1.Pediatric vulvar squamous cell carcinoma in a liver transplantation recipient: a case report.
Na Rae KIM ; Soyi LIM ; Hyun Yee CHO
Journal of Gynecologic Oncology 2011;22(3):207-210
Here we report the first Korean case of a girl who developed noninvasive squamous cell carcinoma of the vulva at the age of 16 years. She was taking tacrolimus, an immunosuppressive agent, after living-related liver transplantation. The vulvar masses were microscopically proved as vulvar intraepithelial neoplasm II and III, even squamous cell carcinoma in situ. Human papillomavirus subtypes (69 and 73) and human papillomavirus types (66, 70, 73, and 43) were detected in the vulvar mass and the cervicovaginal smear, respectively. The outcome of liver transplantation for children has been markedly improved during the last several decades. However, the present case highlights the need to perform periodic genital examinations for the adolescents after liver transplantation. In addition to the high risk and probable high subtypes, uncommonly found human papillomavirus subtypes were extracted from her vulvar cancer. The present case is the first to show the possible relationship between previously unknown and uncommon human papillomavirus subtypes and pediatric post-transplant vulvar squamous cell carcinoma. More attention should be paid to the vulvar and cervical surveillance of pediatric transplant recipients by both medical specialists and general physicians.
Adolescent
;
Carcinoma in Situ
;
Carcinoma, Squamous Cell
;
Child
;
Humans
;
Liver
;
Liver Transplantation
;
Specialization
;
Tacrolimus
;
Vulva
;
Vulvar Neoplasms
2.Sclerosing Sromal Tumor of the Ovary in Postmenopausal Women: A Report of Two Cases.
Chae Min LEE ; Soyi LIM ; Hyun Yi CHO ; Ji Sung LEE ; Jin Woo SHIN
Journal of Menopausal Medicine 2015;21(2):115-119
Sclerosing stromal tumor (SST) was first delineated as a distinct ovarian sex cord stromal tumor in 1973 by Chalvardjian and Scully. It is a benign neoplasm, distinguished from other ovarian stromal tumors by the production of collagen and a pseudolobular pattern, and it tends to occur in the second and third decades of life in diagnosed patients. We discovered two rare cases of SST in post-menopausal women which are the topic of this report. These case studies are accompanied by a brief review of the literature.
Collagen
;
Female
;
Humans
;
Menopause
;
Ovarian Neoplasms
;
Ovary*
;
Sex Cord-Gonadal Stromal Tumors
3.Use of a cognitive computing system for treatment of cervical cancer.
Journal of Gynecologic Oncology 2017;28(5):e67-
No abstract available.
Uterine Cervical Neoplasms*
4.Primary Lung Adenocarcinoma Metastasis to the Vagina: A Case Report.
Seung Yeon HA ; Sanghui PARK ; Eun Kyung CHO ; Soyi LIM ; Jung Suk AN
Journal of Lung Cancer 2009;8(2):111-113
Lung cancer is a malignant tumor that is often fatal. Vaginal metastasis of pulmonary adenocarcinoma is very rare. To the best of our knowledge, this is the second such report worldwide and the first one from Korea. A 67-year-old woman presented with cough, excessive sputum and dyspnea that she had sufferd with for the past one year and she had a palpable lesion in the vagina. Chest CT showed diffuse bronchial wall thickening involving the left main bronchus, the left upper lobar bronchus and the lingular divisional bronchus of the left upper lobe. There were multiple, various sized nodules in both lungs, of which the largest one measured about 1.0 cm in diameter. Both lung and vaginal biopsies were performed and the masses were diagnosed as adenocarcinoma. Immunohistochemically, the tumor cells were positive for cytokeratin 7 and TTF-1, but they were negative for cytokeratin 20. We present this case of primary lung adenocarcinoma metastasis to the vagina.
Adenocarcinoma
;
Aged
;
Biopsy
;
Bronchi
;
Cough
;
Dyspnea
;
Female
;
Humans
;
Keratin-20
;
Keratin-7
;
Korea
;
Lung
;
Lung Neoplasms
;
Neoplasm Metastasis
;
Sputum
;
Thorax
;
Vagina
5.The influence of number of high risk factors on clinical outcomes in patients with early-stage cervical cancer after radical hysterectomy and adjuvant chemoradiation.
Soyi LIM ; Seok Ho LEE ; Kwang Beom LEE ; Chan Yong PARK
Obstetrics & Gynecology Science 2016;59(3):184-191
OBJECTIVE: The purpose of this study was to evaluate the prognosis according to the number of high risk factors in patients with high risk factors after radical hysterectomy and adjuvant chemoradiation therapy for early stage cervical cancer. METHODS: Clinicopathological variables and clinical outcomes of patients with FIGO (International Federation of Gynecology and Obstetrics) stage IB1 to IIA cervical cancer who had one or more high risk factors after radical hysterectomy and adjuvant chemoradiation therapy were retrospectively analyzed. Patients were divided into two groups according to the number of high risk factors (group 1, single high risk factor; group 2, two or more high risk factors). RESULTS: A total of 93 patients were enrolled in the present study. Forty nine out of 93 (52.7%) patients had a single high risk factor, and 44 (47.3%) had two or more high risk factors. Statistically significant differences in stage and stromal invasion were observed between group 1 and group 2. However, age, histology, tumor size, and lymphovascular space invasion did not differ significantly between the groups. Distant recurrence occurred more frequently in group 2, and the probability of recurrence and death was higher in group 2. CONCLUSION: Patients with two or more high risk factors had worse prognosis in early stage cervical cancer. For these patients, consideration of new strategies to improve survival may be worthwhile. Conduct of further clinical trials is warranted for development of adjuvant treatment strategies individualized to each risk group.
Gynecology
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Humans
;
Hysterectomy*
;
Prognosis
;
Recurrence
;
Retrospective Studies
;
Risk Factors*
;
Uterine Cervical Neoplasms*
6.Peritoneal and Nodal Gliomatosis with Endometriosis, Accompanied with Ovarian Immature Teratoma: A Case Study and Literature Review.
Na Rae KIM ; Soyi LIM ; Juhyeon JEONG ; Hyun Yee CHO
Korean Journal of Pathology 2013;47(6):587-591
Gliomatosis peritonei (GP) indicates the peritoneal implantation of mature neuroglial tissue and is usually accompanied by ovarian mature or immature teratoma. Here, we report a case of ovarian immature teratoma associated with gliomatosis involving the peritoneum, lymph nodes and Douglas' pouch, where gliomatosis coexisted with endometriosis. As far as we know, only seven cases of GP have been reported as coexisting with endometriosis. Eight cases with mature glial tissue in the lymph nodes, i.e., nodal gliomatosis, have been published either in association with GP or in its absence. Metaplasia of pluripotent coelomic stem cells has been suggested to be responsible for the pathogenesis of endometriosis and GP rather than implantation metastases of ovarian teratomatous tumor with varying maturation. This theory is also applied to GP independently of ovarian teratomatous tumors. To the best of our knowledge, nodal gliomatosis coexisting with GP and also involving endometriosis has not yet been reported.
Douglas' Pouch
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Endometriosis*
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Female
;
Lymph Nodes
;
Metaplasia
;
Neoplasm Metastasis
;
Ovary
;
Peritoneum
;
Stem Cells
;
Teratoma*
7.Erratum to: Sclerosing Stromal Tumor of the Ovary in Postmenopausal Women: A Report of Two Cases.
Chae Min LEE ; Soyi LIM ; Hyun Yi CHO ; Ji Sung LEE ; Jin Woo SHIN
Journal of Menopausal Medicine 2015;21(3):175-175
In this article, on page 115, the title has been spelled incorrectly in this article.
8.A Clinical Analysis of Brain Metastasis in Gynecologic Cancer: A Retrospective Multi-institute Analysis.
Young Zoon KIM ; Jae Hyun KWON ; Soyi LIM
Journal of Korean Medical Science 2015;30(1):66-73
This study analyzes the clinical characteristics of the brain metastasis (BM) of gynecologic cancer based on the type of cancer. In addition, the study examines the factors influencing the survival. Total 61 BM patients of gynecologic cancer were analyzed retrospectively from January 2000 to December 2012 in terms of clinical and radiological characteristics by using medical and radiological records from three university hospitals. There were 19 (31.1%) uterine cancers, 32 (52.5%) ovarian cancers, and 10 (16.4%) cervical cancers. The mean interval to BM was 25.4 months (21.6 months in ovarian cancer, 27.8 months in uterine cancer, and 33.1 months in cervical cancer). The mean survival from BM was 16.7 months (14.1 months in ovarian cancer, 23.3 months in uterine cancer, and 8.8 months in cervical cancer). According to a multivariate analysis of factors influencing survival, type of primary cancer, Karnofsky performance score, status of primary cancer, recursive partitioning analysis class, and treatment modality, particularly combined therapies, were significantly related to the overall survival. These results suggest that, in addition to traditional prognostic factors in BM, multiple treatment methods such as neurosurgery and combined chemoradiotherapy may play an important role in prolonging the survival for BM patients of gynecologic cancer.
Adult
;
Aged
;
Brain/*pathology
;
Brain Neoplasms/*mortality/*secondary/therapy
;
Chemoradiotherapy
;
Female
;
Genital Neoplasms, Female/*mortality/pathology/therapy
;
Humans
;
Middle Aged
;
Multivariate Analysis
;
Ovarian Neoplasms/mortality/pathology/therapy
;
Prognosis
;
Retrospective Studies
;
Uterine Cervical Neoplasms/mortality/pathology/therapy
;
Uterine Neoplasms/mortality/pathology/therapy
;
Young Adult
9.Retained placenta accreta after a first-trimester abortion manifesting as an uterine mass.
Soyi LIM ; Seung Yeon HA ; Kwang Beom LEE ; Ji Sung LEE
Obstetrics & Gynecology Science 2013;56(3):205-207
Placenta accreta during the first trimester of pregnancy is rare. Only a few cases of placenta accreta manifesting as a uterine mass have been published. Most patients with placenta accreta present with vaginal bleeding during or after pregnancy. This report describes a patient with placenta accreta that caused vaginal bleeding three years after a first trimester abortion. The patient had regular menstruation for three years after the abortion. Initially endometrial cancer or a uterine myoma with degeneration was suspected. This is the first report of a placenta accreta detected as a uterine mass long after a first trimester abortion with delayed vaginal bleeding.
Endometrial Neoplasms
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Female
;
Humans
;
Menstruation
;
Myoma
;
Placenta Accreta
;
Placenta, Retained
;
Pregnancy
;
Pregnancy Trimester, First
;
Uterine Hemorrhage
;
Uterine Neoplasms
10.A case of successful salvage chemotherapy of recurrent ovarian sertoli-leydig cell tumor.
Soyi LIM ; Na Rae KIM ; Kwang Beom LEE
Obstetrics & Gynecology Science 2013;56(3):198-200
Sertoli-Leydig tumors tend to relapse early and due to their rarity, limited data are available regarding a role of chemotherapy in the management of Sertoli-Leydig cell tumors. We present a case of recurrent ovarian Sertoli-Leydig cell tumor whose salvage treatment was successful with paclitaxel and carboplatin chemotherapy.
Carboplatin
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Female
;
Ovary
;
Paclitaxel
;
Recurrence
;
Salvage Therapy
;
Sertoli-Leydig Cell Tumor