1.Effects of different intensities of exercise on folliculogenesis in mice: Which is better?
Fitri Kurnia RAHAYU ; Sri Ratna DWININGSIH ; Ashon SA’ADI ; Lilik HERAWATI
Clinical and Experimental Reproductive Medicine 2021;48(1):43-49
Objective:
Exercise is a risk factor for infertility in women. However, research on the effects of different intensities of exercise on folliculogenesis has not yielded clear results. This study was conducted to analyze the effects of differences in the intensity of exercise on folliculogenesis in mice.
Methods:
Nineteen female BALB/c mice (age, 3–4 months; weight, 13–25 g) were randomly divided into four groups: control, mild exercise, moderate exercise, and high-intensity exercise. The mice in the exercise groups engaged in swimming, with additional loads of 3%, 6%, or 9% of body weight, respectively. There were five swimming sessions per week for 4 weeks, with a gradually increasing duration every week. At the end of the treatment, ovarian extraction was carried out and hematoxylin and eosin staining was performed to identify folliculogenesis.
Results:
There were significant differences in the number of total follicles between the control and moderate-exercise groups (p=0.036) and between the mild- and moderate-exercise groups (p=0.005). The mean number of primary follicles was higher in the moderate-exercise group than in the mild-exercise group (p=0.006). The mean number of secondary, tertiary, and Graafian follicles did not differ significantly among groups (p≥0.05). However, the number of total follicles and follicles in each phase tended to increase after exercise, especially moderate-intensity exercise.
Conclusion
Exercise of different intensities affected the total number of follicles and primary follicles. The number of follicles of each phase tended to increase after exercise. Moderate-intensity exercise had better effects than other intensities of exercise.
2.Development of the SIKRIBO Mobile Health Application for Active Tuberculosis Case Detection in Semarang, Indonesia
Sri Ratna RAHAYU ; Intan ZAINAFREE ; Aufiena Nur Ayu MERZISTYA ; Widya Hary CAHYATI ; Eko FARIDA ; Anggun Dessita WANDASTUTI ; Isbandi ; Nur WAHIDAH ; Muhamad Zakki SAEFURROHIM ; Muhamad Anbiya Nur ISLAM ; Alvy FAJRI ; Mona SUBAGJA
Healthcare Informatics Research 2022;28(4):297-306
Objectives:
This study was conducted to document the development and usability testing of SIKRIBO, a tuberculosis screening application.
Methods:
The SIKRIBO application was developed using design science research methodology, which has six steps: problem identification and motivation, definition of objectives for a solution, product design and development, demonstration, evaluation, and communication. A system usability scale (SUS) questionnaire was used to assess application usability. A total of 20 health cadres (trained community members) and health workers participated in the usability tests.
Results:
Two versions of the application were developed: Android-based for users and web-based for administrators. The Android-based version has four main menus: Find Tuberculosis, Tuberculosis Education, Latest Info, and Profile. The web version is accessible to health workers, as well as the research team and application developers who monitor and manage the user-conducted screenings. The average SUS score was 76 (standard deviation, 8.00).
Conclusions
This application was developed to help detect active tuberculosis cases in the community. The SUS results indicate that the application is highly usable. Thus, SIKRIBO is expected to be broadly implemented to increase tuberculosis case detection through active community participation.