No abstract available.
Japan* ; Sporothrix* ; Sporotrichosis*

No abstract available.
Japan* ; Sporothrix* ; Sporotrichosis*

A case of sporotrichosis, developed on left upper eyelid in 2 weeks after double eyelid operation, was presented. Eruptions were distributed along the operation site and similar to pyoderma or keloid. Painless subcutaneous nodule appeared near the lateral angle of eye in 8 months after onset. Sporotrichum schenckii was cultivated from the tissue fluid of the lesion. PAS positive spores were found extra-cellularly and in histiocytes and multi-nucleated giant cells.
Eyelids* ; Giant Cells ; Histiocytes ; Keloid ; Pyoderma ; Spores ; Sporothrix ; Sporotrichosis*

Sporotrichosis is an infection of worldwide distribution caused by the fungal organiam sporotrichum schenckii. The disease is usually of the primary cutaneous variety with involvement of regionaI lymphatics, although dissemination may occur. A case of lymphatic type of Syorotrichosis affecting 33 years old, barber, who has been suffering from painless multiple nodules on right hand 4 forearm, is presented. The skin lesions developed about 3months ago, and increased sise and numbers of the lesion insidiously. Diagnosis was confirmed by characterietic clinical, mycological, histopathological studies He was treated with potassium iodide and there was markedly improved.
Adult ; Diagnosis ; Forearm ; Hand ; Humans ; Potassium Iodide ; Skin ; Sporothrix ; Sporotrichosis*

The present study was designed to obtain omparative data on in vitro antifungal activities of imidazole derivatives. Minimum inhibitory oncentrations of clotrimazole, miconazole, econazole, ketoconazlole and griseofulvin on 4 strains of Trichophyton mentagrophytes, 3 strains of Trichophyton rubrum, 2 strains of Microsporum canis and ] strain of Sporothriv: schenckii were etermined after 3 week' incubation at room temperature on Sabouraud's dextrose liquid media. In addition, the fungicidal activities of miconazole and econazole were tested against Z'richophyton mentagrophytes and Microsporum canis, using the techniques described by Vanbreuseghern(1967) The results are summarzed as follows: ] In most of the dermatophytes studied, 1 to 10 pg/ml of M1C were detected. Diverse susceptibility pattern was observed among different fungal species, but no or minor variability was noted within the same species. The susceptibility of Z'ri- chophyton rubrum showed at MIC of 0. 01 to 10 pg/ml, T ichophyton mentagro- phyt.es and Mic osporum canis at 0.1 to 10 pg/ml and 0. 1 to 1000 gg/ml respec- tively. The Trichophyton rubrum was the most sensitive. In the susceptibility test of Sporothrix schenckii, the high resistance to clotrimazole and griseofuhin was observed. The fungistatic activities of miconazole, econazole and ketoconazole were observed only at concentrations higher than JpQ pg/ml.
Arthrodermataceae ; Clotrimazole ; Econazole ; Glucose ; Griseofulvin ; Ketoconazole ; Miconazole ; Microsporum ; Sporothrix ; Trichophyton

BACKGROUND: Sporotrichosis is frequently difficult to diagnose because its morphologic appearance may closely resemble mycobacterial infection or noninfectious inflammatory reaction. Sporothrix schenckii may be difficult to identify in histological sections stained with histochemical staining such as haematoxylin and eosin, periodic-acid-Shiff(PAS) and Gomori's-methenamine-silver (GMS). OBJECTIVE: The purpose of this study was to determine whether immunohistochemical staining with a polyclonal anti-Mycobacterium bovis(BCG) antibody, which is known for its interspecies cross-reactivity between microorganisms, is the suitable screening method to detect Sporothrix schenckii of sporotrichosis in skin tissues. METHODS: Thirty sporotrichosis samples of formalin-fixed, paraffin-embedded skin tissues were stained with anti-BCG immunohistochemical stain (anti-BCG stain) and PAS stain. RESULTS: Thirteen cases (43%) of 30 were positive with PAS stain, and 19 cases (63%) were positive with anti-BCG stain. In 24 cases which were positive in fungal culture, 11 were positive in both stains, 1 was positive in PAS stain only, 6 cases were positive in anti-BCG stain only, and 6 were negative in both stains. In 6 cases which were negative in fungal culture, 1 was positive in both stains, 1 was positive in anti-BCG stain, and 4 were negative in both stains. CONCLUSION: Because of its cross-reactivity with fungi as well as its high sensitivity and minimal background staining, the anti-BCG stain can be the useful screening method of detection of S. schenckii in paraffin-embedded specimens of sporotrichosis.
Coloring Agents ; Eosine Yellowish-(YS) ; Fungi ; Mass Screening* ; Skin ; Sporothrix* ; Sporotrichosis

A case of sporotrichosis misdiagnosed as lupus vulgaris was presented. A 56-year-old woman had been to pea sized, nontender pustules and a hypertrophic-scar-like nodule on the right thigh. She denied any trauma before the lesions developed. Histopathologic findings from the lesion showed tuberculosis-like granulomatous changes. And she was diagnosed as lupus vulgaris. She also had pulmonary tuberculosis and had been treated with antituberculous drugs for 1 year. But skin lesions was not cleared. We suspected the lesions as one of deep mycoses and could confirm sporotrichosis by mycologic studies. They showed characteristic gross colonies and microscopic findings of Sporothrix schenckii..
Female ; Humans ; Lupus Vulgaris* ; Middle Aged ; Mycoses ; Peas ; Skin ; Sporothrix ; Sporotrichosis* ; Thigh ; Tuberculosis, Pulmonary

Mold form fungi such as Fusarium, Acremonium, and Sporothrix species are thought to represent contamination or harmless colonization when isolated from immunocompromised patients. More recently, the pathogenic role of these fungi has been clearly established. The role of implantable subcutaneous central catheters as potential portals of entry for mold form fungus has been underestimated. We describe four cases of implantable subcutaneous central catheter- related mold form fungemia in patients with cancer. One patient responded well only after removal of the implantable subcutaneous central catheter, two patients responded after catheter-removal and IV fluconazole but one patient did not in spite of catheter-removal and amphotericin B.
Acremonium ; Amphotericin B ; Catheters ; Central Venous Catheters* ; Colon ; Fluconazole ; Fungemia* ; Fungi ; Fusarium ; Humans ; Immunocompromised Host ; Sporothrix

BACKGROUND: Sporotrichosis is a subacute to chronic, deep fungal infection caused by Sporothrix schenckii and has a wide variety of clinical presentations. Although sporotrichosis is the most common deep fungal infection in Korea, few reports have included a long term investigation and survey of sporotrichosis. OBJECTIVE: We analyzed patients' records for 38 recent years to identify the incidence and changes in clinical findings on sporotrichosis. METHODS: We conducted a retrospective analysis of 71 patients with sporotrichosis for 38 recent years (1968~2005) by reviewing the medical records and making phone calls to patients if needed. RESULTS: The incidence of sporotrichosis is currently on a decreasing trend and incidents were more common for rural residents (43 cases, 60.6%) than urban residents (28 cases, 39.4%). The most frequent occupation of patients was 'farmer' (37 cases, 52%). Seasonally, twenty seven cases (38.0%) occurred in winter (December to February), showing higher incidence than any other season. Lympho-cutaneous type (53 cases, 74.6%) is more common than fixed cutaneous type (18 cases, 25.4%) and the most common site of the initial lesion was left upper extremity. Of 47 patients who had primary lesion on upper extremity, 39 (83%) were of the lympho-cutaneous type, and of 15 patients who had primary lesion on face, 9 (60%) were of the fixed cutaneous type. CONCLUSION: According to this study, some changes in clinical findings and prevalence of sporotrichosis over the study period were noted. Further observation and analysis are required to clarify the meaning of these changes.
Humans ; Incidence ; Korea ; Medical Records ; Occupations ; Prevalence ; Retrospective Studies ; Seasons ; Sporothrix ; Sporotrichosis ; Upper Extremity

We report a case of lymphocutaneous sporotrichosis with unusual clinical features in a 62-year-old male patient, who presented with a painless, well-defined psoriasiform plaque and central ulceration on the dorsam of the right hand which progressively spread into the lymphatics draining area. The fully matared lesions produced a chain of firm. mild prickling subcutaneous nodules on both upper extremities probably due to autoinoculation. The biopsy specimen of the lesion showed hyperkeratosis with chronic granulomatous inflammation and PAS-positive fungal spores in the dermis. Sporothrix schenckii was identified using a fungal culture of tissue specimen. The lesions improved with treatment of a topical antifungal agent and KI solution at the dose of 2 g/day for 1 month, but returned to initial cutaneous manifestation due to the patient failing to the treatment.
Biopsy ; Dermis ; Hand ; Humans ; Inflammation ; Male ; Middle Aged ; Spores, Fungal ; Sporothrix ; Sporotrichosis* ; Ulcer ; Upper Extremity