No Abstract available.
Carcinoma, Squamous Cell* ; Head* ; Neck*

Squamous cell carcinoma of the skin arises mostly in the head and neck regions, less frequently in the rest of the body, and rarely in the palms and soles. We report a case of a 6S-year-old man who had had time-sequential development of multiple squamous cell carcinomas on his palms and soles for the past 12 years. These lesions were, in order of time, ulcerative nodules, ulcerative hyperkeratotic papules, hyperkeratotic plaques, maceratied plaques, dark discolored patchs, and hyperkeratotic papules. They were treated by total excision and cryotherpy apart from the last squatnous cell carcinoma in 1994.
Carcinoma, Squamous Cell* ; Head ; Neck ; Skin ; Ulcer

No abstract available.
Carcinoma, Squamous Cell* ; Head* ; Neck* ; Neoplasm Metastasis*

No Abstract available.
Carcinoma, Squamous Cell* ; Genes, Viral* ; Head* ; Neck*

Sarcomatoid carcinoma is a rare type of head and neck cancer that presents both epithelial squamous cell carcinoma and sarcomatous features. There is much debate on pathogenesis, clinical behavior, therapeutic options and prognostic factors for this tumor. Treatment is similar for squamous cell carcinoma with respect to the state, location and size of the tumor. We report a case of sarcomatoid carcinoma on larynx, which was treated by surgical excision and postoperative radiotherapy. The relevant literature is briefly reviewed.
Carcinoma, Squamous Cell ; Head and Neck Neoplasms ; Larynx

Methyltransferase like 13 (METTL13), a kind of methyltransferase, is implicated in protein binding and synthesis. The upregulation of METTL13 has been reported in a variety of tumors. However, little was known about its potential function in head and neck squamous cell carcinoma (HNSCC) so far. In this study, we found that METTL13 was significantly upregulated in HNSCC at both mRNA and protein level. Increased METTL13 was negatively associated with clinical prognosis. And METTL13 markedly affected HNSCC cellular phenotypes in vivo and vitro. Further mechanism study revealed that METTL13 could regulate EMT signaling pathway by mediating enhancing translation efficiency of Snail, the key transcription factor in EMT, hence regulating the progression of EMT. Furthermore, Snail was verified to mediate METTL13-induced HNSCC cell malignant phenotypes. Altogether, our study had revealed the oncogenic role of METTL13 in HNSCC, and provided a potential therapeutic strategy.
Head and Neck Neoplasms ; Humans ; Squamous Cell Carcinoma of Head and Neck/genetics*

Humans ; Squamous Cell Carcinoma of Head and Neck ; Neoadjuvant Therapy ; Head and Neck Neoplasms ; Carcinoma, Squamous Cell/pathology* ; Immunotherapy

Humans ; Squamous Cell Carcinoma of Head and Neck ; Tumor Microenvironment ; Carcinoma, Squamous Cell/pathology* ; Head and Neck Neoplasms

Ever since human papillomavirus (HPV) has known to be associated with head and neck cancer, there have been many studies investigating the role of HPV as its causative factor. The most important thing among studies for HPV is to obtain HPV from cancer tissue and find out whether the obtained HPV is related to the development of cancer. However, until now, there has been no standardized method in diagnosing HPV infection. The various detecting methods for HPV and difference in sensitivity among experimental methods are one of the reasons for the controversy over the role of HPV. In this review, we present the advantages and disadvantages of HPV detection methods those are currently used and suggest standardized methods that may be used to detect HPV in head and neck cancer in the future.
Carcinoma, Squamous Cell ; Head ; Head and Neck Neoplasms ; Humans

PURPOSE: The purpose of this study was to analyze the relationship between apoptotic index and clinicopathological findings in laryngeal squamous cell carcinomas. MATERIALS AND METHODS: Fourty-one cases of laryngeal squamous cell carcinomas were analyzed for the detection of apoptotic bodies by in situ hybridization. RESULTS: The average apoptotic index was 9.38+/-2.89. The apoptotic indices were 11.26+/-1.86, 8.17+/-2.55, and 4.32+/-2.41 in well differentiated, moderately differentiated and poorly differentiated carcinoma, respectively. The histopathological differences and apoptotic index were statistically significant(p<0.05). But there was no relationship between apoptotic index and T stage, nodal status, recurrence and treatment results. CONCLUSION: The apoptotic index was only related to cellular differentiation. Also these results suggest that the numbers of apoptotic bodies in the tumor tissues can make it possible to presume indirectly the malignant potentiality of the tumor and will help us to understand the biologic behavior of head and neck cancer.
Apoptosis ; Carcinoma, Squamous Cell* ; Head and Neck Neoplasms ; In Situ Hybridization ; Recurrence