OBJECTIVETo establish rabbit model of scoliosis induced with stable asymmetric lumbar loads.

METHODSScoliosis was induced in 10 two-month-old New Zealand rabbits using 316L stainless steel springs placed between the unilateral transverse processes of L2 and L5. Serial radiographs were documented before and at 1, 4, 8, 9 and 12 weeks after the operation. At weeks, the rabbits were randomly divided into SR group (n=5) with the spring removed and SK group (n=5) without spring removal.

RESULTSAll the rabbits survived the experiment with Cobb angle all greater than 10 degree at the end of the experiment. Significant changes were found in the Cobb angles and kyphotic angles at 1, 4 and 8 weeks after the operation (P<0.05). At 8 weeks, the Cobb angle, the kyphotic angle and the length of the spring were similar between SR and SK groups (P>0.05), and in the 4 weeks following spring removal in SR group, the Cobb angle and the kyphosis decreased significantly compared with those in SK group (P<0.05). Micro-CT showed that the BV/TV of the concave side was greater than that of the convex side. The length of the spring did not show obvious changes during the experiment (P>0.05).

CONCLUSIONSAsymmetric lumbar loading is a convenient, time-saving, and highly reproducible approach for establishing rabbit models of scoliosis.

Animals ; Disease Models, Animal ; Rabbits ; Scoliosis ; physiopathology ; Spine ; pathology

OBJECTIVETo compare the differences in the clinical efficacy on tinnitus between the spinal balancing intervention and the conventional acupuncture.

METHODSThe randomized controlled trial were adopted. One hundred and twenty cases of tinnitus were randomized into a spinal balancing group and a conventional acupuncture group, 60 cases in each one. In the spinal balancing group, the comprehensive therapy of acu-puncture and Tuina was applied to the spine, the Back-shu points, Jiaji (EX-B 2), Tinggong (SI 19), Yifeng (TE 17), Fengchi (GB 20), Yuzhen (BL 9), Tianzhu (BL 10), etc. for the balancing intervention. In the conventional acupuncture group, acupuncture was applied to the local points and the points along the affected meridians. In each group, after 3 sessions of treatment, the degree of tinnitus and the accompanied symptoms were scored and compared before and after treatment. The comprehensive efficacy was assessed.

RESULTSIn the spinal balancing group, the clinical curative rate was 70.0% (42/60) and the total effective rate was 98.3% (59/60), which were significantly better than 45.0% (27/60) and 86.7% (52/60) in the conventional acupuncture group separately (P < 0.01, P < 0.05). After treatment, the degree of tinnitus and the accompanied symptom scores were all reduced in both groups (all P < 0.05), but the improvements in the spinal balancing group were better than those in the conventional acupuncture group (all P < 0.05). In 3-month follow-up visit after treatment, the recurrence rate in the spinal balancing group was lower than that in the conventional acupuncture group [5.1% (3/59) vs 13.5% (7/52)] (P < 0.05).

CONCLUSIONThe spinal balancing intervention therapy relieves the symptoms of the patients with tinnitus remarkably. Its clinical efficacy is superior significantly to that of the conventional acupuncture and the recurrence rate is lower.

Acupuncture Therapy ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Spine ; physiopathology ; Tinnitus ; physiopathology ; therapy ; Treatment Outcome

Biomechanical Phenomena ; Humans ; Motion ; Spinal Diseases ; physiopathology ; surgery ; Spinal Fusion ; Spine ; physiopathology ; surgery

OBJECTIVETo investigate degenerative changes of the intervertebral disc and their impact on spinal flexibility in patients with degenerative lumbar scoliosis (DLS).

METHODSRetrospective analysis of 66 patients (average age 58.4 years, 10 males and 56 females) with DLS was conducted from May 2008 to February 2014. For all patients, pre-operative standing X-ray film, Bending X-ray films and thoracolumbar MRI were taken. Cobb's angle was measured in each X-ray film and intervertebral angle was measured in both standing and Bending X-ray films. All discs were graded according to Pfirrmann degeneration grades on T2 weighted saggital MRI imaging. Statistical analyses were performed to determine the correlation between intervertebral disc degeneration with the whole spine flexibility and segmental flexibility.

RESULTSFor all 66 subjects, the average Cobb's angle of pre-operative and bending X-ray film was 36° ± 13°, 21° ± 11°, respectively. The average flexibility was 45% ± 15% in our study. Totally 268 discs were graded, including gradeI8, II 68, III 83, IV 91, V 18. In the main curve, there was significant correlation between the average degree of disc degeneration and the whole spine flexibility(r = -0.727, P < 0.01). There was significant correlation between the grade of segmental disc degeneration and segmental flexibility (P < 0.01) . The apical intervertebral disc had the most degeneration (P < 0.01) and worst flexibility (P < 0.01) , compared with other discs in the main curve.

CONCLUSIONSThe degree of intervertebral disc degeneration is closely correlated with spinal flexibility in DLS. The more the disc degeneration is, the worse the spinal flexibility becomes.

Female ; Humans ; Intervertebral Disc Degeneration ; physiopathology ; Lumbar Vertebrae ; physiopathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Posture ; physiology ; Retrospective Studies ; Scoliosis ; physiopathology ; Spine ; physiopathology

The purpose of this study is to show the correlation between the range of spinal motion and the severity of chronic lower back pain. The subjects of this study were 40 female patients with chronic lower back pain over a 6 months' duration. The range of spinal and hip joint motion was measured with a electrogoniometer, and the severity of back pain was evaluated with the Rolland's score and Pollard's pain disability index. Results were as follows. There was a correlation between the severity of pain and the range of lumbar lateral flexion, rotation, and extension (p< 0.05). Age, height, weight and body mass index had no correlation with the range of spinal motion. These results suggest that the range of lumbar spinal motion can be used as an objective measure for the evaluation of classifying chronic lower back pain patients and for planning and following their treatment.
Adult ; Back Pain/*physiopathology ; Chronic Disease ; Female ; Human ; Middle Age ; *Range of Motion, Articular ; Rotation ; Spine/*physiopathology ; Support, Non-U.S. Gov't

OBJECTIVETo evaluate the values of surface electromyography (sEMG) in the treatment of adolescent idiophathic scoliosis (AIS) with non-surgical therapy.

METHODSFrom October 2011 to May 2012, the data of 33 patients with AIS underwent traditional spinal balanced therapy were analyzed. There were 14 males and 19 females with an average age of (15.40 +/- 3.01) years,ranging in Cobb angle from 13 degrees to 40 degrees, course of disease more than 3 months. X-rays showed 21 cases were type C and 9 cases were type S. Preoperative and postoperative 6 months, Cobb angle, the ratio of averaged electromyography paramete (AEMG), security of treatment were observed.

RESULTSThirty cases (90.9%) accomplished the treatment and detection. No harmful effects to vital sign was found and no fracture, dislocation, apopsychia, infection of pin hole was found. There was positive correlation between the ratio of AEMG and Cobb angle (P = 0.003). The ratio of AEMG decreased after treatment,and indicated the improvement of myosthenic otherness.

CONCLUSIONsEMG can be used as a objective examination in evaluating difference of muscle electricity activity on both concaved and convex sides for patients of AIS, so it is a qualified objective examination for effectiveness evaluation and assessment aggravation risk, and has great value in clinic.

Adolescent ; Child ; Electromyography ; Humans ; Male ; Musculoskeletal Manipulations ; Postural Balance ; Scoliosis ; diagnosis ; physiopathology ; therapy ; Spine ; physiopathology ; Treatment Outcome ; Young Adult

BACKGROUNDThe cause of the adjacent segment degeneration (ASD) after fusion remains unknown. It is reported that adjacent facet joint stresses increase after anterior cervical discectomy and fusion. This increase of stress rate may lead to tissue injury. Thus far, the load rate of the adjacent segment facet joint after fusion remains unclear.

METHODSSix C2-C7 cadaveric spine specimens were loaded under four motion modes: Flexion, extension, rotation, and lateral bending, with a pure moment using a 6° robot arm combined with an optical motion analysis system. The Tecscan pressure test system was used for testing facet joint pressure.

RESULTSThe contact mode of the facet joints and distributions of the force center during different motions were recorded. The adjacent segment facet joint forces increased faster after fusion, compared with intact conditions. While the magnitude of pressures increased, there was no difference in distribution modes before and after fusion. No pressures were detected during flexion. The average growth velocity during extension was the fastest and was significantly faster than lateral bending.

CONCLUSIONSOne of the reasons for cartilage injury was the increasing stress rate of loading. This implies that ASD after fusion may be related to habitual movement before and after fusion. More and faster extension is disadvantageous for the facet joints and should be reduced as much as possible.

Biomechanical Phenomena ; Humans ; In Vitro Techniques ; Lumbar Vertebrae ; physiopathology ; Range of Motion, Articular ; physiology ; Spinal Fusion ; adverse effects ; Spine ; physiopathology

Local back pain and radiculopathy can be debilitating for sufferers of these conditions. There are a multitude of treatment modalities, ranging from conservative approaches such as bed rest, physical therapy and chiropractic manipulation, to more invasive options such as percutaneous spinal intervention (PSI) and surgery. We present here the techniques employed in the use of minimally invasive, image-guided percutaneous techniques under computed tomography fluoroscopy in our institutions. The inherent high spatial and tissue contrast resolution not only allows ease of trajectory planning in avoiding critical structures, but also allows precision needle placement. Cervical, lumbosacral, and sacroiliac pain can therefore be evaluated and treated both safely and effectively.
Administration, Cutaneous ; Fluoroscopy ; methods ; Humans ; Pain, Intractable ; drug therapy ; Spine ; physiopathology ; Tomography, X-Ray Computed ; methods

OBJECTIVETo investigate whether pinching spine (PS, i.e. , a traditional Chinese manipulative therapy) is beneficial to ameliorating the depressive state (including behavioral deficit, retardative weight gain and decreased sucrose consumption) in a rat model of depression induced by chronic unpredictable stress (CUS) and to explore the candidate mechanism of action.

METHODSPS was performed on rats' spine once daily for 1 week after exposure to CUS. The open-field test, body weight measuring, and sucrose intake test were applied on different dates: before stress (d0), at the end of stress (d21) and after PS treatment (d28), respectively. Then the rats' hippocampuses were performed genome-wide microarray analysis, and the expression levels of several genes were evaluated by real-time polymerase chain reaction (PCR).

RESULTSExposure to CUS resulted in decreases of behavioral activity and sucrose consumption, which were reversed significantly after PS treatment. The expression of several genes relevant to energy metabolism, anti-oxidation, and olfactory receptor, etc., were down-regulated, while the expression of those relevant to hemostasis, immunity-inflammation, and restriction of activities and ingestion, etc., were up-regulated in hippocampuses of rats exposed to CUS. PS treatment significantly inverted these changes. Furthermore, increase or decrease in gene expression evaluated by realtime PCR was concordant with up-regulated or down-regulated expression evaluated by microarray analysis.

CONCLUSIONPS showed a potential antidepressant-like effect, of which the action mechanism might be due to gene expression regulation in hippocampus.

Animals ; Depression ; therapy ; Male ; Medicine, Chinese Traditional ; Musculoskeletal Manipulations ; Rats ; Rats, Sprague-Dawley ; Spine ; physiopathology

Spinal "Gucuofeng" mainly is considered as abnormalities of joint function. Manipulative maneuver have obviously effect in adjustment of spinal "Gucuofeng", and the technical key point is utilization of principle of lever to achieve safe, effective and labor-saving purpose. After clinical practice, the general principle of manipulative maneuver in adjustment of spinal "Gucuofeng" can be summed up as pull stretch traction, first-induced instability, reverse adjustment,withdraw along situation.
Adaptation, Psychological ; Exercise Therapy ; Humans ; Low Back Pain ; surgery ; Manipulation, Spinal ; methods ; Social Adjustment ; Spine ; physiopathology