No abstract available.
Humans ; Infant, Newborn* ; Osmolar Concentration* ; Specific Gravity*

Biological monitoring for exposures permits estimation of organ doses or body burdens from exposures through all relevant portals of entry. Biological monitoring data may be used to estimate environmental concentrations when the latter cannot be measured directly. Biological indices are usually surrogates for the concentration of a chemical or its metabolites or its effect at the true receptors. Mercury concentration in urine has-been most-coinmoialy-recommended as a biological exposure index of mercury. For data based on urine analysis, variation in urine volume is the most significant. The urinary concentration related to excretion of the solute provides some correction for fluctuation of urine output. Sampling time must be carefully observed because distribution and elimination of a chemical are kinetic events. This study has evaluated mercury concentration in spot urine compared to the results of 24 hour collected urine by the adjustment methods (specif ic gravity, creatinine) and sampling time. The subjects were 43 workers who had been exposed to the metallic mercury. The results were as follows: 1. The correlation coefficients between mercury concentration in 24 hour urine and that in spot urine were 0.639-0.715 and were not different by adjustment methods. 2. In the high exposure group who were over lOOug/1 of urinary mercury, the correlation coefficients between mercury concentration in 24 hour urine and that in spot urine were 0. 687-0.824 and were not different by adjustment methods. 3. Mercury concentration in spot urine were very variable by sampling time or exposure time. The correlation coefficients between mercury concentration in 24 hour urine and that in spot urine were most highest as 0.85-0.91 at first voiding urine in the morning, and were 0. 77-0.86 at urine collected within four hours before end of shift. In the biological monitoring to exposure of mercury, sampling of spot urine were most proper at first voiding urine in the morning, and then at urine collected within four hours before end of shift. But the adjustment methods of specific gravity and creatinine were no difference of the results.
Body Burden ; Creatinine ; Environmental Monitoring* ; Gravitation ; Specific Gravity

No abstract available.
Child* ; Humans ; Infant, Newborn* ; Osmolar Concentration* ; Specific Gravity*

BACKGROUND: The FDA has approved the storage of frozen red blood cells (RBCs) at -80degrees C for 10 years. After deglycerolization, the RBCs can be stored at 4degrees C for no more than 24 hours, because open systems are currently being used. We evaluated Haemonetics ACP 215, an automated, functionally closed system, for both the glycerolization and deglycerolization processes. METHODS: Thirty packed RBCs that had been glycerolized and stored at -80degrees C for 2 weeks were thawed, deglycerolized and resuspended in AS-3. The RBCs were then stored at 4degrees C for 2 weeks. For the evaluation of the procedure, RBC recovery rate, osmolarity, specific gravity, LDH, K+, Hb-2, 3 DPG, Hb-ATP, and plasma hemoglobin were tested at day 0 and day 14. RESULTS: The recovery rate of RBCs was 83.7+/-2.6% (78.9-88.8%). The Hb ATP and 2, 3-DPG of RBCs were 5.16+/-1.0 mol/g Hb and 10.4+/-2.4 mol/g Hb, respectively, at day 0. The supernatant K+, specific gravity, osmolarity, LDH were 1.3+/-0.6 mmol/L, 1.008+/-0.001, 295.0+/-3.1 mOsm/kgH2O, 175.0+/-39.0 unit/L, respectively. All measurements were acceptable to allow the RBCs deglycerolized on ACP 215 to be stored at 4degrees C for 14 days. The blood cultures were negative at day 0 and day 14. CONCLUSIONS: Haemonetics ACP 215 provides a closed, automated system for RBC glycerolization and deglycerolization. This study showed that the RBCs that were glycerolized and deglycerolized in the automated instrument and stored in AS-3 at 4degrees C for 14 days are of an acceptable quality.
Adenosine Triphosphate ; Cryopreservation* ; Erythrocytes* ; Glycerol ; Osmolar Concentration ; Plasma ; Specific Gravity

BACKGROUND: We aimed to evaluate the performance of the CLINITEK Novus urine chemistry analyzer (Siemens, UK). METHODS: The precision, correlation, and carryover study were performed using two kinds of commercial quality control materials and 40-55 freshly collected patient specimens. We calculated exact and within-1-block agreement, along with kappa agreement, to compare the semi-quantitative results between urine chemistry analyzers. The urine specific gravity taken by a refractometer was compared with the analyzer results. Moreover, we analyzed additional urine specimens for protein to evaluate the agreement of results between those of the CLINITEK Novus and the AU680 analyzers (Beckman Coulter, Japan). RESULTS: The precision study showed acceptable results; within-1-block agreement was 100% in all tested items. The urine chemistry results from the CLNITEK Novus analyzer demonstrated ≥85.1% within-1-block agreements with those of the Uriscan Super, and the kappa test results were ≥0.81. The comparison of specific gravity with manual refractometer showed a good correlation (r=0.991), and the protein comparison with the AU680 analyzer also showed a good correlation (with exact and within-1-block agreements being 75.9% and 100.0%, respectively). The carryover rates were 0% in all tested items, except specific gravity and heavy blood tests. CONCLUSIONS: The CLINITEK Novus analyzer showed good performance in terms of precision, comparison, and carryover in this study. Therefore, the CLINITEK Novus automated urine analysis is expected to be useful for routine urinalysis in a clinical laboratory.
Chemistry* ; Hematologic Tests ; Humans ; Quality Control ; Specific Gravity ; Urinalysis

PURPOSE: The chemoembolization with Lipiodol and doxorubicin hydrochloride is used in patients with hepatocellular carcinoma. What condition is the ideal emulsion of Lipiodol and doxorubicin for excellent anticancer effect? METHOD AND MATERIALS: Microscopic evaluation was performed on the emulsions, which were varied with different specific gravities of doxorubicin solutions, degrees in mixing of the emulsion, and amount of Lipiodol. RESULT: 1. Maximal amount of doxorubicin solution was contained in Lipiodol droplets and the release of doxorubicin from the droplets were delayed, when specific gravity of doxorubicin was equal to that of Lipiodol (SG, 1.28). 2. The optimal therapertic ratio of Lipiodol and doxorubicin was 3:2 at least, as in the emulsion less than 3:2, unmixed free forms of doxorubicin solution were increased. 3. The emulsion mixed by pumping 50--100 times had smaller Lipiodol droplets and contained larger amount of doxorubicin solution in the droplets than by pumping 20 times. CONCLUSION: We recommend the emulsion with specific gravity of doxorubicin equal to Lipiodol (SG. 1.28), the ratio of Lipiodol and doxorubicin closo to 3:2, and the mixture prepased with puming 50--100 times.
Carcinoma, Hepatocellular* ; Doxorubicin ; Emulsions ; Ethiodized Oil ; Humans ; Specific Gravity

BACKGROUND: Vasovagal reaction(VVR) is the most common side reaction of blood donor reactions. The frequencies of VVR have not been yet reported among blood donors in Korea. This study was carried out to investigate VVR among high school students who participated in blood donation. The frequencies of VVR were compared according to sex, experience of blood donation and season. Symptoms, manifesting time and recovery time of VVR were evaluated with the rates and causes of deferral for blood donation. METHODS: 11,607 male and 7,442 female high school students residing in Pusan area who participated in group blood donation were evaluated on their VVR from November, 1996 to July, 1997. RESULTS: The rates of deferral for blood donation were 1.9% and 20.7% in male and female candidates for blood donation, respectively. The most common cause of deferral was low specific gravity of blood in both sexes. Frequencies of VVR were 0.39% and 2.0% in male and female donors, respectively. 2.86% of females and 0.42% of males who gave first blood donation experienced VVR. The frequency of VVR in female donors was higher in summer than in autumn and winter season. 60.5% of male donors and 77.3% of female donors manifested VVR within 5 minutes from blood donation. Dizziness and pale were the most common symptoms in male donors but dizziness, pale and nausea were the most common symtoms in female. 95.4% of male donors and 95.3% of female donors were recoverd from VVR within 10 minutes. CONCLUSION: VVR frequency of female donors was higher than that of male donors and it showed higher in females who gave first blood donation than in any other donors. Because the frequency of VVR in female donors showed higher in summer than in autumn and winter season, attention should be given to group blood donation of female high school students in summer season for the prevention of accidents from blood donation.
Blood Donors* ; Busan ; Dizziness ; Female ; Humans ; Korea ; Male ; Nausea ; Seasons ; Specific Gravity ; Tissue Donors

In order to study about the cause of deleterious effects of mannitol, which is frequently used in severe neurosurgical patients, author had performed a clinical experimental study after infusion of 15% mannitol intravenously. The amount of injection was 1.5 gm to 2.0 gm per kilogram, body weight. Twenty patients who were admitted to the Department of Neurosurgery, Seoul National University Hospital from April, 1976 to August, 1976, were studied. Author had observed changes of pulse rate and blood pressure, urine output and uring specific gravity at 15 minutes, 30 minutes, 45 minutes, 60 minutes, 120 minutes, 180 minutes, 240 minutes, 300 minutes and 360 minutes after completion of mannitol infusion. And author had studied those changes of CBC, electrolyte, serum and urine osmolalities. The results are as following : 1. Blood pressure was decreased 10mmHg in systolic pressure during 30 minutes to one hour after mannitol infusion but pulse rate was not significantly changed. 2. Urine output in 6 hours was 1368cc in average, of which 70 percent was excreted within three hours. 3. Changes of urine specific gravity were raising from one hour and peak value was at 5 hours after mannitol infusion. 4. Serum Na and urine osmolalities were significantly changed after mannitol infusion.
Blood Pressure ; Body Weight ; Heart Rate ; Humans ; Intracranial Pressure* ; Mannitol* ; Neurosurgery ; Osmolar Concentration ; Seoul ; Specific Gravity

BACKGROUND AND OBJECTIVES: A left ventricular mass (LVM) can be used as a prognostic factor in patients with cardiovascular disease, and echocardiographic LVM measurements are most commonly used. We have measured LVM using quantitativel gated myocardial perfusion SPECT (QGS), and compared these results with LVM measured by echocardiography. SUBJECTS AND METHODS: One hundred and sixteen subjects (M/F=66/50, mean age: 58 yrs) underwent both rest QGS with Tc-99m MIBI and echocardiography. On visual interpretation, thirty-six subjects (31%) showed perfusion defects. The myocardial volume was obtained using the AutoQUANT program, and the LVM (LVMSPECT) was calculated by multiplying the volume by the specific gravity of the myocardium. We also measured the echocardiographic LVM (LVMEcho) by the Devereux formula, within one month of the LVMSPECT. RESULTS: The LVMSPECT and LVMEcho were well correlated (r=0.717, p<0.001), but a significant difference was noted between the two values. The mean difference between the LVMSPECT and LVMEcho was 24 g. The LVMEcho was smaller than the LVMSPECT in those subjects with a small LVMEcho, and greater than the LVMSPECT in the subjects with a large LVMEcho. The difference between the LVMEcho and LVMSPECT (LVMEcho-LVMSPECT) was positively correlated with the LVMEcho (r=0.893, p<0.001). CONCLUSION: The LVMs measured by gated myocardial perfusion SPECT and echocardiography were well correlated. But they were significantly different, especially in subjects with large LVMs.
Cardiovascular Diseases ; Echocardiography* ; Humans ; Hypertrophy, Left Ventricular ; Myocardium ; Perfusion* ; Specific Gravity ; Tomography, Emission-Computed, Single-Photon*

PURPOSE: To confirm the effect of water exercise program for treating the gestational edema. METHODS: Both low leg volume, body weight and urine specific gravity were measured in thirty women with gestational edema before and after water exercise program. Fetal heart rate, maternal heart rate and maternal blood pressure were measured before and after water exercise program. RESULTS: Right leg volume was decreased by 286 ml from 1714 to 1428 mL (P<.0001), left leg volume was decreased by 267 mL from 1,644 to 1,377 mL (P<0.0001), and total leg volume was decreased by 553 mL from 3,359 to 2,805 mL (P<0.0001). Urine specific gravity was decreased by 0.0047 from 1.0197 to 1.0150 (P=0.004). Maternal body weight, heart rate, blood pressure, and fetal heart rate were showed no significant change. CONCLUSION: Water exercise program is effective and safe method for treating the gestational edema.
Blood Pressure ; Body Weight ; Edema ; Female ; Heart Rate ; Heart Rate, Fetal ; Humans ; Leg ; Pregnancy ; Specific Gravity