred. Subsequently, intravitreal ranibizumab in the left eye also resulted in significant reduction of macular oedema in the right eye.

OUTCOMEVision and macular oedema in the right eye improved.

CONCLUSIONBevacizumab and ranibizumab may have therapeutic effects in the uninjected eye, possibly because they may escape from the eye into the systemic circulation.

Aged, 80 and over ; Angiogenesis Inhibitors ; administration & dosage ; therapeutic use ; Antibodies, Monoclonal ; administration & dosage ; therapeutic use ; Antibodies, Monoclonal, Humanized ; Bevacizumab ; Eye ; drug effects ; Humans ; Injections ; Macular Edema ; drug therapy ; etiology ; Male ; Ranibizumab ; Retinal Vein Occlusion ; complications ; Treatment Outcome ; Vitreous Body

INTRODUCTIONWe studied the automated intraretinal segmentation on Fourier domain optical coherence tomography (OCT).

MATERIALS AND METHODSThirty eyes from 30 normal subjects were studied using the RTVue-100. Both radial and raster scan protocol were performed 3 times on each subject. The OCT software performs automated intraretinal segmentation and provides macular thickness measurements.

RESULTSBoth scanning protocols provide reproducible inner, outer and full retinal thickness measurements. The inner, outer and full retinal thicknesses at the foveal central subfield were 67.31 +/- 12.27 microm, 151.67 +/- 12.96 microm, 219.33 +/- 23.19 microm, respectively by the raster scan, and 63.27 +/- 10.37 microm, 147.07 +/- 14.54 microm, 209.89 +/- 21.80 microm, respectively by the radial scan. Macular regional variations were consistently observed. The raster scan protocol gives greater retinal thickness measurements than the radial scan protocol (P <0.05), but the latter yields slightly more reproducible results.

CONCLUSIONSFourier domain OCT equipped with the ability to perform automatic intraretinal segmentation is a convenient tool in studying diseases that may differentially affect various parts of the retina. However, the establishment of normative values can be complicated by different scanning protocols, devices used, methods of data presentation and definition of intraretinal boundaries.

Adult ; Humans ; Image Interpretation, Computer-Assisted ; methods ; Macula Lutea ; anatomy & histology ; Middle Aged ; Reference Values ; Retinal Diseases ; diagnosis ; Tomography, Optical Coherence ; instrumentation ; methods ; Young Adult

INTRODUCTIONThis study reports a case of bevacizumab administered to treat choroidal neovascularisation in a woman later discovered to be pregnant.

CLINICAL PICTUREA 25-year-old pregnant woman developed myopic choroidal neovascularisation in both eyes.

TREATMENTBoth eyes were treated with a total of 3 intravitreal injections of bevacizumab sequentially.

OUTCOMEVision improved significantly in both eyes. There were no evident pregnancy-related complications at 1 year postpartum.

CONCLUSIONAlthough anti-vascular endothelial growth factor (VEGF) therapy did not result in any detectable short-term adverse event in this mother and baby, the potential toxicity of these agents must be carefully considered in pregnant patients.

Adult ; Angiogenesis Inhibitors ; administration & dosage ; pharmacology ; therapeutic use ; Antibodies, Monoclonal ; administration & dosage ; pharmacology ; therapeutic use ; Antibodies, Monoclonal, Humanized ; Bevacizumab ; Choroidal Neovascularization ; drug therapy ; Female ; Humans ; Pregnancy ; Pregnancy Complications ; drug therapy ; Treatment Outcome

INTRODUCTIONTo evaluate whether eyes with longer axial lengths are associated more often with clinically significant cataracts than eyes with shorter axial lengths.

MATERIAL AND METHODSCharts of consecutive patients who underwent cataract surgery by 4 resident surgeons at Los Angeles County Hospital from July 2001 through May 2002 were retrospectively reviewed. Those patients whose axial lengths were significantly different between the 2 eyes (>or=0.30 mm) and who had no pathology (other than cataracts) affecting visual acuity were included in the study. The 2 eyes in each patient were compared for preoperative best-corrected visual acuity and severity of cataracts.

RESULTSThirty-four of 353 patients had interocular axial length differences of at least 0.3 mm and were included in this study. Thirty-one patients had worse, 1 had equal, and 2 had better preoperative vision in the eye with longer versus the shorter axial length. Fourteen patients had more severe, 11 had the same, and 1 had less severe posterior subcapsular cataract (PSC) in the eye with longer axial length. In 8 patients, PSC severity could not be assessed due to obscuring nuclear sclerosis. Twenty-four patients had more severe, 7 patients had equal, and 3 patients had less severe nuclear sclerosis in the longer eye. Overall, longer axial lengths correlated with worse visual acuity, posterior subcapsular cataracts, and nuclear sclerosis. Diabetic status did not affect the correlation. The correlations were stronger with greater axial length asymmetry.

CONCLUSIONSEyes with longer axial lengths have a higher prevalence of cataracts.

Cataract ; etiology ; Diagnostic Techniques, Ophthalmological ; Eye ; pathology ; Humans ; Middle Aged ; Retrospective Studies ; Risk Factors

Aged, 80 and over ; Endophthalmitis ; ethnology ; microbiology ; Female ; Humans ; Sepsis ; complications ; microbiology ; Streptococcal Infections ; complications ; Streptococcus agalactiae ; pathogenicity