No abstract available.
Japan* ; Sporothrix* ; Sporotrichosis*

No abstract available.
Japan* ; Sporothrix* ; Sporotrichosis*

The present study was designed to obtain omparative data on in vitro antifungal activities of imidazole derivatives. Minimum inhibitory oncentrations of clotrimazole, miconazole, econazole, ketoconazlole and griseofulvin on 4 strains of Trichophyton mentagrophytes, 3 strains of Trichophyton rubrum, 2 strains of Microsporum canis and ] strain of Sporothriv: schenckii were etermined after 3 week' incubation at room temperature on Sabouraud's dextrose liquid media. In addition, the fungicidal activities of miconazole and econazole were tested against Z'richophyton mentagrophytes and Microsporum canis, using the techniques described by Vanbreuseghern(1967) The results are summarzed as follows: ] In most of the dermatophytes studied, 1 to 10 pg/ml of M1C were detected. Diverse susceptibility pattern was observed among different fungal species, but no or minor variability was noted within the same species. The susceptibility of Z'ri- chophyton rubrum showed at MIC of 0. 01 to 10 pg/ml, T ichophyton mentagro- phyt.es and Mic osporum canis at 0.1 to 10 pg/ml and 0. 1 to 1000 gg/ml respec- tively. The Trichophyton rubrum was the most sensitive. In the susceptibility test of Sporothrix schenckii, the high resistance to clotrimazole and griseofuhin was observed. The fungistatic activities of miconazole, econazole and ketoconazole were observed only at concentrations higher than JpQ pg/ml.
Arthrodermataceae ; Clotrimazole ; Econazole ; Glucose ; Griseofulvin ; Ketoconazole ; Miconazole ; Microsporum ; Sporothrix ; Trichophyton

Sporotrichosis is an infection of worldwide distribution caused by the fungal organiam sporotrichum schenckii. The disease is usually of the primary cutaneous variety with involvement of regionaI lymphatics, although dissemination may occur. A case of lymphatic type of Syorotrichosis affecting 33 years old, barber, who has been suffering from painless multiple nodules on right hand 4 forearm, is presented. The skin lesions developed about 3months ago, and increased sise and numbers of the lesion insidiously. Diagnosis was confirmed by characterietic clinical, mycological, histopathological studies He was treated with potassium iodide and there was markedly improved.
Adult ; Diagnosis ; Forearm ; Hand ; Humans ; Potassium Iodide ; Skin ; Sporothrix ; Sporotrichosis*

A case of sporotrichosis, developed on left upper eyelid in 2 weeks after double eyelid operation, was presented. Eruptions were distributed along the operation site and similar to pyoderma or keloid. Painless subcutaneous nodule appeared near the lateral angle of eye in 8 months after onset. Sporotrichum schenckii was cultivated from the tissue fluid of the lesion. PAS positive spores were found extra-cellularly and in histiocytes and multi-nucleated giant cells.
Eyelids* ; Giant Cells ; Histiocytes ; Keloid ; Pyoderma ; Spores ; Sporothrix ; Sporotrichosis*

Mold form fungi such as Fusarium, Acremonium, and Sporothrix species are thought to represent contamination or harmless colonization when isolated from immunocompromised patients. More recently, the pathogenic role of these fungi has been clearly established. The role of implantable subcutaneous central catheters as potential portals of entry for mold form fungus has been underestimated. We describe four cases of implantable subcutaneous central catheter- related mold form fungemia in patients with cancer. One patient responded well only after removal of the implantable subcutaneous central catheter, two patients responded after catheter-removal and IV fluconazole but one patient did not in spite of catheter-removal and amphotericin B.
Acremonium ; Amphotericin B ; Catheters ; Central Venous Catheters* ; Colon ; Fluconazole ; Fungemia* ; Fungi ; Fusarium ; Humans ; Immunocompromised Host ; Sporothrix

BACKGROUND: Sporotrichosis is a subacute to chronic, deep fungal infection caused by Sporothrix schenckii and has a wide variety of clinical presentations. Although sporotrichosis is the most common deep fungal infection in Korea, few reports have included a long term investigation and survey of sporotrichosis. OBJECTIVE: We analyzed patients' records for 38 recent years to identify the incidence and changes in clinical findings on sporotrichosis. METHODS: We conducted a retrospective analysis of 71 patients with sporotrichosis for 38 recent years (1968~2005) by reviewing the medical records and making phone calls to patients if needed. RESULTS: The incidence of sporotrichosis is currently on a decreasing trend and incidents were more common for rural residents (43 cases, 60.6%) than urban residents (28 cases, 39.4%). The most frequent occupation of patients was 'farmer' (37 cases, 52%). Seasonally, twenty seven cases (38.0%) occurred in winter (December to February), showing higher incidence than any other season. Lympho-cutaneous type (53 cases, 74.6%) is more common than fixed cutaneous type (18 cases, 25.4%) and the most common site of the initial lesion was left upper extremity. Of 47 patients who had primary lesion on upper extremity, 39 (83%) were of the lympho-cutaneous type, and of 15 patients who had primary lesion on face, 9 (60%) were of the fixed cutaneous type. CONCLUSION: According to this study, some changes in clinical findings and prevalence of sporotrichosis over the study period were noted. Further observation and analysis are required to clarify the meaning of these changes.
Humans ; Incidence ; Korea ; Medical Records ; Occupations ; Prevalence ; Retrospective Studies ; Seasons ; Sporothrix ; Sporotrichosis ; Upper Extremity

A case of sporotrichosis misdiagnosed as lupus vulgaris was presented. A 56-year-old woman had been to pea sized, nontender pustules and a hypertrophic-scar-like nodule on the right thigh. She denied any trauma before the lesions developed. Histopathologic findings from the lesion showed tuberculosis-like granulomatous changes. And she was diagnosed as lupus vulgaris. She also had pulmonary tuberculosis and had been treated with antituberculous drugs for 1 year. But skin lesions was not cleared. We suspected the lesions as one of deep mycoses and could confirm sporotrichosis by mycologic studies. They showed characteristic gross colonies and microscopic findings of Sporothrix schenckii..
Female ; Humans ; Lupus Vulgaris* ; Middle Aged ; Mycoses ; Peas ; Skin ; Sporothrix ; Sporotrichosis* ; Thigh ; Tuberculosis, Pulmonary

BACKGROUND: Sporotrichosis is a chronic, deep fungal infection caused by a dimorphic fungus, Sporothrix schenckii. It is widely variable in incidence, distribution and clinical pattern. Clinical manifestations are greatly variable, with important involvement of the skin and the superficial lymphatic system. Although sporotrichosis is the most common deep fungal infection in Korea, few reports have included a long term investigation and survey of sporotrichosis. OBJECTIVE: We investigated patients' records for 42 years to identify the prevalence, epidemiological features and changes in clinical findings on sporotrichosis. METHODS: We carried out a retrospective analysis of 118 patients with sporotrichosis for 42 years (1997~2009) by reviewing the medical records and making phone calls to patients if needed. RESULTS: The incidence of sporotrichosis is on a decreasing tendency at this time and incidents were more common for rural residents (80 cases, 67.8%) than urban residents (38 cases, 32.2%). Lymphocutaneous type (86 cases, 73%) is more common than fixed cutaneous type (32 cases, 27%) and the most frequent occupation of patients was farmer (71 cases, 60%). Seasonally, 42 cases (36%) occurred in winter (December to February), showing higher incidency than any other season. The most common site of the skin lesion was right upper extremity. CONCLUSION: We found considerable changes in prevalence, seasonal distribution and clinical findings of sporotrichosis over 42 years.
Fungi ; Humans ; Incidence ; Korea ; Lymphatic System ; Medical Records ; Occupations ; Prevalence ; Retrospective Studies ; Seasons ; Skin ; Sporothrix ; Sporotrichosis

We report a case of lymphocutaneous sporotrichosis with unusual clinical features in a 62-year-old male patient, who presented with a painless, well-defined psoriasiform plaque and central ulceration on the dorsam of the right hand which progressively spread into the lymphatics draining area. The fully matared lesions produced a chain of firm. mild prickling subcutaneous nodules on both upper extremities probably due to autoinoculation. The biopsy specimen of the lesion showed hyperkeratosis with chronic granulomatous inflammation and PAS-positive fungal spores in the dermis. Sporothrix schenckii was identified using a fungal culture of tissue specimen. The lesions improved with treatment of a topical antifungal agent and KI solution at the dose of 2 g/day for 1 month, but returned to initial cutaneous manifestation due to the patient failing to the treatment.
Biopsy ; Dermis ; Hand ; Humans ; Inflammation ; Male ; Middle Aged ; Spores, Fungal ; Sporothrix ; Sporotrichosis* ; Ulcer ; Upper Extremity