2.Human papilloma virus in oral cancer.
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2016;42(6):327-336
Cervical cancer is the second most prevalent cancer among women, and it arises from cells that originate in the cervix uteri. Among several causes of cervical malignancies, infection with some types of human papilloma virus (HPV) is well known to be the greatest cervical cancer risk factor. Over 150 subtypes of HPV have been identified; more than 40 types of HPVs are typically transmitted through sexual contact and infect the anogenital region and oral cavity. The recently introduced vaccine for HPV infection is effective against certain subtypes of HPV that are associated with cervical cancer, genital warts, and some less common cancers, including oropharyngeal cancer. Two HPV vaccines, quadrivalent and bivalent types that use virus-like particles (VLPs), are currently used in the medical commercial market. While the value of HPV vaccination for oral cancer prevention is still controversial, some evidence supports the possibility that HPV vaccination may be effective in reducing the incidence of oral cancer. This paper reviews HPV-related pathogenesis in cancer, covering HPV structure and classification, trends in worldwide applications of HPV vaccines, effectiveness and complications of HPV vaccination, and the relationship of HPV with oral cancer prevalence.
Cervix Uteri
;
Classification
;
Condylomata Acuminata
;
Female
;
Humans*
;
Incidence
;
Mouth
;
Mouth Neoplasms*
;
Oropharyngeal Neoplasms
;
Papillomaviridae*
;
Papillomavirus Vaccines
;
Prevalence
;
Risk Factors
;
Uterine Cervical Neoplasms
;
Vaccination
3.Peripheral nerve regeneration using a three-dimensionally cultured schwann cell conduit.
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2004;30(1):1-16
The use of artificial nerve conduit containing viable Schwann cells is one of the most promising strategies to repair the peripheral nerve injury. To fabricate an effective nerve conduit whose microstructure and internal environment are more favorable in the nerve regeneration than existing ones, a new three-dimensional Schwann cell culture technique using Matrigel(R) and dorsal root ganglion (DRG) was developed. Nerve conduit of three-dimensionally arranged Schwann cells was fabricated using direct seeding of freshly harvested DRG into a Matrigel(R) filled silicone tube (I.D. 1.98 mm, 14 mm length) and in vitro rafting culture for 2 weeks. The nerve regeneration efficacy of three-dimensionally cultured Schwann cell conduit (3D conduit group, n=6) was assessed using SD rat sciatic nerve defect of 10 mm, and compared with that of silicone conduit filled with Matrigel(R) and Schwann cells prepared from the conventional plain culture method (2D conduit group, n=6). After 12 weeks, sciatic function was evaluated with sciatic function index (SFI) and gait analysis, and histomorphology of nerve conduit and the innervated tissues of sciatic nerve were examined using image analyzer and electromicroscopic methods. The SFI and ankle stance angle (ASA) in the functional evaluation were -60.1+/-13.9, 37.9 degrees +/-5.4 degrees in 3D conduit group (n=5) and -87.0 +/-12.9, 32.2 degrees +/-4.8 degrees in 2D conduit group (n=4), respectively. And the myelinated axon was 44.91%+/-0.13% in 3D conduit group and 13.05%+/-1.95% in 2D conduit group to the sham group. In the TEM study, 3D conduit group showed more abundant myelinated nerve fibers with well organized and thickened extracellular collagen than 2D conduit group, and gastrocnemius muscle and biceps femoris tendon in 3D conduit group were less atrophied and showed decreased fibrosis with less fatty infiltration than 2D conduit group. In conclusion, new three-dimensional Schwann cell culture technique was established, and nerve conduit fabricated using this technique showed much improved nerve regeneration capacity than the silicone tube filled with Matrigel(R) and Schwann cells prepared from the conventional plain culture method.
Animals
;
Ankle
;
Axons
;
Cell Culture Techniques
;
Collagen
;
Diagnosis-Related Groups
;
Fibrosis
;
Gait
;
Ganglia, Spinal
;
Muscle, Skeletal
;
Myelin Sheath
;
Nerve Fibers, Myelinated
;
Nerve Regeneration
;
Peripheral Nerve Injuries
;
Peripheral Nerves*
;
Rats
;
Regeneration*
;
Schwann Cells
;
Sciatic Nerve
;
Silicones
;
Tendons
4.Clinical Observation on the Ureteropelvic Junction Obstruction.
Korean Journal of Urology 1982;23(5):597-602
A clinical Observation was made on the 27 cases of UPJ obstruction of the in-patients in the Department of Urology, Chonnam University Hospital during the period from Sept. 1967 to 1981 and the followings were obtained. 1) The rate of UPJ obstruction accounted for 1.1% of the total in-patients and 21.7% of the total patients with hydronephrosis during the period of 14 years. 2) It is noteworthy that the condition was much more common in the male than the female subject (19 and 8, respectively) and occurred more frequently on the left side (18 and 5, respectively). Bilateral disease was present in 4 cases. 3) The pathological lesions or findings encountered at the UPJ were intrinsic UPJ obstruction in 20 kidneys (64.5%), aberrant vessel in 5 kidneys,. fibrous bands in 3 kidneys, kinks and fibrous bands in 1 kidney and unknown causes in 2 kidneys. 4) The most common presenting symptom was flank pain, affecting 17 cases. Palpable mass was found in 13 cases. Hematuria occurred in 4 cases. Edema was present in 1 case. 5) The degree of hydronephrosis was determined by urography, pathological and operative finding and according to these findings, grade 4 was found in 45.2%, grade 5 in 25.7%, grade 3 in 22.6%, grade 2 in 6.5% of the total kidneys. 6) On laboratory examination, microscopic pyuria was found in 7 cases, microscopic .hematuria in 7 cases, microscopic pyuria and hematuria in 2 cases and BUN was increased in 4 cases. 7) Pyeloplasty was performed in 17 kidneys, primary nephrectomy in 11 kidneys, nephrostomy in 2 kidneys and ureterolysis with nephropexy in 1 kidney.
Edema
;
Female
;
Flank Pain
;
Hematuria
;
Humans
;
Hydronephrosis
;
Jeollanam-do
;
Kidney
;
Male
;
Nephrectomy
;
Pyuria
;
Urography
;
Urology
5.A Clinical Observation on Ureterolithiasis.
Korean Journal of Urology 1982;23(4):502-510
A clinical study was made on 126 cases of ureterolithiasis during the 5 years period from January, 1976 to December, 1980. The following results were obtained. 1. The incidence of the patients with ureterolithiasis was 8.8% of the total inpatients. 2. There were 92 men and 34 women, a ratio of 2.7:1. The ages of the patients ranged from 18 to 72 years. showing the highest incidence in 21 to 50 years (74.6%). 3. The most frequent location of the ureteral calculi when first seen was the lower third of the ureter in 53.7% of the patients. The ureteral calculi were approximately equally frequent on the left and right sides and bilateral ureteral calculi were found in 4.8%. 4. The most common size of the ureteral calculi was 0.7-1.0 cm in the longitudinal diameter in 43 cases (34.1%). 5. The clinical symptoms of ureterolithiasis were flank pain in 94.4%, hematuria in 14.3%, referred pain in 9.5%, nausea and vomiting in 7.9%, frequency in 7.1% and fever with chillness in 7.1%. 6. Microscopic hematuria was found in 68.9%, pyuria in 27.1% and crystalluria in 15.6%. 7. Increased levels of BUN, creatinine, calcium and uric acid in serum were found in 18.4%, 8.3%, 1.2% and 10.3%, respectively. And leukocytosis was found in 25.5%. 8. Excretory urogram revealed mild hydronephrosis in 28.7%, moderate hydronephrosis in 21.8%, marked hydronephrosis in 10.3%. non-visualization in 11.5%, delayed visualization in 13.8% and nephrogram only in 6.9%. 9. Definite past history of urinary calculi was found in 14 cases (11.1%) and average duration of recurrence was 5.5 years. 10. Treatment consisted of surgical intervention in 71.4%, expectant therapy in 17.6%, instrumental manipulation in 2.4% and spontaneous passage in 8.7%. 11. Postoperative complications occurred in 6 cases (6.7%), i.e., a remnant stone with ureterocutaneous urinary leakage in 2 cases, wound infection in 2 cases, ureterocutaneous urinary leakage in 1 case. unimproved uremia in 1 case. 12. The chemical analysis of 42 ureteral calculi showed the mixed type of calcium oxalate and calcium phosphate in 10 cases (23.8%), calcium oxalate in 7 cases (16.7%),calcium phosphate in 6 cases (14.3%), the mixed type of calcium oxalate and calcium phosphate and magnesium phosphate in 6 cases (14.3%), the mixed type of calcium oxalate and calcium phosphate and uric acid in 3 cases (7.1 %). The major components of ureteral calculi were calcium phosphate and calcium oxalate.
Calcium
;
Calcium Oxalate
;
Creatinine
;
Female
;
Fever
;
Flank Pain
;
Hematuria
;
Humans
;
Hydronephrosis
;
Incidence
;
Inpatients
;
Leukocytosis
;
Magnesium
;
Male
;
Nausea
;
Pain, Referred
;
Postoperative Complications
;
Pyuria
;
Recurrence
;
Uremia
;
Ureter
;
Ureteral Calculi
;
Ureterolithiasis*
;
Uric Acid
;
Urinary Calculi
;
Urolithiasis
;
Vomiting
;
Wound Infection
7.Intraoral reinsertion after extracorporeal fixation in condylar fracture
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2021;47(6):476-479
For treatment of mandibular condyle fracture, this article introduces the surgical protocol of intraoral reinsertion after extracorporeal fixation. This efficient, anatomically acceptable, extraoral scar-free, and relatively uncomplicated approach for condylar fracture can be compared with conventional extraoral fixation through various approaches. Clinical step-by-step procedures with a scientific basis were described in this technical strategy note.
9.Clinical Analysis of Traumatic Subdural Hygroma and its Relation with Regional Cerebral Blood Flow Using 99mTc-HMPAO SPECT.
Min Soung LEE ; Bo Yeol MIN ; Soung Min KIM ; Ky Seok CHOI ; Dong Jin YOU ; Meong Su OH ; Chul Hee KIM ; Youn Mo KIM
Journal of Korean Neurosurgical Society 1994;23(8):946-953
Measurement of regional cerebral blood flow with single photon emission computed tomography(SPECT) was performed using 99mTc-HMPAO in 16 patients with traumatic subdural hygroma, and we investigated the relationships between the results and the initial clinical findings and clinical outcomes on 4-month after injury. In patients with complex subdural hygroma, improvement of perfusion on follow up SPECT was correlated with the clinical outcome. But in patients with simple subdural hygroma, the clinical outcomes were good regardless of cerebral perfusion on initial SPECT and cerebral hypoperfusion was improved on follow up SPECT in all patients. These results suggested that associated parenchymal injury, initial perfusion of the frontal cortex, and improvement of perfusion on follow up SPECT were good indicators of clinical outcome. In conclusion, HMPAO-SPECT can be helpful in predicting the prognosis and assessing the effect of surgical treatment in patients with traumatic subdural hygroma.
Follow-Up Studies
;
Humans
;
Perfusion
;
Prognosis
;
Subdural Effusion*
;
Technetium Tc 99m Exametazime*
;
Tomography, Emission-Computed, Single-Photon*