Antineoplastic Agents ; pharmacology ; Bile ; physiology ; Bile Duct Neoplasms ; metabolism ; pathology ; Bile Ducts, Intrahepatic ; Celecoxib ; Cell Division ; drug effects ; Cell Line, Tumor ; Cholangiocarcinoma ; metabolism ; pathology ; Cyclooxygenase 2 ; Dinoprostone ; metabolism ; Humans ; Isoenzymes ; biosynthesis ; genetics ; Membrane Proteins ; Prostaglandin-Endoperoxide Synthases ; biosynthesis ; genetics ; Pyrazoles ; RNA, Messenger ; genetics ; Sphincterotomy, Transduodenal ; adverse effects ; Sulfonamides ; pharmacology ; Up-Regulation

We performed ERCP manometry of Sphincter of Oddi(SO) before and after endoscopic sphincterotomy(EST) for evaluation of the effect af EST on the SO. The subjects were postcholecystectomized common bile duct stone patients(n=l2) and EST was performed by major incision. The pressure gradient between common bile duct and duodenum before EST (8.6 + 3.9 mmHg) decreased significantly after EST(2.4 +1.7 mmHg). The length of SO before EST(8.8 + 0.8mmHg) decreased significantly after EST(2.5 + 0.8mm). But in each patient, the pressure gradient between common bile duct and duodenum remained in spite of the major incision. In conclusion, EST alters the function of the sphincter of the Oddi, but does not destroy its all protective function. The positive pressure in the bile duct is preserved in contrast to the absolute loss of pressure following surgical transduodenal sphincteroplasty.
Bile Ducts ; Cholangiopancreatography, Endoscopic Retrograde ; Common Bile Duct ; Duodenum ; Humans ; Manometry* ; Sphincter of Oddi* ; Sphincterotomy, Endoscopic* ; Sphincterotomy, Transhepatic

The management of intrahepatic stones is very difficult and troublesome because of the high incidence of residual stones and complications. A retrospective study was undertaken to evaluate the results of multimodal treatment for 50 patients with intrahepatic stones who had been treated at the Department of Surgery, Pusan National University Hospital from March 1992 to February 1996. The results obtained are as follows: 1) The incidence of the intrahepatic-stones in the 413 gallstone patients was 12.1% (50 cases). The mean age of intrahepatic stone patients was 50.8 years old, and the ratio of males to females was 1.17:1. Of these 50 cases of intrahepatic stones, 23 cases involved the left hepatic duct, 7 cases the right hepatic duct, and 20 cases both ducts. 2) The most frequent drainage procedure was an end to side hepaticocutaneous jejunostomy (28 cases, 56.0%). This include 8 cases involving a combination of surgeries with hepatic resections. The other major treatment modality was a hepatic resection (16 cases, 32.0%). After the initial operations, the overall incidence of residual stones was 28.0%. The treatment by hepatic resection had the lowest incidence of residual stones, 2 cases (12.5%) of 16 patients. In the 20 cases involving a hepaticocutaneous jejunostomy, 5 (25.0%) had residual stones. Among the 5 choledocoduodenostomies, 2 patients (40.0%) had residual stones. Among the 5 transduodenal sphincteroplasties 2 patients (40.0%) had residual stones. For the 4 cases of other operations, 3 had residual stones (75.0%). 3) Of the 14 cases with residual stones, 11 cases underwent an additional lithotomy: 7 cases of a percutaneoustranshepatic cholangiographic lithotomy (PTC-L), and 4 cases of a choledochoscopic lithotomy through an anchored subcutaneous jejunal limb (Endo-L). All the PTC-Ls were successful. However, two Endo-Ls failed, and these patients were later successfully treated with a PTC-L. In conclusion, the data showed a high incidence of intrahepatic stones in gallstone patients. For the treatment of intrahepatic stones, hepatic resections seemed to be the best choice, showing the lowest incidence of residual stones. For the drainage procedure, the hepaticocutaneous jejunostomy seemed to be the best choice for the following reasons: the ease of performing the frequently required lithotomy using a choledochoscope after the initial operation, and the ease of intervening in case of complications during a PTC-L.
Busan ; Combined Modality Therapy* ; Drainage ; Extremities ; Female ; Gallstones ; Hepatic Duct, Common ; Humans ; Incidence ; Jejunostomy ; Male ; Retrospective Studies ; Sphincterotomy, Transhepatic

PURPOSE: Although duodenal perforation following ERCP is very rare compared to other complications, it can result in a fatal outcome. To find the most effective treatment strategy, the cases experienced at our hospital were reviewed and analyzed. METHODS: A retrospective chart review, conducted at our hospital between December 1994 and April 2006, identified 15 periduodenal perforation cases related to ERCP; a rate of 0.53%. The following parameters were reviewed: clinical presentation of perforation, diagnostic methods, time to diagnosis and operation, method of management, length of stay and outcome. RESULTS: Fourteen patients were managed by surgery and one conservatively. Eleven patients were cured without complications, but four suffered from severe complications, and required several re-operations. Two patients (50%) of the re-operated group died. The mean time to surgery was longer in the re-operated than non-re-operated group (34.3+/-12.4 hours vs. 17.2+/-21.7 hours). The causes for the reoperation were an anastomosis blowout in the duodenotomy for transduodenal sphincteroplasty in 3 and duodenal perforation at the site of transduodenal sphincteroplasty in the remaining patient. All re-operated cases had large retroperitoneal fluid collection, as seen on CT scanning, and had been operated on by inexperienced surgeons. CONCLUSION: The early detection is important for the treatment of a duodenal perforation following ERCP. If surgical treatment is needed, it must be performed within 24 hours. Although the type of surgical procedure will depend on the surgeon's preference, a less invasive procedure, such as simple closure & drainage, will be adequate in cases with a delayed diagnosis, a septic condition or an inexperienced surgeon.
Cholangiopancreatography, Endoscopic Retrograde* ; Delayed Diagnosis ; Diagnosis ; Drainage ; Fatal Outcome ; Humans ; Length of Stay ; Reoperation ; Retrospective Studies ; Sphincterotomy, Transhepatic ; Tomography, X-Ray Computed

A choledochocele is a cyst like herniation of the intramural segment of the distal common bile duct protruding into the duodenal lumen. It is controversial whether this disease entity represents a type III variation of a choledochal cyst or an acquired lesion due to a calculus, papillitis or sphincter of Oddi dysfunction. The choledochocele is the rarest form of choledochal cysts and represents only 1.4-5.0% of all choledochal cysts. The diagnosis of choledochocele can be confirmed with certainly using a cholangiography. During a side viewing duodenoscopy followed by retrograde cholangiopancreatography, the mucosa appears normal but the papilla may be larger than usual. When probing the choledochocele with a cannulating catheter, its surface may be appear to be soft and compressible, similar to the pillow sign. After contrast dye is instilled into the bile duct, a round, cyst-like contrast filled structure can be identified adjacent to the terminatian of the common bile duct and an air halo sign may be visible around it. The established treatment of choledochocele is surgical resection of the cyst with anastomosis of the common bile duct to the small intestine, but transduodenal sphincteroplasty or endoscopic sphincterotomy has been advocated as an alternative to excision because of the very low risk of malignant degeneration, operative complications and morbidity. The choice of therapy for the patients with symptomatic choledochchocele is to establish effective drainage of the common bile duct and pancreatic duct. The objective can be achieved using an endoscopic sphincterotomy or transduodenal sphinateroplasy. It has been determined in recent years that endoscopic sphincterotomy is v effective and often followed by a positive prognosis. We report two patients with reicurrent pancreatitis and the common bile duct dilatation secondary to a choledochoce]e, who were treated effectively by endoscopic sphincterotomy.
Bile Ducts ; Calculi ; Catheters ; Cholangiography ; Choledochal Cyst* ; Common Bile Duct ; Diagnosis ; Dilatation ; Drainage ; Duodenoscopy ; Humans ; Intestine, Small ; Mucous Membrane ; Pancreatic Ducts ; Pancreatitis ; Papilledema ; Prognosis ; Sphincter of Oddi Dysfunction ; Sphincterotomy, Endoscopic* ; Sphincterotomy, Transhepatic

BACKGROUND/AIMS: Diagnostic or thepapeutic endoscopic retrograde cholangiopancreatography (ERCP) is the mainstream for the pancreaticobiliary disease. However, the ERCP related complications are serious and sometimes fatal to the patients. We have reviewed our experiences of the operative management for the ERCP injury. METHODS: Medical records of 13 patients who underwent laparotomic surgical intervention for various ERCP injuries from March 1996 to August 2002 at Department of Surgery, the Catholic University of Korea were reviewed. RESULTS: The age range of the patients was from 28 to 85 years. There were 5 females and 8 males. 6 patients showed the duodenal perforations and 4 patients suffered from bleedings around the ampulla of Vater. One of the 4 bleeding patients had huge expanding submucosal hematomas throughout the entire duodenum. We found massive retroperitoneal extraluminal air density in one patient but we could not find any leakage of the contrast media during the upper gastrointestinal series, however, this patient complained aggravated peritoneal irritation sign, so we explored the abdomen. Most of the patients had free abdominal or retroperitoneal air shadows (n=7) on plain chest or abdominal X-ray. We diagnosed the uncontrolled bleeding from the sphincterotomy site using the gastroduodenal fiberscopes in 3 patients. On the computed tomogaphic images, one patient showed a huge duodenal hematoma, another one had a retroperitoneal fluid collection and another one revealed a retroperitoneal air shadow. One patient showed aggravated pancreatitis on the serial CT scan and finally the patient developed a hemorrhagic necrotizing pancreatitis, then we explored the abdomen and tried peripancreatic drainage but we lost the patient in 19 postoperative day due to sepsis. The other 12 patients survived by the various surgical procedures. For the 6 patients, we performed duodenotomic sphincteroplasty, tube duodenostomy and biliary drainage with T-tube. One patient survived with Whipple's procedure, one patient improved by the pyloric exclusion and one patient cured with the duodenal diverticulization. Other procedures were primary repair of the duodenum, transduodenal sphincteroplasty and just cholecystectomy and T-tube choledochostomy. CONCLUSION: There was tendency to uneventful improvement of patients by the early detection and urgent laparotomic surgical intervention of the ERCP complication.
Abdomen ; Ampulla of Vater ; Cholangiopancreatography, Endoscopic Retrograde* ; Cholecystectomy ; Choledochostomy ; Contrast Media ; Drainage ; Duodenostomy ; Duodenum ; Female ; Hematoma ; Hemorrhage ; Humans ; Korea ; Male ; Medical Records ; Pancreatitis ; Sepsis ; Sphincterotomy, Transhepatic ; Thorax ; Tomography, X-Ray Computed

Inspite of the benign disease process, the management of intrahepatic duct stones is difficult because of complications such as recurrent ascending cholangitis, liver abscess, sepsis, secondary liver cirrhosis, cholangiocarcinoma, and high recurrence rates. Also they are sometimes difficult to remove completely due to their anatomical locations. The principles of their surgical management are composed of complete removal of the stone and prevention of biliary stasis. The commonly used biliary drainage procedures are transduodenal sphincteroplasty, choledochoduodenostomy, and Roux-en-Y choledochojejunostomy. The results of biliary drainage procedures in 82 patients at the Department of Surgery, Taejon St. Mary's Hospital, from January 1985 through December 1994 were reviewed, including a follow-up study. The incidence of biliary drainage procedures, including hepatic resections, was 18.9% of the 433 patients operated on for cholelithiasis. The male- to- female ratio was 1 : 1.5; the sixth decade was the most common age. The common clinical symptoms and physical signs were right upper quadrant and epigastric pain and tenderness (89.0%), jaundice (56%), and fever and chills (47.4%). Fifty-six percent of the cases involved the first incidence of a biliary operation, 34.1% a second incidence, and 9.7% a third. The biliary stones were located at only the intrahepatic area (31.7%), both the intrahepatic and the extrahepatic areas (35.3%), or both the gall bladder and the extrahepatic area (29.0%). Of the intrahepatic stones, the left lobe was involved in 45.5% of the cases, the right lobe in 9%, and both lobes in 45.5%. The indications for biliary drainage procedures were acute obstructive cholangitis (36.5%), recurrent stones (34.1%), biliary dyskinesia (21.9%), and liver abscess (7.3%). The types of biliary drainage procedures were choledochoduodenostomy (43.9%), Roux-en-Y choledochojejunostomy (21.9%), left hepatic lobectomy (14.6%), left lateral hepatic segmentectomy (8.5%), Roux-en-Y hepaticojejunostomy (8.5%), right hepatic lobectomy (1.2%), and transduodenal sphincteroplasty (1.2%). The early postoperative complications were wound infection (24.3%), pulmonary complications (19.5%), anastomosis leakage (2.4%), etc. The operative mortality was 1.2%. The late complications during the follow-up period were recurrent stones (11 cases), ascending cholangitis (8 cases), and liver abscess (5 cases).
Biliary Dyskinesia ; Chills ; Cholangiocarcinoma ; Cholangitis ; Choledochostomy ; Cholelithiasis ; Cholestasis ; Daejeon ; Drainage* ; Female ; Fever ; Follow-Up Studies ; Humans ; Incidence ; Jaundice ; Liver Abscess ; Liver Cirrhosis ; Mastectomy, Segmental ; Mortality ; Postoperative Complications ; Recurrence ; Sepsis ; Sphincterotomy, Transhepatic ; Urinary Bladder ; Wound Infection

Hepatolithiasis is said to exist when stones are present in the right or the left hepatic ducts or their tributaries. Although it is a pathophysiologically benign disease, it causes frequently serious problems-recurrent cholangitis, liver abscess, obstructive jaundice, liver cirrhosis, and sepsis - and has challenged surgeons. Until recently, its fundamental pathogenetic mechanisms have not been elucidated, but bile duct stenosis, bile stasis, and secondary infection are considered as important pathogenetic factors. Therefore, the ultimate goal of the treatment is directed to the correction of these factors. We were retrospectively reviewed 119 cases of patients with hepatolithiasis treated by various surgical methods from Jul. 1989 to Dec. 1996 at the Department of Surgery of Maryknoll Hospital, Pusan. There were 72 women and 47 men, and the mean age was 45.5 years. Thirty-nine patients (32.8%) had previous histories of operations related to biliary stone diseases - cholecystectomy (n=13), T-tube choledocholithotomy (n=21), choledochoduodenostomy (n=9), Roux-en-Y choledochojejunostomy (n=6), and transduodenal sphincteroplasty (n=1). Operative procedures were 24 (20.2%) lithotomy, 60 (50.4%) drainages, and 35 (29.4%) hepatectomies and determined by the location of the stones, the general condition of the patient, and the anatomical change (stenosis or cystic dilatation) in intrahepatic duct. Postoperative complications occurred in 33 (27.7%) patients : wound infection (n=23), atelectasis (n=5), intra-abdominal bile collection (n=3), choledochocutaneous fistula (n=2), hemobilia (n=1), and adhesive ileus (n=1). Residual stones were detected in 39 (32.7%) patients by T-tube cholangiography, ultrasonography, computed tomography. The instances of residual stones was the lowest (17.1%) for hepatectomy compared to 45.8% for a lithotomy and 39.3% for a drainage. The follow-up study showed symptom improvement in 91.5% of the patients with a hepatectomy compared to 58.3% for a lithotomy and 71.7% for a drainage which was statistically significant(P<0.05). Since incomplete stone removal in hepatolithiasis and presence of stenosis in intrahepatic duct frequently require a repeat operation or other invasive management, the authors conclude that a hepatectomy, as an initial treatment for hepatolithiasis, is a safe, satisfactory treatment where possible.
Adhesives ; Bile ; Bile Ducts ; Busan ; Cholangiography ; Cholangitis ; Cholecystectomy ; Choledochostomy ; Coinfection ; Constriction, Pathologic ; Drainage ; Female ; Fistula ; Follow-Up Studies ; Hemobilia ; Hepatectomy ; Hepatic Duct, Common ; Humans ; Ileus ; Jaundice, Obstructive ; Liver Abscess ; Liver Cirrhosis ; Male ; Postoperative Complications ; Pulmonary Atelectasis ; Retrospective Studies ; Sepsis ; Sphincterotomy, Transhepatic ; Surgical Procedures, Operative ; Ultrasonography ; Wound Infection