1.Caspase-1 Level in Synovial Fluid Is High in Patients with Spondyloarthropathy but Not in Patients with Gout.
Chang Nam SON ; So Young BANG ; Ji Hae KIM ; Chan Bum CHOI ; Tae Hwan KIM ; Jae Bum JUN
Journal of Korean Medical Science 2013;28(9):1289-1292
Activation of caspase-1 by NALP3 inflammasomes has been shown to be important in initiating acute gouty arthritis. The objectives of this study were to measure the levels of caspase-1 in synovial fluid in gout and various arthritides, and to elucidate the clinical significance of caspase-1 levels in synovial fluid. Caspase-1, IL-1beta, IL-18, and uric acid were measured in synovial fluid from 112 patients with gout and other arthritides, such as rheumatoid arthritis, osteoarthritis, and spondyloarthropathy. Caspase-1 in synovial fluid from patients with crystal-induced arthritis, inflammatory arthritis, osteoarthritis, and spondyloarthropathy was 35.9 +/- 86.7, 49.7 +/- 107.7, 2.1 +/- 7.0, and 152.6 +/- 155.7 pg/mL, respectively. The mean level and the frequency of high levels (> or =125 pg/mL) of caspase-1 in spondyloarthropathy were significantly higher than those in the other arthritides including gout. Caspase-1 was detectible in the synovial fluid of patients with the various arthritides. Contrary to our hypothesis, the caspase-1 level in the synovial fluid of patients with gout was not higher than in that of other arthritides. High levels of caspase-1 may be helpful in differentiating spondyloarthropathy from other arthritides.
Adult
;
Aged
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Arthritis, Rheumatoid/enzymology/metabolism/pathology
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Caspase 1/*analysis
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Female
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Gout/*enzymology/metabolism/pathology
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Humans
;
Interleukin-18/analysis
;
Interleukin-1beta/analysis
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Leukocyte Count
;
Male
;
Middle Aged
;
Osteoarthritis/enzymology/metabolism/pathology
;
Spondylarthropathies/*enzymology/metabolism/pathology
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Synovial Fluid/*enzymology/metabolism
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Uric Acid/analysis